ATE195312T1 - Prozess für die herstellung von 10-deacethyl- 14beta-hydroxybaccatin iii derivaten und kompositionen, welche diese beinhalten - Google Patents

Prozess für die herstellung von 10-deacethyl- 14beta-hydroxybaccatin iii derivaten und kompositionen, welche diese beinhalten

Info

Publication number: ATE195312T1
Authority: AT; Austria
Prior art keywords: pct; derivatives; deacethyl; 14beta; production
Prior art date: 1995-05-19

Application number

AT96916025T

Other languages

English (en)

Inventor

Ezio Bombardelli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-19

Filing date

1996-05-08

Publication date

2000-08-15

1996-05-08 Application filed by Indena Spa filed Critical Indena Spa

2000-08-15 Application granted granted Critical

2000-08-15 Publication of ATE195312T1 publication Critical patent/ATE195312T1/de

Links

239000000203 mixture Substances 0.000 title 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
ICGQLNMKJVHCIR-UHFFFAOYSA-N 1,3,2-dioxazetidin-4-one Chemical compound O=C1ONO1 ICGQLNMKJVHCIR-UHFFFAOYSA-N 0.000 abstract 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
231100000433 cytotoxic Toxicity 0.000 abstract 1
230000001472 cytotoxic effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
238000007306 functionalization reaction Methods 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Epoxy Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT96916025T 1995-05-19 1996-05-08 Prozess für die herstellung von 10-deacethyl- 14beta-hydroxybaccatin iii derivaten und kompositionen, welche diese beinhalten ATE195312T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI951022A IT1275435B (it)	1995-05-19	1995-05-19	Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono
PCT/EP1996/001919 WO1996036622A1 (en)	1995-05-19	1996-05-08	10-deacetyl-14beta-hydroxybaccatine iii derivatives, a process for the preparation thereof and formulations containing them

Publications (1)

Publication Number	Publication Date
ATE195312T1 true ATE195312T1 (de)	2000-08-15

Family

ID=11371633

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96916025T ATE195312T1 (de)	1995-05-19	1996-05-08	Prozess für die herstellung von 10-deacethyl- 14beta-hydroxybaccatin iii derivaten und kompositionen, welche diese beinhalten

Country Status (17)

Country	Link
US (1)	US5917056A (de)
EP (1)	EP0862563B1 (de)
JP (1)	JP4112001B2 (de)
KR (1)	KR100399330B1 (de)
CN (1)	CN100335469C (de)
AT (1)	ATE195312T1 (de)
AU (1)	AU696366B2 (de)
CA (1)	CA2212357C (de)
DE (1)	DE69609723T2 (de)
DK (1)	DK0862563T3 (de)
ES (1)	ES2148766T3 (de)
GR (1)	GR3034321T3 (de)
IT (1)	IT1275435B (de)
NO (1)	NO316378B1 (de)
PT (1)	PT862563E (de)
RU (1)	RU2161615C2 (de)
WO (1)	WO1996036622A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1283633B1 (it) *	1996-05-10	1998-04-23	Indena Spa	Derivati tassanici loro sintesi e formulazioni che li contengono
US5917062A (en) *	1997-11-21	1999-06-29	Indena S.P.A	Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
IT1318678B1 (it) *	2000-08-10	2003-08-27	Indena Spa	Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) *	2000-11-28	2003-11-18	Indena Spa	Procedimento per la preparazione di derivati tassanici.
ITMI20012185A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
KR101009467B1 (ko) *	2006-03-13	2011-01-19	주식회사 셀트리온화학연구소	도세탁셀의 합성에 유용한 탁산 유도체 및 그 제조방법
BRPI0818370A2 (pt) *	2007-10-09	2017-05-16	Segetis Inc	métodos de fabricar cetais e acetais
DK2080764T3 (da)	2008-01-18	2012-09-24	Indena Spa	Faste former af ortataxel
US8252137B2 (en) *	2009-08-31	2012-08-28	Fleming Iii Joseph C	Building panel having plant-imitating structural core
CN104650109B (zh) *	2013-11-22	2019-01-01	江苏天士力帝益药业有限公司	紫杉烷类化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
IT1254517B (it) *	1992-03-06	1995-09-25	Indena Spa	14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
US5475011A (en) *	1993-03-26	1995-12-12	The Research Foundation Of State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

1995
- 1995-05-19 IT ITMI951022A patent/IT1275435B/it active IP Right Grant
1996
- 1996-05-05 US US08/875,770 patent/US5917056A/en not_active Expired - Lifetime
- 1996-05-08 KR KR1019970706156A patent/KR100399330B1/ko not_active Expired - Fee Related
- 1996-05-08 RU RU97112894/04A patent/RU2161615C2/ru not_active IP Right Cessation
- 1996-05-08 AU AU58939/96A patent/AU696366B2/en not_active Ceased
- 1996-05-08 CN CNB961924209A patent/CN100335469C/zh not_active Expired - Fee Related
- 1996-05-08 WO PCT/EP1996/001919 patent/WO1996036622A1/en not_active Ceased
- 1996-05-08 ES ES96916025T patent/ES2148766T3/es not_active Expired - Lifetime
- 1996-05-08 AT AT96916025T patent/ATE195312T1/de active
- 1996-05-08 JP JP53451996A patent/JP4112001B2/ja not_active Expired - Fee Related
- 1996-05-08 PT PT96916025T patent/PT862563E/pt unknown
- 1996-05-08 EP EP96916025A patent/EP0862563B1/de not_active Expired - Lifetime
- 1996-05-08 CA CA002212357A patent/CA2212357C/en not_active Expired - Fee Related
- 1996-05-08 DE DE69609723T patent/DE69609723T2/de not_active Expired - Lifetime
- 1996-05-08 DK DK96916025T patent/DK0862563T3/da active
1997
- 1997-08-01 NO NO19973545A patent/NO316378B1/no not_active IP Right Cessation
2000
- 2000-09-01 GR GR20000402008T patent/GR3034321T3/el unknown

Also Published As

Publication number	Publication date
JP4112001B2 (ja)	2008-07-02
ITMI951022A0 (it)	1995-05-19
PT862563E (pt)	2000-11-30
DK0862563T3 (da)	2000-10-30
US5917056A (en)	1999-06-29
KR19980702749A (ko)	1998-08-05
IT1275435B (it)	1997-08-07
HK1011537A1 (en)	1999-07-16
EP0862563A1 (de)	1998-09-09
CA2212357A1 (en)	1996-11-21
DE69609723D1 (de)	2000-09-14
NO973545L (no)	1997-11-17
KR100399330B1 (ko)	2003-12-31
CA2212357C (en)	2002-08-13
NO316378B1 (no)	2004-01-19
EP0862563B1 (de)	2000-08-09
DE69609723T2 (de)	2000-12-14
CN100335469C (zh)	2007-09-05
JPH11505232A (ja)	1999-05-18
NO973545D0 (no)	1997-08-01
ES2148766T3 (es)	2000-10-16
CN1177961A (zh)	1998-04-01
AU696366B2 (en)	1998-09-10
ITMI951022A1 (it)	1996-11-19
GR3034321T3 (en)	2000-12-29
AU5893996A (en)	1996-11-29
RU2161615C2 (ru)	2001-01-10
WO1996036622A1 (en)	1996-11-21

Similar Documents

Publication	Publication Date	Title
ATE195312T1 (de)	2000-08-15	Prozess für die herstellung von 10-deacethyl- 14beta-hydroxybaccatin iii derivaten und kompositionen, welche diese beinhalten
DE3483629D1 (de)	1991-01-03	2-pyrimidinyl-l-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
RO115522B1 (ro)	2000-03-30	Derivaţi de indolină, procedee pentru prepararea acestora, compoziţii farmaceutice care îi conţin şi metodă de tratament
BR0013949A (pt)	2002-05-14	Prodroga de taxano, composição farmacêutica, e, método de tratamento de um paciente mamìfero
DE69738935D1 (de)	2008-10-02	Zusammensetzungen enthaltend Thalidomide und Dexamethason für die Behandlung von Krebs
MA26733A1 (fr)	2004-12-20	Derives d'isothiazole nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
ATE252080T1 (de)	2003-11-15	Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel
HUT76829A (en)	1997-11-28	Semi-synthetic taxanes, process for producing them and pharmaceutical compositions containing them
DZ2300A1 (fr)	2002-12-25	Dérivés 6,5-hétérobicycliques substitués, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2299A1 (fr)	2002-12-25	Dérivés 6,6-hétérobicycliques substitués, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DZ2188A1 (fr)	2002-12-02	Dérivés de quinoxalinedone, procédés et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant.
ATE193286T1 (de)	2000-06-15	10- deacetylbaccatin iii und 10- deacetyl 14 beta hydroxybaccatin iii derivaten, verfahren zu deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen
NO303715B1 (no)	1998-08-24	Stabilt, vandig apparat
RU1833372C (ru)	1993-08-07	Cпocoб пoлучehия пpoизboдhыx 2,4,5-зameщehhыx бehзoлa
FR2793793B1 (fr)	2004-02-27	Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2563832B1 (fr)	1989-08-18	Nouveaux derives cephem, procede pour la preparation de ces nouveaux composes, compositions pharmaceutiques contenant au moins un de ces composes et intermediaires de synthese pour leur preparation
DE68916174D1 (de)	1994-07-21	Mevalonolactone vom Thienopyridin-Typ.
OA07390A (fr)	1984-11-30	Nouveaux dérivés de carbapenem, compositions pharmaceutiques les contenant, composés intermédiaires pour leur préparation, et leurs procédés de production.
ATE152118T1 (de)	1997-05-15	Kardioaktive 17b-(3-furyl) und 17b-(4- pyridazinyl)-5beta, 14beta-androstan derivate, verfahren zu ihrer herstellung und pharmazeutische präparate davon
FR2763335B1 (fr)	2000-11-24	Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ATE123492T1 (de)	1995-06-15	Benzocycloalkylaminopyridinamine und verwandte verbindungen, verfahren zu ihrer herstellung, zwischenverbindungen und ihre verwendung als arzneimittel.
HUT70185A (en)	1995-09-28	Novel thiomarinol derivatives pharmaceutical compositions containing them and process for producing them
OA08165A (fr)	1987-03-31	Nouveaux dérivés thiosulfonates, leur procédé de préparation ainsi que les compositions pharmaceutiques les contenant.
FR2651227B1 (fr)	1992-07-31	Nouveaux derives de l'aminopropanol, procede pour leur preparation et compositions pharmaceutiques contenant de tels derives.
DE3885022D1 (de)	1993-11-25	Thiosulfinsäurederivate, und die Verwendung von Thiosulfinsäurederivaten zur Herstellung von Arzneimitteln für die Behandlung von Entzündungserkrankungen.

Legal Events

Date	Code	Title	Description
2001-01-15	UEP	Publication of translation of european patent specification