ATE199085T1 - Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten - Google Patents

Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten

Info

Publication number: ATE199085T1
Authority: AT; Austria
Prior art keywords: spir; tetracyclic; compounds; production; receptor antagonists
Prior art date: 1994-12-22

Application number

AT95942116T

Other languages

English (en)

Inventor

Laramie Mary Gaster

Francis David King

Paul Adrian Wyman

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-22

Filing date

1995-12-06

Publication date

2001-02-15

1994-12-22 Priority claimed from GBGB9426029.6A external-priority patent/GB9426029D0/en

1995-06-24 Priority claimed from GBGB9512920.1A external-priority patent/GB9512920D0/en

1995-12-06 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2001-02-15 Application granted granted Critical

2001-02-15 Publication of ATE199085T1 publication Critical patent/ATE199085T1/de

Links

101710138068 5-hydroxytryptamine receptor 1D Proteins 0.000 title 1
KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT95942116T 1994-12-22 1995-12-06 Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten ATE199085T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9426029.6A GB9426029D0 (en)	1994-12-22	1994-12-22	Novel compounds
GBGB9512920.1A GB9512920D0 (en)	1995-06-24	1995-06-24	Novel compounds
PCT/EP1995/004889 WO1996019477A1 (en)	1994-12-22	1995-12-06	Tetracyclic spiro compounds, process for their preparation and their use as 5ht1d receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE199085T1 true ATE199085T1 (de)	2001-02-15

Family

ID=26306239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95942116T ATE199085T1 (de)	1994-12-22	1995-12-06	Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten

Country Status (27)

Country	Link
US (1)	US5972951A (de)
EP (1)	EP0799226B1 (de)
JP (1)	JPH10510821A (de)
CN (1)	CN1175256A (de)
AP (1)	AP757A (de)
AR (1)	AR002011A1 (de)
AT (1)	ATE199085T1 (de)
AU (1)	AU697361B2 (de)
BG (1)	BG61977B1 (de)
BR (1)	BR9510419A (de)
CA (1)	CA2208244A1 (de)
CZ (1)	CZ192397A3 (de)
DE (1)	DE69520075T2 (de)
DZ (1)	DZ1957A1 (de)
ES (1)	ES2153907T3 (de)
FI (1)	FI972583L (de)
HU (1)	HUT77650A (de)
IL (1)	IL116486A0 (de)
MA (1)	MA23753A1 (de)
MX (1)	MX9704777A (de)
NO (1)	NO972910L (de)
NZ (1)	NZ298036A (de)
OA (1)	OA10610A (de)
PL (1)	PL321048A1 (de)
SK (1)	SK80297A3 (de)
TR (1)	TR199501597A2 (de)
WO (1)	WO1996019477A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9519033D0 (en) *	1995-09-18	1995-11-15	Smithkline Beecham Plc	Treatment
GB9522845D0 (en) *	1995-11-08	1996-01-10	Smithkline Beecham Plc	Novel compounds
WO1997017351A1 (en) *	1995-11-08	1997-05-15	Smithkline Beecham Plc	Spiro piperidine derivatives as 5mt receptor antagonists
WO1997019070A1 (en) *	1995-11-22	1997-05-29	Smithkline Beecham Plc	Tricyclic spiro compounds as 5ht1d receptor antagonists
GB9605883D0 (en) *	1996-03-20	1996-05-22	Smithkline Beecham Plc	Novel compounds
GB9606396D0 (en) *	1996-03-27	1996-06-05	Smithkline Beecham Plc	Novel compounds
US6156783A (en) *	1996-04-30	2000-12-05	Smithkline Beecham P.L.C.	Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
FR2761069A1 (fr) *	1997-03-20	1998-09-25	Pf Medicament	Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments
EP1122252A4 (de) *	1998-10-16	2002-06-26	Takeda Chemical Industries Ltd	Stickstoffhaltige annelierte heterocyclen, verfahren zu ihrer herstellung und agentien, die diese enthalten
DE10051981A1 (de)	2000-10-20	2002-05-02	Bayer Ag	Substituierte Phenyluracile
US7144911B2 (en)	2002-12-31	2006-12-05	Deciphera Pharmaceuticals Llc	Anti-inflammatory medicaments
US7279576B2 (en)	2002-12-31	2007-10-09	Deciphera Pharmaceuticals, Llc	Anti-cancer medicaments
US7202257B2 (en)	2003-12-24	2007-04-10	Deciphera Pharmaceuticals, Llc	Anti-inflammatory medicaments
PT1656370E (pt) *	2003-06-03	2012-11-29	Rib X Pharmaceuticals Inc	Compostos biaril-heterocíclicos e métodos de os produzir e de os utilizar
US20050165025A1 (en) *	2004-01-22	2005-07-28	Recordati Ireland Ltd.	Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
CN101346336B (zh)	2005-12-26	2013-02-27	日产化学工业株式会社	1,3-二(取代苯基)-3-取代-2-丙烯-1-酮化合物和其盐
AU2008242720A1 (en)	2007-04-20	2008-10-30	Deciphera Pharmaceuticals, Llc	Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
EP2520561B1 (de)	2007-06-08	2016-02-10	MannKind Corporation	IRE-1a-Inhibitoren
US8952175B2 (en)	2007-06-27	2015-02-10	Nissan Chemical Industries, Ltd.	Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound
WO2010045251A2 (en)	2008-10-17	2010-04-22	Xenon Pharmaceuticals, Inc.	Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
AU2010306768B2 (en)	2009-10-14	2016-08-04	Xenon Pharmaceuticals Inc.	Synthetic methods for spiro-oxindole compounds
MY165117A (en)	2010-02-26	2018-02-28	Xenon Pharmaceuticals Inc	Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
US8461179B1 (en)	2012-06-07	2013-06-11	Deciphera Pharmaceuticals, Llc	Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
AR103636A1 (es)	2015-02-05	2017-05-24	Teva Pharmaceuticals Int Gmbh	Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol
US11498903B2 (en)	2017-08-17	2022-11-15	Bristol-Myers Squibb Company	2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
SG11202007198WA (en)	2018-01-31	2020-08-28	Deciphera Pharmaceuticals Llc	Combination therapy for the treatment of gastrointestinal stromal tumors
EA202091763A1 (ru)	2018-01-31	2020-12-14	ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи	Комбинированная терапия для лечения мастоцитоза
EP3938363A1 (de)	2019-03-11	2022-01-19	Teva Pharmaceuticals International GmbH	Festkörperformen von ripretinib
WO2020183011A1 (en)	2019-03-14	2020-09-17	Institut Curie	Htr1d inhibitors and uses thereof in the treatment of cancer
WO2021030405A1 (en)	2019-08-12	2021-02-18	Deciphera Pharmaceuticals, Llc	Ripretinib for treating gastrointestinal stromal tumors
JP7818502B2 (ja)	2019-08-12	2026-02-20	デシフェラ・ファーマシューティカルズ，エルエルシー	胃腸間質腫瘍を治療するためのリプレチニブ
AU2020417282B2 (en)	2019-12-30	2023-08-31	Deciphera Pharmaceuticals, Llc	Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
SI4084778T1 (sl)	2019-12-30	2024-01-31	Deciphera Pharmaceuticals, Llc	Formulacije inhibitorja amorfne kinaze in načini njihove uporabe
AU2021303146A1 (en)	2020-06-29	2023-02-02	Bacainn Biotherapeutics, Ltd.	Probenecid compounds for the treatment of inflammasome-mediated lung disease
US11779572B1 (en)	2022-09-02	2023-10-10	Deciphera Pharmaceuticals, Llc	Methods of treating gastrointestinal stromal tumors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2162792T3 (es)	1991-09-18	2002-01-16	Glaxo Group Ltd	Derivados de benzanilida como antagonistas de 5-ht1d.
GB9119932D0 (en) *	1991-09-18	1991-10-30	Glaxo Group Ltd	Chemical compounds

1995
- 1995-12-06 EP EP95942116A patent/EP0799226B1/de not_active Expired - Lifetime
- 1995-12-06 AT AT95942116T patent/ATE199085T1/de active
- 1995-12-06 JP JP8519477A patent/JPH10510821A/ja active Pending
- 1995-12-06 PL PL95321048A patent/PL321048A1/xx unknown
- 1995-12-06 US US08/849,932 patent/US5972951A/en not_active Expired - Fee Related
- 1995-12-06 FI FI972583A patent/FI972583L/fi unknown
- 1995-12-06 WO PCT/EP1995/004889 patent/WO1996019477A1/en not_active Ceased
- 1995-12-06 CZ CZ971923A patent/CZ192397A3/cs unknown
- 1995-12-06 NZ NZ298036A patent/NZ298036A/en unknown
- 1995-12-06 HU HU9800158A patent/HUT77650A/hu unknown
- 1995-12-06 CN CN95197616A patent/CN1175256A/zh active Pending
- 1995-12-06 MX MX9704777A patent/MX9704777A/es unknown
- 1995-12-06 DE DE69520075T patent/DE69520075T2/de not_active Expired - Fee Related
- 1995-12-06 SK SK802-97A patent/SK80297A3/sk unknown
- 1995-12-06 AP APAP/P/1997/001006A patent/AP757A/en active
- 1995-12-06 ES ES95942116T patent/ES2153907T3/es not_active Expired - Lifetime
- 1995-12-06 AU AU43433/96A patent/AU697361B2/en not_active Ceased
- 1995-12-06 CA CA002208244A patent/CA2208244A1/en not_active Abandoned
- 1995-12-06 BR BR9510419A patent/BR9510419A/pt not_active Application Discontinuation
- 1995-12-19 AR ARP950100629A patent/AR002011A1/es unknown
- 1995-12-19 TR TR95/01597A patent/TR199501597A2/xx unknown
- 1995-12-20 MA MA24106A patent/MA23753A1/fr unknown
- 1995-12-20 DZ DZ950140A patent/DZ1957A1/fr active
- 1995-12-21 IL IL11648695A patent/IL116486A0/xx unknown
1997
- 1997-06-20 OA OA70033A patent/OA10610A/en unknown
- 1997-06-20 NO NO972910A patent/NO972910L/no unknown
- 1997-07-01 BG BG101715A patent/BG61977B1/bg unknown

Also Published As

Publication number	Publication date
FI972583A0 (fi)	1997-06-17
NO972910L (no)	1997-08-14
FI972583A7 (fi)	1997-08-19
SK80297A3 (en)	1998-12-02
CA2208244A1 (en)	1996-06-27
US5972951A (en)	1999-10-26
BR9510419A (pt)	1998-05-19
MA23753A1 (fr)	1996-07-01
EP0799226B1 (de)	2001-02-07
DE69520075D1 (de)	2001-03-15
AR002011A1 (es)	1998-01-07
DE69520075T2 (de)	2001-08-02
OA10610A (en)	2002-09-06
AU697361B2 (en)	1998-10-01
NO972910D0 (no)	1997-06-20
HUT77650A (hu)	1998-07-28
AP9701006A0 (en)	1997-07-31
ES2153907T3 (es)	2001-03-16
WO1996019477A1 (en)	1996-06-27
BG61977B1 (bg)	1998-11-30
AU4343396A (en)	1996-07-10
FI972583L (fi)	1997-08-19
EP0799226A1 (de)	1997-10-08
NZ298036A (en)	1998-11-25
IL116486A0 (en)	1997-08-14
DZ1957A1 (fr)	2002-02-17
CN1175256A (zh)	1998-03-04
JPH10510821A (ja)	1998-10-20
TR199501597A2 (tr)	1996-07-21
MX9704777A (es)	1997-10-31
CZ192397A3 (en)	1997-09-17
BG101715A (bg)	1998-02-27
AP757A (en)	1999-09-06
PL321048A1 (en)	1997-11-24

Publication	Publication Date	Title
ATE199085T1 (de)	2001-02-15	Tetrazyklische spiroverbindungen, verfahren zu ihrer herstellung und ihre verwendung als 5ht1d- rezeptor antagonisten
DE69508762D1 (de)	1999-05-06	Quaternäre ammoniumderivate, verfahren zu ihrer herstellung und ihre verwendung als oberflächenaktive verbindungen
ATE169018T1 (de)	1998-08-15	Tetracyclische derivate, verfahren zu ihrer herstellung und ihre verwendung
ATE272631T1 (de)	2004-08-15	Neue hydroxyindole, deren verwendung als inhibitoren der phosphodiesterase 4 und verfahren zu deren herstellung
DE69320050D1 (de)	1998-09-03	Substituierte pyrazolderivate, verfahren zu ihrer herstellung und ihre verwendung als herbizide
ATE252578T1 (de)	2003-11-15	1,3-oxazolin- und 1,3-thiazolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als schädlingsbekämpfungsmittel
DE69101144D1 (de)	1994-03-17	Mikrokugeln, verfahren zu ihrer herstellung und ihre verwendung.
DE69726593D1 (de)	2004-01-15	Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumor- und antivirale mittel
ATE234842T1 (de)	2003-04-15	Epithilonderivate, verfahren zu deren herstellung und deren verwendung
ATE250686T1 (de)	2003-10-15	Vliesverbund, verfahren zu dessen herstellung und dessen verwendung
DE50011818D1 (de)	2006-01-12	Hochkratzfeste mehrschichtlackierung, verfahren zu ihrer herstellung und ihre verwendung
ATA198791A (de)	1994-02-15	Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
ATE210638T1 (de)	2001-12-15	Biphenylsulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament
ATE192738T1 (de)	2000-05-15	(aminoalkyl- und acylaminoalkyl- oxy)benzyloxychinoline, verfahren zu deren herstellung und ihre verwendung als bradykinin- rezeptorantagonisten
DE59912402D1 (de)	2005-09-15	Polycyclische thiazolidin-2-yliden amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE59610666D1 (de)	2003-09-18	Mehrlagenfolie, verfahren zu ihrer herstellung und ihre verwendung
DE69908371D1 (de)	2003-07-03	Thioethergruppen enthaltende distamycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
AT399880B (de)	1995-08-25	Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE69922378D1 (de)	2005-01-05	Oxidierte sulfurierte distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
DE69712048D1 (de)	2002-05-23	Dihalopropenverbindungen, deren verwendung als insektizide/akarizide, und zwischenverbindungen zu deren herstellung
DE59506861D1 (de)	1999-10-28	Schwefelorganische Goldverbindungen, Verfahren zu ihrer Herstellung und Verwendung derselben
DE59902408D1 (de)	2002-09-26	Biphenylsulfonylcyanamide, verfahren zu ihrer herstellung und ihre verwendung als medikament
DE59704380D1 (de)	2001-09-27	Neue synthetische catecholderivate, verfahren zu ihrer herstellung und ihre verwendung
ATE263755T1 (de)	2004-04-15	Neue antiestrogene, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
ATE313556T1 (de)	2006-01-15	Memno-peptide, verfahren zu ihrer herstellung und ihre verwendung