ES2183163T3 - B.sindolilmaleimidas sustituidas para la inhibicion de la proliferacion celular - Google Patents

B.sindolilmaleimidas sustituidas para la inhibicion de la proliferacion celular

Info

Publication number
ES2183163T3
ES2183163T3 ES97918934T ES97918934T ES2183163T3 ES 2183163 T3 ES2183163 T3 ES 2183163T3 ES 97918934 T ES97918934 T ES 97918934T ES 97918934 T ES97918934 T ES 97918934T ES 2183163 T3 ES2183163 T3 ES 2183163T3
Authority
ES
Spain
Prior art keywords
rent
hydrogen
arilo
formula
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97918934T
Other languages
English (en)
Inventor
Urvashi Hooda Dhingra
Donna Mary Huryn
Dennis Dalton Keith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2183163T3 publication Critical patent/ES2183163T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE: R 1 Y R 1'' SON INDEPENDIENTEMENTE ALQUILO, ARILO, ALQUENILO O ALQUINILO; R 2 Y R 2'' SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO, ARALQUILO, ALCOXIALQUILO, HIDROXIALQUILO, HALOALQUILO, AMINOALQUILO, MONOALQUILAMINOALQUILO, DIALQUILAMINOALQUILO, ACILAMINOALQUILO, ALQUILSULFONILAMINOALQUILO, ARILSULFONIL - AMINOALQUILO, MERCAPTOALQUILO, ALQUILTIOALQUILO, CARBOXIALQUILO, ALCOXICARBONILALQUILO, AMINOCARBONILALQUILO, ALQUILTIO O ALQUILSULFINILO; R 4 , R 5 , R 6 , R SUP,7 , R 4'' , R 5'' , R 6'' Y R 7'' , CADA UNO I NDEPENDIENTEMENTE, SON HIDROGENO, FORMULA (II), CO 2 R SUP,9 , CH 2 OR 10 , CHO, CH 2 NR 11 R 12 , C ON(R 13 ) 2 , HALOGENO, CIANO, ARILO, ALQUILO, HIDROXILO, ALCOXI, ARILOXI, HALOALQUILO, NITRO, AMINO, ARALQUILOXI, ACILAMINO, MONOALQUILAMINO, DIALQUILAMINO, TIO, ALQUILTIO, ALQUILSULFINILO, ALQUILSULFONILO, ARILSULFINILO, AZIDA, FOSFATO O FOSFONATO, A CONDICION DE QUE AL MENOS UNO DE R 4 , R 5 , R 6 Y R 7 , Y AL MENOS UNO DE R 4'' ,R 5'' , R 6'' Y R 7'' SON DISTINTOS DE HIDROGENO, CON LA CONDICION DE QUE CUANDO R 6 SEA METOXI, R 5 O R 5'' NO SEAN METOXI; R 8 ES ALQUILO O ARILO; R 9 ES ALQUILO O ARILO; R 10 ES HIDROGENO, ALQUILO O ARILO; R 11 Y R 12 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO, ARILO, ARALQUILO O ACILO; R 13 ES HIDROGENO, ALQUILO, ARILO O ARALQUILO; Y UNO DE X E Y REPRESENTA O Y EL OTRO REPRESENTA O, S, (H, OH) O (H, H); ASI COMO PRECURSORES ACEPTABLES DE LOS MISMOS O SALES FARMACEUTICAMENTE ACEPTABLES DE COMPUESTOS ACIDOS DE FORMULA (I) CON BASES, O DE COMPUESTOS BASICOS DE FORMULA (I) CON ACIDOS. DICHOS COMPUESTOS SON AGENTE SANTIPROLIFERATIVOS, UTILES EN EL TRATAMIENTO DEL CANCER.
ES97918934T 1996-07-29 1997-07-19 B.sindolilmaleimidas sustituidas para la inhibicion de la proliferacion celular Expired - Lifetime ES2183163T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2207896P 1996-07-29 1996-07-29
US4849697P 1997-06-03 1997-06-03

Publications (1)

Publication Number Publication Date
ES2183163T3 true ES2183163T3 (es) 2003-03-16

Family

ID=26695475

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97918934T Expired - Lifetime ES2183163T3 (es) 1996-07-29 1997-07-19 B.sindolilmaleimidas sustituidas para la inhibicion de la proliferacion celular

Country Status (20)

Country Link
US (1) US6228877B1 (es)
EP (1) EP0915870B1 (es)
JP (1) JP2000516588A (es)
KR (1) KR20000029640A (es)
CN (1) CN1077571C (es)
AR (1) AR007969A1 (es)
AT (1) ATE224889T1 (es)
AU (1) AU740011B2 (es)
BR (1) BR9711607A (es)
CA (1) CA2262089A1 (es)
CO (1) CO4900054A1 (es)
DE (1) DE69715870T2 (es)
DK (1) DK0915870T3 (es)
ES (1) ES2183163T3 (es)
HR (1) HRP970415A2 (es)
MA (1) MA24354A1 (es)
PE (1) PE91598A1 (es)
PT (1) PT915870E (es)
TR (1) TR199900186T2 (es)
WO (1) WO1998004551A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1064279E (pt) * 1998-03-17 2003-10-31 Hoffmann La Roche Bisindolilmaleimidas substituidas para a inibicao da proliferacao celular
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
CA2385071A1 (en) * 1999-10-12 2001-04-19 Norman Kong Substituted pyrroles as antiproliferative agents for the treatment of cancer
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
EP1441772A2 (en) * 2001-10-29 2004-08-04 Nektar Therapeutics Al, Corporation Polymer conjugates of protein kinase c inhibitors
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
KR100941205B1 (ko) 2005-02-09 2010-02-10 아르퀼 인코포레이티드 말레이미드 유도체, 약제학적 조성물 및 암을 치료하는방법
ES2410955T3 (es) * 2006-12-19 2013-07-04 Novartis Ag Derivados de indolilmaleimida como inhibidores de la quinasa
EP2170870B1 (en) * 2007-06-22 2014-03-05 ArQule, Inc. Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
CA2912546A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Compositions and methods for treatment of cancer
KR20100024494A (ko) 2007-06-22 2010-03-05 아르퀼 인코포레이티드 퀴나졸리논 화합물 및 이의 사용 방법
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
EP3741375A1 (en) 2014-07-17 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CN109535158B (zh) * 2016-04-26 2021-04-23 浙江工业大学 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用
CN107973785B (zh) * 2017-11-27 2019-12-31 浙江工业大学上虞研究院有限公司 一种用于检测银离子的荧光探针及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
US5380746A (en) 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
JPH0539289A (ja) 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
AU3761393A (en) 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
DE4217964A1 (de) 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
JP2000516588A (ja) 2000-12-12
EP0915870A1 (en) 1999-05-19
ATE224889T1 (de) 2002-10-15
CN1226248A (zh) 1999-08-18
AU740011B2 (en) 2001-10-25
TR199900186T2 (xx) 1999-03-22
BR9711607A (pt) 1999-08-24
CA2262089A1 (en) 1998-02-05
WO1998004551A1 (en) 1998-02-05
CN1077571C (zh) 2002-01-09
HRP970415A2 (en) 1998-08-31
PE91598A1 (es) 1998-12-24
DK0915870T3 (da) 2003-02-03
DE69715870T2 (de) 2003-06-18
PT915870E (pt) 2003-01-31
US6228877B1 (en) 2001-05-08
KR20000029640A (ko) 2000-05-25
DE69715870D1 (de) 2002-10-31
MA24354A1 (fr) 1998-07-01
EP0915870B1 (en) 2002-09-25
AR007969A1 (es) 1999-11-24
CO4900054A1 (es) 2000-03-27
AU4296397A (en) 1998-02-20

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