FI20002725L - 2,5-diokso-2,5-dihydro-1Hbents[b]atsepiinit NMDA-reseptorin antagonisteina - Google Patents

2,5-diokso-2,5-dihydro-1Hbents[b]atsepiinit NMDA-reseptorin antagonisteina Download PDF

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Publication number
FI20002725L
FI20002725L FI20002725A FI20002725A FI20002725L FI 20002725 L FI20002725 L FI 20002725L FI 20002725 A FI20002725 A FI 20002725A FI 20002725 A FI20002725 A FI 20002725A FI 20002725 L FI20002725 L FI 20002725L
Authority
FI
Finland
Prior art keywords
1hbenz
azepines
dioxo
dihydro
receptor antagonists
Prior art date
Application number
FI20002725A
Other languages
English (en)
Swedish (sv)
Other versions
FI20002725A7 (fi
Inventor
Marc Jerome Chapdelaine
Gregory David Harris
Paul Francis Jackson
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of FI20002725A7 publication Critical patent/FI20002725A7/fi
Publication of FI20002725L publication Critical patent/FI20002725L/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI20002725A 1992-06-10 2000-12-12 2,5-diokso-2,5-dihydro-1Hbents[b]atsepiinit NMDA-reseptorin antagonisteina FI20002725L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929212308A GB9212308D0 (en) 1992-06-10 1992-06-10 Therapeutic compositions
PCT/GB1993/001218 WO1993025534A1 (en) 1992-06-10 1993-06-09 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS

Publications (2)

Publication Number Publication Date
FI20002725A7 FI20002725A7 (fi) 2000-12-12
FI20002725L true FI20002725L (fi) 2000-12-12

Family

ID=10716859

Family Applications (2)

Application Number Title Priority Date Filing Date
FI945807A FI106714B (fi) 1992-06-10 1994-12-09 Menetelmä terapeuttisesti käyttökelpoisten 2,5-diokso-2,5-dihydro-1H-bents[b]atsepiiniyhdisteiden valmistamiseksi
FI20002725A FI20002725L (fi) 1992-06-10 2000-12-12 2,5-diokso-2,5-dihydro-1Hbents[b]atsepiinit NMDA-reseptorin antagonisteina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI945807A FI106714B (fi) 1992-06-10 1994-12-09 Menetelmä terapeuttisesti käyttökelpoisten 2,5-diokso-2,5-dihydro-1H-bents[b]atsepiiniyhdisteiden valmistamiseksi

Country Status (18)

Country Link
US (3) US5492905A (fi)
EP (1) EP0644878B1 (fi)
JP (1) JPH09502157A (fi)
KR (1) KR100298377B1 (fi)
AT (1) ATE205480T1 (fi)
AU (1) AU672799B2 (fi)
CA (1) CA2137834A1 (fi)
DE (1) DE69330754T2 (fi)
DK (1) DK0644878T3 (fi)
ES (1) ES2161718T3 (fi)
FI (2) FI106714B (fi)
GB (1) GB9212308D0 (fi)
HU (1) HUT71404A (fi)
NO (1) NO305168B1 (fi)
NZ (1) NZ253252A (fi)
PT (1) PT644878E (fi)
RU (1) RU94046322A (fi)
WO (1) WO1993025534A1 (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5476933A (en) * 1994-11-16 1995-12-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Azepine synthesis via a diels-alder reaction
MY133587A (en) 2002-05-29 2007-11-30 Glaxo Group Ltd Aromatic sulfones and their medical use
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
CN102264736B (zh) 2008-10-22 2013-08-14 阵列生物制药公司 作为TRK激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
WO2016199789A1 (ja) * 2015-06-08 2016-12-15 国立大学法人名古屋大学 トリフルオロメチル置換セミスクアレートの製造方法、トリフルオロメチル置換セミスクアレートを起点とするトリフルオロメチル化合物の製造方法及びトリフルオロメチル基含有化合物
MX392604B (es) * 2016-05-18 2025-03-24 Array Biopharma Inc Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo.
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB130538A (en) * 1918-12-13 1919-08-07 John Algernon Launder Improvements in or relating to Means for Supporting Garments and Garment Hangers.
GB1340334A (en) * 1970-07-06 1973-12-12 Rees A H Synthesis of benzazetropolones and hence of kynurenic acids
JPS5129522B2 (fi) * 1972-07-13 1976-08-26
JPS5520970B2 (fi) * 1972-07-15 1980-06-06
CY1403A (en) * 1981-08-11 1987-12-18 Ciba Geigy Ag Benzazepin-2-ones
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DE3323568C2 (de) * 1983-06-30 1987-01-29 Bayerische Motoren Werke AG, 8000 München Heiz- und/oder Klimaanlage für Kraftfahrzeuge
US4477446A (en) * 1983-07-01 1984-10-16 Usv Pharmaceutical Corporation 1-Benzazepines and their pharmaceutical uses
DE3416695A1 (de) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
KR0167349B1 (ko) * 1989-10-20 1999-02-18 오스카 아끼히꼬 벤조헤테로 고리 화합물
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
JPH05105292A (ja) * 1991-10-15 1993-04-27 Nec Corp ロール紙のカール解消装置
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
DK0647137T3 (da) * 1992-06-22 2008-12-08 State Of Oregon Through Oregon Glycinreceptorantagonister og anvendelse deraf
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles

Also Published As

Publication number Publication date
RU94046322A (ru) 1996-11-10
DE69330754T2 (de) 2002-07-04
FI20002725A7 (fi) 2000-12-12
FI945807A0 (fi) 1994-12-09
DK0644878T3 (da) 2002-03-18
JPH09502157A (ja) 1997-03-04
KR100298377B1 (ko) 2001-12-01
NO305168B1 (no) 1999-04-12
NO944781L (no) 1995-01-30
ES2161718T3 (es) 2001-12-16
US5654295A (en) 1997-08-05
EP0644878B1 (en) 2001-09-12
US5492905A (en) 1996-02-20
PT644878E (pt) 2002-02-28
US5712272A (en) 1998-01-27
NZ253252A (en) 1996-11-26
HUT71404A (en) 1995-11-28
ATE205480T1 (de) 2001-09-15
GB9212308D0 (en) 1992-07-22
EP0644878A1 (en) 1995-03-29
WO1993025534A1 (en) 1993-12-23
FI106714B (fi) 2001-03-30
AU4343693A (en) 1994-01-04
NO944781D0 (no) 1994-12-09
CA2137834A1 (en) 1993-12-23
DE69330754D1 (de) 2001-10-18
AU672799B2 (en) 1996-10-17
FI945807A7 (fi) 1994-12-09

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