EE04053B1 - (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod - Google Patents

(S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod

Info

Publication number
EE04053B1
EE04053B1 EE9700320A EE9700320A EE04053B1 EE 04053 B1 EE04053 B1 EE 04053B1 EE 9700320 A EE9700320 A EE 9700320A EE 9700320 A EE9700320 A EE 9700320A EE 04053 B1 EE04053 B1 EE 04053B1
Authority
EE
Estonia
Prior art keywords
aminomethyl
methylhexanoic acid
alkali
earth metal
alkaline earth
Prior art date
Application number
EE9700320A
Other languages
English (en)
Estonian (et)
Other versions
EE9700320A (et
Inventor
Michel Grote Todd
Keith Huckabee Brian
Martin Sobieray Denis
Daniel Titus Robert
Mulhern Thomas
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE9700320A publication Critical patent/EE9700320A/xx
Publication of EE04053B1 publication Critical patent/EE04053B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
EE9700320A 1995-06-07 1996-05-13 (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod EE04053B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/006819 WO1996040617A1 (en) 1995-06-07 1996-05-13 Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (2)

Publication Number Publication Date
EE9700320A EE9700320A (et) 1998-06-15
EE04053B1 true EE04053B1 (et) 2003-06-16

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700320A EE04053B1 (et) 1995-06-07 1996-05-13 (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod

Country Status (18)

Country Link
US (4) US5637767A (de)
EP (1) EP0830338B1 (de)
JP (1) JP3874306B2 (de)
AT (1) ATE210628T1 (de)
CA (1) CA2219150C (de)
CZ (2) CZ291147B6 (de)
DE (1) DE69617948T2 (de)
DK (1) DK0830338T3 (de)
EE (1) EE04053B1 (de)
ES (1) ES2170231T3 (de)
GE (1) GEP19991870B (de)
HU (2) HU229957B1 (de)
NZ (2) NZ308319A (de)
PL (3) PL185560B1 (de)
PT (1) PT830338E (de)
SI (1) SI0830338T1 (de)
SK (2) SK282865B6 (de)
WO (1) WO1996040617A1 (de)

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US5858736A (en) * 1996-05-17 1999-01-12 E. I. Du Pont De Nemours And Company Preparation of lactams from aliphatic α,ω-dinitriles
US6001876A (en) 1996-07-24 1999-12-14 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
US6194459B1 (en) 1997-08-19 2001-02-27 Warner-Lambert Company Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotors stimulants
CA2374755C (en) * 1999-06-10 2010-03-30 Warner-Lambert Company Mono- and disubstituted 3-propyl gamma-aminobutyric acids
SI1250311T1 (en) * 2000-01-27 2004-10-31 Warner-Lambert Company Asymmetric synthesis of pregabalin
GB2368579A (en) * 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
US7169812B2 (en) * 2003-07-01 2007-01-30 Medtronic, Inc. Process for producing injectable gabapentin compositions
EP1543831A1 (de) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Zusammensetzung enthaltend Pregabalin
DE602005002253T2 (de) * 2004-03-12 2008-05-29 Warner-Lambert Company Llc C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
AP2466A (en) * 2004-06-21 2012-09-17 Warner Lambert Co Preparation of pregabalin and related compounds
US7417165B2 (en) * 2005-04-06 2008-08-26 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
WO2006110783A2 (en) * 2005-04-11 2006-10-19 Teva Pharmaceutical Industries Ltd. Process for making (s)-pregabalin
KR100893312B1 (ko) * 2005-05-10 2009-04-15 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린 및 이의 염의 제조 방법
WO2006121557A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
WO2006122259A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
KR20070067077A (ko) * 2005-05-10 2007-06-27 테바 파마슈티컬 인더스트리즈 리미티드 이소부틸글루타르산을 함유하지 않는 프레가발린 및 이의제조 방법
WO2007035890A1 (en) 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid
NL2000281C2 (nl) * 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
WO2007127309A2 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
WO2007139933A2 (en) * 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
US20080015385A1 (en) * 2006-05-31 2008-01-17 Lilach Hedvati Preparation of (S)-pregabalin-nitrile
EP2071032A3 (de) 2006-05-31 2009-07-08 Teva Pharmaceutical Industries Ltd Enzymatische Auflösung für die Herstellung von Pregablin-Zwischenprodukten
WO2008007145A2 (en) 2006-07-12 2008-01-17 Generics [Uk] Limited Process of preparing a gamma-amino acid
WO2008062460A2 (en) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
WO2008118427A2 (en) * 2007-03-22 2008-10-02 Teva Pharmaceutical Industries Ltd. Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
EP1992609A1 (de) * 2007-05-14 2008-11-19 Dipharma Francis S.r.l. Verfahren für die Herstellung einer (S)(+)-3-(Aminomethyl)-5-Methylhexan-Säure
WO2009001372A2 (en) 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
WO2009044409A2 (en) * 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
ITMI20072262A1 (it) * 2007-12-03 2009-06-04 Dipharma Francis Srl Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
CA2710152A1 (en) * 2007-12-26 2009-07-02 Generics (Uk) Limited Processes to pregabalin
WO2009084493A1 (ja) * 2007-12-27 2009-07-09 Toray Fine Chemicals Co., Ltd. 光学活性３－アミノピロリジン塩及びその製造方法並びに３－アミノピロリジンの光学分割方法
US8592625B2 (en) * 2008-01-02 2013-11-26 Zheinjiang Jiuzhou Pharmaceutical Co., Ltd. Process for resolving S-3-(aminomethyl)-5-methylhexanoic acid
US20110144383A1 (en) * 2008-02-18 2011-06-16 Matrix Laboratories Limited Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid
AU2009233536A1 (en) * 2008-04-04 2009-10-08 Generics [Uk] Limited Novel process
EP2110372A1 (de) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Zwischenprodukte für die Herstellung von Pregabalin und deren Herstellungsverfahren
CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
KR20110025917A (ko) * 2008-05-21 2011-03-14 산도즈 아게 ５－메틸－３－니트로메틸－헥산산 에스테르의 입체선택적 효소 가수분해 방법
CN102112436A (zh) * 2008-06-03 2011-06-29 基因里克斯(英国)有限公司 用于合成氨基酸的新的和有效方法
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010061403A2 (en) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Process to prepare highly pure (s)-pregabalin
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
IT1394292B1 (it) 2009-05-07 2012-06-06 Dipharma Francis Srl Procedimento per la sintesi di pregabalina
ES2362913B1 (es) 2009-12-24 2012-05-24 Moehs Iberica S.L. Nuevo método para la preparación de (s)-pregabalina.
HUP1000186A2 (en) 2010-04-08 2011-10-28 Richter Gedeon Nyrt Novel industrial process of preparing (s)-(+) pregabalin
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
EP2700645A4 (de) 2011-04-20 2014-09-24 Kemphys Ltd Siliciumhaltiges carbonsäurederivat
EP2527319A1 (de) 2011-05-24 2012-11-28 Laboratorios Del. Dr. Esteve, S.A. Kristalline Formen von Pregabalin und Co-Formern zur Behandlung von Schmerzen
US9353134B2 (en) * 2012-10-18 2016-05-31 Kemphys Ltd. Silicon-containing carboxylic acid derivative
EP2916832B1 (de) 2012-11-07 2019-01-16 Hikal Limited Verfahren zur herstellung von pregabalin
CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
CN106488906B (zh) 2014-06-12 2018-10-26 斯福瑞有限公司 β-取代的γ-氨基羧酸的制备方法
CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
JP2018520112A (ja) 2015-05-26 2018-07-26 オディディ，イサ 制御持続放出プレガバリン
CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
CA3199166A1 (en) 2020-12-04 2022-06-09 Cecilia Jannette Munoz Martinez Stable, coated, and solid pharmaceutical drug composition containing an opioid analgesic and an antiepileptic to relieve pain
CN112939809A (zh) * 2020-12-30 2021-06-11 江苏恒沛药物科技有限公司 一种1-氰基-3-甲基丁基丙二酸二乙酯的制备方法
CN116041214B (zh) * 2022-11-15 2025-04-22 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

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JPS54100316A (en) * 1978-01-25 1979-08-08 Meiji Seika Kaisha Ltd Preparation of derivative of aminobutyric acid
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Also Published As

Publication number Publication date
US5840956A (en) 1998-11-24
HU229957B1 (hu) 2015-03-30
EP0830338A1 (de) 1998-03-25
GEP19991870B (en) 1999-12-06
CA2219150C (en) 2008-11-18
SK282865B6 (sk) 2003-01-09
PT830338E (pt) 2002-04-29
SI0830338T1 (en) 2002-04-30
AU700091B2 (en) 1998-12-24
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
HUP9802504A3 (en) 2000-06-28
SK283507B6 (sk) 2003-08-05
PL185425B1 (pl) 2003-05-30
AU5792196A (en) 1996-12-30
JP3874306B2 (ja) 2007-01-31
CZ296895B6 (cs) 2006-07-12
US5637767A (en) 1997-06-10
PL185557B1 (pl) 2003-06-30
DE69617948D1 (de) 2002-01-24
MX9708652A (es) 1998-06-30
US20010016665A1 (en) 2001-08-23
WO1996040617A1 (en) 1996-12-19
ATE210628T1 (de) 2001-12-15
EE9700320A (et) 1998-06-15
PL185560B1 (pl) 2003-06-30
ES2170231T3 (es) 2002-08-01
CZ384697A3 (cs) 1998-03-18
HU228194B1 (en) 2013-01-28
NZ501628A (en) 2001-09-28
CA2219150A1 (en) 1996-12-19
DE69617948T2 (de) 2002-06-13
SK164597A3 (en) 1998-05-06
CZ291147B6 (cs) 2002-12-11
HUP9802504A2 (hu) 1999-02-01
HU0500934D0 (en) 2005-12-28
JPH11506726A (ja) 1999-06-15
DK0830338T3 (da) 2002-04-02
US6046353A (en) 2000-04-04
EP0830338B1 (de) 2001-12-12

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