DK0915870T3 - Substituerede bisindolylmaleimider til bekæmpelse af celleprofileration - Google Patents

Substituerede bisindolylmaleimider til bekæmpelse af celleprofileration

Info

Publication number
DK0915870T3
DK0915870T3 DK97918934T DK97918934T DK0915870T3 DK 0915870 T3 DK0915870 T3 DK 0915870T3 DK 97918934 T DK97918934 T DK 97918934T DK 97918934 T DK97918934 T DK 97918934T DK 0915870 T3 DK0915870 T3 DK 0915870T3
Authority
DK
Denmark
Prior art keywords
cell profiling
bisindolylmaleimides
substituted
combat
combat cell
Prior art date
Application number
DK97918934T
Other languages
English (en)
Inventor
Urvashi Hooda Dhingra
Donna Mary Huryn
Dennis Dalton Keith
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0915870T3 publication Critical patent/DK0915870T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK97918934T 1996-07-29 1997-07-19 Substituerede bisindolylmaleimider til bekæmpelse af celleprofileration DK0915870T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2207896P 1996-07-29 1996-07-29
US4849697P 1997-06-03 1997-06-03
PCT/EP1997/003888 WO1998004551A1 (en) 1996-07-29 1997-07-19 Substituted bisindolylmaleimides for the inhibition of cell proliferation

Publications (1)

Publication Number Publication Date
DK0915870T3 true DK0915870T3 (da) 2003-02-03

Family

ID=26695475

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97918934T DK0915870T3 (da) 1996-07-29 1997-07-19 Substituerede bisindolylmaleimider til bekæmpelse af celleprofileration

Country Status (20)

Country Link
US (1) US6228877B1 (da)
EP (1) EP0915870B1 (da)
JP (1) JP2000516588A (da)
KR (1) KR20000029640A (da)
CN (1) CN1077571C (da)
AR (1) AR007969A1 (da)
AT (1) ATE224889T1 (da)
AU (1) AU740011B2 (da)
BR (1) BR9711607A (da)
CA (1) CA2262089A1 (da)
CO (1) CO4900054A1 (da)
DE (1) DE69715870T2 (da)
DK (1) DK0915870T3 (da)
ES (1) ES2183163T3 (da)
HR (1) HRP970415A2 (da)
MA (1) MA24354A1 (da)
PE (1) PE91598A1 (da)
PT (1) PT915870E (da)
TR (1) TR199900186T2 (da)
WO (1) WO1998004551A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1064279E (pt) * 1998-03-17 2003-10-31 Hoffmann La Roche Bisindolilmaleimidas substituidas para a inibicao da proliferacao celular
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
PL357441A1 (en) * 1999-10-12 2004-07-26 F.Hoffmann-La Roche Ag Substituted pyrroles as antiproliferative agents for the treatment of cancer
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
KR20050040832A (ko) * 2001-10-29 2005-05-03 넥타르 테라퓨틱스 에이엘, 코포레이션 단백질 키나아제 ｃ 억제제의 중합체 공액
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
RS51826B (sr) 2005-02-09 2012-02-29 Arqule Inc. Maleimid derivati, farmaceutske kompozicije i postupak lečenja kancera
JP2010513386A (ja) * 2006-12-19 2010-04-30 ノバルティス アーゲー キナーゼ阻害剤としてのインドリルマレイミド誘導体
CA2690782C (en) 2007-06-22 2016-02-02 Arqule, Inc. Compositions and methods for treatment of cancer
CN101801937A (zh) 2007-06-22 2010-08-11 艾科尔公司 喹唑啉酮化合物及其使用方法
CA2690799C (en) * 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CN105777751B (zh) * 2016-04-26 2018-12-11 浙江工业大学 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用
CN107973785B (zh) * 2017-11-27 2019-12-31 浙江工业大学上虞研究院有限公司 一种用于检测银离子的荧光探针及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5380746A (en) 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
JPH0539289A (ja) 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
AU3761393A (en) 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
DE4217964A1 (de) 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
TR199900186T2 (xx) 1999-03-22
KR20000029640A (ko) 2000-05-25
MA24354A1 (fr) 1998-07-01
CN1077571C (zh) 2002-01-09
BR9711607A (pt) 1999-08-24
PT915870E (pt) 2003-01-31
WO1998004551A1 (en) 1998-02-05
CN1226248A (zh) 1999-08-18
CO4900054A1 (es) 2000-03-27
AR007969A1 (es) 1999-11-24
ATE224889T1 (de) 2002-10-15
DE69715870D1 (de) 2002-10-31
EP0915870A1 (en) 1999-05-19
AU740011B2 (en) 2001-10-25
PE91598A1 (es) 1998-12-24
HRP970415A2 (en) 1998-08-31
DE69715870T2 (de) 2003-06-18
US6228877B1 (en) 2001-05-08
EP0915870B1 (en) 2002-09-25
AU4296397A (en) 1998-02-20
CA2262089A1 (en) 1998-02-05
JP2000516588A (ja) 2000-12-12
ES2183163T3 (es) 2003-03-16

Similar Documents

Publication Publication Date Title
ID24314A (id) Tempat umpan bersekat-sekat
DK0915872T3 (da) Substituerede bisindolylmaleimider til inhibering af celleproliferation
ID19875A (id) Poliolefin yang dimodifikasi menurut reologi
NO20010112D0 (no) Full-löps kanonsystem
DE69910024D1 (de) Rückstossloses wassergewehr
NO985533D0 (no) Additiver til brennstoff
ATE224889T1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
DK1064279T3 (da) Substituerede bisindolylmaleimider til inhibering af celleproliferation
ATA56496A (de) Fassadenkonstruktion
ID17786A (id) Sel fotoelektrokima
ATE347551T1 (de) Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
SK1467U (sk) Rozpierka
DE69833024D1 (de) Dachrinne
ID27048A (id) Metode untuk mencegah mrp1
DE69727301D1 (de) Driftzelle
ATA198296A (de) Peltonrad - vorspannung
ID19276A (id) Konstruksi pembakar
NO964898D0 (no) Elektrokjemisk anlegg
LU90002B1 (de) Fassadenkonstruktion
DE69722799D1 (de) Zellzusammenstellungen
DK199801231A (da) Bue til ruse
BR9705758A (pt) Aperfeiçoamentos introduzidos em escada doméstica
KR980004488U (ko) 권총식 취루탄환
BR9600036A (pt) Aperfeiçoamentos introduzidos em fogão
SE9600211L (sv) Grillgaller