ES2148347T3 - Antagonistas del receptor de la bradiquinina pseudo y no peptidica. - Google Patents

Antagonistas del receptor de la bradiquinina pseudo y no peptidica.

Info

Publication number: ES2148347T3
Authority: ES; Spain
Prior art keywords: bradykinin; bradiquinine; peptidic; pseudo; receptor antagonists
Prior art date: 1993-09-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES94929158T

Other languages

English (en)

Spanish (es)

Inventor

Donald James Kyle

Babu Joseph Mavunkel

Zhijian Lu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Scios LLC

Original Assignee

Scios LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-09

Filing date

1994-09-09

Publication date

2000-10-16

1993-09-09 Priority claimed from US08/118,981 external-priority patent/US5444048A/en

1994-07-28 Priority claimed from US08/281,907 external-priority patent/US5541286A/en

1994-07-28 Priority claimed from US08/281,904 external-priority patent/US5686565A/en

1994-09-09 Application filed by Scios LLC filed Critical Scios LLC

2000-10-16 Application granted granted Critical

2000-10-16 Publication of ES2148347T3 publication Critical patent/ES2148347T3/es

2014-09-09 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
101800004538 Bradykinin Proteins 0.000 abstract 2
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 2
102100035792 Kininogen-1 Human genes 0.000 abstract 2
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
102000010183 Bradykinin receptor Human genes 0.000 abstract 1
108050001736 Bradykinin receptor Proteins 0.000 abstract 1
UYRCOTSOPWOSJK-JXTBTVDRSA-N bradykinin antagonist Chemical class C1C2=CC=CC=C2CC1[C@@H](NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)[C@H]1N(C[C@H](O)C1)C(=O)C1N(CCC1)C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=N)CCCCCCC(=N)N[C@H](CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)N1C(CCC1)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)NCC(=O)NC(C1CC2=CC=CC=C2C1)C(=O)NC(CO)C(=O)N[C@H](C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O)C1CC2=CC=CC=C2C1)C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(=N)N)C(O)=O UYRCOTSOPWOSJK-JXTBTVDRSA-N 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ES94929158T 1993-09-09 1994-09-09 Antagonistas del receptor de la bradiquinina pseudo y no peptidica. Expired - Lifetime ES2148347T3 (es)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US11934193A	1993-09-09	1993-09-09
US11855893A	1993-09-09	1993-09-09
US08/118,981 US5444048A (en)	1992-10-08	1993-09-09	Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
US08/118,550 US5552383A (en)	1992-10-08	1993-09-09	Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US28190694A	1994-07-28	1994-07-28
US28190894A	1994-07-28	1994-07-28
US08/281,907 US5541286A (en)	1992-10-08	1994-07-28	Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
US08/281,904 US5686565A (en)	1992-10-08	1994-07-28	Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins

Publications (1)

Publication Number	Publication Date
ES2148347T3 true ES2148347T3 (es)	2000-10-16

Family

ID=27574846

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES94929158T Expired - Lifetime ES2148347T3 (es)	1993-09-09	1994-09-09	Antagonistas del receptor de la bradiquinina pseudo y no peptidica.

Country Status (7)

Country	Link
EP (1)	EP0716661B1 (de)
JP (1)	JPH11500100A (de)
AT (1)	ATE191486T1 (de)
CA (1)	CA2171446C (de)
DE (1)	DE69423899T2 (de)
ES (1)	ES2148347T3 (de)
WO (1)	WO1995007294A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100360639B1 (ko) *	1994-03-09	2003-01-30	코르텍, 인크.	N-치환글리신함유브라디키닌길항제펩티드
DE69601765T2 (de) *	1995-09-07	1999-07-08	Oreal	Extrakt von Iridaceen und Zusammensetzungen, die ihn enthalten
FR2746647B1 (fr) *	1996-03-27	1998-05-15	Oreal	Composition apaisante comprenant un extrait d'iridacee
FR2739553B1 (fr) *	1995-10-06	1998-01-02	Oreal	Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
DE19612067A1 (de) *	1996-03-27	1997-10-02	Hoechst Ag	Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
DE19642289A1 (de) *	1996-10-14	1998-04-16	Hoechst Ag	Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit
FR2756566B1 (fr)	1996-12-04	1999-01-08	Fournier Ind & Sante	Peptides agonistes du recepteur b2 de la bradykinine, procede de preparation et utilisation en therapeutique
WO2002024697A1 (en) *	2000-09-25	2002-03-28	Toray Industries, Inc.	Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient
JP4712384B2 (ja)	2002-09-09	2011-06-29	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
JP4861976B2 (ja)	2004-03-11	2012-01-25	アクテリオンファーマシューティカルズリミテッド	インドール−１−イル酢酸誘導体
US7714132B2 (en)	2004-03-11	2010-05-11	Actelion Pharmaceuticals, Ltd.	Tetrahydropyridoindole derivatives
KR101213912B1 (ko)	2004-08-26	2012-12-18	액테리온 파마슈티칼 리미티드	Ｃｒｔｈ2 길항제로서의2-설파닐-벤조이미다졸-1-일-아세틱 애시드 유도체
BRPI0719123A2 (pt) *	2006-09-01	2013-12-17	Cylene Pharmaceuticals Inc	Moduladores de serina-treonina proteína cinase e parp
US8703948B2 (en)	2006-11-28	2014-04-22	Janssen Pharmaceutica Nv	Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
RU2338745C1 (ru) *	2007-03-21	2008-11-20	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
CA2683598C (en)	2007-04-09	2015-11-17	Janssen Pharmaceutica Nv	1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
WO2009120717A2 (en)	2008-03-24	2009-10-01	Medivation Technologies, Inc.	Pyrido [3, 4-b] indoles and methods of use
CN102711467A (zh) *	2009-09-23	2012-10-03	梅迪维新技术公司	吡啶并[3,4-b]吲哚类及使用方法
PH12022553378A1 (en)	2020-06-10	2024-03-25	Univ Leuven Kath	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
AU2022306289A1 (en)	2021-07-09	2024-01-18	Aligos Therapeutics, Inc.	Anti-viral compounds
WO2023043816A1 (en)	2021-09-17	2023-03-23	Aligos Therapeutics, Inc.	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1989009230A1 (en) *	1988-03-25	1989-10-05	Administrators Of The Tulane Educational Fund	Therapeutic peptides
CA2106762C (en) *	1991-04-19	2000-10-10	Donald J. Kyle	Bradykinin antagonist peptides
US5521158A (en) *	1992-10-08	1996-05-28	Scios Nova Inc.	Pseudopeptide bradykinin receptor antagonists

1994
- 1994-09-09 JP JP7508795A patent/JPH11500100A/ja active Pending
- 1994-09-09 WO PCT/US1994/010128 patent/WO1995007294A1/en not_active Ceased
- 1994-09-09 ES ES94929158T patent/ES2148347T3/es not_active Expired - Lifetime
- 1994-09-09 CA CA002171446A patent/CA2171446C/en not_active Expired - Lifetime
- 1994-09-09 DE DE69423899T patent/DE69423899T2/de not_active Expired - Lifetime
- 1994-09-09 AT AT94929158T patent/ATE191486T1/de active
- 1994-09-09 EP EP94929158A patent/EP0716661B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2171446C (en)	2004-11-23
WO1995007294A1 (en)	1995-03-16
EP0716661A1 (de)	1996-06-19
JPH11500100A (ja)	1999-01-06
DE69423899D1 (de)	2000-05-11
CA2171446A1 (en)	1995-03-16
DE69423899T2 (de)	2000-11-09
ATE191486T1 (de)	2000-04-15
EP0716661B1 (de)	2000-04-05

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