GR3036083T3 - Process for the preparation and isolation of atracurium besylate - Google Patents

Process for the preparation and isolation of atracurium besylate

Info

Publication number: GR3036083T3
Authority: GR; Greece
Prior art keywords: atracurium besylate; besylate; isolation; preparation; reaction mixture
Prior art date: 1996-02-16

Application number

GR20010400928T

Other languages

English (en)

Inventor

Steven A Chamberlin

Ashok V Bhatia

Deborah A Davis

Keith A Drengler

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-16

Filing date

2001-06-19

Publication date

2001-09-28

2001-06-19 Application filed by Abbott Lab filed Critical Abbott Lab

2001-09-28 Publication of GR3036083T3 publication Critical patent/GR3036083T3/el

Links

229960002945 atracurium besylate Drugs 0.000 title abstract 3
XXZSQOVSEBAPGS-UHFFFAOYSA-L atracurium besylate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1.[O-]S(=O)(=O)C1=CC=CC=C1.C1=C(OC)C(OC)=CC=C1CC1[N+](CCC(=O)OCCCCCOC(=O)CC[N+]2(C)C(C3=CC(OC)=C(OC)C=C3CC2)CC=2C=C(OC)C(OC)=CC=2)(C)CCC2=CC(OC)=C(OC)C=C21 XXZSQOVSEBAPGS-UHFFFAOYSA-L 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
238000002955 isolation Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
239000011541 reaction mixture Substances 0.000 abstract 2
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
229940125904 compound 1 Drugs 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
CZXGXYBOQYQXQD-UHFFFAOYSA-N methyl benzenesulfonate Chemical compound COS(=O)(=O)C1=CC=CC=C1 CZXGXYBOQYQXQD-UHFFFAOYSA-N 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Paints Or Removers (AREA)
Organic Insulating Materials (AREA)
Photoreceptors In Electrophotography (AREA)
Element Separation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)

GR20010400928T 1996-02-16 2001-06-19 Process for the preparation and isolation of atracurium besylate GR3036083T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/602,945 US5684154A (en)	1996-02-16	1996-02-16	Process for the preparation and isolation of atracurium besylate
PCT/US1997/002196 WO1997030033A1 (en)	1996-02-16	1997-02-12	Process for the preparation and isolation of atracurium besylate

Publications (1)

Publication Number	Publication Date
GR3036083T3 true GR3036083T3 (en)	2001-09-28

Family

ID=24413409

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR20010400928T GR3036083T3 (en)	1996-02-16	2001-06-19	Process for the preparation and isolation of atracurium besylate

Country Status (10)

Country	Link
US (1)	US5684154A (el)
EP (1)	EP0882020B1 (el)
JP (1)	JP2000513328A (el)
AT (1)	ATE200485T1 (el)
DE (1)	DE69704553T2 (el)
DK (1)	DK0882020T3 (el)
ES (1)	ES2158499T3 (el)
GR (1)	GR3036083T3 (el)
PT (1)	PT882020E (el)
WO (1)	WO1997030033A1 (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5213137B2 (ja) *	2006-12-06	2013-06-19	コーネルリサーチファウンデーション，インコーポレイテッド	中程度の持続時間の神経筋遮断剤およびそのアンタゴニスト
AU2008222298A1 (en) *	2007-03-08	2008-09-12	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
WO2008117271A1 (en) *	2007-03-26	2008-10-02	Chemagis Ltd.	(1r,1'r)-atracurium salts separation process
AU2008273724B2 (en) *	2007-05-01	2013-05-23	Chemagis Ltd.	Process for Producing Cisatracurium and Associated Intermediates
WO2008132748A1 (en) *	2007-05-01	2008-11-06	Chemagis Ltd.	Process for producing cisatracurium compounds and associated intermediates
WO2009007946A1 (en) *	2007-07-09	2009-01-15	Chemagis Ltd.	Process for producing cisatracurium and associated intermediates
AU2008264802A1 (en) *	2007-06-18	2008-12-24	Chemagis Ltd.	(1R,1'R)-atracurium salts separation process
WO2009057086A1 (en) *	2007-10-29	2009-05-07	Chemagis Ltd.	Novel r,r'-atracurium salts
BRPI0907656A2 (pt) *	2008-05-01	2019-08-27	Chemagis Ltd	composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio
WO2010107488A1 (en)	2009-03-17	2010-09-23	Cornell University	Reversible nondepolarizing neuromuscular blockade agents and methods for their use
CN102573794B (zh)	2009-08-19	2017-03-15	康奈尔大学	供生理注射用的半胱氨酸
CN114014806B (zh) *	2021-12-03	2024-11-12	江苏诚信药业有限公司	一种新晶型顺苯磺酸阿曲库铵及其结晶方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU506657B2 (en) *	1975-12-10	1980-01-17	Wellcome Foundation Limited, The	Isoquinoline derivatives
GB1579822A (en) *	1976-10-29	1980-11-26	Wellcome Found	Tetrahydroisoquinolinium muscle relaxants
US5453510A (en) *	1990-07-13	1995-09-26	Burroughs Wellcome Co.	Neuromuscular blocking agents
GB9015473D0 (en) *	1990-07-13	1990-08-29	Wellcome Found	Neuromuscular blocking agents

1996
- 1996-02-16 US US08/602,945 patent/US5684154A/en not_active Expired - Lifetime
1997
- 1997-02-12 DK DK97905920T patent/DK0882020T3/da active
- 1997-02-12 AT AT97905920T patent/ATE200485T1/de not_active IP Right Cessation
- 1997-02-12 JP JP09529450A patent/JP2000513328A/ja not_active Ceased
- 1997-02-12 WO PCT/US1997/002196 patent/WO1997030033A1/en not_active Ceased
- 1997-02-12 EP EP97905920A patent/EP0882020B1/en not_active Expired - Lifetime
- 1997-02-12 DE DE69704553T patent/DE69704553T2/de not_active Expired - Fee Related
- 1997-02-12 PT PT97905920T patent/PT882020E/pt unknown
- 1997-02-12 ES ES97905920T patent/ES2158499T3/es not_active Expired - Lifetime
2001
- 2001-06-19 GR GR20010400928T patent/GR3036083T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5684154A (en)	1997-11-04
DE69704553T2 (de)	2001-11-08
ES2158499T3 (es)	2001-09-01
EP0882020B1 (en)	2001-04-11
EP0882020A1 (en)	1998-12-09
PT882020E (pt)	2001-09-28
JP2000513328A (ja)	2000-10-10
ATE200485T1 (de)	2001-04-15
WO1997030033A1 (en)	1997-08-21
DK0882020T3 (da)	2001-08-20
DE69704553D1 (de)	2001-05-17

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Legal Events

Date	Code	Title	Description
2010-09-06	ML	Lapse due to non-payment of fees