ATE210628T1 - Verfahren zur herstellung von 3-(aminomethyl)-5- methylhexansäure - Google Patents

Verfahren zur herstellung von 3-(aminomethyl)-5- methylhexansäure

Info

Publication number
ATE210628T1
ATE210628T1 AT96914618T AT96914618T ATE210628T1 AT E210628 T1 ATE210628 T1 AT E210628T1 AT 96914618 T AT96914618 T AT 96914618T AT 96914618 T AT96914618 T AT 96914618T AT E210628 T1 ATE210628 T1 AT E210628T1
Authority
AT
Austria
Prior art keywords
aminomethyl
alkali
earth metal
alkaline earth
carboxylate salt
Prior art date
Application number
AT96914618T
Other languages
English (en)
Inventor
Todd Michel Grote
Brian Keith Huckabee
Thomas Mulhern
Denis Martin Sobieray
Robert Daniel Titus
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE210628T1 publication Critical patent/ATE210628T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
AT96914618T 1995-06-07 1996-05-13 Verfahren zur herstellung von 3-(aminomethyl)-5- methylhexansäure ATE210628T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/006819 WO1996040617A1 (en) 1995-06-07 1996-05-13 Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (1)

Publication Number Publication Date
ATE210628T1 true ATE210628T1 (de) 2001-12-15

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96914618T ATE210628T1 (de) 1995-06-07 1996-05-13 Verfahren zur herstellung von 3-(aminomethyl)-5- methylhexansäure

Country Status (18)

Country Link
US (4) US5637767A (de)
EP (1) EP0830338B1 (de)
JP (1) JP3874306B2 (de)
AT (1) ATE210628T1 (de)
CA (1) CA2219150C (de)
CZ (2) CZ296895B6 (de)
DE (1) DE69617948T2 (de)
DK (1) DK0830338T3 (de)
EE (1) EE04053B1 (de)
ES (1) ES2170231T3 (de)
GE (1) GEP19991870B (de)
HU (2) HU229957B1 (de)
NZ (2) NZ501628A (de)
PL (3) PL185557B1 (de)
PT (1) PT830338E (de)
SI (1) SI0830338T1 (de)
SK (2) SK283507B6 (de)
WO (1) WO1996040617A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858736A (en) * 1996-05-17 1999-01-12 E. I. Du Pont De Nemours And Company Preparation of lactams from aliphatic α,ω-dinitriles
NZ332762A (en) 1996-07-24 2000-09-29 Warner Lambert Co Isobutylgaba and its derivatives for the treatment of pain
US6194459B1 (en) 1997-08-19 2001-02-27 Warner-Lambert Company Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotors stimulants
CA2374755C (en) * 1999-06-10 2010-03-30 Warner-Lambert Company Mono- and disubstituted 3-propyl gamma-aminobutyric acids
ME00921B (me) * 2000-01-27 2012-06-20 Warner Lambert Co Asimetrična sinteza pregabalina
GB2368579A (en) * 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
US7169812B2 (en) * 2003-07-01 2007-01-30 Medtronic, Inc. Process for producing injectable gabapentin compositions
EP1543831A1 (de) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Zusammensetzung enthaltend Pregabalin
ATE371496T1 (de) * 2004-03-12 2007-09-15 Warner Lambert Co C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
CN102102114B (zh) * 2004-06-21 2013-08-14 沃尼尔·朗伯有限责任公司 普瑞巴林和相关化合物的制备
EP1866275A1 (de) * 2005-04-06 2007-12-19 Teva Pharmaceutical Industries Ltd. Kristalline formen des pregabalins
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
MX2007012606A (es) * 2005-04-11 2008-01-11 Teva Pharma Proceso para elaborar (s)-pregabalina.
WO2006122259A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
WO2006121557A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
CA2604602A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Method for the preparation of pregabalin and salts thereof
US7462737B2 (en) * 2005-05-10 2008-12-09 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
CA2619472A1 (en) * 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
WO2007127309A2 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
TW200815323A (en) * 2006-05-24 2008-04-01 Teva Pharma Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
EP2071032A3 (de) 2006-05-31 2009-07-08 Teva Pharmaceutical Industries Ltd Enzymatische Auflösung für die Herstellung von Pregablin-Zwischenprodukten
WO2008007145A2 (en) 2006-07-12 2008-01-17 Generics [Uk] Limited Process of preparing a gamma-amino acid
WO2008062460A2 (en) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
KR101036536B1 (ko) * 2007-03-22 2011-05-24 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성
WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
EP1992609A1 (de) * 2007-05-14 2008-11-19 Dipharma Francis S.r.l. Verfahren für die Herstellung einer (S)(+)-3-(Aminomethyl)-5-Methylhexan-Säure
WO2009001372A2 (en) 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
WO2009044409A2 (en) * 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin
WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
ITMI20072262A1 (it) * 2007-12-03 2009-06-04 Dipharma Francis Srl Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
US20100312010A1 (en) * 2007-12-18 2010-12-09 Watson Pharma Private Limited Process for the Preparation of (S)-Pregabalin
AU2008339583A1 (en) * 2007-12-26 2009-07-02 Generics [Uk] Limited Processes to pregabalin
JP5403517B2 (ja) * 2007-12-27 2014-01-29 東レ・ファインケミカル株式会社 光学活性３−アミノピロリジン塩及びその製造方法並びに３−アミノピロリジンの光学分割方法
US8592625B2 (en) * 2008-01-02 2013-11-26 Zheinjiang Jiuzhou Pharmaceutical Co., Ltd. Process for resolving S-3-(aminomethyl)-5-methylhexanoic acid
US20110144383A1 (en) * 2008-02-18 2011-06-16 Matrix Laboratories Limited Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid
WO2009122215A1 (en) * 2008-04-04 2009-10-08 Generics [Uk] Limited Novel process
EP2110372A1 (de) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Zwischenprodukte für die Herstellung von Pregabalin und deren Herstellungsverfahren
CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
EP2294207B1 (de) * 2008-05-21 2012-09-26 Sandoz AG Verfahren zur stereoselektiven enzymatischen Hydrolyse von 5-methyl-3-nitromethylhexansäureester
CA2723871A1 (en) * 2008-06-03 2009-12-10 Generics [Uk] Limited Process for the synthesis of .gamma. -amino acids
WO2009158343A1 (en) * 2008-06-23 2009-12-30 Teva Pharmaceutical Industries, Ltd. Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010061403A2 (en) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Process to prepare highly pure (s)-pregabalin
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
IT1394292B1 (it) 2009-05-07 2012-06-06 Dipharma Francis Srl Procedimento per la sintesi di pregabalina
ES2362913B1 (es) 2009-12-24 2012-05-24 Moehs Iberica S.L. Nuevo método para la preparación de (s)-pregabalina.
HUP1000186A2 (en) 2010-04-08 2011-10-28 Richter Gedeon Nyrt Novel industrial process of preparing (s)-(+) pregabalin
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
EP2700645A4 (de) 2011-04-20 2014-09-24 Kemphys Ltd Siliciumhaltiges carbonsäurederivat
EP2527319A1 (de) 2011-05-24 2012-11-28 Laboratorios Del. Dr. Esteve, S.A. Kristalline Formen von Pregabalin und Co-Formern zur Behandlung von Schmerzen
US9353134B2 (en) * 2012-10-18 2016-05-31 Kemphys Ltd. Silicon-containing carboxylic acid derivative
JP6482465B2 (ja) 2012-11-07 2019-03-13 ハイカル リミテッド プレガバリンの調製方法
CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
EP3154930B1 (de) 2014-06-12 2018-04-18 Siegfried Ltd. Verfahren zur herstellung von beta-substituierten gamma-amino-carbonsäuren
CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
CA2953225A1 (en) 2015-05-26 2016-12-01 Isa Odidi Controlled extended release pregabalin
CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
WO2022119430A1 (es) 2020-12-04 2022-06-09 Laboratorios Silanes S.A. De C.V. Composición farmacéutica sólida recubierta y estable de un analgésico opioide y un antiepiléptico para el dolor
CN112939809A (zh) * 2020-12-30 2021-06-11 江苏恒沛药物科技有限公司 一种1-氰基-3-甲基丁基丙二酸二乙酯的制备方法
CN116041214B (zh) * 2022-11-15 2025-04-22 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2516307A (en) * 1949-01-06 1950-07-25 Gen Mills Inc Vinyl resins plasticized with cyano esters
US3133954A (en) * 1959-08-18 1964-05-19 Rohm & Haas Process for preparing chlorinated cyanoesters
US3110723A (en) * 1959-08-18 1963-11-12 Rohm & Haas Process for preparing monochlorinated cyanoesters
US3444161A (en) * 1965-09-02 1969-05-13 Shionogi Seiyaku Kk Alkyl cyano aluminum compounds and process for introducing a cyano group into an alpha,beta unsaturated carbonyl compound
DE1793347A1 (de) * 1968-09-04 1972-02-03 Dynamit Nobel Ag Verfahren zur Herstellung von substituierten Cyanbuttersaeuren
JPS54100316A (en) * 1978-01-25 1979-08-08 Meiji Seika Kaisha Ltd Preparation of derivative of aminobutyric acid
US4428887A (en) * 1982-07-14 1984-01-31 Monsanto Company Method of producing mono-substituted terminal diesters
DE3227388A1 (de) * 1982-07-22 1984-01-26 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von (alpha)-substituierten ss-dicarbonyl-, ss-cyancarbonyl- und ss-dicyanverbindungen
US4760089A (en) * 1985-09-09 1988-07-26 Smithkline Beckman Corporation Irreversible dopamine-β-hydroxylase inhibitors
US5132451A (en) * 1989-08-25 1992-07-21 Warner-Lambert Company Process for cyclic amino acid anticonvulsant compounds
US5077425A (en) * 1990-04-02 1991-12-31 E. I. Du Pont De Nemours And Company Nitrile-accelerated hydrocarboxylation
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors
FI945426A0 (fi) * 1992-05-20 1994-11-18 Univ Northwestern GABA- ja L-glutamiinihappoanalogit kohtauksenvastaiseen käsittelyyn

Also Published As

Publication number Publication date
HU229957B1 (hu) 2015-03-30
DE69617948D1 (de) 2002-01-24
MX9708652A (es) 1998-06-30
CZ291147B6 (cs) 2002-12-11
HU0500934D0 (en) 2005-12-28
PL185560B1 (pl) 2003-06-30
JPH11506726A (ja) 1999-06-15
EE04053B1 (et) 2003-06-16
US5637767A (en) 1997-06-10
SK282865B6 (sk) 2003-01-09
PL185557B1 (pl) 2003-06-30
EP0830338B1 (de) 2001-12-12
CA2219150A1 (en) 1996-12-19
US20010016665A1 (en) 2001-08-23
DK0830338T3 (da) 2002-04-02
AU5792196A (en) 1996-12-30
GEP19991870B (en) 1999-12-06
ES2170231T3 (es) 2002-08-01
SI0830338T1 (en) 2002-04-30
SK283507B6 (sk) 2003-08-05
PT830338E (pt) 2002-04-29
US6046353A (en) 2000-04-04
US5840956A (en) 1998-11-24
HUP9802504A2 (hu) 1999-02-01
HUP9802504A3 (en) 2000-06-28
EP0830338A1 (de) 1998-03-25
JP3874306B2 (ja) 2007-01-31
EE9700320A (et) 1998-06-15
PL185425B1 (pl) 2003-05-30
NZ501628A (en) 2001-09-28
CZ296895B6 (cs) 2006-07-12
CZ384697A3 (cs) 1998-03-18
DE69617948T2 (de) 2002-06-13
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
SK164597A3 (en) 1998-05-06
AU700091B2 (en) 1998-12-24
HU228194B1 (en) 2013-01-28
WO1996040617A1 (en) 1996-12-19
CA2219150C (en) 2008-11-18

Similar Documents

Publication Publication Date Title
ATE210628T1 (de) Verfahren zur herstellung von 3-(aminomethyl)-5- methylhexansäure
DE69619809D1 (de) Verfahren zur herstellung von (s)-3-(aminoethyl)-5-metylhexansäure
ATE153332T1 (de) Verfahren zur herstellung von oxetanonen
ES466949A1 (es) Un procedimiento para preparar compuestos de 1-oxadestiace- fam
ATE327219T1 (de) Verfahren zur herstellung von hydroxymethylthiobuttersäure
SE9601600D0 (sv) Improved process
DE69920708D1 (de) Verfahren zur herstellung von 1,4-bis[[2-(dimethylamino)ethyl amino]-5,8-dihydroxyanthracene-9,10-dion
TW338035B (en) Process for the production of enantiomerically-pure-azetidine-2-carboxylic acid
ATE158281T1 (de) Verfahren zur herstellung unsymmetrisch substituierter triazine
DE69513408D1 (de) Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl-lipopeptiden
DE69011677D1 (de) Verfahren zur herstellung von substituierten ethenen.
DE59408553D1 (de) Verfahren zur herstellung von n-substituierten glycinsäuren oder glycinestern und verwendung des verfahrens zur indigosynthese
ATE222585T1 (de) Verfahren zur herstellung von 4-hydroxy-2- pyrrolidon
DE50102604D1 (de) VERFAHREN ZUR HERSTELLUNG VON w-AMINOALKANSULFONSÄUREN
ATE356214T1 (de) Mikrobiologisches verfahren zur herstellung von l-carnitin
ATE233822T1 (de) Verfahren zur stereoselektiven herstellung von substituierten cyclohexylcyanhydrinen
ATE258547T1 (de) Verfahren zur herstellung von 2-hydroxy-6- trifluormethylpyridin
DE69819504D1 (de) Verfahren zur herstellung von 2-alkylthiobenzonitril-derivaten
DE59203126D1 (de) Verfahren zur herstellung glänzender verzinkter oder mit einer zinklegierung überzogener formteile.
DE60028998D1 (de) Verfahren zur herstellung einer benzylamin-verbindung
BR9916676B1 (pt) método para a substituição estereosseletiva de compostos de éster beta-amino n-não substituidos.
CA2219278A1 (en) Methods of making (s)-3-(aminomethyl)-5-methylhexanoic acid
ATE236135T1 (de) Verfahren zur herstellung von 4,6- dichlorpyrimidin
ATE141949T1 (de) Verfahren zur herstellung von 3- hydroxyphenylessigsäure
ES2005880A6 (es) Procedimiento para la obtencion de inihibidores del enzima transformador de angiotensina.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification