IL113778A - Condensed-indan derivatives pharmaceutical compositions containing the same and methods for the preparation thereof - Google Patents
Condensed-indan derivatives pharmaceutical compositions containing the same and methods for the preparation thereofInfo
- Publication number
- IL113778A IL113778A IL11377895A IL11377895A IL113778A IL 113778 A IL113778 A IL 113778A IL 11377895 A IL11377895 A IL 11377895A IL 11377895 A IL11377895 A IL 11377895A IL 113778 A IL113778 A IL 113778A
- Authority
- IL
- Israel
- Prior art keywords
- group
- substituted
- optionally substituted
- ring
- nitrogenous heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyesters Or Polycarbonates (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10719094 | 1994-05-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL113778A0 IL113778A0 (en) | 1995-08-31 |
| IL113778A true IL113778A (en) | 1999-09-22 |
Family
ID=14452758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11377895A IL113778A (en) | 1994-05-20 | 1995-05-18 | Condensed-indan derivatives pharmaceutical compositions containing the same and methods for the preparation thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US5733918A (de) |
| EP (1) | EP0713870B1 (de) |
| KR (1) | KR100190732B1 (de) |
| CN (1) | CN1131216C (de) |
| AT (1) | ATE203236T1 (de) |
| AU (1) | AU685631B2 (de) |
| CA (1) | CA2167382C (de) |
| DE (1) | DE69521770T2 (de) |
| DK (1) | DK0713870T3 (de) |
| ES (1) | ES2158109T3 (de) |
| FI (1) | FI111721B (de) |
| GR (1) | GR3036795T3 (de) |
| HU (1) | HU218308B (de) |
| IL (1) | IL113778A (de) |
| NO (1) | NO305555B1 (de) |
| NZ (1) | NZ285448A (de) |
| PT (1) | PT713870E (de) |
| RU (1) | RU2124017C1 (de) |
| TW (1) | TW440562B (de) |
| WO (1) | WO1995032187A1 (de) |
| ZA (1) | ZA954077B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3141148B2 (ja) * | 1995-08-08 | 2001-03-05 | 大鵬薬品工業株式会社 | 縮合インダン誘導体及びその塩 |
| DE19538088A1 (de) * | 1995-10-13 | 1997-04-17 | Bernd Prof Dr Clement | Phenanthridinderivate und ihre Herstellung |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| US6956035B2 (en) * | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| RU2315050C2 (ru) * | 2001-10-05 | 2008-01-20 | Ф.Хоффманн-Ля Рош Аг | Полициклические соединения, обладающие противоопухолевой активностью |
| US6946472B2 (en) | 2002-04-30 | 2005-09-20 | Hoffman-La Roche Inc. | Polycyclic compounds exhibiting anti-tumor activities |
| CL2004000366A1 (es) * | 2003-02-26 | 2005-01-07 | Pharmacia Corp Sa Organizada B | USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. |
| JP2007501857A (ja) * | 2003-02-28 | 2007-02-01 | イノテック ファーマシューティカルズ コーポレーション | 四環系ベンズアミド誘導体およびその使用方法 |
| EA200601558A1 (ru) * | 2004-02-26 | 2007-08-31 | Инотек Фармасьютикалз Корпорейшн | Производные изохинолинов и способы их использования |
| US20050261288A1 (en) * | 2004-02-26 | 2005-11-24 | Prakash Jagtap | Tetracyclic lactam derivatives and uses thereof |
| CA2571001A1 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceuticals Corporation | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| WO2006091769A1 (en) * | 2005-02-24 | 2006-08-31 | Janssen Pharmaceutica N.V. | Novel quinoline derivatives as potassium ion channel openers |
| WO2006093677A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic sulfonamide compounds and methods of use thereof |
| JP2008531561A (ja) * | 2005-02-25 | 2008-08-14 | イノテック ファーマシューティカルズ コーポレイション | イソキノリン化合物およびその使用方法 |
| RU2007135362A (ru) * | 2005-02-25 | 2009-03-27 | Инотек Фармасьютикалз Корпорейшн (Us) | Тетрациклические амино- и карбоксамидосоединения и способ их применения |
| CN101316592A (zh) * | 2005-08-24 | 2008-12-03 | 伊诺泰克制药公司 | 茚并异喹啉酮类似物及其用法 |
| MX2009009183A (es) * | 2007-02-28 | 2009-09-07 | Inotek Pharmaceuticals Corp | Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos. |
| CN103102304B (zh) * | 2013-01-19 | 2015-03-11 | 安徽师范大学 | N-磺酰基取代四氢异喹啉衍生物的制备方法 |
| EP3037424B1 (de) | 2013-08-22 | 2017-11-08 | Taiho Pharmaceutical Co., Ltd. | Neuartige chinolinsubstituierte verbindung |
| IL266239B2 (en) | 2016-10-31 | 2023-10-01 | Taiho Pharmaceutical Co Ltd | A selective inhibitor of EGFR with an EXON 20 insertion mutation |
| HUE066587T2 (hu) | 2017-09-01 | 2024-08-28 | Taiho Pharmaceutical Co Ltd | Exon-18- és/vagy exon-21-mutáns EGFR-szelektív inhibitor |
| EP4086290A1 (de) * | 2021-05-04 | 2022-11-09 | SHPP Global Technologies B.V. | Gekapptes bisphenolpolyindanoligomer und zusammensetzung, verfahren zur herstellung und daraus hergestellte artikel |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60169482A (ja) * | 1984-02-14 | 1985-09-02 | Mitsubishi Chem Ind Ltd | アミノ化フタライド−イソキノリン類の製法 |
| JPH0633263B2 (ja) * | 1985-05-27 | 1994-05-02 | 鐘淵化学工業株式会社 | ７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤 |
| SU1574598A1 (ru) * | 1987-11-03 | 1990-06-30 | Институт Химической Кинетики И Горения Со Ан Ссср | Способ получени 4-диалкиламино-2-алкил(или фенил)нафто[2,3- @ ]хинолин-7,12-дионов |
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
-
1995
- 1995-05-17 TW TW084104882A patent/TW440562B/zh not_active IP Right Cessation
- 1995-05-18 PT PT95918733T patent/PT713870E/pt unknown
- 1995-05-18 NZ NZ285448A patent/NZ285448A/en unknown
- 1995-05-18 WO PCT/JP1995/000944 patent/WO1995032187A1/ja not_active Ceased
- 1995-05-18 KR KR1019960700277A patent/KR100190732B1/ko not_active Expired - Fee Related
- 1995-05-18 AU AU24542/95A patent/AU685631B2/en not_active Ceased
- 1995-05-18 CN CN95190639A patent/CN1131216C/zh not_active Expired - Fee Related
- 1995-05-18 EP EP95918733A patent/EP0713870B1/de not_active Expired - Lifetime
- 1995-05-18 ZA ZA954077A patent/ZA954077B/xx unknown
- 1995-05-18 IL IL11377895A patent/IL113778A/xx not_active IP Right Cessation
- 1995-05-18 DK DK95918733T patent/DK0713870T3/da active
- 1995-05-18 CA CA002167382A patent/CA2167382C/en not_active Expired - Fee Related
- 1995-05-18 US US08/578,542 patent/US5733918A/en not_active Expired - Fee Related
- 1995-05-18 AT AT95918733T patent/ATE203236T1/de not_active IP Right Cessation
- 1995-05-18 ES ES95918733T patent/ES2158109T3/es not_active Expired - Lifetime
- 1995-05-18 RU RU96105034A patent/RU2124017C1/ru not_active IP Right Cessation
- 1995-05-18 HU HU9600130A patent/HU218308B/hu not_active IP Right Cessation
- 1995-05-18 DE DE69521770T patent/DE69521770T2/de not_active Expired - Fee Related
-
1996
- 1996-01-19 NO NO960239A patent/NO305555B1/no unknown
- 1996-01-19 FI FI960280A patent/FI111721B/fi active
- 1996-09-12 US US08/713,224 patent/US5710162A/en not_active Expired - Fee Related
-
1997
- 1997-08-12 US US08/909,934 patent/US6028079A/en not_active Expired - Fee Related
-
2001
- 2001-10-04 GR GR20010401657T patent/GR3036795T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU685631B2 (en) | 1998-01-22 |
| CA2167382C (en) | 1999-08-31 |
| WO1995032187A1 (en) | 1995-11-30 |
| NZ285448A (en) | 1997-11-24 |
| KR100190732B1 (ko) | 1999-06-01 |
| ATE203236T1 (de) | 2001-08-15 |
| KR960703864A (ko) | 1996-08-31 |
| FI960280A0 (fi) | 1996-01-19 |
| DE69521770D1 (de) | 2001-08-23 |
| EP0713870A1 (de) | 1996-05-29 |
| IL113778A0 (en) | 1995-08-31 |
| HU218308B (en) | 2000-07-28 |
| TW440562B (en) | 2001-06-16 |
| HUT75651A (en) | 1997-05-28 |
| EP0713870A4 (de) | 1996-12-18 |
| AU2454295A (en) | 1995-12-18 |
| CN1131216C (zh) | 2003-12-17 |
| ZA954077B (en) | 1996-01-19 |
| NO305555B1 (no) | 1999-06-21 |
| US5733918A (en) | 1998-03-31 |
| CA2167382A1 (en) | 1995-11-30 |
| FI111721B (fi) | 2003-09-15 |
| ES2158109T3 (es) | 2001-09-01 |
| NO960239L (no) | 1996-03-18 |
| DK0713870T3 (da) | 2001-09-24 |
| CN1130903A (zh) | 1996-09-11 |
| DE69521770T2 (de) | 2002-05-23 |
| NO960239D0 (no) | 1996-01-19 |
| US6028079A (en) | 2000-02-22 |
| RU2124017C1 (ru) | 1998-12-27 |
| EP0713870B1 (de) | 2001-07-18 |
| US5710162A (en) | 1998-01-20 |
| FI960280A7 (fi) | 1996-03-18 |
| PT713870E (pt) | 2001-11-30 |
| GR3036795T3 (en) | 2002-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |