ATE205480T1 - 2,5-dioxo-2,5-dihydro-1h-benz(b)azepine als nmda rezeptor antagonisten - Google Patents

2,5-dioxo-2,5-dihydro-1h-benz(b)azepine als nmda rezeptor antagonisten

Info

Publication number: ATE205480T1
Authority: AT; Austria
Prior art keywords: benz; azepine; dioxo; dihydro; receptor antagonists
Prior art date: 1992-06-10

Application number

AT93913323T

Other languages

English (en)

Inventor

Marc Jerome Chapdelaine

Gregory David Harris

Paul Francis Jackson

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-10

Filing date

1993-06-09

Publication date

2001-09-15

1993-06-09 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE205480T1 publication Critical patent/ATE205480T1/de

Links

CIVZHVZUMZYFJP-UHFFFAOYSA-N 1h-1-benzazepine-2,5-dione Chemical compound N1C(=O)C=CC(=O)C2=CC=CC=C21 CIVZHVZUMZYFJP-UHFFFAOYSA-N 0.000 title 1
229940127523 NMDA Receptor Antagonists Drugs 0.000 title 1
DQFQCHIDRBIESA-UHFFFAOYSA-N 1-benzazepine Chemical class N1C=CC=CC2=CC=CC=C12 DQFQCHIDRBIESA-UHFFFAOYSA-N 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT93913323T 1992-06-10 1993-06-09 2,5-dioxo-2,5-dihydro-1h-benz(b)azepine als nmda rezeptor antagonisten ATE205480T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929212308A GB9212308D0 (en)	1992-06-10	1992-06-10	Therapeutic compositions
PCT/GB1993/001218 WO1993025534A1 (en)	1992-06-10	1993-06-09	2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS

Publications (1)

Publication Number	Publication Date
ATE205480T1 true ATE205480T1 (de)	2001-09-15

Family

ID=10716859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93913323T ATE205480T1 (de)	1992-06-10	1993-06-09	2,5-dioxo-2,5-dihydro-1h-benz(b)azepine als nmda rezeptor antagonisten

Country Status (18)

Country	Link
US (3)	US5492905A (de)
EP (1)	EP0644878B1 (de)
JP (1)	JPH09502157A (de)
KR (1)	KR100298377B1 (de)
AT (1)	ATE205480T1 (de)
AU (1)	AU672799B2 (de)
CA (1)	CA2137834A1 (de)
DE (1)	DE69330754T2 (de)
DK (1)	DK0644878T3 (de)
ES (1)	ES2161718T3 (de)
FI (2)	FI106714B (de)
GB (1)	GB9212308D0 (de)
HU (1)	HUT71404A (de)
NO (1)	NO305168B1 (de)
NZ (1)	NZ253252A (de)
PT (1)	PT644878E (de)
RU (1)	RU94046322A (de)
WO (1)	WO1993025534A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9212308D0 (en) *	1992-06-10	1992-07-22	Ici Plc	Therapeutic compositions
GB9311948D0 (en) *	1993-06-10	1993-07-28	Zeneca Ltd	Substituted nitrogen heterocycles
US5476933A (en) *	1994-11-16	1995-12-19	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	Azepine synthesis via a diels-alder reaction
TWI281914B (en)	2002-05-29	2007-06-01	Glaxo Group Ltd	Compounds
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (de)	2006-11-30	2012-04-18	Probiodrug AG	Neue inhibitoren von glutaminylcyclase
CA2679446C (en)	2007-03-01	2016-05-17	Probiodrug Ag	New use of glutaminyl cyclase inhibitors
US9656991B2 (en)	2007-04-18	2017-05-23	Probiodrug Ag	Inhibitors of glutaminyl cyclase
PT3106463T (pt)	2008-10-22	2018-05-18	Array Biopharma Inc	Compostos de pirazolo[1,5-]pirimidina substituídos como inibidores de cinase trk
BR112012008346B1 (pt)	2009-09-11	2021-12-21	Vivoryon Therapeutics N.V.	Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
DK2545047T3 (da)	2010-03-10	2014-07-28	Probiodrug Ag	Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (de)	2010-04-21	2016-01-06	Probiodrug AG	Hemmer der glutaminylzyklase
WO2012123563A1 (en)	2011-03-16	2012-09-20	Probiodrug Ag	Benz imidazole derivatives as inhibitors of glutaminyl cyclase
JPWO2016199789A1 (ja) *	2015-06-08	2018-03-29	国立大学法人名古屋大学	トリフルオロメチル置換セミスクアレートの製造方法、トリフルオロメチル置換セミスクアレートを起点とするトリフルオロメチル化合物の製造方法及びトリフルオロメチル基含有化合物
ES2952056T3 (es) *	2016-05-18	2023-10-26	Loxo Oncology Inc	Preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
PL3461819T3 (pl)	2017-09-29	2020-11-30	Probiodrug Ag	Inhibitory cyklazy glutaminylowej

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB130538A (en) *	1918-12-13	1919-08-07	John Algernon Launder	Improvements in or relating to Means for Supporting Garments and Garment Hangers.
GB1340334A (en) *	1970-07-06	1973-12-12	Rees A H	Synthesis of benzazetropolones and hence of kynurenic acids
JPS5129522B2 (de) *	1972-07-13	1976-08-26
JPS5520970B2 (de) *	1972-07-15	1980-06-06
CY1403A (en) *	1981-08-11	1987-12-18	Ciba Geigy Ag	Benzazepin-2-ones
US4410520A (en) *	1981-11-09	1983-10-18	Ciba-Geigy Corporation	3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) *	1982-07-19	1984-09-25	Ciba-Geigy Corporation	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4575503A (en) *	1983-02-10	1986-03-11	Ciba-Geigy Corporation	3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DE3323568C2 (de) *	1983-06-30	1987-01-29	Bayerische Motoren Werke AG, 8000 München	Heiz- und/oder Klimaanlage für Kraftfahrzeuge
US4477446A (en) *	1983-07-01	1984-10-16	Usv Pharmaceutical Corporation	1-Benzazepines and their pharmaceutical uses
DE3416695A1 (de) *	1984-05-05	1985-11-07	Bayer Ag, 5090 Leverkusen	Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
KR0167349B1 (ko) *	1989-10-20	1999-02-18	오스카 아끼히꼬	벤조헤테로 고리 화합물
GB9100028D0 (en) *	1991-01-02	1991-02-20	Ici Plc	Compounds
JPH05105292A (ja) *	1991-10-15	1993-04-27	Nec Corp	ロール紙のカール解消装置
GB9212308D0 (en) *	1992-06-10	1992-07-22	Ici Plc	Therapeutic compositions
ES2313714T3 (es) *	1992-06-22	2009-03-01	The Regents Of The University Of California	Antagonistas de receptores de glicina y uso de los mismos.
GB9311948D0 (en) *	1993-06-10	1993-07-28	Zeneca Ltd	Substituted nitrogen heterocycles

1992
- 1992-06-10 GB GB929212308A patent/GB9212308D0/en active Pending
1993
- 1993-06-09 RU RU94046322/14A patent/RU94046322A/ru unknown
- 1993-06-09 DE DE69330754T patent/DE69330754T2/de not_active Expired - Fee Related
- 1993-06-09 WO PCT/GB1993/001218 patent/WO1993025534A1/en not_active Ceased
- 1993-06-09 NZ NZ253252A patent/NZ253252A/en unknown
- 1993-06-09 AU AU43436/93A patent/AU672799B2/en not_active Ceased
- 1993-06-09 KR KR1019940704503A patent/KR100298377B1/ko not_active Expired - Fee Related
- 1993-06-09 ES ES93913323T patent/ES2161718T3/es not_active Expired - Lifetime
- 1993-06-09 PT PT93913323T patent/PT644878E/pt unknown
- 1993-06-09 EP EP93913323A patent/EP0644878B1/de not_active Expired - Lifetime
- 1993-06-09 HU HU9403498A patent/HUT71404A/hu unknown
- 1993-06-09 JP JP6501262A patent/JPH09502157A/ja not_active Ceased
- 1993-06-09 AT AT93913323T patent/ATE205480T1/de not_active IP Right Cessation
- 1993-06-09 CA CA002137834A patent/CA2137834A1/en not_active Abandoned
- 1993-06-09 DK DK93913323T patent/DK0644878T3/da active
- 1993-06-10 US US08/074,907 patent/US5492905A/en not_active Expired - Fee Related
1994
- 1994-12-09 NO NO944781A patent/NO305168B1/no unknown
- 1994-12-09 FI FI945807A patent/FI106714B/fi not_active IP Right Cessation
1995
- 1995-09-07 US US08/524,557 patent/US5654295A/en not_active Expired - Fee Related
1997
- 1997-01-13 US US08/782,279 patent/US5712272A/en not_active Expired - Fee Related
2000
- 2000-12-12 FI FI20002725A patent/FI20002725A7/fi unknown

Also Published As

Publication number	Publication date
NO944781D0 (no)	1994-12-09
NO305168B1 (no)	1999-04-12
FI945807A0 (fi)	1994-12-09
FI20002725L (fi)	2000-12-12
PT644878E (pt)	2002-02-28
DE69330754T2 (de)	2002-07-04
NO944781L (no)	1995-01-30
FI106714B (fi)	2001-03-30
KR100298377B1 (ko)	2001-12-01
DK0644878T3 (da)	2002-03-18
WO1993025534A1 (en)	1993-12-23
RU94046322A (ru)	1996-11-10
CA2137834A1 (en)	1993-12-23
JPH09502157A (ja)	1997-03-04
US5654295A (en)	1997-08-05
US5492905A (en)	1996-02-20
HUT71404A (en)	1995-11-28
FI945807A7 (fi)	1994-12-09
EP0644878B1 (de)	2001-09-12
GB9212308D0 (en)	1992-07-22
AU672799B2 (en)	1996-10-17
AU4343693A (en)	1994-01-04
ES2161718T3 (es)	2001-12-16
DE69330754D1 (de)	2001-10-18
NZ253252A (en)	1996-11-26
EP0644878A1 (de)	1995-03-29
FI20002725A7 (fi)	2000-12-12
US5712272A (en)	1998-01-27

Legal Events

Date	Code	Title	Description
2006-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE205480T1 (de)	2001-09-15	2,5-dioxo-2,5-dihydro-1h-benz(b)azepine als nmda rezeptor antagonisten
MY116002A (en)	2003-10-31	Nk-1 receptor antagonists and 5ht3 receptor antagonists for the treatment of emesis
NZ223772A (en)	1991-09-25	Substituted benzodiazepine derivatives and pharmaceutical compositions
UA29416C2 (uk)	2000-11-15	Похідні 1,5 - бензодіазепіну, що є антагоністами гастрину та холецистокініну, спосіб їх одержання, фармацевтична композиція
IL127244A (en)	2005-11-20	Substituted amines, methods of their preparation and pharmaceutical compositions containing them
DK0411668T3 (da)	1995-03-27	Central-cholecystokinin-antagonister til behandling af psykiatriske forstyrrelser
CA2118704A1 (en)	1993-04-01	Fused Tricyclic Nitrogen Containing Heterocycles as Substance P Receptor Antagonists
MX9605023A (es)	1997-06-28	Compuestos substituidos de imidazolidin-2,4-diona como substancias farmaceuticamente activas.
IL117824A (en)	2000-08-31	Pharmaceutical compositions containing 2-aryl-imidazol¬1,2-a¾pyridine-3-acetamide derivatives for treatment of neuropsychiatric syndromes associated with dysfunction of the neural circuits of the basal ganglia
IL104853A0 (en)	1993-06-10	Benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them
ATE163409T1 (de)	1998-03-15	Benz(b)azepin-2,5-dione verwendbar in der behandlung neurodegenerativer störungen
IL113365A0 (en)	1995-07-31	5-heterocyclo-1,5-benzodiazepine derivatives, their preparation and use and pharmaceutical compositions containing them
IL101514A0 (en)	1992-12-30	Cholecystokinin antagonists and pharmaceutical compositions containing them
GR3034354T3 (en)	2000-12-29	IMIDAZO 1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
MX9708557A (es)	1997-12-31	Nuevo uso farmacologico de los antagonistas del receptor aii.
BG102229A (en)	1998-09-30	Endothelium receptor antagonists
HU9502848D0 (en)	1995-11-28	Imidazoloquinoxalinone derivatives as eaa antagonists
ITTO930661A1 (it)	1995-03-09	Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.
IL102880A0 (en)	1993-01-31	Hexahydrobenzo(f)quinolinones
EP0778833A4 (de)	1998-12-16	Endothelin-rezeptor-antagonisten
DE69005241D1 (de)	1994-01-27	Calcitonin enthaltende pharmazeutische Zusammensetzungen.
BR9714184A (pt)	2000-02-29	Utilização de bonzoillquil-1,2,3,6-tetraidropiridinas
MX9804631A (es)	1998-12-31	Antagonistas quinazolin-4-ona del ampa.