ATE212631T1 - 8-azabicyclo(3.2.1)0ctan-3-methanaminderivate als liganden der dopamin-rezeptoren d2 und d3 und der serotonin-rezeptoren 5ht1a und 5ht2 - Google Patents

8-azabicyclo(3.2.1)0ctan-3-methanaminderivate als liganden der dopamin-rezeptoren d2 und d3 und der serotonin-rezeptoren 5ht1a und 5ht2

Info

Publication number
ATE212631T1
ATE212631T1 AT98947615T AT98947615T ATE212631T1 AT E212631 T1 ATE212631 T1 AT E212631T1 AT 98947615 T AT98947615 T AT 98947615T AT 98947615 T AT98947615 T AT 98947615T AT E212631 T1 ATE212631 T1 AT E212631T1
Authority
AT
Austria
Prior art keywords
receptors
methanamene
0ctan
5ht1a
azabicyclo
Prior art date
Application number
AT98947615T
Other languages
English (en)
Inventor
Benoit Marabout
Mireille Sevrin
Pascal George
Jean-Pierre Merly
Peretti Daniele De
Jocelyne Roy
David Machnik
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9712580A external-priority patent/FR2769628B1/fr
Priority claimed from FR9712583A external-priority patent/FR2769629B1/fr
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of ATE212631T1 publication Critical patent/ATE212631T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT98947615T 1997-10-09 1998-10-07 8-azabicyclo(3.2.1)0ctan-3-methanaminderivate als liganden der dopamin-rezeptoren d2 und d3 und der serotonin-rezeptoren 5ht1a und 5ht2 ATE212631T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9712580A FR2769628B1 (fr) 1997-10-09 1997-10-09 Derives de n-(2,3-dihydro-1h-inden-2-yl)-n-propyl-8- azabicyclo[3.2.1.]octane-3-methanamine, leur preparation et leur application en therapeutique
FR9712583A FR2769629B1 (fr) 1997-10-09 1997-10-09 Derives de 8-azabicyclo[3.2.1]octane-3-methanamine, leur preparation et leur application en therapeutique
PCT/FR1998/002137 WO1999019325A1 (fr) 1997-10-09 1998-10-07 Derives de 8-azabicyclo [3.2.1] octane-3-methanamine en tant que ligands des recepteurs de dopamine d2 et d3 et de serotonine 5ht1a et 5ht2

Publications (1)

Publication Number Publication Date
ATE212631T1 true ATE212631T1 (de) 2002-02-15

Family

ID=26233854

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98947615T ATE212631T1 (de) 1997-10-09 1998-10-07 8-azabicyclo(3.2.1)0ctan-3-methanaminderivate als liganden der dopamin-rezeptoren d2 und d3 und der serotonin-rezeptoren 5ht1a und 5ht2

Country Status (30)

Country Link
US (1) US6221879B1 (de)
EP (1) EP1021442B1 (de)
JP (1) JP4505135B2 (de)
KR (1) KR20010015717A (de)
CN (1) CN1140526C (de)
AR (1) AR017300A1 (de)
AT (1) ATE212631T1 (de)
AU (1) AU746935B2 (de)
BG (1) BG64859B1 (de)
BR (1) BR9812752A (de)
CA (1) CA2305468C (de)
CO (1) CO5011097A1 (de)
CZ (1) CZ290679B6 (de)
DE (1) DE69803689T2 (de)
DK (1) DK1021442T3 (de)
EE (1) EE04347B1 (de)
ES (1) ES2171306T3 (de)
HU (1) HUP0102086A3 (de)
IL (2) IL135520A0 (de)
NO (1) NO325170B1 (de)
NZ (1) NZ503829A (de)
PL (1) PL186998B1 (de)
PT (1) PT1021442E (de)
RU (1) RU2203281C2 (de)
SI (1) SI1021442T1 (de)
SK (1) SK283080B6 (de)
TR (1) TR200000942T2 (de)
TW (1) TW444014B (de)
UA (1) UA58476C2 (de)
WO (1) WO1999019325A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
DE122008000002I1 (de) 2000-02-15 2008-04-17 Sugen Inc Pyrrol substituierte indolin-2-on protein kinase inhibitoren
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
ATE520659T1 (de) * 2004-10-14 2011-09-15 Abbott Gmbh & Co Kg Zur behandlung von auf die modulation des dopamin-d3-rezeptors ansprechenden erkrankungen geeignete azabicycloheptylverbindungen
AU2006214233A1 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI475015B (zh) 2010-03-11 2015-03-01 Sumitomo Dainippon Pharma Co Ltd Ｎ－醯基環狀胺衍生物或其醫藥上容許之鹽
EP3230256B1 (de) * 2014-12-09 2019-11-13 Ezekiel Golan Ersatz für alkoholische getränke
EP3230255B1 (de) 2014-12-09 2020-03-18 Ezekiel Golan Regulatoren für komatrinken
KR102128782B1 (ko) 2018-09-20 2020-07-01 한양대학교 에리카산학협력단 트로페인(Tropane) 알칼로이드 화합물 및 순차적 산화반응을 이용한 이의 제조방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
JPS5592384A (en) * 1978-12-30 1980-07-12 Beecham Group Ltd Compound having pharmacological activity
US4350691A (en) * 1979-12-20 1982-09-21 Beecham Group Limited Certain azabicyclocarboxamides and compositions containing same
US4910302A (en) * 1988-12-19 1990-03-20 American Home Products Corporation Psychotropic polycyclic imides
FR2659323B1 (fr) * 1990-03-07 1992-06-12 Synthelabo Derives de 4-(aminomethyl) piperidine, leur preparation et leur application en therapeutique.
NZ241481A (en) * 1991-02-04 1994-06-27 Hoechst Roussel Pharma Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof
FR2681320B1 (fr) 1991-09-12 1994-01-14 Synthelabo Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
FR2681325B1 (fr) * 1991-09-16 1993-12-17 Fabre Medicament Pierre Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
DE4135474A1 (de) 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
FR2702211B1 (fr) 1993-03-04 1995-06-02 Pf Medicament Nouveaux dérivés de la phénoxy-2 éthylamine, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
TR200000942T2 (tr) 2000-09-21
NZ503829A (en) 2002-03-28
JP2001519431A (ja) 2001-10-23
EE04347B1 (et) 2004-08-16
NO20001810L (no) 2000-06-09
PL186998B1 (pl) 2004-04-30
UA58476C2 (uk) 2003-08-15
SK283080B6 (sk) 2003-02-04
CA2305468C (en) 2007-09-25
BG104309A (en) 2001-05-31
AR017300A1 (es) 2001-09-05
AU9446898A (en) 1999-05-03
CO5011097A1 (es) 2001-02-28
TW444014B (en) 2001-07-01
RU2203281C2 (ru) 2003-04-27
BR9812752A (pt) 2000-08-29
CZ290679B6 (cs) 2002-09-11
IL135520A0 (en) 2001-05-20
CN1281455A (zh) 2001-01-24
KR20010015717A (ko) 2001-02-26
SK5042000A3 (en) 2001-03-12
SI1021442T1 (en) 2002-08-31
CA2305468A1 (en) 1999-04-22
NO20001810D0 (no) 2000-04-07
ES2171306T3 (es) 2002-09-01
US6221879B1 (en) 2001-04-24
DE69803689T2 (de) 2002-10-10
WO1999019325A1 (fr) 1999-04-22
PL339764A1 (en) 2001-01-02
HUP0102086A3 (en) 2002-09-30
EP1021442A1 (de) 2000-07-26
NO325170B1 (no) 2008-02-11
PT1021442E (pt) 2002-06-28
CN1140526C (zh) 2004-03-03
DK1021442T3 (da) 2002-05-13
EP1021442B1 (de) 2002-01-30
HK1029108A1 (en) 2001-03-23
HUP0102086A2 (hu) 2001-12-28
BG64859B1 (bg) 2006-07-31
IL135520A (en) 2007-07-24
EE200000207A (et) 2001-04-16
AU746935B2 (en) 2002-05-09
DE69803689D1 (de) 2002-03-14
JP4505135B2 (ja) 2010-07-21
CZ20001278A3 (cs) 2000-07-12

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UEP Publication of translation of european patent specification