ATE191486T1 - Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste - Google Patents

Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste

Info

Publication number: ATE191486T1
Authority: AT; Austria
Prior art keywords: bradykinin; pseudo; receptor antagonist; bradykinin receptor; compounds
Prior art date: 1993-09-09

Application number

AT94929158T

Other languages

English (en)

Inventor

Donald James Kyle

Babu Joseph Mavunkel

Zhijian Lu

Original Assignee

Scios Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-09

Filing date

1994-09-09

Publication date

2000-04-15

1993-09-09 Priority claimed from US08/118,981 external-priority patent/US5444048A/en

1994-07-28 Priority claimed from US08/281,907 external-priority patent/US5541286A/en

1994-07-28 Priority claimed from US08/281,904 external-priority patent/US5686565A/en

1994-09-09 Application filed by Scios Inc filed Critical Scios Inc

2000-04-15 Application granted granted Critical

2000-04-15 Publication of ATE191486T1 publication Critical patent/ATE191486T1/de

Links

229940122155 Bradykinin receptor antagonist Drugs 0.000 title 1
239000003152 bradykinin antagonist Substances 0.000 title 1
101800004538 Bradykinin Proteins 0.000 abstract 2
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 2
102100035792 Kininogen-1 Human genes 0.000 abstract 2
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
102000010183 Bradykinin receptor Human genes 0.000 abstract 1
108050001736 Bradykinin receptor Proteins 0.000 abstract 1
UYRCOTSOPWOSJK-JXTBTVDRSA-N bradykinin antagonist Chemical class C1C2=CC=CC=C2CC1[C@@H](NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)[C@H]1N(C[C@H](O)C1)C(=O)C1N(CCC1)C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=N)CCCCCCC(=N)N[C@H](CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N1C(CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)NC(C1CC2=CC=CC=C2C1)C(=O)NC(CO)C(=O)N[C@H](C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O)C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(=N)N)C(O)=O UYRCOTSOPWOSJK-JXTBTVDRSA-N 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT94929158T 1993-09-09 1994-09-09 Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste ATE191486T1 (de)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
US11934193A	1993-09-09	1993-09-09
US11855893A	1993-09-09	1993-09-09
US08/118,981 US5444048A (en)	1992-10-08	1993-09-09	Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
US08/118,550 US5552383A (en)	1992-10-08	1993-09-09	Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US28190694A	1994-07-28	1994-07-28
US28190894A	1994-07-28	1994-07-28
US08/281,907 US5541286A (en)	1992-10-08	1994-07-28	Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
US08/281,904 US5686565A (en)	1992-10-08	1994-07-28	Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
PCT/US1994/010128 WO1995007294A1 (en)	1993-09-09	1994-09-09	Pseudo- and non-peptide bradykinin receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE191486T1 true ATE191486T1 (de)	2000-04-15

Family

ID=27574846

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94929158T ATE191486T1 (de)	1993-09-09	1994-09-09	Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste

Country Status (7)

Country	Link
EP (1)	EP0716661B1 (de)
JP (1)	JPH11500100A (de)
AT (1)	ATE191486T1 (de)
CA (1)	CA2171446C (de)
DE (1)	DE69423899T2 (de)
ES (1)	ES2148347T3 (de)
WO (1)	WO1995007294A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100360639B1 (ko) *	1994-03-09	2003-01-30	코르텍, 인크.	N-치환글리신함유브라디키닌길항제펩티드
DE69601765T2 (de) *	1995-09-07	1999-07-08	Oreal	Extrakt von Iridaceen und Zusammensetzungen, die ihn enthalten
FR2746647B1 (fr) *	1996-03-27	1998-05-15	Oreal	Composition apaisante comprenant un extrait d'iridacee
FR2739553B1 (fr) *	1995-10-06	1998-01-02	Oreal	Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
DE19612067A1 (de) *	1996-03-27	1997-10-02	Hoechst Ag	Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
DE19642289A1 (de) *	1996-10-14	1998-04-16	Hoechst Ag	Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit
FR2756566B1 (fr)	1996-12-04	1999-01-08	Fournier Ind & Sante	Peptides agonistes du recepteur b2 de la bradykinine, procede de preparation et utilisation en therapeutique
WO2002024697A1 (en) *	2000-09-25	2002-03-28	Toray Industries, Inc.	Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient
JP4712384B2 (ja)	2002-09-09	2011-06-29	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
JP4861976B2 (ja)	2004-03-11	2012-01-25	アクテリオンファーマシューティカルズリミテッド	インドール−１−イル酢酸誘導体
US7714132B2 (en)	2004-03-11	2010-05-11	Actelion Pharmaceuticals, Ltd.	Tetrahydropyridoindole derivatives
KR101213912B1 (ko)	2004-08-26	2012-12-18	액테리온 파마슈티칼 리미티드	Ｃｒｔｈ2 길항제로서의2-설파닐-벤조이미다졸-1-일-아세틱 애시드 유도체
BRPI0719123A2 (pt) *	2006-09-01	2013-12-17	Cylene Pharmaceuticals Inc	Moduladores de serina-treonina proteína cinase e parp
US8703948B2 (en)	2006-11-28	2014-04-22	Janssen Pharmaceutica Nv	Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
RU2338745C1 (ru) *	2007-03-21	2008-11-20	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
CA2683598C (en)	2007-04-09	2015-11-17	Janssen Pharmaceutica Nv	1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
WO2009120717A2 (en)	2008-03-24	2009-10-01	Medivation Technologies, Inc.	Pyrido [3, 4-b] indoles and methods of use
CN102711467A (zh) *	2009-09-23	2012-10-03	梅迪维新技术公司	吡啶并[3,4-b]吲哚类及使用方法
PH12022553378A1 (en)	2020-06-10	2024-03-25	Univ Leuven Kath	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
AU2022306289A1 (en)	2021-07-09	2024-01-18	Aligos Therapeutics, Inc.	Anti-viral compounds
WO2023043816A1 (en)	2021-09-17	2023-03-23	Aligos Therapeutics, Inc.	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1989009230A1 (en) *	1988-03-25	1989-10-05	Administrators Of The Tulane Educational Fund	Therapeutic peptides
CA2106762C (en) *	1991-04-19	2000-10-10	Donald J. Kyle	Bradykinin antagonist peptides
US5521158A (en) *	1992-10-08	1996-05-28	Scios Nova Inc.	Pseudopeptide bradykinin receptor antagonists

1994
- 1994-09-09 JP JP7508795A patent/JPH11500100A/ja active Pending
- 1994-09-09 WO PCT/US1994/010128 patent/WO1995007294A1/en not_active Ceased
- 1994-09-09 ES ES94929158T patent/ES2148347T3/es not_active Expired - Lifetime
- 1994-09-09 CA CA002171446A patent/CA2171446C/en not_active Expired - Lifetime
- 1994-09-09 DE DE69423899T patent/DE69423899T2/de not_active Expired - Lifetime
- 1994-09-09 AT AT94929158T patent/ATE191486T1/de active
- 1994-09-09 EP EP94929158A patent/EP0716661B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2171446C (en)	2004-11-23
WO1995007294A1 (en)	1995-03-16
EP0716661A1 (de)	1996-06-19
JPH11500100A (ja)	1999-01-06
DE69423899D1 (de)	2000-05-11
CA2171446A1 (en)	1995-03-16
DE69423899T2 (de)	2000-11-09
ES2148347T3 (es)	2000-10-16
EP0716661B1 (de)	2000-04-05

Publication	Publication Date	Title
ATE191486T1 (de)	2000-04-15	Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste
DK0610743T3 (da)	1999-06-07	Immunsuppressive aminoethylen-peptider
AU7581094A (en)	1995-05-04	Alkylsiloxanes as adjuvants for agriculture
ATE210148T1 (de)	2001-12-15	Neuartige opioid-peptide
EP0706657A4 (de)	2002-10-24	Wechselwirkungen von inhibierungsproteinen
ATE223913T1 (de)	2002-09-15	Bicyclische amine als insektizide
AU9065891A (en)	1992-06-25	Novel renin inhibiting peptides
FI890966A7 (fi)	1989-09-03	Fjaederben foer fordon.
DE69025194D1 (de)	1996-03-14	Aminosäure-beta-lyase-enzyminhibitoren als deodorantien
CA2128784A1 (en)	1993-08-05	Large, latent complexes of tgf-beta2 and tgf-beta3
AU6368890A (en)	1991-04-11	Anticoagulant peptides
EP0341607A3 (de)	1991-03-27	Antikoagulierende Peptid-Alkohole
EP0372503A3 (de)	1991-06-12	Antikoagulierende Peptide
AU7254891A (en)	1991-08-05	Renin inhibiting peptides having an alpha-heteroatom amino acid at the p3 position
GR3021660T3 (en)	1997-02-28	Anticoagulant peptides
AU2280895A (en)	1995-11-10	Synthesis n-protected amino acids, especially n-boc-l-propargylglycine by zinc-mediated addition or organic halides to glycine cation equivalent
DE68920715D1 (de)	1995-03-02	Teleskopantennen für Fahrzeuge.
FI935060A0 (fi)	1993-11-16	Kompensaatiojärjestely
FI941118A0 (fi)	1994-03-09	Bentsyyli-imidatsopyridiinijohdannainen angiotensiini II reseptoriantagonistina
AU1779088A (en)	1988-12-22	Guanidine-related compounds comprising a tetraphenylborate ion, process for obtaining these compounds and use of the compounds in peptide synthesis
CA2216856A1 (en)	1996-10-24	Methods of screening for therapeutic agents using novel apoptosis-modulating proteins
DE69623344D1 (de)	2002-10-02	Zufuhrvorrichtung für schlegelmäher
FI935392L (fi)	1993-12-02	Rambalk foer fordon
KR970004621U (ko)	1997-02-19	자동차용 타각기의 안정장치
FIU930016U0 (fi)	1993-01-14	Isolerat kyl/vaermeblock