ATE194293T1 - Radioaktiv markiierte blutplättchen-gpiib/iiia- rezeptor-antagonisten als bildgebende wirkstoffe zur diagnose von thromboembolischen erkrankungen - Google Patents

Radioaktiv markiierte blutplättchen-gpiib/iiia- rezeptor-antagonisten als bildgebende wirkstoffe zur diagnose von thromboembolischen erkrankungen

Info

Publication number
ATE194293T1
ATE194293T1 AT94912870T AT94912870T ATE194293T1 AT E194293 T1 ATE194293 T1 AT E194293T1 AT 94912870 T AT94912870 T AT 94912870T AT 94912870 T AT94912870 T AT 94912870T AT E194293 T1 ATE194293 T1 AT E194293T1
Authority
AT
Austria
Prior art keywords
imaging agents
plateet
gpiib
receptor antagonists
radioactively labeled
Prior art date
Application number
AT94912870T
Other languages
English (en)
Inventor
William Frank Degrado
Shaker Ahmed Mousa
Michael Sworin
John Andrew Barrett
David Scott Edwards
Thomas David Harris
Milind Rajopadhye
Shuang Liu
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Application granted granted Critical
Publication of ATE194293T1 publication Critical patent/ATE194293T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT94912870T 1993-03-30 1994-03-29 Radioaktiv markiierte blutplättchen-gpiib/iiia- rezeptor-antagonisten als bildgebende wirkstoffe zur diagnose von thromboembolischen erkrankungen ATE194293T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4033693A 1993-03-30 1993-03-30
US08/218,861 US5879657A (en) 1993-03-30 1994-03-28 Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
PCT/US1994/003256 WO1994022494A1 (en) 1993-03-30 1994-03-29 RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS

Publications (1)

Publication Number Publication Date
ATE194293T1 true ATE194293T1 (de) 2000-07-15

Family

ID=21910453

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94912870T ATE194293T1 (de) 1993-03-30 1994-03-29 Radioaktiv markiierte blutplättchen-gpiib/iiia- rezeptor-antagonisten als bildgebende wirkstoffe zur diagnose von thromboembolischen erkrankungen

Country Status (26)

Country Link
US (2) US5879657A (de)
EP (2) EP0995761A3 (de)
JP (1) JP3042887B2 (de)
KR (1) KR960701666A (de)
CN (1) CN1122577A (de)
AT (1) ATE194293T1 (de)
AU (2) AU6524894A (de)
BG (1) BG100036A (de)
BR (2) BR9406055A (de)
CA (1) CA2159445A1 (de)
DE (1) DE69425138T2 (de)
DK (1) DK0692982T3 (de)
ES (1) ES2149266T3 (de)
FI (1) FI954655L (de)
GR (1) GR3034272T3 (de)
HU (1) HUT72889A (de)
LV (1) LV11106B (de)
NO (1) NO307568B1 (de)
NZ (1) NZ263970A (de)
PL (1) PL178252B1 (de)
PT (1) PT692982E (de)
RU (1) RU2145608C1 (de)
TW (1) TW445267B (de)
UA (1) UA32577C2 (de)
WO (1) WO1994022494A1 (de)
ZA (1) ZA942262B (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
AU687080B2 (en) * 1993-04-08 1998-02-19 Cis Bio International Radiolabeled compounds for thrombus imaging
US6083481A (en) * 1992-05-21 2000-07-04 Diatide, Inc. Thrombus imaging agents
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
WO1996024571A1 (en) * 1995-02-07 1996-08-15 Brusilow Saul W Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders
US5879659A (en) * 1996-03-13 1999-03-09 Dupont Pharmaceuticals Company Ternary radiopharmaceutical complexes
WO1997033627A2 (en) * 1996-03-13 1997-09-18 Du Pont Pharmaceuticals Company New ternary radiopharmaceutical complexes
EP0910416A2 (de) * 1996-06-10 1999-04-28 G.D. Searle & Co. Radiomarkierte verbindungen zur thrombus-bilderzeugung
ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents
EP0999856B1 (de) * 1996-10-07 2003-05-14 Bristol-Myers Squibb Pharma Company Radiopharmazeutische mittel zur bildgebung von infektionen und entzündungen
DE19736772A1 (de) * 1997-08-23 1999-02-25 Merck Patent Gmbh Cyclopeptidderivate
AU4067899A (en) * 1998-02-06 1999-08-30 Trustees Of The University Of Pennsylvania, The Stereoselective tc-99m ligands
WO2000021980A1 (en) * 1998-10-13 2000-04-20 Du Pont Pharmaceuticals Company Chelator incorporated arg-gly-asp (rgd) mimetic synthetic disintegrins as imaging agents
CA2364753A1 (en) * 1999-03-26 2000-10-05 Joel Lazewatsky Method for localization of blood clots
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6171578B1 (en) * 1999-04-14 2001-01-09 Diatide, Inc. Benzodiazepine derivatives for imaging thrombi
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6685914B1 (en) * 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US6518244B2 (en) 2000-03-09 2003-02-11 Intimax Corporation Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof
US7524628B2 (en) * 2000-07-25 2009-04-28 The Trustees Of The University Of Pennsylvania Method for detecting molecules expressing a selected epitope via fluorescent dyes
US6743592B1 (en) * 2000-07-25 2004-06-01 The Trustees Of The University Of Pennsylvania Methods, systems and kits for immuno-detection of epitopes expressed on molecules
US7045286B2 (en) 2000-07-25 2006-05-16 The Trustees Of The University Of Pennsylvania Methods of detecting molecules expressing selected epitopes via fluorescent dyes
US7341831B2 (en) * 2001-07-18 2008-03-11 The Trustees Of The University Of Pennsylvania Method for immuno-detection of epitopes
WO2003099845A2 (en) 2002-05-23 2003-12-04 Trustees Of The University Of Pennsylvania Fas peptide mimetics and uses thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
CA2538520C (en) 2003-07-24 2015-02-10 The Queen's Medical Center Preparation and use of alkylating agents
BRPI0414512B8 (pt) * 2003-09-17 2021-05-25 Board Of Regentes The Univ Of Texas System composição para reproduzir imagens de um pâncreas e uso desta
EP1776470A4 (de) * 2004-02-20 2010-10-27 Univ Pennsylvania Reagenzien, kits und verfahren für den immunnachweis von epitopen auf molekülen
EP2392586A1 (de) 2004-02-20 2011-12-07 The Trustees of The University of Pennsylvania Bindende Peptidomimetika und deren Verwendungen
CA2558064A1 (en) * 2004-02-25 2005-09-01 Astellas Pharma Inc. Contrast medium for thrombus formation
EP1771205B1 (de) 2004-06-18 2016-10-26 Ambrx, Inc. Neuartige antigen-bindende polypeptide und ihre verwendungen
US7292198B2 (en) * 2004-08-18 2007-11-06 Ruckus Wireless, Inc. System and method for an omnidirectional planar antenna apparatus with selectable elements
FI20050753A7 (fi) 2004-09-03 2006-03-04 Licentia Oy Uudet peptidit
ES2410207T3 (es) 2006-10-16 2013-07-01 The Salk Institute For Biological Studies Antagonistas de la somatostatina selectivos para receptor(SSTR2)
US8691761B2 (en) 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
DK2474523T3 (da) 2006-12-26 2020-07-13 Lantheus Medical Imaging Inc Ligander til billeddannelse af hjerte-innervation
EP2150248A4 (de) 2007-01-16 2011-06-29 Univ Johns Hopkins Glutamat-rezeptorantagonisten und anwendungsverfahren
CA2699394C (en) 2007-09-17 2020-03-24 The Regents Of The University Of California Internalizing human monoclonal antibodies targeting prostate cancer cells in situ
GB2453589A (en) 2007-10-12 2009-04-15 King S College London Protease inhibition
US20140170068A1 (en) 2011-03-11 2014-06-19 Board Of Regents Of The University Of Nebraska Biomarker for coronary artery disease
EP3263102A1 (de) 2011-09-30 2018-01-03 Horizon Therapeutics, LLC Verfahren zur therapeutischen überwachung von stickstoffabsorbierenden wirkstoffen
BR112014026138A2 (pt) 2012-04-20 2017-06-27 Hyperion Therapeutics Inc métodos de monitoramento terapêutico de pró-fármacos de ácido fenilacético
HUE036133T2 (hu) 2012-11-21 2018-06-28 Horizon Therapeutics Llc Eljárások hepatikus enkefalopátia kezelésére szolgáló nitrogénelvonó gyógyszerek beadására és értékelésére
JP6404349B2 (ja) 2013-07-30 2018-10-10 インダストリー−アカデミック コーポレーション ファウンデーション，ヨンセイ ユニバーシティ サクサチリン−Ｆｃ融合タンパク質及びその用途
EP3383920B1 (de) 2015-11-30 2024-01-10 The Regents of the University of California Freisetzung von tumorspezifischer nutzlast und immunaktivierung mit einem menschlichen antikörper gegen hochspezifisches tumorzellenoberflächenantigen
US9914692B2 (en) 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
EP3538551A4 (de) 2016-11-10 2020-11-11 Fortis Therapeutics, Inc. Cd46-specifische effektorzellen und verwendungen davon
US10668040B2 (en) 2017-09-11 2020-06-02 Horizon Therapeutics, Llc Treatment of urea cycle disorders in neonates and infants
JP2023534765A (ja) 2020-08-07 2023-08-10 フォーティス セラピューティクス，インク． 免疫複合体を標的とするｃｄ４６およびその使用方法
CN118165073B (zh) * 2024-05-14 2024-07-19 中国药科大学 一种fap抑制剂及其制备方法和应用

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4517686A (en) * 1982-08-04 1985-05-21 La Jolla Cancer Research Foundation Polypeptide
US5041380A (en) * 1982-08-04 1991-08-20 La Jolla Cancer Research Foundation Tetrapeptide
US4589881A (en) * 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4661111A (en) * 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
US4670545A (en) * 1984-05-11 1987-06-02 University Patents, Inc. Chelating agents for technetium-99M
US4963688A (en) * 1984-07-19 1990-10-16 University Of Florida Compounds for site-enhanced delivery of radionuclides and uses thereof
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4746505A (en) * 1985-04-26 1988-05-24 President And Fellows Of Harvard College Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
US4879237A (en) * 1985-05-24 1989-11-07 La Jolla Cancer Research Foundation Use of peptides in control of cell attachment and detachment
US4988621A (en) * 1985-05-24 1991-01-29 La Jolla Cancer Research Foundation Peptides in cell detachment and aggregation
US5082930A (en) * 1986-05-29 1992-01-21 Mallinckrodt Medical, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US5279811A (en) * 1987-02-18 1994-01-18 The Du Pont Merck Pharmaceutical Company Ester-substituted diaminedithiols and radiolabeled complexes thereof
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
EP0284071B1 (de) * 1987-03-26 1994-06-08 Neorx Corporation Metall-Radionuklid-markierte Proteine und Glykoproteine zur Diagnose und Therapie
US5192745A (en) * 1987-05-21 1993-03-09 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
US5236898A (en) * 1987-05-21 1993-08-17 Merrell Dow Pharmaceuticals Inc. Cyclic anticoagulant peptides
WO1989000051A1 (en) * 1987-07-07 1989-01-12 Cytrx Biopool Ltd. Fibrin-binding compound and method
DE3728600A1 (de) * 1987-08-27 1989-03-09 Hoechst Ag Verfahren zur markierung von substanzen mit technetium oder rhenium
CA1335725C (en) * 1987-09-25 1995-05-30 Stephen W. Hadley Method of diagnosing blood clots using fibrin-binding proteins
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
IL89222A (en) * 1988-02-09 1995-03-30 Mallinckrodt Inc Preparation of metal-radionuclide-labelled proteins, certain novel compounds used therein and radiopharmaceutical compositions containing the labelled proteins
US5202451A (en) * 1988-02-17 1993-04-13 Neorx Corporation Anchimeric radiometal chelating compounds
CA1324954C (en) * 1988-03-10 1993-12-07 Erkki I. Ruoslahti Inhibition of cell migration with synthetic peptides
US4883862A (en) * 1988-04-13 1989-11-28 Albert Einstein College Of Medicine - Of Yeshiva University Mercaptosuccinyl glycyl-glycyl-glycine a complex thereof with Tc-99m, and methods of making the same
EP0381713B1 (de) * 1988-04-29 1994-01-19 Mallinckrodt, Inc. Diaminedithiol-chelatierungsmittel für radioarzneimittel
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
KR940009084B1 (ko) * 1988-05-18 1994-09-29 체크 포인트 시스템스, 인코오퍼레이티드 자기 및 공명회로 검출용 안테나 시스템
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5144043A (en) * 1988-06-15 1992-09-01 Centocor Cleavable bifunctional coupling agents
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
WO1989012680A1 (en) * 1988-06-20 1989-12-28 Washington University USE OF MODIFIED tPA TO DETECT BLOOD CLOTS
US5180816A (en) * 1988-08-24 1993-01-19 Centocor One vial method for labeling protein/linker conjugates with technetium-99M
US4925650A (en) * 1988-11-16 1990-05-15 Mallinckrodt, Inc. Technetium -99m complex for examining the renal function
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
ATE135584T1 (de) * 1988-12-20 1996-04-15 Jolla Cancer Res Found Polypeptid-polymer-konjugate mit wundheilender wirkung
US5270030A (en) * 1988-12-29 1993-12-14 Bio-Technology General Corp. Fibrin binding domain polypeptide and method of producing
GB8902362D0 (en) * 1989-02-03 1989-03-22 Amersham Int Plc Cationic complexes of technetium-99m
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
US5095111A (en) * 1989-03-17 1992-03-10 The John Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
US5120829A (en) * 1989-03-20 1992-06-09 La Jolla Cancer Research Foundation Hydrophobic attachment site for adhesion peptides
FR2655339B2 (fr) * 1989-04-19 1992-04-10 Medgenix Group Sa Composes et complexes utiles notamment en imagerie medicale.
US5250666A (en) * 1989-06-16 1993-10-05 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
DE69023616T2 (de) * 1989-06-16 1996-04-18 Neorx Corp Radionukleid-chelatverbindungen zur radiomarkierung von proteinen.
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
FR2650672A1 (fr) * 1989-08-02 1991-02-08 Medgenix Group Sa Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
EP0489061A4 (en) * 1989-08-24 1992-10-14 Australian Nuclear Science And Technology Organisation Radio-labelled antibodies for imaging
GB8919488D0 (en) * 1989-08-29 1989-10-11 Amersham Int Plc New cores for technetium radiopharmaceuticals
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
ZA907743B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Radiolabeled anticoagulant peptides
CA2027936C (en) * 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
EP0593452A1 (de) * 1989-11-30 1994-04-27 Mallinckrodt Medical, Inc. Verfahren zur herstellung eines mit metallradionuklid markierten proteins
DE69006698T2 (de) * 1989-12-12 1994-05-26 Amersham Int Plc Phenyldiaminodithiolderivate.
US5080884A (en) * 1989-12-12 1992-01-14 Medi-Physics, Inc. Hydrocarbylphenyl diaminodithiol radionuclide complexes and their use in imaging
US5026913A (en) * 1989-12-12 1991-06-25 Medi-Physics, Inc. Hydrocarbylphenyl diaminodithiol derivatives
JP2816880B2 (ja) * 1989-12-19 1998-10-27 横浜ゴム株式会社 乗用車用空気入りラジアルタイヤ
ATE155482T1 (de) * 1990-04-06 1997-08-15 Jolla Cancer Res Found Verfahren und verbindung zur behandlung von thrombose
CS136091A3 (en) * 1990-05-10 1992-04-15 Zymo Genetics Agents for determining thrombi and their application
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
AU8721591A (en) * 1990-09-14 1992-04-15 Mallinckrodt Medical, Inc. Novel nitrogen-sulfur ligands useful in radiographic imaging agents
US5175256A (en) * 1990-09-28 1992-12-29 Neorx Corporation Protein labeling reagents
US5037631A (en) * 1990-10-29 1991-08-06 Mallinckrodt Medical, Inc. Technetium-99M complex for examinating the renal function
US5116598A (en) * 1990-10-29 1992-05-26 Mallinckrodt Medical, Inc. N4 technetium-99 m complexes for use as radiopharmaceuticals
EP0555328A1 (de) * 1990-11-02 1993-08-18 Genentech, Inc. Blutplättchenaggregationshemmstoffe
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
EP0576492A1 (de) * 1991-03-20 1994-01-05 British Technology Group Ltd Makrozyklische Thioetherliganden und ihre Verwendung als Zwischenprodukte zum Binden von Ionen an Sustrate
AU1995392A (en) * 1991-05-08 1992-12-21 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
IL103252A (en) * 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
WO1993012819A1 (en) * 1992-01-03 1993-07-08 Rhomed Incorporated Protein- and peptide-metal ion pharmaceutical applications
CA2129033A1 (en) * 1992-02-05 1993-08-19 Leon Lyle Radiolabelled peptide compounds
DE69332470D1 (de) * 1992-02-06 2002-12-12 Biosynthema Inc Liganden zur verbesserung der metallchelatbildungskinetik
DE69332879T2 (de) * 1992-03-13 2004-02-19 Diatide, Inc. Technetium-99-markierte peptide zur visualisierung vom entzuendungen
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
GB9209641D0 (en) * 1992-05-02 1992-06-17 Johnson Matthey Plc Improvements in radiolabelling
DE69334033D1 (de) * 1992-05-21 2006-07-27 Diatide Inc Technetium-99M markierte Peptide zur Bilderzeugung von Thrombus
CA2148945A1 (en) * 1992-11-18 1994-05-26 Gregory James Wells Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein iib/iiia
EP0691987A1 (de) * 1993-03-29 1996-01-17 The Du Pont Merck Pharmaceutical Company Zyklische verbindungen als inhibitoren des platelet-glykoproteins iib/iiia
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
AU7112794A (en) * 1993-06-18 1995-01-17 La Jolla Cancer Research Foundation Method and composition for treating thrombosis

Also Published As

Publication number Publication date
DK0692982T3 (da) 2000-10-23
AU6524894A (en) 1994-10-24
ZA942262B (en) 1995-10-02
NO307568B1 (no) 2000-04-25
DE69425138D1 (de) 2000-08-10
LV11106A (lv) 1996-04-20
HUT72889A (en) 1996-06-28
EP0692982A4 (de) 1998-03-11
WO1994022494A1 (en) 1994-10-13
ES2149266T3 (es) 2000-11-01
US6022523A (en) 2000-02-08
FI954655A7 (fi) 1995-11-02
DE69425138T2 (de) 2001-03-01
AU689643B2 (en) 1998-04-02
RU2145608C1 (ru) 2000-02-20
US5879657A (en) 1999-03-09
NO953886D0 (no) 1995-09-29
JP3042887B2 (ja) 2000-05-22
BR9406820A (pt) 1996-09-10
KR960701666A (ko) 1996-03-28
EP0995761A3 (de) 2000-07-12
NO953886L (no) 1995-11-30
FI954655A0 (fi) 1995-09-29
EP0692982A1 (de) 1996-01-24
CA2159445A1 (en) 1994-10-13
PT692982E (pt) 2000-11-30
UA32577C2 (uk) 2001-02-15
EP0995761A2 (de) 2000-04-26
BR9406055A (pt) 1996-09-10
TW445267B (en) 2001-07-11
LV11106B (en) 1997-04-20
GR3034272T3 (en) 2000-12-29
BG100036A (bg) 1996-11-29
CN1122577A (zh) 1996-05-15
PL178252B1 (pl) 2000-03-31
PL311037A1 (en) 1996-01-22
AU3452595A (en) 1996-03-21
JPH08509710A (ja) 1996-10-15
FI954655L (fi) 1995-11-02
NZ263970A (en) 1996-09-25
EP0692982B1 (de) 2000-07-05
HU9502862D0 (en) 1995-11-28

Similar Documents

Publication Publication Date Title
DE69425138D1 (de) RADIOAKTIV MARKIIERTE BLUTPLÄTTCHEN-GPIIb/IIIa-REZEPTOR-ANTAGONISTEN ALS BILDGEBENDE WIRKSTOFFE ZUR DIAGNOSE VON THROMBOEMBOLISCHEN ERKRANKUNGEN
ATE153701T1 (de) Immunchromatographischer assay und verfahren zur nutzung desselben
ATE530671T1 (de) Verbindungen und verfahren zur diagnose von tuberkulose
EA199800025A1 (ru) Стойкие реагенты для получения радиофармпрепаратов
DE69002623D1 (de) Verfahren zur abtrennung und reinigung von sialyl-transferasen.
CY1109093T1 (el) Πρωτεϊνες των υποδοχεων θηλαστικων, σχετικα αντιδραστηρια και σχετικες μεθοδοι
DE59009716D1 (de) Verfahren zur Prüfung der Qualität und der Qualitätsänderungen von biologischen Systemen und mit ihnen wechselwirkenden organisch-chemischen Verbindungen mittels Messung der ultraschwachen Photonenemission.
BR1100946A (pt) Reagente para a preparação de um agente de formação de imagem de coágulo para formar imagens de coágulos dentro do corpo de mamìferos, agente cintilográfico de formação de imagens, complexo, kit de preparação de um preparado farmacêutico radioativo, método para formação de imagens de coágulos dentro do corpo de mamìferos, método de marcação de um peptìdeo, e, composto
WO1998014220A3 (en) Technetium-99m labeled chelator incorporated cyclic peptides
DE69422634D1 (de) Adeno-assozierter virus - dessen diagnostischen anwendung für frühe abtreibung
ATE265533T1 (de) Saeugetierchemokine
ATE90381T1 (de) Monoklonale antikoerper und verfahren zum nachweis von pathogenen pilzen.
DE69840895D1 (de) Monospezifische antikörper gegen fibrinogen und fibrinopeptide b
SE8901127D0 (sv) Reagenssats och dess anvaending foer att bilda (spap-anti-spap) -immunkomplex samt diagnostiskt foerfarand vid vilket spap detekteras
ATE210644T1 (de) Piperidyl-4-substituierte thyrosin-derivate als szintigraphische kontrastmittel zur diagnose von thrombosen
DE68922858D1 (de) Bildformungsmittel auf basis von technetium.
GEP19991861B (en) Radiolabeled Platelet GPIIb/IIIa Receptor Antagonists as Imaging Agents for the Diagnosis of Thromboembolic Disorders
CA2070961A1 (en) Thiol-reactive maleimido-based radiolabeling reagents
MX9704717A (es) Antigeno, anticuerpos y ensayo de diagnostico para la enfermedad de alzheimer.
ES2075803B1 (es) Procedimiento de la deteccion de neumolisina
YOON New insights into schizophrenia through novel antipsychotics
ATE222777T1 (de) Sequestrierte bilderzeugungsmitteln

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee