ATE199085T1 - Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten - Google Patents

Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten

Info

Publication number: ATE199085T1
Authority: AT; Austria
Prior art keywords: spir; tetracyclic; compounds; production; receptor antagonists
Prior art date: 1994-12-22

Application number

AT95942116T

Other languages

English (en)

Inventor

Laramie Mary Gaster

Francis David King

Paul Adrian Wyman

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-22

Filing date

1995-12-06

Publication date

2001-02-15

1994-12-22 Priority claimed from GBGB9426029.6A external-priority patent/GB9426029D0/en

1995-06-24 Priority claimed from GBGB9512920.1A external-priority patent/GB9512920D0/en

1995-12-06 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE199085T1 publication Critical patent/ATE199085T1/de

Links

101710138068 5-hydroxytryptamine receptor 1D Proteins 0.000 title 1
KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT95942116T 1994-12-22 1995-12-06 Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten ATE199085T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9426029.6A GB9426029D0 (en)	1994-12-22	1994-12-22	Novel compounds
GBGB9512920.1A GB9512920D0 (en)	1995-06-24	1995-06-24	Novel compounds
PCT/EP1995/004889 WO1996019477A1 (en)	1994-12-22	1995-12-06	Tetracyclic spiro compounds, process for their preparation and their use as 5ht1d receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE199085T1 true ATE199085T1 (de)	2001-02-15

Family

ID=26306239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95942116T ATE199085T1 (de)	1994-12-22	1995-12-06	Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten

Country Status (27)

Country	Link
US (1)	US5972951A (de)
EP (1)	EP0799226B1 (de)
JP (1)	JPH10510821A (de)
CN (1)	CN1175256A (de)
AP (1)	AP757A (de)
AR (1)	AR002011A1 (de)
AT (1)	ATE199085T1 (de)
AU (1)	AU697361B2 (de)
BG (1)	BG61977B1 (de)
BR (1)	BR9510419A (de)
CA (1)	CA2208244A1 (de)
CZ (1)	CZ192397A3 (de)
DE (1)	DE69520075T2 (de)
DZ (1)	DZ1957A1 (de)
ES (1)	ES2153907T3 (de)
FI (1)	FI972583L (de)
HU (1)	HUT77650A (de)
IL (1)	IL116486A0 (de)
MA (1)	MA23753A1 (de)
MX (1)	MX9704777A (de)
NO (1)	NO972910L (de)
NZ (1)	NZ298036A (de)
OA (1)	OA10610A (de)
PL (1)	PL321048A1 (de)
SK (1)	SK80297A3 (de)
TR (1)	TR199501597A2 (de)
WO (1)	WO1996019477A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9519033D0 (en) *	1995-09-18	1995-11-15	Smithkline Beecham Plc	Treatment
GB9522845D0 (en) *	1995-11-08	1996-01-10	Smithkline Beecham Plc	Novel compounds
EP0861257A1 (de) *	1995-11-08	1998-09-02	Smithkline Beecham Plc	Spiro-piperdin derivate als 5ht-receptor antagonisten
EP0862565A1 (de) *	1995-11-22	1998-09-09	Smithkline Beecham Plc	Tricyclische spiroverbindungen als 5ht1d-rezeptorantagonisten
GB9605883D0 (en) *	1996-03-20	1996-05-22	Smithkline Beecham Plc	Novel compounds
GB9606396D0 (en) *	1996-03-27	1996-06-05	Smithkline Beecham Plc	Novel compounds
US6156783A (en) *	1996-04-30	2000-12-05	Smithkline Beecham P.L.C.	Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
FR2761069A1 (fr) *	1997-03-20	1998-09-25	Pf Medicament	Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments
CA2347095A1 (en) *	1998-10-16	2000-04-27	Takeda Chemical Industries, Ltd.	Nitrogen-containing condensed heterocyclic derivatives, their production and agent
DE10051981A1 (de)	2000-10-20	2002-05-02	Bayer Ag	Substituierte Phenyluracile
US7144911B2 (en)	2002-12-31	2006-12-05	Deciphera Pharmaceuticals Llc	Anti-inflammatory medicaments
US7202257B2 (en)	2003-12-24	2007-04-10	Deciphera Pharmaceuticals, Llc	Anti-inflammatory medicaments
US7279576B2 (en)	2002-12-31	2007-10-09	Deciphera Pharmaceuticals, Llc	Anti-cancer medicaments
EP1656370B1 (de) *	2003-06-03	2012-08-15	Rib-X Pharmaceuticals, Inc.	Heterocyclische biarylverbindungen und verfahren zu deren herstellung und anwendung
US20050165025A1 (en) *	2004-01-22	2005-07-28	Recordati Ireland Ltd.	Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
US7700808B2 (en)	2005-12-26	2010-04-20	Nissan Chemical Industries, Ltd.	1-3-bis(substituted phenyl)-3-hydroxypropan-1-one or 2-propen-1-one compound, and salt thereof
WO2008131276A1 (en)	2007-04-20	2008-10-30	Deciphera Pharmaceuticals, Llc	Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
MX2009013332A (es)	2007-06-08	2010-01-25	Mannkind Corp	Inhibidores de ire-1 alfa.
US8952175B2 (en)	2007-06-27	2015-02-10	Nissan Chemical Industries, Ltd.	Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound
JO3032B1 (ar)	2008-10-17	2016-09-05	Xenon Pharmaceuticals Inc	مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية.
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
KR20120099429A (ko)	2009-10-14	2012-09-10	제논 파마슈티칼스 인크.	스피로-옥스인돌 화합물의 합성 방법
WO2011106729A2 (en)	2010-02-26	2011-09-01	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
US8461179B1 (en)	2012-06-07	2013-06-11	Deciphera Pharmaceuticals, Llc	Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
WO2016127068A1 (en)	2015-02-05	2016-08-11	Teva Pharmaceuticals International Gmbh	Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
WO2019036024A1 (en)	2017-08-17	2019-02-21	Bristol-Myers Squibb Company	2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
CN118416236A (zh)	2018-01-31	2024-08-02	德西费拉制药有限责任公司	治疗胃肠道间质瘤的组合疗法
IL276398B2 (en)	2018-01-31	2026-03-01	Deciphera Pharmaceuticals Llc	Combination therapy for mastocytosis
WO2020185812A1 (en)	2019-03-11	2020-09-17	Teva Pharmaceuticals International Gmbh	Solid state forms of ripretinib
WO2020183011A1 (en)	2019-03-14	2020-09-17	Institut Curie	Htr1d inhibitors and uses thereof in the treatment of cancer
EP4013412B1 (de)	2019-08-12	2026-01-28	Deciphera Pharmaceuticals, LLC	Ripretinib zur behandlung gastrointestinaler stromakarzinome
TWI878335B (zh)	2019-08-12	2025-04-01	美商迪賽孚爾製藥有限公司	治療胃腸道基質瘤方法
EP4084779B1 (de)	2019-12-30	2024-10-09	Deciphera Pharmaceuticals, LLC	Zusammensetzungen von 1-(4-brom-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorphenyl)-3-phenylharnstoff
MX2022008103A (es)	2019-12-30	2022-09-19	Deciphera Pharmaceuticals Llc	Formulaciones de inhibidores de la cinasa amorfa y metodos de estas.
US12577211B2 (en)	2020-06-29	2026-03-17	Bacainn Biotherapeutics, Ltd.	Probenecid compounds for the treatment of inflammasome-mediated lung disease
US11779572B1 (en)	2022-09-02	2023-10-10	Deciphera Pharmaceuticals, Llc	Methods of treating gastrointestinal stromal tumors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT533268E (pt)	1991-09-18	2002-02-28	Glaxo Group Ltd	Derivados de benzanilida como antagonistas de 5-ht1d
GB9119932D0 (en) *	1991-09-18	1991-10-30	Glaxo Group Ltd	Chemical compounds

1995
- 1995-12-06 CZ CZ971923A patent/CZ192397A3/cs unknown
- 1995-12-06 AT AT95942116T patent/ATE199085T1/de active
- 1995-12-06 AP APAP/P/1997/001006A patent/AP757A/en active
- 1995-12-06 US US08/849,932 patent/US5972951A/en not_active Expired - Fee Related
- 1995-12-06 MX MX9704777A patent/MX9704777A/es unknown
- 1995-12-06 CN CN95197616A patent/CN1175256A/zh active Pending
- 1995-12-06 ES ES95942116T patent/ES2153907T3/es not_active Expired - Lifetime
- 1995-12-06 AU AU43433/96A patent/AU697361B2/en not_active Ceased
- 1995-12-06 PL PL95321048A patent/PL321048A1/xx unknown
- 1995-12-06 WO PCT/EP1995/004889 patent/WO1996019477A1/en not_active Ceased
- 1995-12-06 CA CA002208244A patent/CA2208244A1/en not_active Abandoned
- 1995-12-06 EP EP95942116A patent/EP0799226B1/de not_active Expired - Lifetime
- 1995-12-06 HU HU9800158A patent/HUT77650A/hu unknown
- 1995-12-06 NZ NZ298036A patent/NZ298036A/en unknown
- 1995-12-06 JP JP8519477A patent/JPH10510821A/ja active Pending
- 1995-12-06 FI FI972583A patent/FI972583L/fi unknown
- 1995-12-06 BR BR9510419A patent/BR9510419A/pt not_active Application Discontinuation
- 1995-12-06 SK SK802-97A patent/SK80297A3/sk unknown
- 1995-12-06 DE DE69520075T patent/DE69520075T2/de not_active Expired - Fee Related
- 1995-12-19 AR ARP950100629A patent/AR002011A1/es unknown
- 1995-12-19 TR TR95/01597A patent/TR199501597A2/xx unknown
- 1995-12-20 MA MA24106A patent/MA23753A1/fr unknown
- 1995-12-20 DZ DZ950140A patent/DZ1957A1/fr active
- 1995-12-21 IL IL11648695A patent/IL116486A0/xx unknown
1997
- 1997-06-20 NO NO972910A patent/NO972910L/no unknown
- 1997-06-20 OA OA70033A patent/OA10610A/en unknown
- 1997-07-01 BG BG101715A patent/BG61977B1/bg unknown

Also Published As

Publication number	Publication date
DE69520075T2 (de)	2001-08-02
AU4343396A (en)	1996-07-10
HUT77650A (hu)	1998-07-28
EP0799226A1 (de)	1997-10-08
PL321048A1 (en)	1997-11-24
SK80297A3 (en)	1998-12-02
WO1996019477A1 (en)	1996-06-27
AR002011A1 (es)	1998-01-07
AP9701006A0 (en)	1997-07-31
BG61977B1 (bg)	1998-11-30
AU697361B2 (en)	1998-10-01
TR199501597A2 (tr)	1996-07-21
NZ298036A (en)	1998-11-25
MX9704777A (es)	1997-10-31
EP0799226B1 (de)	2001-02-07
IL116486A0 (en)	1997-08-14
DZ1957A1 (fr)	2002-02-17
CN1175256A (zh)	1998-03-04
FI972583A0 (fi)	1997-06-17
JPH10510821A (ja)	1998-10-20
CZ192397A3 (en)	1997-09-17
CA2208244A1 (en)	1996-06-27
AP757A (en)	1999-09-06
NO972910L (no)	1997-08-14
US5972951A (en)	1999-10-26
BR9510419A (pt)	1998-05-19
ES2153907T3 (es)	2001-03-16
FI972583A7 (fi)	1997-08-19
DE69520075D1 (de)	2001-03-15
MA23753A1 (fr)	1996-07-01
BG101715A (bg)	1998-02-27
FI972583L (fi)	1997-08-19
OA10610A (en)	2002-09-06
NO972910D0 (no)	1997-06-20

Publication	Publication Date	Title
ATE199085T1 (de)	2001-02-15	Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten
DE69508762D1 (de)	1999-05-06	Quaternäre ammoniumderivate, verfahren zu ihrer herstellung und ihre verwendung als oberflächenaktive verbindungen
ATE169018T1 (de)	1998-08-15	Tetracyclische derivate, verfahren zu ihrer herstellung und ihre verwendung
ATE294785T1 (de)	2005-05-15	2-aminothiazolederivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
ATE272631T1 (de)	2004-08-15	Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung
ATE252578T1 (de)	2003-11-15	1,3-oxazolin- und 1,3-thiazolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als schädlingsbekämpfungsmittel
DE69101144D1 (de)	1994-03-17	Mikrokugeln, verfahren zu ihrer herstellung und ihre verwendung.
DE69726593D1 (de)	2004-01-15	Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel
DE59707976D1 (de)	2002-09-19	Neue guanidinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE234842T1 (de)	2003-04-15	Epithilonderivate, verfahren zu deren herstellung und deren verwendung
ATE250686T1 (de)	2003-10-15	Vliesverbund, verfahren zu dessen herstellung und dessen verwendung
DE50011818D1 (de)	2006-01-12	Hochkratzfeste mehrschichtlackierung, verfahren zu ihrer herstellung und ihre verwendung
ATA198791A (de)	1994-02-15	Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
ATE210638T1 (de)	2001-12-15	Biphenylsulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament
ATE192738T1 (de)	2000-05-15	(aminoalkyl- und acylaminoalkyl- oxy)benzyloxychinoline, verfahren zu deren herstellung und ihre verwendung als bradykinin- rezeptorantagonisten
DE60032956T8 (de)	2007-09-13	Ionenselektive membranen, verfahren zu ihrer herstellung, verwendung der ionenselektiven membranen und vorrichtungen, die mit den ionenselektiven membranen versehen sind
DE59912402D1 (de)	2005-09-15	Polycyclische thiazolidin-2-yliden amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE69529467D1 (de)	2003-02-27	Substituierte pyrazolyl-pyrazol-derivate, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung
DE59610666D1 (de)	2003-09-18	Mehrlagenfolie, verfahren zu ihrer herstellung und ihre verwendung
DE69908371D1 (de)	2003-07-03	Thioethergruppen enthaltende distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
AT399880B (de)	1995-08-25	Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE69922378D1 (de)	2005-01-05	Oxidierte sulfurierte distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
DE69712048D1 (de)	2002-05-23	Dihalopropenverbindungen, deren verwendung als insektizide/akarizide, und zwischenverbindungen zu deren herstellung
DE59902408D1 (de)	2002-09-26	Biphenylsulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament
ATE204563T1 (de)	2001-09-15	Neue synthetische catecholderivate, verfahren zu ihrer herstellung und ihre verwendung