ATE203236T1 - Neue kondensierte indan-derivate und ihre pharmazeutisch verträglichen salze - Google Patents

Neue kondensierte indan-derivate und ihre pharmazeutisch verträglichen salze

Info

Publication number
ATE203236T1
ATE203236T1 AT95918733T AT95918733T ATE203236T1 AT E203236 T1 ATE203236 T1 AT E203236T1 AT 95918733 T AT95918733 T AT 95918733T AT 95918733 T AT95918733 T AT 95918733T AT E203236 T1 ATE203236 T1 AT E203236T1
Authority
AT
Austria
Prior art keywords
group
substituted
optionally substituted
ring
nitrogenous heterocyclic
Prior art date
Application number
AT95918733T
Other languages
English (en)
Inventor
Shinji Okazaki
Tetsuji Asao
Motoji Wakida
Keisuke Ishida
Masato Washinosu
Teruhiro Utsugi
Yuji Yamada
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE203236T1 publication Critical patent/ATE203236T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95918733T 1994-05-20 1995-05-18 Neue kondensierte indan-derivate und ihre pharmazeutisch verträglichen salze ATE203236T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10719094 1994-05-20
PCT/JP1995/000944 WO1995032187A1 (en) 1994-05-20 1995-05-18 Novel fused indan derivative and pharmaceutically acceptable salt thereof

Publications (1)

Publication Number Publication Date
ATE203236T1 true ATE203236T1 (de) 2001-08-15

Family

ID=14452758

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95918733T ATE203236T1 (de) 1994-05-20 1995-05-18 Neue kondensierte indan-derivate und ihre pharmazeutisch verträglichen salze

Country Status (21)

Country Link
US (3) US5733918A (de)
EP (1) EP0713870B1 (de)
KR (1) KR100190732B1 (de)
CN (1) CN1131216C (de)
AT (1) ATE203236T1 (de)
AU (1) AU685631B2 (de)
CA (1) CA2167382C (de)
DE (1) DE69521770T2 (de)
DK (1) DK0713870T3 (de)
ES (1) ES2158109T3 (de)
FI (1) FI111721B (de)
GR (1) GR3036795T3 (de)
HU (1) HU218308B (de)
IL (1) IL113778A (de)
NO (1) NO305555B1 (de)
NZ (1) NZ285448A (de)
PT (1) PT713870E (de)
RU (1) RU2124017C1 (de)
TW (1) TW440562B (de)
WO (1) WO1995032187A1 (de)
ZA (1) ZA954077B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3141148B2 (ja) * 1995-08-08 2001-03-05 大鵬薬品工業株式会社 縮合インダン誘導体及びその塩
DE19538088A1 (de) * 1995-10-13 1997-04-17 Bernd Prof Dr Clement Phenanthridinderivate und ihre Herstellung
US20030096833A1 (en) * 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
US6956035B2 (en) * 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
PL370530A1 (en) 2001-10-05 2005-05-30 F.Hoffmann-La Roche Ag Polycyclic compounds having anti-tumor activity
US6946472B2 (en) * 2002-04-30 2005-09-20 Hoffman-La Roche Inc. Polycyclic compounds exhibiting anti-tumor activities
CL2004000366A1 (es) * 2003-02-26 2005-01-07 Pharmacia Corp Sa Organizada B USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
AU2004258801A1 (en) * 2003-02-28 2005-02-03 Inotek Pharmaceuticals Corporation Tetracyclic Benzamide Derivatives and methods of use thereof
RU2006134024A (ru) * 2004-02-26 2008-04-10 Инотек Фармасьютикалз Корпорейшн (Us) Тетрациклические производные лактама и их использование
WO2005082368A1 (en) * 2004-02-26 2005-09-09 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
EP1784186A4 (de) * 2004-06-16 2008-05-14 Inotek Pharmaceuticals Corp Verfahren zur behandlung und vorbeugung von erektionsstörungen und harninkontinenz
CN101128431B (zh) * 2005-02-24 2011-05-25 詹森药业有限公司 作为钾离子通道打开剂的喹啉衍生物
EP1855676A4 (de) * 2005-02-25 2008-05-21 Inotek Pharmaceuticals Corp Tetrazyklische amino- und carboxamidoverbindungen sowie verfahren zu ihrer verwendung
KR20070116016A (ko) * 2005-02-25 2007-12-06 이노텍 파마슈티컬스 코포레이션 이소퀴놀린 화합물 및 그의 이용 방법
US20060287311A1 (en) * 2005-02-25 2006-12-21 Inotek Pharmaceuticals Corporation Tetracyclic Sulfonamide Compounds and methods of use thereof
AU2006283078A1 (en) * 2005-08-24 2007-03-01 Inotek Pharmaceuticals Corporation Indenoisoquinolinone Analogs and methods of use thereof
US8119654B2 (en) * 2007-02-28 2012-02-21 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
CN103102304B (zh) * 2013-01-19 2015-03-11 安徽师范大学 N-磺酰基取代四氢异喹啉衍生物的制备方法
EP3037424B1 (de) 2013-08-22 2017-11-08 Taiho Pharmaceutical Co., Ltd. Neuartige chinolinsubstituierte verbindung
JOP20190073A1 (ar) 2016-10-31 2019-04-07 Taiho Pharmaceutical Co Ltd مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20
JP7065103B2 (ja) 2017-09-01 2022-05-11 大鵬薬品工業株式会社 エクソン１８及び／又はエクソン２１変異型ｅｇｆｒ選択的阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60169482A (ja) * 1984-02-14 1985-09-02 Mitsubishi Chem Ind Ltd アミノ化フタライド−イソキノリン類の製法
JPH0633263B2 (ja) * 1985-05-27 1994-05-02 鐘淵化学工業株式会社 ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
SU1574598A1 (ru) * 1987-11-03 1990-06-30 Институт Химической Кинетики И Горения Со Ан Ссср Способ получени 4-диалкиламино-2-алкил(или фенил)нафто[2,3- @ ]хинолин-7,12-дионов
US5223506A (en) * 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds

Also Published As

Publication number Publication date
DE69521770T2 (de) 2002-05-23
CN1130903A (zh) 1996-09-11
IL113778A0 (en) 1995-08-31
NO960239L (no) 1996-03-18
TW440562B (en) 2001-06-16
FI111721B (fi) 2003-09-15
DK0713870T3 (da) 2001-09-24
EP0713870A1 (de) 1996-05-29
US5710162A (en) 1998-01-20
US6028079A (en) 2000-02-22
WO1995032187A1 (en) 1995-11-30
US5733918A (en) 1998-03-31
EP0713870A4 (de) 1996-12-18
IL113778A (en) 1999-09-22
KR960703864A (ko) 1996-08-31
FI960280A0 (fi) 1996-01-19
EP0713870B1 (de) 2001-07-18
FI960280A7 (fi) 1996-03-18
NZ285448A (en) 1997-11-24
PT713870E (pt) 2001-11-30
AU2454295A (en) 1995-12-18
KR100190732B1 (ko) 1999-06-01
RU2124017C1 (ru) 1998-12-27
CA2167382A1 (en) 1995-11-30
HU218308B (en) 2000-07-28
NO305555B1 (no) 1999-06-21
HUT75651A (en) 1997-05-28
ZA954077B (en) 1996-01-19
AU685631B2 (en) 1998-01-22
NO960239D0 (no) 1996-01-19
GR3036795T3 (en) 2002-01-31
DE69521770D1 (de) 2001-08-23
ES2158109T3 (es) 2001-09-01
CA2167382C (en) 1999-08-31
CN1131216C (zh) 2003-12-17

Similar Documents

Publication Publication Date Title
ATE203236T1 (de) Neue kondensierte indan-derivate und ihre pharmazeutisch verträglichen salze
TW349098B (en) Naphthalene derivatives, process for the preparation thereof, and intermediates therefor
ATE339409T1 (de) Trizyklische verbindungen
FI956270A0 (fi) Piperdiinijohdannaisia ja menetelmä niiden valmistamiseksi
DK1178967T3 (da) Quinolinderivater som inhibitorer af MEK-enzymer
NZ330656A (en) Tricyclic compounds, their production and use
ATE205199T1 (de) Quinolin- oder quinazolinderivate, deren herstellung und verwendung
ATE116964T1 (de) Substituierte aminoalkylbiphenylderivate, antimykotische präparate damit und zwischenprodukte für ihre herstellung.
ATE116301T1 (de) Chinolinderivate, deren herstellung und verwendung.
DE69311165D1 (de) Kondensierte heterocyclische Ketonderivate, ihre Herstellung und ihre Verwendung
IE862630L (en) 3-VINYL AND 3-ETHYNYL-ß-CARBOLINES
AU6158486A (en) Dihydro pyridine derivatives
ATE192927T1 (de) Neue cephem-derivate
EP0604352A3 (de) Arylsubstituierte heterocyclische Verbindungen.
ATE226572T1 (de) Kondensierte indan-derivate und ihre salze
NO975493D0 (no) Kondenserte polycykliske heterocykliske derivater
WO2001022951A3 (en) Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of multiple sclerosis
CA2202031A1 (en) Condensed indan derivatives and salts thereof
PL342826A1 (en) Derivatives of cycloalkenes, their production and application

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee