DK0830338T3 - Fremgangsmåde til fremstilling af 3-(aminomethyl)-5-methylhexansyre - Google Patents

Fremgangsmåde til fremstilling af 3-(aminomethyl)-5-methylhexansyre

Info

Publication number
DK0830338T3
DK0830338T3 DK96914618T DK96914618T DK0830338T3 DK 0830338 T3 DK0830338 T3 DK 0830338T3 DK 96914618 T DK96914618 T DK 96914618T DK 96914618 T DK96914618 T DK 96914618T DK 0830338 T3 DK0830338 T3 DK 0830338T3
Authority
DK
Denmark
Prior art keywords
aminomethyl
methylhexanoic acid
alkali
earth metal
alkaline earth
Prior art date
Application number
DK96914618T
Other languages
Danish (da)
English (en)
Inventor
Todd Michel Grote
Thomas Mulhern
Denis Martin Sobieray
Robert Daniel Titus
Keith Huckabee Brian
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK0830338T3 publication Critical patent/DK0830338T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
DK96914618T 1995-06-07 1996-05-13 Fremgangsmåde til fremstilling af 3-(aminomethyl)-5-methylhexansyre DK0830338T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/006819 WO1996040617A1 (en) 1995-06-07 1996-05-13 Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (1)

Publication Number Publication Date
DK0830338T3 true DK0830338T3 (da) 2002-04-02

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96914618T DK0830338T3 (da) 1995-06-07 1996-05-13 Fremgangsmåde til fremstilling af 3-(aminomethyl)-5-methylhexansyre

Country Status (18)

Country Link
US (4) US5637767A (de)
EP (1) EP0830338B1 (de)
JP (1) JP3874306B2 (de)
AT (1) ATE210628T1 (de)
CA (1) CA2219150C (de)
CZ (2) CZ291147B6 (de)
DE (1) DE69617948T2 (de)
DK (1) DK0830338T3 (de)
EE (1) EE04053B1 (de)
ES (1) ES2170231T3 (de)
GE (1) GEP19991870B (de)
HU (2) HU228194B1 (de)
NZ (2) NZ308319A (de)
PL (3) PL185560B1 (de)
PT (1) PT830338E (de)
SI (1) SI0830338T1 (de)
SK (2) SK283507B6 (de)
WO (1) WO1996040617A1 (de)

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KR20070087596A (ko) * 2005-09-19 2007-08-28 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-(+)-3-(아미노메틸)-5-메틸헥산산의 비대칭 합성
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EP1912931A2 (de) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. (s)-prägabalin-nitril-präparat
EP2054375A2 (de) 2006-07-12 2009-05-06 Merck Generics (UK) Limited Verfahren zur herstellung einer gamma-aminosäure
WO2008062460A2 (en) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
MX2008014759A (es) * 2007-03-22 2009-03-09 Teva Pharma Sintesis del acido (s)-(+)-3-(aminometil)-5-metil hexanoico.
WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
EP1992609A1 (de) * 2007-05-14 2008-11-19 Dipharma Francis S.r.l. Verfahren für die Herstellung einer (S)(+)-3-(Aminomethyl)-5-Methylhexan-Säure
WO2009001372A2 (en) * 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
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KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
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WO2009081208A1 (en) * 2007-12-26 2009-07-02 Generics [Uk] Limited Processes to pregabalin
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EP2280930A1 (de) * 2008-06-03 2011-02-09 Generics [UK] Limited Neues und effizientes verfahren zur synthese einer aminosäure
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WO2010061403A2 (en) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Process to prepare highly pure (s)-pregabalin
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IT1394292B1 (it) 2009-05-07 2012-06-06 Dipharma Francis Srl Procedimento per la sintesi di pregabalina
ES2362913B1 (es) 2009-12-24 2012-05-24 Moehs Iberica S.L. Nuevo método para la preparación de (s)-pregabalina.
HUP1000186A2 (en) * 2010-04-08 2011-10-28 Richter Gedeon Nyrt Novel industrial process of preparing (s)-(+) pregabalin
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CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
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CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
JP2018520112A (ja) 2015-05-26 2018-07-26 オディディ，イサ 制御持続放出プレガバリン
CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
WO2022119430A1 (es) 2020-12-04 2022-06-09 Laboratorios Silanes S.A. De C.V. Composición farmacéutica sólida recubierta y estable de un analgésico opioide y un antiepiléptico para el dolor
CN112939809A (zh) * 2020-12-30 2021-06-11 江苏恒沛药物科技有限公司 一种1-氰基-3-甲基丁基丙二酸二乙酯的制备方法
CN116041214B (zh) * 2022-11-15 2025-04-22 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

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Also Published As

Publication number Publication date
ES2170231T3 (es) 2002-08-01
US5637767A (en) 1997-06-10
CZ384697A3 (cs) 1998-03-18
HUP9802504A2 (hu) 1999-02-01
WO1996040617A1 (en) 1996-12-19
SK283507B6 (sk) 2003-08-05
CZ296895B6 (cs) 2006-07-12
PL185425B1 (pl) 2003-05-30
AU700091B2 (en) 1998-12-24
EE04053B1 (et) 2003-06-16
HU0500934D0 (en) 2005-12-28
CA2219150C (en) 2008-11-18
SI0830338T1 (en) 2002-04-30
CA2219150A1 (en) 1996-12-19
EP0830338B1 (de) 2001-12-12
US20010016665A1 (en) 2001-08-23
PL185560B1 (pl) 2003-06-30
HUP9802504A3 (en) 2000-06-28
US5840956A (en) 1998-11-24
EP0830338A1 (de) 1998-03-25
GEP19991870B (en) 1999-12-06
AU5792196A (en) 1996-12-30
ATE210628T1 (de) 2001-12-15
HU228194B1 (en) 2013-01-28
NZ501628A (en) 2001-09-28
EE9700320A (et) 1998-06-15
CZ291147B6 (cs) 2002-12-11
JP3874306B2 (ja) 2007-01-31
JPH11506726A (ja) 1999-06-15
PL185557B1 (pl) 2003-06-30
MX9708652A (es) 1998-06-30
PT830338E (pt) 2002-04-29
DE69617948T2 (de) 2002-06-13
US6046353A (en) 2000-04-04
DE69617948D1 (de) 2002-01-24
SK282865B6 (sk) 2003-01-09
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
HU229957B1 (hu) 2015-03-30
SK164597A3 (en) 1998-05-06

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