ATE210192T1 - VERFAHREN ZUR DIREKTEN SEQUENZIERUNG WÄHREND ßTEMPLATEß-AMPLIFIKATION - Google Patents

VERFAHREN ZUR DIREKTEN SEQUENZIERUNG WÄHREND ßTEMPLATEß-AMPLIFIKATION

Info

Publication number
ATE210192T1
ATE210192T1 AT97924670T AT97924670T ATE210192T1 AT E210192 T1 ATE210192 T1 AT E210192T1 AT 97924670 T AT97924670 T AT 97924670T AT 97924670 T AT97924670 T AT 97924670T AT E210192 T1 ATE210192 T1 AT E210192T1
Authority
AT
Austria
Prior art keywords
btemplates
amplification
direct sequencing
sequencing during
during
Prior art date
Application number
AT97924670T
Other languages
English (en)
Inventor
Hubert Koester
Den Boom Dirk Van
Andreas Ruppert
Original Assignee
Sequenom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequenom Inc filed Critical Sequenom Inc
Application granted granted Critical
Publication of ATE210192T1 publication Critical patent/ATE210192T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT97924670T 1996-05-09 1997-05-09 VERFAHREN ZUR DIREKTEN SEQUENZIERUNG WÄHREND ßTEMPLATEß-AMPLIFIKATION ATE210192T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/647,368 US5928906A (en) 1996-05-09 1996-05-09 Process for direct sequencing during template amplification
PCT/US1997/007966 WO1997042348A1 (en) 1996-05-09 1997-05-09 Process for direct sequencing during template amplification

Publications (1)

Publication Number Publication Date
ATE210192T1 true ATE210192T1 (de) 2001-12-15

Family

ID=24596716

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97924670T ATE210192T1 (de) 1996-05-09 1997-05-09 VERFAHREN ZUR DIREKTEN SEQUENZIERUNG WÄHREND ßTEMPLATEß-AMPLIFIKATION

Country Status (8)

Country Link
US (1) US5928906A (de)
EP (1) EP0901531B1 (de)
JP (1) JP2000510341A (de)
AT (1) ATE210192T1 (de)
AU (1) AU718238B2 (de)
CA (1) CA2252795A1 (de)
DE (1) DE69708865T2 (de)
WO (1) WO1997042348A1 (de)

Families Citing this family (512)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US6436635B1 (en) 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
ATE267877T1 (de) 1993-01-07 2004-06-15 Sequenom Inc Dns - sequenzierung durch massenspektronomie
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US6146854A (en) * 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
US6051378A (en) * 1996-03-04 2000-04-18 Genetrace Systems Inc. Methods of screening nucleic acids using mass spectrometry
US6214555B1 (en) * 1996-05-01 2001-04-10 Visible Genetics Inc. Method compositions and kit for detection
US6022688A (en) 1996-05-13 2000-02-08 Sequenom, Inc. Method for dissociating biotin complexes
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
CA2270132A1 (en) * 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US7285422B1 (en) 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
US6140053A (en) * 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
CA2274587A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
US6399304B1 (en) 1996-12-20 2002-06-04 Roche Diagnostics Gmbh Sequential activation of one or more enzymatic activities within a thermocycling reaction for synthesizing DNA molecules
DE19653494A1 (de) * 1996-12-20 1998-06-25 Svante Dr Paeaebo Verfahren zur entkoppelten, direkten, exponentiellen Amplifikation und Sequenzierung von DNA Molekülen unter Zugabe einer zweiten thermostabilen DNA Polymerase und dessen Anwendung
US6828094B2 (en) * 1996-12-20 2004-12-07 Roche Diagnostics Gmbh Method for the uncoupled, direct, exponential amplification and sequencing of DNA molecules with the addition of a second thermostable DNA polymerase and its application
DE19653439A1 (de) * 1996-12-20 1998-07-02 Svante Dr Paeaebo Verfahren zur direkten, exponentiellen Amplifikation und Sequenzierung von DNA Molekülen und dessen Anwendung
JP3435416B2 (ja) 1997-03-12 2003-08-11 ピーイー コーポレイション(エヌワイ) 改善された標識ヌクレオチド取込み特性を有するdnaポリメラーゼ
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US20110166040A1 (en) * 1997-09-05 2011-07-07 Ibis Biosciences, Inc. Compositions for use in identification of strains of e. coli o157:h7
WO1999054455A1 (fr) * 1998-04-23 1999-10-28 Takara Shuzo Co., Ltd. Procede de synthese de l'adn
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US20030138834A1 (en) * 1998-08-19 2003-07-24 Dawson Elliott P. Method for determining polynucleotide sequence variations
US20040121394A1 (en) * 1998-08-19 2004-06-24 Dawson Elliott P. Method for determining polynucleotide sequence variations
CA2336546A1 (en) * 1998-08-19 2000-03-02 Vanderbilt University Method for determining polynucleotide sequence variations
JP2002537762A (ja) * 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
AU775179B2 (en) 1999-03-15 2004-07-22 Applied Biosystems, Llc Probe/mobility modifier complexes for multiplex nucleic acid detection
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
EP2325198A1 (de) 1999-06-01 2011-05-25 Baylor College Of Medicine Zusammensetzungen und Verfahren zur therapeutischen Verwendung einer atonal-assoziierten Sequenz
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6942964B1 (en) * 1999-07-09 2005-09-13 Sigma-Aldrich Co. Tracer reagents that enhance reaction-product analysis
US20020045182A1 (en) * 1999-07-16 2002-04-18 Lynx Therapeutics, Inc. Multiplexed differential displacement for nucleic acid determinations
EP1218546A4 (de) * 1999-09-30 2005-01-05 New England Biolabs Inc Einbau von modifizierten nukleotiden durch die archaeon-dna-polymerasen und damit zusammenhängende methoden
US20030207297A1 (en) * 1999-10-13 2003-11-06 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US7332275B2 (en) * 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
AU776811C (en) 1999-10-13 2005-07-28 Agena Bioscience, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
CN1336960A (zh) * 1999-11-26 2002-02-20 株式会社百尼尔 采用多种dna聚合酶的dna测序方法和所用的试剂盒
DE10010282B4 (de) 2000-02-25 2006-11-16 Epigenomics Ag Verfahren zur Detektion von Cytosin-Methylierung in DNA Proben
AU2001268468A1 (en) 2000-06-13 2001-12-24 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
US20020164715A1 (en) 2000-07-10 2002-11-07 Lin Ji Chromosome 3p21.3 genes are tumor suppressors
GB0021286D0 (en) * 2000-08-30 2000-10-18 Gemini Genomics Ab Identification of drug metabolic capacity
US20020142483A1 (en) 2000-10-30 2002-10-03 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
US7575924B2 (en) 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
US7045290B2 (en) 2001-02-15 2006-05-16 The University Of Chicago Yeast screens for treatment of human disease
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
US20030027135A1 (en) * 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121314A1 (en) * 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in containers
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US20040121310A1 (en) * 2002-12-18 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in forensic studies
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
JP2004523243A (ja) * 2001-03-12 2004-08-05 カリフォルニア インスティチュート オブ テクノロジー 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
DE10132785A1 (de) * 2001-07-06 2003-01-16 Clondiag Chip Tech Gmbh Verfahren zum Nachweis von in einer Polymerase-Kettenreaktion amplifizierten Nukleinsäuremolekülen
JP3935487B2 (ja) * 2001-07-16 2007-06-20 フーベルト・ケスター 捕獲化合物、その収集物、ならびにプロテオームおよび複合組成物の分析方法
ATE527347T1 (de) 2001-08-02 2011-10-15 Inst Clayton De La Rech Verfahren und zusammensetzungen im zusammenhang mit verbesserten lentivirusvektor- produktionssystemen
WO2003023000A2 (en) * 2001-09-07 2003-03-20 Baylor College Of Medicine Linear dna fragments for gene expression
US20050042629A1 (en) 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
CA2462628C (en) * 2001-10-02 2019-08-20 Institut Clayton De La Recherche Restricted expression lentiviral vectors
US20030170678A1 (en) * 2001-10-25 2003-09-11 Neurogenetics, Inc. Genetic markers for Alzheimer's disease and methods using the same
US20030224380A1 (en) * 2001-10-25 2003-12-04 The General Hospital Corporation Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
AU2002364945A1 (en) * 2001-10-25 2003-07-09 Neurogenetics, Inc. Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
JP2005507074A (ja) * 2001-10-26 2005-03-10 セクエノム, インコーポレイテッド ハイスループットのサンプル取り扱いプロセスラインのための方法および装置
AU2002348417B9 (en) 2001-10-26 2010-02-04 Baylor College Of Medicine A composition and method to alter lean body mass and bone properties in a subject
CA2466133A1 (en) * 2001-11-02 2003-05-15 Rice University Recycling system for manipulation of intracellular nadh availability
AU2002346498A1 (en) 2001-11-30 2003-06-17 Applera Corporation Thermus brockianus nucleic acid polymerases
AR037778A1 (es) 2001-12-11 2004-12-01 Advisys Inc Suplementacion mediada por plasmido para el tratamiento de sujetos cronicamente enfermos
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US20030166282A1 (en) 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
EP1478656B1 (de) 2002-02-01 2009-09-16 Life Technologies Corporation Oligonukleotidzusammensetzungen mit verbesserter effizienz
EP1474532A4 (de) * 2002-02-12 2005-05-04 Applera Corp Polymerasezusammensetzungen
ES2319634T3 (es) * 2002-03-11 2009-05-11 Caprotec Bioanalytics Gmbh Compuestos y metodos para analizar el proteoma.
KR101002955B1 (ko) * 2002-04-26 2010-12-21 인스티튜트 클레이톤 드 라 리쎄르셰 개선된 키메라 당단백질 및 슈도타입 렌티바이러스 벡터
CA2484676A1 (en) 2002-05-03 2003-11-13 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof, and related methods
WO2003093303A1 (en) 2002-05-06 2003-11-13 Board Of Regents, The University Of Texas System Targeting proteins to deliver therapeutic or diagnostic reagents
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
WO2003101177A2 (en) * 2002-06-04 2003-12-11 Sequenom, Inc. Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions
WO2004002296A2 (en) * 2002-06-27 2004-01-08 Sequenom, Inc. Therapeutic methods for reducing fat deposition and treating associated conditions
WO2004002295A2 (en) * 2002-06-27 2004-01-08 Sequenom, Inc. Diagnosing predisposition to fat deposition and associated condition
EP1636561B1 (de) 2002-07-15 2011-02-09 Board Of Regents, The University Of Texas System Screening kombinatorischer proteinbibliotheken mittels periplasmatischer expression
US20050042646A1 (en) * 2002-08-05 2005-02-24 Davidson Beverly L. RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US20080274989A1 (en) 2002-08-05 2008-11-06 University Of Iowa Research Foundation Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
US20040023390A1 (en) * 2002-08-05 2004-02-05 Davidson Beverly L. SiRNA-mediated gene silencing with viral vectors
US20050255086A1 (en) * 2002-08-05 2005-11-17 Davidson Beverly L Nucleic acid silencing of Huntington's Disease gene
US20080176812A1 (en) * 2002-08-05 2008-07-24 Davidson Beverly L Allele-specific silencing of disease genes
US20040241854A1 (en) * 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
US20050106731A1 (en) * 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
WO2004014314A2 (en) 2002-08-12 2004-02-19 David Kirn Methods and compositions concerning poxviruses and cancer
US20040109853A1 (en) * 2002-09-09 2004-06-10 Reactive Surfaces, Ltd. Biological active coating components, coatings, and coated surfaces
US20050277118A1 (en) * 2002-09-11 2005-12-15 Roth Richard B Methods for identifying subjects at risk of melanoma and treatments thereof
WO2004044164A2 (en) * 2002-11-06 2004-05-27 Sequenom, Inc. Method for identifying risk of melanoma and treatments thereof
CA2506798C (en) * 2002-11-22 2013-01-22 Institut Clayton De La Recherche Compositions and systems for the regulation of genes
WO2004048546A2 (en) * 2002-11-25 2004-06-10 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
WO2004048548A2 (en) * 2002-11-25 2004-06-10 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
CA2505786C (en) * 2002-11-25 2011-06-21 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
EP2112229A3 (de) 2002-11-25 2009-12-02 Sequenom, Inc. Verfahren zum Identifizieren des Brustkrebsrisikos und zugehörige Behandlungen
CN1774511B (zh) * 2002-11-27 2013-08-21 斯昆诺有限公司 用于序列变异检测和发现的基于断裂的方法和系统
EP1583972B1 (de) * 2003-01-16 2010-11-24 caprotec bioanalytics GmbH Verfahren zur identifizierung von auf arzneimittel nicht-zielgerichteten proteinen
US7312202B2 (en) 2003-02-18 2007-12-25 Board Of Regents, The University Of Texas System Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy
WO2004081040A2 (en) 2003-03-12 2004-09-23 Advisys, Inc. Insulin-like growth factor (igf-i) plasmid-mediated supplementation for therapeutic applications
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
TW200424214A (en) * 2003-04-21 2004-11-16 Advisys Inc Plasmid mediated GHRH supplementation for renal failures
EP1618216A2 (de) * 2003-04-25 2006-01-25 Sequenom, Inc. Auf fragmentierung beruhende verfahren und systeme zur de-novo-sequenzierung
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7572581B2 (en) * 2003-06-30 2009-08-11 Roche Molecular Systems, Inc. 2′-terminator nucleotide-related methods and systems
CN1894581B (zh) 2003-07-09 2012-02-01 生命技术公司 检测蛋白-蛋白相互作用的方法
US20070224615A1 (en) * 2003-07-09 2007-09-27 Invitrogen Corporation Methods for assaying protein-protein interactions
US20050233341A1 (en) * 2003-07-23 2005-10-20 Roth Richard R Methods for identifying risk of melanoma and treatments thereof
WO2005014846A2 (en) * 2003-07-24 2005-02-17 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
WO2005054466A2 (en) 2003-07-25 2005-06-16 Ambion, Inc. Methods and compositions for preparing rna from a fixed sample
WO2005012578A1 (en) 2003-07-31 2005-02-10 Sequenom, Inc. Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms
AU2003269991A1 (en) * 2003-08-20 2005-03-10 Applera Corporation Polymerase compositions
WO2005024068A2 (en) * 2003-09-05 2005-03-17 Sequenom, Inc. Allele-specific sequence variation analysis
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20120122102A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US20100129811A1 (en) * 2003-09-11 2010-05-27 Ibis Biosciences, Inc. Compositions for use in identification of pseudomonas aeruginosa
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
WO2005073409A2 (en) * 2004-01-26 2005-08-11 Applera Corporation Methods, compositions, and kits for amplifying and sequencing polynucleotides
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
ATE463584T1 (de) 2004-02-19 2010-04-15 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
EP1727911B1 (de) * 2004-03-26 2013-01-23 Sequenom, Inc. Basenspezifische spaltung methylierungsspezifischer amplifikationsprodukte in kombination mit massenanalyse
AU2005323451B2 (en) * 2004-05-21 2010-11-18 Qiagen Sciences Llc Kits and processes for removing contaminants from nucleic acids in environmental and biological samples
JP4810533B2 (ja) 2004-05-24 2011-11-09 アイビス バイオサイエンシズ インコーポレイティッド ディジタルスレショルド化による選択的イオン濾過作用を用いた質量分光測定法
EP1766090B1 (de) 2004-05-25 2011-04-27 Helicos Biosciences Corporation Verfahren zur nukleinsäureimmobilisierung
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
CA2567973A1 (en) * 2004-05-27 2005-12-15 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
JP2008522951A (ja) * 2004-07-19 2008-07-03 ベイラー・カレツジ・オブ・メデイシン サイトカインシグナル伝達調節物質の調節および免疫療法のための応用
US20080199480A1 (en) * 2004-07-22 2008-08-21 Sequenom, Inc. Methods for Identifying Risk of Type II Diabetes and Treatments Thereof
US20060073501A1 (en) * 2004-09-10 2006-04-06 Van Den Boom Dirk J Methods for long-range sequence analysis of nucleic acids
CN104644627A (zh) 2004-09-14 2015-05-27 科罗拉多大学董事会 基于基因靶向使用布新洛尔的治疗方法
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US20060205081A1 (en) * 2005-02-18 2006-09-14 Linhong Li Use of methyltransferase inhibitors to enhance transgene expression
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
US20060286006A1 (en) * 2005-06-21 2006-12-21 Mcdaniel C S Method and apparatus for the treatment of fluid waste streams
CN101501055B (zh) * 2005-06-23 2016-05-11 贝勒医学院 负性免疫调节因子的调节和免疫疗法应用
US8026084B2 (en) 2005-07-21 2011-09-27 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
US20070026012A1 (en) 2005-08-01 2007-02-01 Cornell Research Foundation, Inc. Compositions and methods for monitoring and altering protein folding and solubility
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
AU2007281934B2 (en) 2006-01-18 2012-11-15 University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US8088582B2 (en) 2006-04-06 2012-01-03 Ibis Biosciences, Inc. Compositions for the use in identification of fungi
US8298818B2 (en) * 2006-04-28 2012-10-30 University Of Florida Research Foundation, Inc. Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
EP3260556B1 (de) 2006-05-31 2019-07-31 Sequenom, Inc. Verfahren zur nukleinsäureextraktion aus einer probe
US7479550B2 (en) * 2006-06-02 2009-01-20 The Board Of Regents Of The University Of Texas System Amyloid β gene vaccines
US8153369B2 (en) 2006-06-05 2012-04-10 Cancer Care Ontario Assessment of risk for colorectal cancer
US20100055113A1 (en) 2006-07-27 2010-03-04 The University Of Maryland, Baltimore Cellular receptor for antiproliferative factor
WO2008143627A2 (en) 2006-09-14 2008-11-27 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
WO2009016433A2 (en) 2006-09-15 2009-02-05 Ottawa Health Research Institute Oncolytic rhabdovirus
EP2647711B1 (de) 2006-11-29 2018-01-10 University of Iowa Research Foundation Alternative Exportwege für über einen Vektor exprimierte RNA-Interferenz
DK2102239T3 (da) 2006-11-30 2012-05-29 Res Dev Foundation Forbedrede immunoglobulin-biblioteker
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
EP2118298B1 (de) 2007-02-08 2013-01-09 Sequenom, Inc. Tests auf nukleinsäurebasis für rhd-typisierung
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的dna分析法
AU2008222563A1 (en) 2007-03-05 2008-09-12 Cancer Care Ontario Assessment of risk for colorectal cancer
EP2140031A4 (de) 2007-03-26 2011-04-20 Sequenom Inc Restriktionsendonukleaseverstärkte polymorphe sequenzerfassung
WO2008118324A2 (en) 2007-03-26 2008-10-02 Macrogenics, Inc. Composition and method of treating cancer with an anti-uroplakin ib antibody
US8629245B2 (en) 2007-05-01 2014-01-14 Research Development Foundation Immunoglobulin Fc libraries
US20100291544A1 (en) * 2007-05-25 2010-11-18 Ibis Biosciences, Inc. Compositions for use in identification of strains of hepatitis c virus
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
US20110045456A1 (en) * 2007-06-14 2011-02-24 Ibis Biosciences, Inc. Compositions for use in identification of adventitious contaminant viruses
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
US8450106B2 (en) * 2007-10-17 2013-05-28 The Ohio State University Research Foundation Oncolytic virus
US9273100B2 (en) 2007-11-09 2016-03-01 Board Of Trustees Of Michigan State University Use of Galerina marginata genes and proteins for peptide production
US9518097B2 (en) * 2007-11-09 2016-12-13 Board Of Trustees Of Michigan State University Identification and use of genes encoding amatoxin and phallotoxin
EP2222344A4 (de) * 2007-11-30 2012-11-07 Baylor College Medicine Impfstoffzusammensetzungen mit dendritischen zellen und ihre verwendung
WO2009102509A2 (en) 2008-01-10 2009-08-20 Research Development Foundation Vaccines and diagnostics for the ehrlichioses
US20110097704A1 (en) * 2008-01-29 2011-04-28 Ibis Biosciences, Inc. Compositions for use in identification of picornaviruses
WO2009114543A2 (en) 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
WO2009120808A2 (en) 2008-03-26 2009-10-01 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
JP5779090B2 (ja) 2008-04-09 2015-09-16 マックスサイト インコーポレーティッド 新規に単離された細胞の治療組成物の操作および送達
WO2009155103A2 (en) * 2008-05-30 2009-12-23 Ibis Biosciences, Inc. Compositions for use in identification of tick-borne pathogens
US20110177515A1 (en) * 2008-05-30 2011-07-21 Ibis Biosciences, Inc. Compositions for use in identification of francisella
WO2009148995A2 (en) * 2008-06-02 2009-12-10 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
ES2587395T3 (es) 2008-06-04 2016-10-24 Cellular Dynamics International, Inc. Procedimientos para la producción de células IPS usando un enfoque no vírico
WO2010019569A1 (en) 2008-08-12 2010-02-18 Cellular Dynamics International. Inc. Methods for the production of ips cells
CA2734325A1 (en) 2008-08-18 2010-02-25 University Of Maryland, Baltimore Derivatives of apf and methods of use
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
EP2347254A2 (de) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Probenverarbeitungseinheiten, -systeme und damit verbundene verfahren
EP2344893B1 (de) 2008-09-16 2014-10-15 Ibis Biosciences, Inc. Mikroplatten-handhabungssysteme und verfahren
EP2349549B1 (de) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Mischpatronen, mischstationen und verwandte ausrüstungen, und system
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US20110189687A1 (en) * 2008-10-02 2011-08-04 Ibis Bioscience, Inc. Compositions for use in identification of members of the bacterial genus mycoplasma
US20110200985A1 (en) * 2008-10-02 2011-08-18 Rangarajan Sampath Compositions for use in identification of herpesviruses
WO2010039848A2 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of streptococcus pneumoniae
US20110183346A1 (en) * 2008-10-03 2011-07-28 Ibis Biosciences, Inc. Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria
US20110183344A1 (en) * 2008-10-03 2011-07-28 Rangarajan Sampath Compositions for use in identification of clostridium difficile
WO2010039763A2 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of antibiotic-resistant bacteria
US20110183343A1 (en) * 2008-10-03 2011-07-28 Rangarajan Sampath Compositions for use in identification of members of the bacterial class alphaproteobacter
US20110262477A1 (en) 2008-10-06 2011-10-27 University Of Chicago Compositions and Methods Related to Bacterial EAP, EMP, and/or ADSA Proteins
US8388904B1 (en) 2008-12-22 2013-03-05 Reactive Surfaces, Ltd., Llp Equipment decontamination system and method
WO2010075441A1 (en) 2008-12-22 2010-07-01 Trustees Of Boston University Modular nucleic acid-based circuits for counters, binary operations, memory, and logic
IL313131A (en) 2009-02-11 2024-07-01 Caris Mpi Inc Molecular characterization of tumors
EP2396803A4 (de) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ionisationssondenanordnungen
WO2010104798A1 (en) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Bioagent detection methods
CN102428191A (zh) * 2009-03-18 2012-04-25 塞昆纳姆股份有限公司 热稳定性内切核酸酶在产生报道分子中的应用
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US8771948B2 (en) 2009-04-03 2014-07-08 Sequenom, Inc. Nucleic acid preparation compositions and methods
HRP20160274T1 (hr) 2009-04-03 2016-04-08 University Of Chicago Pripravci i metode vezane za varijante proteina a (spa)
CN105925535A (zh) 2009-06-05 2016-09-07 细胞动力国际有限公司 重编程t细胞和造血细胞的方法
JP5785942B2 (ja) 2009-06-29 2015-09-30 ルミネックス コーポレーション ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法
WO2011008972A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systems for bioagent identification
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US9416409B2 (en) * 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
US9080209B2 (en) 2009-08-06 2015-07-14 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
EP2470653A1 (de) 2009-08-26 2012-07-04 Research Development Foundation Verfahren zur erstellung von antikörperbibliotheken
US20110065111A1 (en) * 2009-08-31 2011-03-17 Ibis Biosciences, Inc. Compositions For Use In Genotyping Of Klebsiella Pneumoniae
WO2011032088A1 (en) 2009-09-11 2011-03-17 Arca Biopharma, Inc. Polymorphisms in the pde3a gene
KR101838472B1 (ko) 2009-09-14 2018-03-15 신라젠(주) 종양 용해 백시니아 바이러스 병용 암 치료요법
US9808504B2 (en) 2009-09-22 2017-11-07 Yale University Immunogenic epitopes as targets for universal cancer vaccines
US9890408B2 (en) 2009-10-15 2018-02-13 Ibis Biosciences, Inc. Multiple displacement amplification
CA2779223A1 (en) 2009-10-27 2011-05-12 Caris Mpi, Inc. Molecular profiling for personalized medicine
EP2501414B1 (de) 2009-11-17 2018-01-10 The Trustees Of The University Of Pennsylvania Smn-delta-7-degron: neuartige zusammensetzungen und verfahren zu ihrer verwendung
WO2011070440A2 (en) 2009-12-10 2011-06-16 Ottawa Hospital Research Institute Oncolytic rhabdovirus
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
ES2587191T3 (es) 2009-12-23 2016-10-21 Arca Biopharma, Inc. Métodos y composiciones para enfermedades y afecciones cardiovasculares
WO2011100508A2 (en) 2010-02-12 2011-08-18 Arizona Board Of Regents For And On Behalf Of Arizona State University Methods and compositions related to glycoprotein-immunoglobulin fusions
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
WO2011115840A2 (en) * 2010-03-14 2011-09-22 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
EP2548030B1 (de) 2010-03-18 2015-05-27 Cornell University Engineering korrekt gefalteter antikörper mit membraninterner anzeige von twin-arginin-translokations-zwischenprodukten
EP2555794A4 (de) 2010-04-05 2014-01-15 Univ Chicago Zusammensetzungen und verfahren im zusammenhang mit protein-a-(spa)-antikörpern als immunreaktionsverstärker
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US8785385B2 (en) 2010-04-19 2014-07-22 Research Development Foundation RTEF-1 variants and uses thereof
CA2802249A1 (en) 2010-06-15 2011-12-22 Cellular Dynamics International, Inc. Generation of induced pluripotent stem cells from small volumes of peripheral blood
AU2011274367B2 (en) 2010-07-02 2015-04-23 The University Of Chicago Compositions and methods related to protein A (SpA) variants
JP5897002B2 (ja) 2010-07-07 2016-04-13 セルラー ダイナミクス インターナショナル, インコーポレイテッド プログラミングによる内皮細胞の産生
US9458509B2 (en) 2010-07-22 2016-10-04 President And Fellows Of Harvard College Multiple input biologic classifier circuits for cells
EP2601289B1 (de) 2010-08-04 2017-07-12 Cellular Dynamics International, Inc. Neuprogrammierung immortalisierter b-zellen
BR112013005711A2 (pt) 2010-09-08 2017-06-13 Univ Texas método para tratar um tumor, mutante, molécula de ácido nucleico isolada, construção de expressão, composição, e, método para administrar uma terapia
JP5793194B2 (ja) 2010-09-09 2015-10-14 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago 感染防御ブドウ球菌抗原が関与する方法および組成物
US9919047B2 (en) 2011-01-04 2018-03-20 Sillajen, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
CA2826467C (en) 2011-02-07 2019-11-12 Research Development Foundation Engineered immunoglobulin fc polypeptides
WO2012109208A2 (en) 2011-02-08 2012-08-16 Cellular Dynamics International, Inc. Hematopoietic precursor cell production by programming
US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
EP2683835B1 (de) 2011-03-08 2017-01-11 King Abdullah University Of Science And Technology Molekulares biomarker-set zur früherkennung von eierstockkrebs
EP2693887B1 (de) 2011-04-06 2020-10-28 The Board of Regents of the University of Texas System Modulation bakterieller mam-polypeptide in einer pathogenen krankheit
EP2694534B1 (de) 2011-04-08 2018-06-20 Evaxion Biotech ApS Proteine und nukleinsäuren zur verwendung für impstoffe gegen staphylococcus aureus
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
SG10201900183VA (en) 2011-04-28 2019-05-30 Univ Leland Stanford Junior Identification of polynucleotides associated with a sample
WO2012149339A2 (en) 2011-04-29 2012-11-01 Sequenom, Inc. Quantification of a minority nucleic acid species
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
EP2718427B1 (de) 2011-06-08 2017-01-11 Children's Hospital of Eastern Ontario Research Institute Inc. Zusammensetzungen zur behandlung von glioblastomen
WO2013009825A1 (en) 2011-07-11 2013-01-17 Cellular Dynamics International, Inc. Methods for cell reprogramming and genome engineering
CN104203287B (zh) 2011-07-12 2017-07-14 费城健康及教育公司,d/b/a,德雷克塞尔大学医学院 新型艰难梭菌dna疫苗
US20130101664A1 (en) 2011-08-18 2013-04-25 Donald W. Kufe Muc1 ligand traps for use in treating cancers
WO2013036799A2 (en) 2011-09-09 2013-03-14 Fred Hutchinson Cancer Research Center Methods and compositions involving nkg2d inhibitors and cancer
EP2766388A1 (de) 2011-10-12 2014-08-20 Møller, Niels Iversen Peptide aus campylobacter jejuni und ihre verwendung bei der impfung
EP3269820A1 (de) 2011-12-22 2018-01-17 Ibis Biosciences, Inc. Kit für die amplifizierung einer sequenz aus einer ribonukleinsäure
WO2013116778A2 (en) 2012-02-02 2013-08-08 Board Of Regents Immunogenic adenovirus
WO2013116698A2 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
EP4155401A1 (de) 2012-03-02 2023-03-29 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
WO2013155439A1 (en) 2012-04-13 2013-10-17 Massachusetts Institute Of Technology Analog and mixed-signal computation and circuits in living cells
WO2013162746A1 (en) 2012-04-26 2013-10-31 University Of Chicago Staphylococcal coagulase antigens and methods of their use
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014039513A2 (en) 2012-09-04 2014-03-13 The Trustees Of The University Of Pennsylvania Inhibition of diacylglycerol kinase to augment adoptive t cell transfer
EP3901280B1 (de) 2012-10-17 2025-03-12 10x Genomics Sweden AB Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe
EP2912058A1 (de) 2012-10-23 2015-09-02 The Board of Regents of The University of Texas System Antikörper mit manipulierten igg-fc-domänen
JP6419082B2 (ja) 2012-12-13 2018-11-07 マサチューセッツ インスティテュート オブ テクノロジー リコンビナーゼに基づく論理/メモリシステム
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
US9896728B2 (en) 2013-01-29 2018-02-20 Arcticrx Ltd. Method for determining a therapeutic approach for the treatment of age-related macular degeneration (AMD)
RU2019107976A (ru) 2013-02-21 2019-08-23 Тёрнстоун Лимитед Партнершип Композиция вакцины
CN105229144A (zh) 2013-02-22 2016-01-06 细胞动力学国际有限公司 通过组合的遗传工程和化学工程经由正向编程产生肝细胞
US20160015749A1 (en) 2013-03-05 2016-01-21 Baylor College Of Medicine Engager cells for immunotherapy
HK1220111A1 (zh) 2013-03-05 2017-04-28 Baylor College Of Medicine 人类t淋巴细胞中类肝素酶的表达
CN105339498A (zh) 2013-03-07 2016-02-17 贝勒医学院 癌症中靶向cd138
EP2964763B1 (de) 2013-03-08 2019-09-18 Yale University Zusammensetzungen und verfahren zur verminderung der hautpigmentierung
US20160015750A1 (en) 2013-03-09 2016-01-21 Baylor College Of Medicine Vascular-targeted t-cell therapy
EP3597774A1 (de) 2013-03-13 2020-01-22 Sequenom, Inc. Primer zur analyse der dna-methylierung
EP2972327B1 (de) 2013-03-13 2018-11-21 Trustees of Boston University Einstellbare steuerung von proteinabbau in synthetischen und endogenen bakteriellen systemen
CN111500680B (zh) 2013-06-25 2024-04-16 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
DK3878952T1 (da) 2013-07-01 2022-03-21 Massachusetts Inst Technology Funktionalisering af endogene bakterier
EP4074330A1 (de) 2013-09-05 2022-10-19 Massachusetts Institute of Technology Abstimmung von mikrobiellen populationen mit programmierbaren nukleasen
EP4786600A2 (de) 2013-09-09 2026-08-05 FibroBiologics, Inc. Gentherapie zur regeneration von chondrozyten oder knorpelzellen
EP3052193B1 (de) 2013-10-03 2018-01-31 Oklahoma Medical Research Foundation Biomarker für die krankheitsaktivität, die intensität und das auftreten von systemischem lupus erythematodes
US10028902B2 (en) 2013-11-08 2018-07-24 Baylor Research Institute Nuclear localization of GLP-1 stimulates myocardial regeneration and reverses heart failure
US20170002064A1 (en) 2013-11-08 2017-01-05 The Board Of Regents Of The University Of Texas System Vh4 antibodies against gray matter neuron and astrocyte
CN114317461A (zh) 2013-11-22 2022-04-12 德那翠丝有限公司 表达免疫细胞刺激受体激动剂的腺病毒
WO2015080981A1 (en) 2013-11-27 2015-06-04 Baylor College Of Medicine Csgp4-specific chimeric antigen receptor for cancer
EP3077820B1 (de) 2013-12-03 2025-02-26 Evaxion Biotech A/S Proteine und nukleinsäuren zur verwendung für impfstoffe gegen staphylococcus aureus
US9512406B2 (en) 2013-12-20 2016-12-06 The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone Generating hepatocytes
JP6608368B2 (ja) 2013-12-30 2019-11-20 アトレカ インコーポレイテッド 核酸バーコードを用いた単一細胞と関連づけられた核酸の分析方法
CN106132992B (zh) 2014-01-29 2020-08-07 达娜-法勃肿瘤研究所公司 针对muc1-c/胞外结构域(muc1-c/ecd)的抗体
WO2015117033A2 (en) 2014-01-31 2015-08-06 Biogen Ma Inc. Methods of increasing protein production in mammalian cells
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2015164228A1 (en) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US9737598B2 (en) 2014-06-30 2017-08-22 Regents Of The University Of Minnesota CD200 inhibitors and methods of use thereof
JP2017528430A (ja) 2014-07-17 2017-09-28 ブライアン ジェイ ツェルニキCZERNIECKI, Brian, J. 免疫に基づく療法のための、免疫原性mhcクラスiiペプチドの同定
ES2851123T1 (es) 2014-09-26 2021-09-03 Baylor College Medicine Receptores quiméricos de antígeno específicos de glipicano-3 para inmunoterapia adoptiva
EP3777883A1 (de) 2014-11-13 2021-02-17 Evaxion Biotech ApS Aus acinetobacter baumannii abgeleitete peptide und deren verwendung bei der impfung
US20180057839A1 (en) 2014-11-26 2018-03-01 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
WO2016100980A1 (en) 2014-12-19 2016-06-23 Dana-Farber Cancer Institute, Inc. Carbonic anhydrase ix specific chimeric antigen receptors and methods of use thereof
RU2017125531A (ru) 2014-12-19 2019-01-21 Дана-Фарбер Кэнсер Инститьют, Инк. Химерные антигенные рецепторы и способы их применения
MA41346A (fr) 2015-01-12 2017-11-21 Juno Therapeutics Inc Eléments régulateurs post-transcriptionnels d'hépatite modifiée
EP3485907B1 (de) 2015-01-12 2023-06-28 Evaxion Biotech ApS Behandlung und prophylaxe von k.-pneumoniae-infektionen
MA41433A (fr) 2015-01-26 2017-12-05 Baylor College Medicine Cellules immunitaires universelles pour l'immunothérapie anticancéreuse
US20180002656A1 (en) 2015-01-28 2018-01-04 Sabic Global Technologies B.V. Methods and compositions for high-efficiency production of biofuel and/or biomass
JP6724023B2 (ja) 2015-02-09 2020-07-15 リサーチ ディベロップメント ファウンデーション 改善された補体活性化を示す操作された免疫グロブリンfcポリペプチド
WO2016134293A1 (en) 2015-02-20 2016-08-25 Baylor College Of Medicine p63 INACTIVATION FOR THE TREATMENT OF HEART FAILURE
EP3070178B1 (de) 2015-03-20 2020-02-12 Albert-Ludwigs-Universität Freiburg Verfahren zur diagnose von brustkrebs
EP4321627A3 (de) 2015-04-10 2024-04-17 10x Genomics Sweden AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
MA41962A (fr) 2015-04-23 2018-02-28 Baylor College Medicine Récepteur antigénique chimérique ciblant le cd5 pour une thérapie adoptive à base de cellules t
EP3981438A1 (de) 2015-05-04 2022-04-13 The Brigham and Women's Hospital, Inc. Onkolytischer hsv1-vektor und verfahren zur verwendung
US11040094B2 (en) 2015-07-01 2021-06-22 Colleen M. O'Connor Compositions and methods for treating immunological dysfunction
EP4116316A1 (de) 2015-07-04 2023-01-11 Evaxion Biotech A/S Proteine und nukleinsäuren, die in impfstoffen gegen pseudomonas aeruginosa nützlich sind
CN114350752B (zh) 2015-07-17 2025-02-25 布鲁克空间生物学公司 在横切面组织的用户定义区域中的基因表达的同时定量
US10526408B2 (en) 2015-08-28 2020-01-07 Research Development Foundation Engineered antibody FC variants
WO2017059245A2 (en) 2015-09-30 2017-04-06 Trustees Of Boston University Deadman and passcode microbial kill switches
AU2016337408B2 (en) 2015-10-16 2022-11-03 Astrazeneca Ab Inducible modification of a cell genome
WO2017070333A1 (en) 2015-10-20 2017-04-27 Cellular Dynamics International, Inc. Multi-lineage hematopoietic precursor cell production by genetic programming
US10865396B2 (en) 2015-10-29 2020-12-15 Temple University—Of the Commonwealth System of Higher Education Modification of 3′ terminal ends of nucleic acids by DNA polymerase theta
KR102929174B1 (ko) 2015-10-30 2026-02-20 더 리전츠 오브 더 유니버시티 오브 캘리포니아 줄기세포로부터 t-세포를 생산하는 방법 및 상기 t-세포를 이용한 면역치료 방법
KR20180095511A (ko) 2015-10-30 2018-08-27 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 표적화된 암 요법
SI3370733T1 (sl) 2015-11-02 2021-11-30 Board Of Regents The University Of Texas System Postopek za aktivacijo CD40 in blokada imunske nadzorne točke
AU2016349897B2 (en) 2015-11-03 2021-11-04 Regents Of The University Of Minnesota CD200 inhibitors and methods of use thereof
US20190038713A1 (en) 2015-11-07 2019-02-07 Multivir Inc. Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
WO2017083296A1 (en) 2015-11-09 2017-05-18 The Children's Hospital Of Philadelphia Glypican 2 as a cancer marker and therapeutic target
WO2017122096A1 (en) 2016-01-15 2017-07-20 Astrazeneca Ab Gene modification assays
US20190160098A1 (en) 2016-02-16 2019-05-30 Dana-Farber Cancer Institute, Inc. Chimeric antigen receptors and methods of use thereof
CN108697798A (zh) 2016-02-16 2018-10-23 达纳-法伯癌症研究所有限公司 免疫疗法组合物及方法
US10946084B2 (en) 2016-02-22 2021-03-16 Evaxion Biotech Aps Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus
CA3019635A1 (en) 2016-03-31 2017-10-05 Baylor Research Institute Angiopoietin-like protein 8 (angptl8)
EP3448369B1 (de) 2016-04-29 2025-06-25 The Regents of The University of Colorado, A Body Corporate Hemmung oder abbau von hdac11 zur behandlung von fettleibigkeit, hyperlipidämie, typ-ii-diabetes, metabolischem syndrom oder insulinresistenz, und zur förderung der gewichtsabnahme und/oder zur linderung oder verhinderung einer gewichtszunahme
AU2017290805B2 (en) 2016-07-01 2023-11-16 Research Development Foundation Elimination of proliferating cells from stem cell-derived grafts
JP7483373B2 (ja) 2016-07-29 2024-05-15 ジュノー セラピューティクス インコーポレイテッド 複製可能ウイルスの存在または非存在を評価するための方法
US9963498B2 (en) 2016-08-18 2018-05-08 Wisconsin Alumni Research Foundation Peptides that inhibit syndecan-1 activation of VLA-4 and IGF-1R
US11208664B2 (en) 2016-09-12 2021-12-28 Massachusetts Institute Of Technology Transcriptional sensor for bile acids in bacteroides thetaiotaomicron
CA3038690A1 (en) 2016-10-05 2018-04-12 FUJIFILM Cellular Dynamics, Inc. Generating mature lineages from induced pluripotent stem cells with mecp2 disruption
JP7212615B2 (ja) 2016-10-05 2023-01-25 フジフィルム セルラー ダイナミクス,インコーポレイテッド 多能性幹細胞からhlaホモ接合免疫細胞への指向分化方法
US20180127759A1 (en) 2016-10-28 2018-05-10 Massachusetts Institute Of Technology Dynamic genome engineering
CN109996809A (zh) 2016-11-14 2019-07-09 诺华股份有限公司 与促融合蛋白minion相关的组合物、方法和治疗用途
WO2018111902A1 (en) 2016-12-12 2018-06-21 Multivir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
EP3565576A1 (de) 2017-01-05 2019-11-13 Evaxion Biotech ApS Impfstoffe gegen pseudomonas aeruginosa
EP3574114B1 (de) 2017-01-26 2022-06-29 Oklahoma Medical Research Foundation Biomarker für die krankheitsaktivität, die intensität und das auftreten von systemischem lupus erythematodes
WO2018152197A1 (en) 2017-02-15 2018-08-23 Massachusetts Institute Of Technology Dna writers, molecular recorders and uses thereof
CN110582574A (zh) 2017-03-13 2019-12-17 麻省理工学院 合成启动子
JP2020509773A (ja) 2017-03-17 2020-04-02 センティ バイオサイエンシズ インコーポレイテッド 免疫調節性細胞回路
WO2018175476A1 (en) 2017-03-20 2018-09-27 Baylor College Of Medicine Transgenic c-mpl provides ligand-dependent co-stimulation and cytokine signals to tcr-engineered cells
US12492430B2 (en) * 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
KR20190141695A (ko) 2017-04-13 2019-12-24 센티 바이오사이언시스, 인코포레이티드 병용 암 면역요법
CN110891967B (zh) 2017-04-18 2025-03-14 富士胶片细胞动力公司 抗原特异性免疫效应细胞
US12140592B2 (en) 2017-06-16 2024-11-12 Oklahoma Medical Research Foundation Biomarkers for assessing risk of transitioning to systemic lupus erythematosus classification and disease pathogenesis
BR112020001060A2 (pt) 2017-07-27 2020-07-14 Novartis Ag variantes de trem2 resistentes a shedase
WO2019027414A1 (en) 2017-07-31 2019-02-07 Massachusetts Institute Of Technology HIGH PERFORMANCE MULTIPLE INPUT MICRO-RNA DETECTORS AND USES THEREOF
US11795455B2 (en) 2017-07-31 2023-10-24 Massachusetts Institute Of Technology RNA cleavage-induced transcript stabilizer and uses thereof
US20200255487A1 (en) 2017-10-12 2020-08-13 The Regents Of The University Of California A Cell-Based Seeding Assay for Huntingtin Aggregation
KR20200115584A (ko) 2018-01-30 2020-10-07 칠드런'즈 메디컬 센터 코포레이션 바실루스 시스템을 이용한 보툴리눔 신경독소의 생산
CN111918972A (zh) 2018-01-31 2020-11-10 朱诺治疗学股份有限公司 评估存在或不存在有复制能力的病毒的方法和试剂
WO2019178356A1 (en) 2018-03-14 2019-09-19 Dana-Farber Cancer Institute, Inc. Engineered cells, t cell immune modulating antibodies and methods for using the same
CA3094329A1 (en) 2018-03-19 2020-02-20 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer
EP4714496A3 (de) 2018-05-01 2026-04-29 OrfoNeuro ApS Behandlung von neuronaler ceroid-lipofuszinose
US12478588B2 (en) 2018-05-25 2025-11-25 The Penn State Research Foundation Nanoparticle for protein delivery
UY38247A (es) 2018-05-30 2019-12-31 Novartis Ag Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
US11339395B2 (en) 2018-08-01 2022-05-24 Massachusetts Institute Of Technology RNA-based regulatory technologies for miRNA sensors
US20200056189A1 (en) 2018-08-01 2020-02-20 Massachusetts Institute Of Technology Phosphorylation-based mirna sensor
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
KR20210102870A (ko) 2018-08-30 2021-08-20 테나야 테라퓨틱스, 인코포레이티드 미오카르딘 및 ascl1을 사용한 심장 세포 재프로그래밍
CN113038967B (zh) 2018-09-06 2026-07-14 宾夕法尼亚大学理事会 人源化抗c5抗体及其用途
UY38407A (es) 2018-10-15 2020-05-29 Novartis Ag Anticuerpos estabilizadores de trem2
EP3867645B1 (de) 2018-10-18 2024-06-05 Oklahoma Medical Research Foundation Biomarker für krankheitsaktivitätimmunindex von systemischem lupus erythematodes (sle) zur charakterisierung der krankheitsaktivität
US12510539B2 (en) 2018-10-18 2025-12-30 Progentec Diagnostics, Inc. Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity
EP3870207A1 (de) 2018-10-22 2021-09-01 Evaxion Biotech ApS Impfstoff gegen m. catharrhalis
JP7649239B2 (ja) 2018-11-30 2025-03-19 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド キメラ抗原受容体ファクトリおよびその使用方法
KR20210111254A (ko) 2018-11-30 2021-09-10 캐리스 엠피아이, 아이엔씨. 차세대 분자 프로파일링
EP3894585A2 (de) 2018-12-10 2021-10-20 10X Genomics, Inc. Erzeugung von erfassungssonden zur räumlichen analyse
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
JP7663237B2 (ja) 2019-01-14 2025-04-16 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ がん免疫療法のためのcd200arリガンド
EP3931206A1 (de) 2019-02-27 2022-01-05 Evaxion Biotech ApS Impfstoffe gegen h. influenzae
WO2020181058A1 (en) 2019-03-05 2020-09-10 Massachusetts Institute Of Technology Dna launched rna replicon system (drep) and uses thereof
US12209250B2 (en) 2019-03-14 2025-01-28 Massachusetts Institute Of Technology Engineered Herpes Simplex Virus-1 (HSV-1) vectors and uses thereof
CN114450411A (zh) 2019-04-01 2022-05-06 特纳亚治疗股份有限公司 具有工程化衣壳的腺相关病毒
WO2020209929A1 (en) 2019-04-09 2020-10-15 Massachusetts Institute Of Technology Mutant subgenomic promoter library and uses thereof
KR20240033101A (ko) 2019-05-02 2024-03-12 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 합성 단백질 안정성을 증가시키기 위한 시스템 및 방법
CA3139981A1 (en) 2019-05-14 2020-11-19 The University Of Chicago Methods and compositions comprising staphylococcus protein a (spa) variants
US12203069B2 (en) 2019-05-17 2025-01-21 Massachusetts Institute Of Technology Engineered post-poly A signal RNA and uses thereof
EP3976820A1 (de) 2019-05-30 2022-04-06 10X Genomics, Inc. Verfahren zum nachweis der räumlichen heterogenität einer biologischen probe
EP3997226A1 (de) 2019-07-11 2022-05-18 Tenaya Therapeutics, Inc. Umprogrammierung von herzzellen mit mikrornas und anderen faktoren
JP2022541538A (ja) 2019-07-19 2022-09-26 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア グリピカン2結合ドメインを含有するキメラ抗原受容体
EP3772543B1 (de) 2019-08-09 2023-09-27 Albert-Ludwigs-Universität Freiburg Verfahren zur diagnose von brustkrebs
EP4025698A1 (de) 2019-09-03 2022-07-13 Sana Biotechnology, Inc. Cd24-assoziierte partikel und verwandte verfahren und verwendungen davon
CN114929205B (zh) 2019-09-06 2024-09-03 世代生物公司 包括末端封闭式dna和可切割脂质的脂质纳米颗粒组合物及其使用方法
WO2021048381A1 (en) 2019-09-13 2021-03-18 Evaxion Biotech Aps Method for identifying stable mhc binding peptides using mass spectrometry
US20220334129A1 (en) 2019-09-13 2022-10-20 Evaxion Biotech A/S Method for identifying T-cell epitopes
EP4031118B1 (de) 2019-09-16 2026-01-28 The Children's Hospital of Philadelphia Mithramycinanalog zur behandlung von mutierten swi-snf-tumoren
JP2022548881A (ja) 2019-09-18 2022-11-22 ノバルティス アーゲー Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
TW202124446A (zh) 2019-09-18 2021-07-01 瑞士商諾華公司 與entpd2抗體之組合療法
WO2021062096A1 (en) 2019-09-26 2021-04-01 Massachusetts Institute Of Technology Microrna-based logic gates and uses thereof
US11834659B2 (en) 2019-09-26 2023-12-05 Massachusetts Institute Of Technology Trans-activated functional RNA by strand displacement and uses thereof
CA3155930A1 (en) 2019-09-27 2021-04-01 Starkage Therapeutics Senescent cell-associated antigen-binding domains, antibodies and chimeric antigen receptors comprising the same, and uses thereof
AU2020385378A1 (en) 2019-11-22 2022-04-07 Generation Bio Co. Ionizable lipids and nanoparticle compositions thereof
IL293489A (en) 2019-12-02 2022-08-01 Caris Mpi Inc predictor of pan-cancer platinum response
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
US20230008380A1 (en) 2019-12-09 2023-01-12 University Of Georgia Research Foundation, Inc. M. tuberculosis ag85 proteins and methods of use
CN121022991A (zh) 2019-12-23 2025-11-28 10X基因组学有限公司 使用rna模板化连接进行空间分析的方法
EP4081656A1 (de) 2019-12-23 2022-11-02 10X Genomics, Inc. Zusammensetzungen und verfahren zur verwendung von fixierten biologischen proben bei partitionsbasierten tests
EP4752521A3 (de) 2019-12-23 2026-08-12 10X Genomics, Inc. Reversible fixierreagenzien und verfahren zur verwendung davon
US20230050225A1 (en) 2020-01-06 2023-02-16 Evaxion Biotech A/S Vaccines targeting Neisseria gonorrhoeae
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US12129516B2 (en) 2020-02-07 2024-10-29 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
CN116157533A (zh) 2020-02-21 2023-05-23 10X基因组学有限公司 使用杂交方法捕获遗传靶标
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
IL295964A (en) 2020-02-28 2022-10-01 Takeda Pharmaceuticals Co A method for producing natural killer cells from pluripotent stem cells
CN115552022A (zh) 2020-03-02 2022-12-30 特纳亚治疗股份有限公司 由心肌细胞表达的微rna控制的基因载体
IL296662A (en) 2020-03-24 2022-11-01 Generation Bio Co Non-viral dna vectors and uses thereof for expressing gaucher therapeutics
IL296660A (en) 2020-03-24 2022-11-01 Generation Bio Co Non-viral DNA vectors and their use for therapeutic expression of factor ix
EP4127148A1 (de) 2020-03-25 2023-02-08 Erasmus University Rotterdam Medical Center Reportersystem zur radionuklidbildgebung
US12534435B2 (en) 2020-03-27 2026-01-27 Generation Bio Co. Lipids and nanoparticle compositions thereof
AU2021248815A1 (en) 2020-03-31 2022-10-13 Flagship Pioneering Innovations V, Inc. Targeted lipid particles and compositions and uses thereof
EP4139485B1 (de) 2020-04-22 2023-09-06 10X Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau
US20230190871A1 (en) 2020-05-20 2023-06-22 Sana Biotechnology, Inc. Methods and compositions for treatment of viral infections
AU2021275906A1 (en) 2020-05-22 2022-12-22 10X Genomics, Inc. Spatial analysis to detect sequence variants
EP4153775B1 (de) 2020-05-22 2024-07-24 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
KR20230019453A (ko) 2020-05-29 2023-02-08 후지필름 셀룰러 다이내믹스, 인코포레이티드 망막 색소 상피 세포 및 광수용체의 이중 세포 응집체 및 이의 사용 방법
IL298254A (en) 2020-05-29 2023-01-01 Fujifilm Cellular Dynamics Inc Double layer of retinal pigment epithelium and photoreceptors and their uses
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4450639B1 (de) 2020-06-25 2025-10-15 10X Genomics, Inc. Räumliche analyse der dna-methylierung
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
WO2022047316A1 (en) 2020-08-28 2022-03-03 Sana Biotechnology, Inc. Modified anti-viral binding agents
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
JP7415042B2 (ja) 2020-10-09 2024-01-16 テナヤ セラピューティクス, インコーポレイテッド プラコフィリン2遺伝子治療の方法および組成物
MX2023004299A (es) 2020-10-13 2023-07-07 Univ Pennsylvania Direccionamiento de células t cd4+ in vivo para terapeuticos de arnm.
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
US20240018528A1 (en) 2020-12-02 2024-01-18 Massachusetts Institute Of Technology A tunable phosphorylation-based feedback controller of mammalian gene expression
WO2022140028A1 (en) * 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
WO2022155500A1 (en) 2021-01-14 2022-07-21 Senti Biosciences, Inc. Secretable payload regulation
EP4277658A4 (de) 2021-01-15 2025-06-04 Board of Regents, The University of Texas System Trans-komplementierungssystem für sars-cov-2
WO2022173767A1 (en) 2021-02-09 2022-08-18 University Of Houston System Oncolytic virus for systemic delivery and enhanced anti-tumor activities
EP4305196B1 (de) 2021-04-14 2025-04-02 10X Genomics, Inc. Verfahren zur messung der fehllokalisierung eines analyten
JP2024515788A (ja) 2021-04-27 2024-04-10 ジェネレーション バイオ カンパニー 治療抗体を発現する非ウイルスdnaベクター及びその使用
US20240216535A1 (en) 2021-04-27 2024-07-04 Generation Bio Co. Non-viral dna vectors expressing anti-coronavirus antibodies and uses thereof
AU2022270611A1 (en) 2021-05-03 2023-10-12 Astellas Institute For Regenerative Medicine Methods of generating mature corneal endothelial cells
US20240262917A1 (en) 2021-05-06 2024-08-08 Dana-Farber Cancer Institute, Inc. Antibodies against alk and methods of use thereof
EP4320271B1 (de) 2021-05-06 2025-03-19 10X Genomics, Inc. Verfahren zur erhöhung der auflösung von räumlicher analyse
CA3217861A1 (en) 2021-05-07 2022-11-10 Astellas Institute For Regenerative Medicine Methods of generating mature hepatocytes
WO2022251443A1 (en) 2021-05-26 2022-12-01 FUJIFILM Cellular Dynamics, Inc. Methods to prevent rapid silencing of genes in pluripotent stem cells
US20250304626A1 (en) 2021-05-26 2025-10-02 Evaxion Biotech A/S Vaccination targeting intracellular pathogens
IL308836A (en) 2021-05-28 2024-01-01 Sana Biotechnology Inc Lipid Particles Containing Baboon Truncated Endogenous Retrovirus (BAEV) Envelope Glycoprotein and Related Methods and Uses
ES3030033T3 (en) 2021-06-03 2025-06-26 10X Genomics Inc Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
CN117642380A (zh) 2021-06-14 2024-03-01 世代生物公司 阳离子脂质及其组合物
CN117813374A (zh) 2021-06-15 2024-04-02 武田药品工业株式会社 从多能干细胞产生自然杀伤细胞的方法
CA3224564A1 (en) 2021-07-05 2023-01-12 Andreas Holm MATTSSON Vaccines targeting neisseria gonorrhoeae
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
EP4419707A1 (de) 2021-11-10 2024-08-28 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position eines analyten in einer biologischen probe
EP4305195A2 (de) 2021-12-01 2024-01-17 10X Genomics, Inc. Verfahren, zusammensetzungen und systeme für verbesserten in-situ-nachweis von analyten und raumanalyse
WO2023114543A2 (en) 2021-12-17 2023-06-22 Dana-Farber Cancer Institute, Inc. Platform for antibody discovery
WO2023114544A1 (en) 2021-12-17 2023-06-22 Dana-Farber Cancer Institute, Inc. Antibodies and uses thereof
US20250059239A1 (en) 2021-12-17 2025-02-20 Sana Biotechnology, Inc. Modified paramyxoviridae fusion glycoproteins
EP4448775A1 (de) 2021-12-17 2024-10-23 Sana Biotechnology, Inc. Modifizierte paramyxoviridae-bindungsglycoproteine
AU2023232045A1 (en) 2022-03-09 2024-09-26 Dana-Farber Cancer Institute, Inc. Genetically engineered b cells and methods of use thereof
EP4493212A1 (de) 2022-03-14 2025-01-22 Generation Bio Co. Heterologe prime-boost-impfstoffzusammensetzungen und verfahren zur verwendung
US20230295661A1 (en) 2022-03-16 2023-09-21 University Of Houston System Persistent hsv gene delivery system
WO2023201207A1 (en) 2022-04-11 2023-10-19 Tenaya Therapeutics, Inc. Adeno-associated virus with engineered capsid
US20250283118A1 (en) 2022-05-05 2025-09-11 University Of Rochester Modified bacteria and methods of use for bioglass microlenses
CA3255627A1 (en) 2022-05-06 2023-11-09 Novartis Ag NEW VP2 FUSION POLYPEPTIDES OF RECOMBINANT AAV
WO2023239940A1 (en) 2022-06-10 2023-12-14 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof
US20240003871A1 (en) 2022-06-29 2024-01-04 FUJIFILM Cellular Dynamics, Inc. Ipsc-derived astrocytes and methods of use thereof
WO2024040222A1 (en) 2022-08-19 2024-02-22 Generation Bio Co. Cleavable closed-ended dna (cedna) and methods of use thereof
EP4590688A1 (de) 2022-09-21 2025-07-30 Sana Biotechnology, Inc. Lipidpartikel mit varianten paramyxovirus-bindungsglycoproteinen und verwendungen davon
EP4602174A1 (de) 2022-10-13 2025-08-20 Sana Biotechnology, Inc. Auf hämatopoetische stammzellen abzielende virale partikel
EP4685239A1 (de) 2022-11-09 2026-01-28 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position mehrerer analyten in einer biologischen probe
JP2025541726A (ja) 2022-12-01 2025-12-23 ジェネレーション バイオ カンパニー 細胞標的化のためのステルス脂質ナノ粒子組成物
WO2024119157A1 (en) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
WO2024191808A1 (en) 2023-03-10 2024-09-19 University Of Rochester Etiological therapeutics for fragile x syndrome
WO2024220597A2 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Digital droplet based assay for detecting replication competent lentiviral vector
AU2024274792A1 (en) 2023-05-23 2025-10-23 Sana Biotechnology, Inc. Tandem fusogens and related lipid particles
EP4777523A1 (de) 2023-09-12 2026-07-22 Evaxion A/S Immunogene varianten des humanen cytomegalovirus-glycoproteins b
WO2025104700A2 (en) 2023-11-16 2025-05-22 Takeda Pharmaceutical Company Limited Improved methods for cryopreservation and fitness of natural killer cells, and compositions thereof
WO2025184529A1 (en) 2024-03-01 2025-09-04 Sana Biotechnology, Inc. Viral particles with fusogen display and related compositions and methods
WO2025217379A1 (en) 2024-04-10 2025-10-16 University Of Rochester Drug treatment for macular degeneration
WO2025245202A1 (en) 2024-05-21 2025-11-27 FUJIFILM Cellular Dynamics, Inc. Particle counting and biomass measurements of aggregated cell compositions
WO2026085495A1 (en) 2024-10-18 2026-04-23 Generation Bio Co. Synthetic partially single-stranded nucleic acid compositions and uses and methods therefor
WO2026132377A1 (en) 2024-12-20 2026-06-25 Universidad De Navarra Replication-competent oncolytic virus comprising a sequence encoding an antibody or antibody fragment
WO2026150302A1 (en) 2025-01-09 2026-07-16 Novartis Ag Novel aav rep/cap encoding constructs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003059A (en) * 1988-06-20 1991-03-26 Genomyx, Inc. Determining DNA sequences by mass spectrometry
US5108892A (en) * 1989-08-03 1992-04-28 Promega Corporation Method of using a taq dna polymerase without 5'-3'-exonuclease activity
US5427911A (en) * 1990-05-01 1995-06-27 Yale University Coupled amplification and sequencing of DNA
CA2114124A1 (en) * 1991-07-24 1993-02-04 Keith Gregg Single step amplification and sequencing of nucleic acids
US5674679A (en) * 1991-09-27 1997-10-07 Amersham Life Science, Inc. DNA cycle sequencing
ATE267877T1 (de) * 1993-01-07 2004-06-15 Sequenom Inc Dns - sequenzierung durch massenspektronomie

Also Published As

Publication number Publication date
HK1018080A1 (en) 1999-12-10
DE69708865T2 (de) 2002-04-18
WO1997042348A1 (en) 1997-11-13
CA2252795A1 (en) 1997-11-13
EP0901531B1 (de) 2001-12-05
AU718238B2 (en) 2000-04-13
DE69708865D1 (de) 2002-01-17
US5928906A (en) 1999-07-27
AU3003497A (en) 1997-11-26
JP2000510341A (ja) 2000-08-15
EP0901531A1 (de) 1999-03-17

Similar Documents

Publication Publication Date Title
DE69708865D1 (de) Verfahren zur direkten sequenzierung während "template"-amplifikation
DE69607830D1 (de) Verfahren zur isothermer amplifikation von nukleinsäure molekülen
EP1961826A3 (de) Verfahren zur direkten Sequenzierung von Nukleinsäuren
DE69329636D1 (de) Verfahren zur Vervielfältigung von Nukleinsäuresequenzen
EP0777750A4 (de) Verfahren mit einer hohen umsatzrate für das auffinden von sequenzen oder genetischen veränderungen in nukleinsäuren
ATE210734T1 (de) Verfahren zur quantifizierung von genomischer dna
DE69627189D1 (de) Verfahren zum nachweis und zur entfernung von mutantsequenzen, die während enzymatischer amplifikation entstehen
ATE216729T1 (de) Eine methode und ein gerät für die durchführung einer vervielfältigung von nukleinsäuren an trägern
DE69838839D1 (de) Verfahren zur entfernung von nukleinsäureverunreinigungen in amplifizierungsreaktionen
ATE311474T1 (de) Verfahren zur amplifikation und zur sequenzierung von nukleinsäuren
DE69710077D1 (de) Verfahren zur erkennung von verbindungen, die die interaktion von rna und rna-bindeproteinen beeinflussen
AU2500197A (en) Method, apparatus and kits for sequencing of nucleic acids using multiple dyes
DE69508617D1 (de) Vorrichtung zur dürchführung von magnetischen zyklusreactionen
DE69619864D1 (de) Verfahren zur amplifizierung spezifischer nukleinsäuresequenzen
HK1046433A1 (zh) 基因描述法:為證明多種生物體存在而提供的複雜生物樣本的快速測試方法
DE60039772D1 (de) Verfahren zur amplifikation von signal-flankierend
DE602004026912D1 (de) Formulierungen und verfahren zum denaturieren von proteinen
DE69637579D1 (de) Methode zur Amplifizierung von Nukleinsäure und entsprechende Regenzien dafür
DE69823372T8 (de) Verfahren und reagentiensatz zur amplifizierung, sequenzierung und typisierung von hla i genen
ES2175095T3 (es) Marcadores de adn respecto al tamaño de una camada de cerdos.
DE59608651D1 (de) Verfahren zur sequenzierung durch oligomerhybridisierung
DE59712415D1 (de) Verfahren zur amplifikation von nukleinsäure
DE69604051D1 (de) Verfahren zum sensitiven nachweis von reverser transcriptase
DE69938774D1 (de) Verfahren zur isolierung, amplifizierung und charakterisierung von dns
DE69636725D1 (de) Verfahren zur trennung und/oder erkennung von dns-molekülen