ATE225340T1 - Einschlusskomplexe von taxol oder taxotere oder taxus-extrakten und cyclodextrinen, ihre herstellung und ihre verwendung - Google Patents

Einschlusskomplexe von taxol oder taxotere oder taxus-extrakten und cyclodextrinen, ihre herstellung und ihre verwendung

Info

Publication number
ATE225340T1
ATE225340T1 AT94918994T AT94918994T ATE225340T1 AT E225340 T1 ATE225340 T1 AT E225340T1 AT 94918994 T AT94918994 T AT 94918994T AT 94918994 T AT94918994 T AT 94918994T AT E225340 T1 ATE225340 T1 AT E225340T1
Authority
AT
Austria
Prior art keywords
taxotere
taxol
preparation
cyclodextrins
inclusion complexes
Prior art date
Application number
AT94918994T
Other languages
English (en)
Inventor
Lajos Szente
Jozsef Szejili
Andrasne Vikmon
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Application granted granted Critical
Publication of ATE225340T1 publication Critical patent/ATE225340T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Epoxy Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT94918994T 1993-05-12 1994-05-09 Einschlusskomplexe von taxol oder taxotere oder taxus-extrakten und cyclodextrinen, ihre herstellung und ihre verwendung ATE225340T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9301373A HU213200B (en) 1993-05-12 1993-05-12 The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
PCT/HU1994/000012 WO1994026728A1 (en) 1993-05-12 1994-05-09 Inclusion complexes of taxol or taxotere or taxus extract formed with cyclodextrins, its preparation and use

Publications (1)

Publication Number Publication Date
ATE225340T1 true ATE225340T1 (de) 2002-10-15

Family

ID=10983581

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94918994T ATE225340T1 (de) 1993-05-12 1994-05-09 Einschlusskomplexe von taxol oder taxotere oder taxus-extrakten und cyclodextrinen, ihre herstellung und ihre verwendung

Country Status (23)

Country Link
US (1) US6284746B1 (de)
EP (1) EP0698018B1 (de)
JP (1) JP3693341B2 (de)
CN (1) CN1123030A (de)
AT (1) ATE225340T1 (de)
AU (1) AU693101B2 (de)
BG (1) BG100207A (de)
BR (1) BR9406292A (de)
CA (1) CA2162716C (de)
CZ (1) CZ291495A3 (de)
DE (1) DE69431476T2 (de)
DK (1) DK0698018T3 (de)
ES (1) ES2184764T3 (de)
FI (1) FI955424L (de)
HU (1) HU213200B (de)
IL (1) IL109613A (de)
NO (1) NO954545L (de)
OA (1) OA10323A (de)
PL (1) PL311561A1 (de)
PT (1) PT698018E (de)
SK (1) SK140595A3 (de)
WO (1) WO1994026728A1 (de)
YU (1) YU26894A (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2149150C (en) 1992-11-27 2000-08-01 David R. Carver Injectable taxol composition with improved stability
US5994341A (en) * 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
HUT73844A (en) * 1994-11-11 1996-09-30 Chinoin Gyogyszer Es Vegyeszet New taxol complexes and pharmaceutical compositions containing them
HUP9701945A3 (en) * 1997-11-10 2000-04-28 Hexal Ag Pharmaceutical composition for injection containing cyclodextrin and taxoids
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
KR20080016756A (ko) * 1998-02-05 2008-02-21 노파르티스 아게 유기화합물 함유 조성물
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
TWI321054B (en) * 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
GB0127677D0 (en) * 2001-11-19 2002-01-09 Vianex S A Inclusion complex
US20040106199A1 (en) * 2002-12-02 2004-06-03 Eliseev Alexey V. Charged cyclodextrin derivatives and their use in plant cell and tissue culture growth media
CN100486645C (zh) * 2006-09-12 2009-05-13 南京师范大学 含有环糊精紫杉醇包合物的药物组合物及其制备方法
CN100411688C (zh) * 2006-09-12 2008-08-20 南京师范大学 含有环糊精/多烯紫杉醇包合物的药物组合物及其制备方法
CN101278929B (zh) * 2007-04-02 2011-05-18 王效山 含有藤黄酸类化合物的药物及藤黄酸类化合物的包合物的制备方法
ES2310122B1 (es) * 2007-04-20 2009-10-30 Instituto Cientifico Y Tecnologico De Navarra, S.A Nanoparticulas que comprenden una ciclodextrina y una molecula biologicamente activa y sus aplicaciones.
ITMI20071321A1 (it) * 2007-07-04 2009-01-05 Sea Marconi Technologies Di Va Nanospugne a base di ciclodestrine come veicolo per farmaci antitumorali
CL2007003876A1 (es) * 2007-12-28 2008-03-07 Univ De Concepcion Y Lab Andro Complejo de inclusion que esta formado por disulfiram y ciclodextrina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de la dependencia de alcohol y cocaina.
WO2010021750A2 (en) 2008-08-21 2010-02-25 The Johns Hopkins University Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
US20180161274A1 (en) * 2014-01-14 2018-06-14 The Johns Hopkins University Liposome Compositions Encapsulating Modified Cyclodextrin Complexes and Uses Thereof
CN103920163B (zh) * 2014-03-14 2016-09-14 南京大学 一种紫杉醇复合物、制备方法及其应用
WO2017079563A1 (en) 2015-11-06 2017-05-11 The Johns Hopkins University Methods of treating liver fibrosis by administering 3-bromopyruvate
GB201715008D0 (en) 2017-09-18 2017-11-01 Inst De Medicina Molecular Faculdade De Medicina Univ De Lisboa TRPV2 Antagonists
EP3827822B1 (de) 2018-07-25 2024-11-06 Bika Biotechnology (Guangzhou) Co., Ltd. Docetaxelzusammensetzung zur injektion und herstellungsverfahren dafür

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU181703B (en) * 1980-05-09 1983-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing aqueus solutuins of water insoluble or hardly soluble vitamines, steroides, localanesthetics, prostanoides and non-steroid and antiphlogistic agents
HU191101B (en) * 1983-02-14 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups
JPS62120324A (ja) * 1985-11-20 1987-06-01 Nippon Junyaku Kk 有機物質の水溶化方法
JP2651567B2 (ja) * 1986-03-20 1997-09-10 花王株式会社 メチル化β−シクロデキストリン
IE62095B1 (en) * 1988-03-29 1994-12-14 Univ Florida Pharmaceutical formulations for parenteral use
JP2929108B2 (ja) * 1988-10-28 1999-08-03 株式会社資生堂 化粧料および粉末化粧料
IT1227626B (it) 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
JPH02200671A (ja) * 1989-01-30 1990-08-08 Agency Of Ind Science & Technol インドールを抽出分離する方法およびインドール包接分離用薬剤
JPH035438A (ja) * 1989-05-31 1991-01-11 Kaken Pharmaceut Co Ltd フルルビプロフェン包接化合物およびこの包接化合物を用いる消炎鎮痛剤
GB8920135D0 (en) * 1989-09-06 1989-10-18 Erba Carlo Spa Use of dehydrated cyclodextrins for improving drug dissolution
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
HU211648A9 (en) 1990-03-28 1995-12-28 Chinoin Gyogyszer Es Vegyeszet Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same
KR927003645A (ko) * 1990-05-21 1992-12-18 후지다 히로미찌 씨클로덱스트린 유도체
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
JPH0753396A (ja) * 1993-08-19 1995-02-28 Ensuiko Sugar Refining Co Ltd タキソールのサイクロデキストリン包接物，その製造法および用途
JPH06157330A (ja) * 1992-11-27 1994-06-03 Ensuiko Sugar Refining Co Ltd タキソールのサイクロデキストリン包接物，その製造法と用途
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor

Also Published As

Publication number Publication date
HU213200B (en) 1997-03-28
NO954545D0 (no) 1995-11-10
FI955424A0 (fi) 1995-11-10
FI955424A7 (fi) 1995-11-10
BG100207A (bg) 1996-05-31
SK140595A3 (en) 1996-10-02
DE69431476T2 (de) 2003-06-18
YU26894A (sh) 1997-05-28
JPH08510232A (ja) 1996-10-29
ES2184764T3 (es) 2003-04-16
IL109613A0 (en) 1994-08-26
EP0698018A1 (de) 1996-02-28
CZ291495A3 (en) 1996-04-17
CN1123030A (zh) 1996-05-22
AU693101B2 (en) 1998-06-25
DK0698018T3 (da) 2003-02-10
AU7008194A (en) 1994-12-12
FI955424L (fi) 1995-11-10
BR9406292A (pt) 1995-12-26
DE69431476D1 (de) 2002-11-07
NO954545L (no) 1995-11-10
PL311561A1 (en) 1996-02-19
EP0698018B1 (de) 2002-10-02
CA2162716A1 (en) 1994-11-24
IL109613A (en) 1997-09-30
HU9301373D0 (en) 1993-09-28
US6284746B1 (en) 2001-09-04
PT698018E (pt) 2003-02-28
HUT68589A (en) 1995-06-28
JP3693341B2 (ja) 2005-09-07
WO1994026728A1 (en) 1994-11-24
CA2162716C (en) 2005-03-08
OA10323A (en) 1997-10-07

Similar Documents

Publication Publication Date Title
DE69431476D1 (de) Einschlusskomplexe von taxol oder taxotere oder taxus-extrakten und cyclodextrinen, ihre herstellung und ihre verwendung
BR9307401A (pt) Composi-{es de extrato da casca de carvalho composi-{es sint-ticas relacionadas e m-todo de usar as mesmas
ATE274347T1 (de) Stabile injizierbare paclitaxel lösung
DE69703294D1 (de) Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten
NO964433L (no) Farmasöytiske preparater på basis av derivater av taxanklassen
KR900700128A (ko) 외상 치료법
DK1167354T3 (da) Racemisk huperzin A
ATE196083T1 (de) Verwendung von ferrioxamin-b zur behandlung septischen schocks
DE69333396T2 (de) Einschlusskomplex von Taxol mit Cyclodextrin, Verfahren zu seiner Herstellung und Verwendung
DE69705110D1 (de) Topische pharmazeutische zusammensetzungen, welche heparin enthalten
ATE136465T1 (de) Verwendung von gibberellinen zur herstellung eines arzneimittels zur behandlung von prostatitis
DE69815100D1 (de) Zusammensetzungen, die dolastatin-15-analoge in kombination mit taxane und dessen derivaten enthalten
ATE157010T1 (de) Amylin oder amylinanaloga enthaltende zusammensetzung, welche auch wahlweise insulin enthält, zur behandlung von anorexie und verwandten zuständen
DE69433923D1 (de) Salbe enthaltend mometason-furoat und salicylsäure zur topischen behandlung von psoriasis
ES2113647T3 (es) Composicion.
ATE229803T1 (de) Verwendung eines flavonoid enthaltenden extraktes der planze euphorbia prostrata zur herstellung eines medikamentes zur behandlung von anoraktalen oder kolonbeschwerden
ATE127118T1 (de) 2-alkyl-3-benzoylbenzofurane zur behandlung von herzarrhythmia.
ATE175349T1 (de) Verwendung von etofibrat und pharmazeutische zusammensetzungen, enthaltend etofibrat, zur behandlung der diabetischen angio- und retinopathie
RU93056862A (ru) Способ предотвращения рестеноза или снижения его степени

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0698018

Country of ref document: EP

EEIH Change in the person of patent owner