OA10610A - Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists. - Google Patents

Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists. Download PDF

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Publication number
OA10610A
OA10610A OA70033A OA70033A OA10610A OA 10610 A OA10610 A OA 10610A OA 70033 A OA70033 A OA 70033A OA 70033 A OA70033 A OA 70033A OA 10610 A OA10610 A OA 10610A
Authority
OA
OAPI
Prior art keywords
dichloro
benzimidazol
cyclopentanediol
hydroxymethyl
compound
Prior art date
Application number
OA70033A
Other languages
English (en)
Inventor
Laramie Mary Gaster
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9426029.6A external-priority patent/GB9426029D0/en
Priority claimed from GBGB9512920.1A external-priority patent/GB9512920D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of OA10610A publication Critical patent/OA10610A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA70033A 1994-12-22 1997-06-20 Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists. OA10610A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9426029.6A GB9426029D0 (en) 1994-12-22 1994-12-22 Novel compounds
GBGB9512920.1A GB9512920D0 (en) 1995-06-24 1995-06-24 Novel compounds

Publications (1)

Publication Number Publication Date
OA10610A true OA10610A (en) 2002-09-06

Family

ID=26306239

Family Applications (1)

Application Number Title Priority Date Filing Date
OA70033A OA10610A (en) 1994-12-22 1997-06-20 Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists.

Country Status (27)

Country Link
US (1) US5972951A (de)
EP (1) EP0799226B1 (de)
JP (1) JPH10510821A (de)
CN (1) CN1175256A (de)
AP (1) AP757A (de)
AR (1) AR002011A1 (de)
AT (1) ATE199085T1 (de)
AU (1) AU697361B2 (de)
BG (1) BG61977B1 (de)
BR (1) BR9510419A (de)
CA (1) CA2208244A1 (de)
CZ (1) CZ192397A3 (de)
DE (1) DE69520075T2 (de)
DZ (1) DZ1957A1 (de)
ES (1) ES2153907T3 (de)
FI (1) FI972583L (de)
HU (1) HUT77650A (de)
IL (1) IL116486A0 (de)
MA (1) MA23753A1 (de)
MX (1) MX9704777A (de)
NO (1) NO972910L (de)
NZ (1) NZ298036A (de)
OA (1) OA10610A (de)
PL (1) PL321048A1 (de)
SK (1) SK80297A3 (de)
TR (1) TR199501597A2 (de)
WO (1) WO1996019477A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9519033D0 (en) * 1995-09-18 1995-11-15 Smithkline Beecham Plc Treatment
GB9522845D0 (en) * 1995-11-08 1996-01-10 Smithkline Beecham Plc Novel compounds
WO1997017351A1 (en) * 1995-11-08 1997-05-15 Smithkline Beecham Plc Spiro piperidine derivatives as 5mt receptor antagonists
WO1997019070A1 (en) * 1995-11-22 1997-05-29 Smithkline Beecham Plc Tricyclic spiro compounds as 5ht1d receptor antagonists
GB9605883D0 (en) * 1996-03-20 1996-05-22 Smithkline Beecham Plc Novel compounds
GB9606396D0 (en) * 1996-03-27 1996-06-05 Smithkline Beecham Plc Novel compounds
US6156783A (en) * 1996-04-30 2000-12-05 Smithkline Beecham P.L.C. Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
FR2761069A1 (fr) * 1997-03-20 1998-09-25 Pf Medicament Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments
EP1122252A4 (de) * 1998-10-16 2002-06-26 Takeda Chemical Industries Ltd Stickstoffhaltige annelierte heterocyclen, verfahren zu ihrer herstellung und agentien, die diese enthalten
DE10051981A1 (de) 2000-10-20 2002-05-02 Bayer Ag Substituierte Phenyluracile
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
PT1656370E (pt) * 2003-06-03 2012-11-29 Rib X Pharmaceuticals Inc Compostos biaril-heterocíclicos e métodos de os produzir e de os utilizar
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
CN101346336B (zh) 2005-12-26 2013-02-27 日产化学工业株式会社 1,3-二(取代苯基)-3-取代-2-丙烯-1-酮化合物和其盐
AU2008242720A1 (en) 2007-04-20 2008-10-30 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
EP2520561B1 (de) 2007-06-08 2016-02-10 MannKind Corporation IRE-1a-Inhibitoren
US8952175B2 (en) 2007-06-27 2015-02-10 Nissan Chemical Industries, Ltd. Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound
WO2010045251A2 (en) 2008-10-17 2010-04-22 Xenon Pharmaceuticals, Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
AU2010306768B2 (en) 2009-10-14 2016-08-04 Xenon Pharmaceuticals Inc. Synthetic methods for spiro-oxindole compounds
MY165117A (en) 2010-02-26 2018-02-28 Xenon Pharmaceuticals Inc Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
AR103636A1 (es) 2015-02-05 2017-05-24 Teva Pharmaceuticals Int Gmbh Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol
US11498903B2 (en) 2017-08-17 2022-11-15 Bristol-Myers Squibb Company 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
SG11202007198WA (en) 2018-01-31 2020-08-28 Deciphera Pharmaceuticals Llc Combination therapy for the treatment of gastrointestinal stromal tumors
EA202091763A1 (ru) 2018-01-31 2020-12-14 ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Комбинированная терапия для лечения мастоцитоза
EP3938363A1 (de) 2019-03-11 2022-01-19 Teva Pharmaceuticals International GmbH Festkörperformen von ripretinib
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer
WO2021030405A1 (en) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib for treating gastrointestinal stromal tumors
JP7818502B2 (ja) 2019-08-12 2026-02-20 デシフェラ・ファーマシューティカルズ，エルエルシー 胃腸間質腫瘍を治療するためのリプレチニブ
AU2020417282B2 (en) 2019-12-30 2023-08-31 Deciphera Pharmaceuticals, Llc Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
SI4084778T1 (sl) 2019-12-30 2024-01-31 Deciphera Pharmaceuticals, Llc Formulacije inhibitorja amorfne kinaze in načini njihove uporabe
AU2021303146A1 (en) 2020-06-29 2023-02-02 Bacainn Biotherapeutics, Ltd. Probenecid compounds for the treatment of inflammasome-mediated lung disease
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2162792T3 (es) 1991-09-18 2002-01-16 Glaxo Group Ltd Derivados de benzanilida como antagonistas de 5-ht1d.
GB9119932D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
FI972583A0 (fi) 1997-06-17
NO972910L (no) 1997-08-14
FI972583A7 (fi) 1997-08-19
SK80297A3 (en) 1998-12-02
CA2208244A1 (en) 1996-06-27
US5972951A (en) 1999-10-26
BR9510419A (pt) 1998-05-19
MA23753A1 (fr) 1996-07-01
EP0799226B1 (de) 2001-02-07
DE69520075D1 (de) 2001-03-15
AR002011A1 (es) 1998-01-07
DE69520075T2 (de) 2001-08-02
AU697361B2 (en) 1998-10-01
NO972910D0 (no) 1997-06-20
HUT77650A (hu) 1998-07-28
AP9701006A0 (en) 1997-07-31
ES2153907T3 (es) 2001-03-16
WO1996019477A1 (en) 1996-06-27
BG61977B1 (bg) 1998-11-30
ATE199085T1 (de) 2001-02-15
AU4343396A (en) 1996-07-10
FI972583L (fi) 1997-08-19
EP0799226A1 (de) 1997-10-08
NZ298036A (en) 1998-11-25
IL116486A0 (en) 1997-08-14
DZ1957A1 (fr) 2002-02-17
CN1175256A (zh) 1998-03-04
JPH10510821A (ja) 1998-10-20
TR199501597A2 (tr) 1996-07-21
MX9704777A (es) 1997-10-31
CZ192397A3 (en) 1997-09-17
BG101715A (bg) 1998-02-27
AP757A (en) 1999-09-06
PL321048A1 (en) 1997-11-24

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