BG61977B1 - Тетрациклени спиросъединения, метод за тяхното получаване иприложението им като 5нт1d рецепторни антагонисти - Google Patents

Тетрациклени спиросъединения, метод за тяхното получаване иприложението им като 5нт1d рецепторни антагонисти Download PDF

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Publication number
BG61977B1
BG61977B1 BG101715A BG10171597A BG61977B1 BG 61977 B1 BG61977 B1 BG 61977B1 BG 101715 A BG101715 A BG 101715A BG 10171597 A BG10171597 A BG 10171597A BG 61977 B1 BG61977 B1 BG 61977B1
Authority
BG
Bulgaria
Prior art keywords
methyl
piperidine
furo
carbonyl
indole
Prior art date
Application number
BG101715A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG101715A (bg
Inventor
Laramie M. Gaster
Francis D. King
Paul A. Wyman
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9426029.6A external-priority patent/GB9426029D0/en
Priority claimed from GBGB9512920.1A external-priority patent/GB9512920D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BG101715A publication Critical patent/BG101715A/xx
Publication of BG61977B1 publication Critical patent/BG61977B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG101715A 1994-12-22 1997-07-01 Тетрациклени спиросъединения, метод за тяхното получаване иприложението им като 5нт1d рецепторни антагонисти BG61977B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9426029.6A GB9426029D0 (en) 1994-12-22 1994-12-22 Novel compounds
GBGB9512920.1A GB9512920D0 (en) 1995-06-24 1995-06-24 Novel compounds
PCT/EP1995/004889 WO1996019477A1 (en) 1994-12-22 1995-12-06 Tetracyclic spiro compounds, process for their preparation and their use as 5ht1d receptor antagonists

Publications (2)

Publication Number Publication Date
BG101715A BG101715A (bg) 1998-02-27
BG61977B1 true BG61977B1 (bg) 1998-11-30

Family

ID=26306239

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101715A BG61977B1 (bg) 1994-12-22 1997-07-01 Тетрациклени спиросъединения, метод за тяхното получаване иприложението им като 5нт1d рецепторни антагонисти

Country Status (27)

Country Link
US (1) US5972951A (de)
EP (1) EP0799226B1 (de)
JP (1) JPH10510821A (de)
CN (1) CN1175256A (de)
AP (1) AP757A (de)
AR (1) AR002011A1 (de)
AT (1) ATE199085T1 (de)
AU (1) AU697361B2 (de)
BG (1) BG61977B1 (de)
BR (1) BR9510419A (de)
CA (1) CA2208244A1 (de)
CZ (1) CZ192397A3 (de)
DE (1) DE69520075T2 (de)
DZ (1) DZ1957A1 (de)
ES (1) ES2153907T3 (de)
FI (1) FI972583L (de)
HU (1) HUT77650A (de)
IL (1) IL116486A0 (de)
MA (1) MA23753A1 (de)
MX (1) MX9704777A (de)
NO (1) NO972910L (de)
NZ (1) NZ298036A (de)
OA (1) OA10610A (de)
PL (1) PL321048A1 (de)
SK (1) SK80297A3 (de)
TR (1) TR199501597A2 (de)
WO (1) WO1996019477A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9519033D0 (en) * 1995-09-18 1995-11-15 Smithkline Beecham Plc Treatment
EP0861257A1 (de) * 1995-11-08 1998-09-02 Smithkline Beecham Plc Spiro-piperdin derivate als 5ht-receptor antagonisten
GB9522845D0 (en) * 1995-11-08 1996-01-10 Smithkline Beecham Plc Novel compounds
EP0862565A1 (de) * 1995-11-22 1998-09-09 Smithkline Beecham Plc Tricyclische spiroverbindungen als 5ht1d-rezeptorantagonisten
GB9605883D0 (en) * 1996-03-20 1996-05-22 Smithkline Beecham Plc Novel compounds
GB9606396D0 (en) * 1996-03-27 1996-06-05 Smithkline Beecham Plc Novel compounds
US6156783A (en) * 1996-04-30 2000-12-05 Smithkline Beecham P.L.C. Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
FR2761069A1 (fr) * 1997-03-20 1998-09-25 Pf Medicament Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments
CA2347095A1 (en) * 1998-10-16 2000-04-27 Takeda Chemical Industries, Ltd. Nitrogen-containing condensed heterocyclic derivatives, their production and agent
DE10051981A1 (de) 2000-10-20 2002-05-02 Bayer Ag Substituierte Phenyluracile
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
TWI378092B (en) * 2003-06-03 2012-12-01 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
US7700808B2 (en) 2005-12-26 2010-04-20 Nissan Chemical Industries, Ltd. 1-3-bis(substituted phenyl)-3-hydroxypropan-1-one or 2-propen-1-one compound, and salt thereof
WO2008140895A1 (en) 2007-04-20 2008-11-20 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
ES2569660T3 (es) 2007-06-08 2016-05-12 Mannkind Corporation Inhibidores de la IRE-1alfa
EP2172462A4 (de) 2007-06-27 2010-12-15 Nissan Chemical Ind Ltd Verfahren zur herstellung einer 3-hydroxypropan-1-onverbindung, verfahren zur herstellung einer 2-propen-1-onverbindung und verfahren zur herstellung einer isoxazolinverbindung
HRP20150882T1 (hr) 2008-10-17 2015-09-25 Xenon Pharmaceuticals Inc. Spirooksindolski spojevi i njihova upotreba kao terapijska sredstva
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
PE20170202A1 (es) 2009-10-14 2017-03-24 Xenon Pharmaceuticals Inc Metodos sinteticos para compuestos espiro-oxoindol
RU2596488C2 (ru) 2010-02-26 2016-09-10 Ксенон Фармасьютикалз Инк. Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
AR103636A1 (es) 2015-02-05 2017-05-24 Teva Pharmaceuticals Int Gmbh Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol
WO2019036024A1 (en) 2017-08-17 2019-02-21 Bristol-Myers Squibb Company 2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
CN118903436A (zh) 2018-01-31 2024-11-08 德西费拉制药有限责任公司 治疗肥大细胞增多症的组合疗法
KR102708177B1 (ko) 2018-01-31 2024-09-23 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양의 치료를 위한 병용 요법
IL330104A (en) 2019-03-11 2026-08-01 Deciphera Pharmaceuticals Llc Crystalline forms of rifatinib
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer
US12691108B2 (en) 2019-08-12 2026-07-28 Deciphera Pharmaceuticals, Llc Methods for treating vascular malformations
HRP20260411T1 (hr) 2019-08-12 2026-05-08 Deciphera Pharmaceuticals, Llc Ripretinib za liječenje gastrointestinalnih stromalnih tumora
FI4084779T3 (fi) 2019-12-30 2024-12-16 Deciphera Pharmaceuticals Llc 1-(4-bromi-5-(1-etyyli-7-(metyyliamino)-2-okso-1,2-dihydro-1,6-naftyridin-3-yyli)-2-fluorifenyyli)-3-fenyyliurean koostumuksia
CN115989219B (zh) 2020-06-29 2026-02-13 贝凯恩生物医疗技术有限公司 用于治疗炎症小体介导的肺部疾病的丙磺舒化合物
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9119932D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
ES2162792T3 (es) 1991-09-18 2002-01-16 Glaxo Group Ltd Derivados de benzanilida como antagonistas de 5-ht1d.

Also Published As

Publication number Publication date
TR199501597A2 (tr) 1996-07-21
MX9704777A (es) 1997-10-31
NO972910D0 (no) 1997-06-20
JPH10510821A (ja) 1998-10-20
FI972583A7 (fi) 1997-08-19
EP0799226B1 (de) 2001-02-07
FI972583A0 (fi) 1997-06-17
AU697361B2 (en) 1998-10-01
CA2208244A1 (en) 1996-06-27
AU4343396A (en) 1996-07-10
DZ1957A1 (fr) 2002-02-17
OA10610A (en) 2002-09-06
AP9701006A0 (en) 1997-07-31
ATE199085T1 (de) 2001-02-15
BR9510419A (pt) 1998-05-19
SK80297A3 (en) 1998-12-02
AR002011A1 (es) 1998-01-07
CN1175256A (zh) 1998-03-04
WO1996019477A1 (en) 1996-06-27
NZ298036A (en) 1998-11-25
BG101715A (bg) 1998-02-27
NO972910L (no) 1997-08-14
US5972951A (en) 1999-10-26
CZ192397A3 (en) 1997-09-17
HUT77650A (hu) 1998-07-28
EP0799226A1 (de) 1997-10-08
ES2153907T3 (es) 2001-03-16
FI972583L (fi) 1997-08-19
PL321048A1 (en) 1997-11-24
MA23753A1 (fr) 1996-07-01
AP757A (en) 1999-09-06
IL116486A0 (en) 1997-08-14
DE69520075T2 (de) 2001-08-02
DE69520075D1 (de) 2001-03-15

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