ZA954077B - Condensed-indan derivatives and pharmaceutically acceptable salts thereof - Google Patents

Condensed-indan derivatives and pharmaceutically acceptable salts thereof

Info

Publication number: ZA954077B
Authority: ZA; South Africa
Prior art keywords: group; substituted; optionally substituted; ring; nitrogenous heterocyclic
Prior art date: 1994-05-20

Application number

ZA954077A

Other languages

English (en)

Inventor

Shinji Okazaki

Motoji Wakida

Masato Washinosu

Yuji Yamada

Tetsuji Asao

Keisuke Ishida

Teruhiro Utsugi

Original Assignee

Taiho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-20

Filing date

1995-05-18

Publication date

1996-01-19

1995-05-18 Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd

1996-01-19 Publication of ZA954077B publication Critical patent/ZA954077B/xx

Links

150000003839 salts Chemical class 0.000 title abstract 2
125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
125000000623 heterocyclic group Chemical group 0.000 abstract 5
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000005530 alkylenedioxy group Chemical group 0.000 abstract 2
UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical class C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical class C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polyesters Or Polycarbonates (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA954077A 1994-05-20 1995-05-18 Condensed-indan derivatives and pharmaceutically acceptable salts thereof ZA954077B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP10719094		1994-05-20

Publications (1)

Publication Number	Publication Date
ZA954077B true ZA954077B (en)	1996-01-19

Family

ID=14452758

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA954077A ZA954077B (en)	1994-05-20	1995-05-18	Condensed-indan derivatives and pharmaceutically acceptable salts thereof

Country Status (21)

Country	Link
US (3)	US5733918A (de)
EP (1)	EP0713870B1 (de)
KR (1)	KR100190732B1 (de)
CN (1)	CN1131216C (de)
AT (1)	ATE203236T1 (de)
AU (1)	AU685631B2 (de)
CA (1)	CA2167382C (de)
DE (1)	DE69521770T2 (de)
DK (1)	DK0713870T3 (de)
ES (1)	ES2158109T3 (de)
FI (1)	FI111721B (de)
GR (1)	GR3036795T3 (de)
HU (1)	HU218308B (de)
IL (1)	IL113778A (de)
NO (1)	NO305555B1 (de)
NZ (1)	NZ285448A (de)
PT (1)	PT713870E (de)
RU (1)	RU2124017C1 (de)
TW (1)	TW440562B (de)
WO (1)	WO1995032187A1 (de)
ZA (1)	ZA954077B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3141148B2 (ja) *	1995-08-08	2001-03-05	大鵬薬品工業株式会社	縮合インダン誘導体及びその塩
DE19538088A1 (de) *	1995-10-13	1997-04-17	Bernd Prof Dr Clement	Phenanthridinderivate und ihre Herstellung
US20030096833A1 (en) *	2001-08-31	2003-05-22	Jagtap Prakash G.	Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
US6956035B2 (en) *	2001-08-31	2005-10-18	Inotek Pharmaceuticals Corporation	Isoquinoline derivatives and methods of use thereof
RU2315050C2 (ru) *	2001-10-05	2008-01-20	Ф.Хоффманн-Ля Рош Аг	Полициклические соединения, обладающие противоопухолевой активностью
US6946472B2 (en)	2002-04-30	2005-09-20	Hoffman-La Roche Inc.	Polycyclic compounds exhibiting anti-tumor activities
CL2004000366A1 (es) *	2003-02-26	2005-01-07	Pharmacia Corp Sa Organizada B	USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
JP2007501857A (ja) *	2003-02-28	2007-02-01	イノテックファーマシューティカルズコーポレーション	四環系ベンズアミド誘導体およびその使用方法
EA200601558A1 (ru) *	2004-02-26	2007-08-31	Инотек Фармасьютикалз Корпорейшн	Производные изохинолинов и способы их использования
US20050261288A1 (en) *	2004-02-26	2005-11-24	Prakash Jagtap	Tetracyclic lactam derivatives and uses thereof
CA2571001A1 (en) *	2004-06-16	2006-01-26	Inotek Pharmaceuticals Corporation	Methods for treating or preventing erectile dysfunction or urinary incontinence
WO2006091769A1 (en) *	2005-02-24	2006-08-31	Janssen Pharmaceutica N.V.	Novel quinoline derivatives as potassium ion channel openers
WO2006093677A1 (en) *	2005-02-25	2006-09-08	Inotek Pharmaceuticals Corporation	Tetracyclic sulfonamide compounds and methods of use thereof
JP2008531561A (ja) *	2005-02-25	2008-08-14	イノテックファーマシューティカルズコーポレイション	イソキノリン化合物およびその使用方法
RU2007135362A (ru) *	2005-02-25	2009-03-27	Инотек Фармасьютикалз Корпорейшн (Us)	Тетрациклические амино- и карбоксамидосоединения и способ их применения
CN101316592A (zh) *	2005-08-24	2008-12-03	伊诺泰克制药公司	茚并异喹啉酮类似物及其用法
MX2009009183A (es) *	2007-02-28	2009-09-07	Inotek Pharmaceuticals Corp	Analogos de indenoisoquinolinona y metodos de utilizacion de los mismos.
CN103102304B (zh) *	2013-01-19	2015-03-11	安徽师范大学	N-磺酰基取代四氢异喹啉衍生物的制备方法
EP3037424B1 (de)	2013-08-22	2017-11-08	Taiho Pharmaceutical Co., Ltd.	Neuartige chinolinsubstituierte verbindung
IL266239B2 (en)	2016-10-31	2023-10-01	Taiho Pharmaceutical Co Ltd	A selective inhibitor of EGFR with an EXON 20 insertion mutation
HUE066587T2 (hu)	2017-09-01	2024-08-28	Taiho Pharmaceutical Co Ltd	Exon-18- és/vagy exon-21-mutáns EGFR-szelektív inhibitor
EP4086290A1 (de) *	2021-05-04	2022-11-09	SHPP Global Technologies B.V.	Gekapptes bisphenolpolyindanoligomer und zusammensetzung, verfahren zur herstellung und daraus hergestellte artikel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60169482A (ja) *	1984-02-14	1985-09-02	Mitsubishi Chem Ind Ltd	アミノ化フタライド−イソキノリン類の製法
JPH0633263B2 (ja) *	1985-05-27	1994-05-02	鐘淵化学工業株式会社	７−ヒドロキシグアニン誘導体及びその製造方法並びにそれを有効成分とする抗腫瘍剤
SU1574598A1 (ru) *	1987-11-03	1990-06-30	Институт Химической Кинетики И Горения Со Ан Ссср	Способ получени 4-диалкиламино-2-алкил(или фенил)нафто[2,3- @ ]хинолин-7,12-дионов
US5223506A (en) *	1991-06-04	1993-06-29	Glaxo Inc.	Cyclic antitumor compounds

1995
- 1995-05-17 TW TW084104882A patent/TW440562B/zh not_active IP Right Cessation
- 1995-05-18 PT PT95918733T patent/PT713870E/pt unknown
- 1995-05-18 NZ NZ285448A patent/NZ285448A/en unknown
- 1995-05-18 WO PCT/JP1995/000944 patent/WO1995032187A1/ja not_active Ceased
- 1995-05-18 KR KR1019960700277A patent/KR100190732B1/ko not_active Expired - Fee Related
- 1995-05-18 AU AU24542/95A patent/AU685631B2/en not_active Ceased
- 1995-05-18 CN CN95190639A patent/CN1131216C/zh not_active Expired - Fee Related
- 1995-05-18 EP EP95918733A patent/EP0713870B1/de not_active Expired - Lifetime
- 1995-05-18 ZA ZA954077A patent/ZA954077B/xx unknown
- 1995-05-18 IL IL11377895A patent/IL113778A/xx not_active IP Right Cessation
- 1995-05-18 DK DK95918733T patent/DK0713870T3/da active
- 1995-05-18 CA CA002167382A patent/CA2167382C/en not_active Expired - Fee Related
- 1995-05-18 US US08/578,542 patent/US5733918A/en not_active Expired - Fee Related
- 1995-05-18 AT AT95918733T patent/ATE203236T1/de not_active IP Right Cessation
- 1995-05-18 ES ES95918733T patent/ES2158109T3/es not_active Expired - Lifetime
- 1995-05-18 RU RU96105034A patent/RU2124017C1/ru not_active IP Right Cessation
- 1995-05-18 HU HU9600130A patent/HU218308B/hu not_active IP Right Cessation
- 1995-05-18 DE DE69521770T patent/DE69521770T2/de not_active Expired - Fee Related
1996
- 1996-01-19 NO NO960239A patent/NO305555B1/no unknown
- 1996-01-19 FI FI960280A patent/FI111721B/fi active
- 1996-09-12 US US08/713,224 patent/US5710162A/en not_active Expired - Fee Related
1997
- 1997-08-12 US US08/909,934 patent/US6028079A/en not_active Expired - Fee Related
2001
- 2001-10-04 GR GR20010401657T patent/GR3036795T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU685631B2 (en)	1998-01-22
CA2167382C (en)	1999-08-31
WO1995032187A1 (en)	1995-11-30
NZ285448A (en)	1997-11-24
KR100190732B1 (ko)	1999-06-01
ATE203236T1 (de)	2001-08-15
KR960703864A (ko)	1996-08-31
FI960280A0 (fi)	1996-01-19
DE69521770D1 (de)	2001-08-23
EP0713870A1 (de)	1996-05-29
IL113778A0 (en)	1995-08-31
HU218308B (en)	2000-07-28
TW440562B (en)	2001-06-16
HUT75651A (en)	1997-05-28
EP0713870A4 (de)	1996-12-18
AU2454295A (en)	1995-12-18
CN1131216C (zh)	2003-12-17
NO305555B1 (no)	1999-06-21
US5733918A (en)	1998-03-31
CA2167382A1 (en)	1995-11-30
FI111721B (fi)	2003-09-15
ES2158109T3 (es)	2001-09-01
NO960239L (no)	1996-03-18
DK0713870T3 (da)	2001-09-24
CN1130903A (zh)	1996-09-11
DE69521770T2 (de)	2002-05-23
NO960239D0 (no)	1996-01-19
US6028079A (en)	2000-02-22
RU2124017C1 (ru)	1998-12-27
EP0713870B1 (de)	2001-07-18
US5710162A (en)	1998-01-20
FI960280A7 (fi)	1996-03-18
IL113778A (en)	1999-09-22
PT713870E (pt)	2001-11-30
GR3036795T3 (en)	2002-01-31

Publication	Publication Date	Title
ZA954077B (en)	1996-01-19	Condensed-indan derivatives and pharmaceutically acceptable salts thereof
AU6052594A (en)	1994-11-03	New heterocyclic compounds
TW349098B (en)	1999-01-01	Naphthalene derivatives, process for the preparation thereof, and intermediates therefor
NO20015448D0 (no)	2001-11-07	Kinolinderivater som inhibitorer av MEK enzymer
FI956270A0 (fi)	1995-12-27	Piperdiinijohdannaisia ja menetelmä niiden valmistamiseksi
NO940737L (de)	1994-05-03
EP0979821A4 (de)	2002-04-24	Trizyklische verbindungen
ATE123778T1 (de)	1995-06-15	Beta-lactam-derivate.
IL95839A0 (en)	1991-06-30	Quinoline derivatives,their production and use
MY128323A (en)	2007-01-31	Thiazole derivatives for inhibition of cytokine production and of cell adhesion
AU6366386A (en)	1987-04-09	3-vinyl- and 3- ethinyl-beta-carboline derivatives their production and their use as drugs
CA2152817A1 (en)	1994-07-21	Novel Pyridone Carboxylic Acid Derivatives
AU6158486A (en)	1987-02-26	Dihydro pyridine derivatives
ATE14880T1 (de)	1985-08-15	Cephalosporinverbindungen und ihre herstellung.
KR950704333A (ko)	1995-11-17	신규한 세펨 유도체(novel cephem derivatives)
ATE284401T1 (de)	2004-12-15	Verknüpfte polycyclische heterocyclische verbindungen
EP0785191A4 (de)	1999-10-27	Kondensierte indanderivate und ihre salze
DK0466662T3 (da)	1995-11-27	6,7-Disubstituerede-2-aminotetraliner, der er aktive som immunmodulatorer, samt farmaceutiske præparater indeholdende sådanne forbindelser
CA2202031A1 (en)	1997-02-20	Condensed indan derivatives and salts thereof