ES2148347T3 - Antagonistas del receptor de la bradiquinina pseudo y no peptidica. - Google Patents

Antagonistas del receptor de la bradiquinina pseudo y no peptidica.

Info

Publication number
ES2148347T3
ES2148347T3 ES94929158T ES94929158T ES2148347T3 ES 2148347 T3 ES2148347 T3 ES 2148347T3 ES 94929158 T ES94929158 T ES 94929158T ES 94929158 T ES94929158 T ES 94929158T ES 2148347 T3 ES2148347 T3 ES 2148347T3
Authority
ES
Spain
Prior art keywords
bradykinin
bradiquinine
peptidic
pseudo
receptor antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94929158T
Other languages
English (en)
Inventor
Donald James Kyle
Babu Joseph Mavunkel
Zhijian Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scios LLC
Original Assignee
Scios LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/118,981 external-priority patent/US5444048A/en
Priority claimed from US08/281,904 external-priority patent/US5686565A/en
Priority claimed from US08/281,907 external-priority patent/US5541286A/en
Application filed by Scios LLC filed Critical Scios LLC
Application granted granted Critical
Publication of ES2148347T3 publication Critical patent/ES2148347T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

EN LA INVENCION SE PRESENTAN COMPUESTOS ANTAGONISTAS DE LA BRADIQUININA EN DONDE MUCHOS (O TODOS) LOS ENLACES PEPTIDICOS DE BRADIQUININA SE ELIMINAN PARA OBTENER COMPUESTOS QUE COMPITAN ESPECIFICAMENTE CON LA BRADIQUININA PARA ENLAZARSE AL RECEPTOR DE BRADIQUININA. DE MANERA MAS PARTICULAR, LA INVENCION SE REFIERE A COMPUESTOS QUE TIENEN, SEGUN UNA DISPOSICION ESPACIAL APROPIADA, DOS UNIDADES CARGADAS POSITIVAMENTE QUE LINDAN CON UNA UNIDAD ORGANICA HIDROFOBA Y UNA UNIDAD QUE IMITA LA CONFORMACION DE ESPIRAS BETA.
ES94929158T 1993-09-09 1994-09-09 Antagonistas del receptor de la bradiquinina pseudo y no peptidica. Expired - Lifetime ES2148347T3 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11934193A 1993-09-09 1993-09-09
US11855893A 1993-09-09 1993-09-09
US08/118,981 US5444048A (en) 1992-10-08 1993-09-09 Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
US08/118,550 US5552383A (en) 1992-10-08 1993-09-09 Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US28190894A 1994-07-28 1994-07-28
US28190694A 1994-07-28 1994-07-28
US08/281,904 US5686565A (en) 1992-10-08 1994-07-28 Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US08/281,907 US5541286A (en) 1992-10-08 1994-07-28 Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids

Publications (1)

Publication Number Publication Date
ES2148347T3 true ES2148347T3 (es) 2000-10-16

Family

ID=27574846

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94929158T Expired - Lifetime ES2148347T3 (es) 1993-09-09 1994-09-09 Antagonistas del receptor de la bradiquinina pseudo y no peptidica.

Country Status (7)

Country Link
EP (1) EP0716661B1 (es)
JP (1) JPH11500100A (es)
AT (1) ATE191486T1 (es)
CA (1) CA2171446C (es)
DE (1) DE69423899T2 (es)
ES (1) ES2148347T3 (es)
WO (1) WO1995007294A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2184824A1 (en) * 1994-03-09 1995-09-14 Val S. Goodfellow Bradykinin antagonist peptides incorporating n-substituted glycines
ES2132855T3 (es) * 1995-09-07 1999-08-16 Oreal Extracto de iridaceas y composiciones que lo contienen.
FR2746647B1 (fr) * 1996-03-27 1998-05-15 Oreal Composition apaisante comprenant un extrait d'iridacee
FR2739553B1 (fr) * 1995-10-06 1998-01-02 Oreal Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
DE19612067A1 (de) * 1996-03-27 1997-10-02 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
DE19642289A1 (de) * 1996-10-14 1998-04-16 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit
FR2756566B1 (fr) * 1996-12-04 1999-01-08 Fournier Ind & Sante Peptides agonistes du recepteur b2 de la bradykinine, procede de preparation et utilisation en therapeutique
DE60122555T2 (de) 2000-09-25 2007-07-12 Toray Industries, Inc. Spiroverbindungen und diese als wirkstoff enthaltende adhäsionsmolekülinhibitoren
NZ538307A (en) 2002-09-09 2008-04-30 Janssen Pharmaceutica Nv Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
AU2005229356B2 (en) * 2004-03-11 2011-06-09 Idorsia Pharmaceuticals Ltd Tetrahydropyridoindole derivatives
CA2558545C (en) 2004-03-11 2012-10-16 Actelion Pharmaceuticals Ltd Indol-1-yl-acetic acid derivatives
JP5063348B2 (ja) 2004-08-26 2012-10-31 アクテリオン ファーマシューティカルズ リミテッド ２−スルファニル−ベンゾイミダゾール−１−イル−酢酸誘導体
US7956064B2 (en) * 2006-09-01 2011-06-07 Cylene Pharmaceuticals, Inc. Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators
CN103202840B (zh) 2006-11-28 2015-02-11 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
RU2338745C1 (ru) * 2007-03-21 2008-11-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
JP5490677B2 (ja) 2007-04-09 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
TWI443098B (zh) 2008-03-24 2014-07-01 Medivation Technologies Inc 吡啶并〔３，４－ｂ〕吲哚及使用方法
EP2480079A4 (en) * 2009-09-23 2015-04-08 Medivation Technologies Inc PYRIDO- (3,4-B-) INDOLE AND USE METHOD THEREFOR
PH12022553378A1 (en) 2020-06-10 2024-03-25 Univ Leuven Kath Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
JP2024525589A (ja) 2021-07-09 2024-07-12 アリゴス セラピューティクス インコーポレイテッド 抗ウイルス化合物
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3428089A (en) * 1988-03-25 1989-10-16 The Administrators Of The Tulane Eductional Fund Therapeutic peptides
EP0618810B1 (en) * 1991-04-19 2001-07-04 Scios Nova Inc. Bradykinin antagonist peptides
US5521158A (en) * 1992-10-08 1996-05-28 Scios Nova Inc. Pseudopeptide bradykinin receptor antagonists

Also Published As

Publication number Publication date
ATE191486T1 (de) 2000-04-15
CA2171446A1 (en) 1995-03-16
WO1995007294A1 (en) 1995-03-16
DE69423899T2 (de) 2000-11-09
EP0716661A1 (en) 1996-06-19
CA2171446C (en) 2004-11-23
EP0716661B1 (en) 2000-04-05
DE69423899D1 (de) 2000-05-11
JPH11500100A (ja) 1999-01-06

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