ATE226247T1 - Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes - Google Patents

Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes

Info

Publication number
ATE226247T1
ATE226247T1 AT91908704T AT91908704T ATE226247T1 AT E226247 T1 ATE226247 T1 AT E226247T1 AT 91908704 T AT91908704 T AT 91908704T AT 91908704 T AT91908704 T AT 91908704T AT E226247 T1 ATE226247 T1 AT E226247T1
Authority
AT
Austria
Prior art keywords
methods
acetylcholine receptor
human neuronal
receptor compounds
neuronal nicotine
Prior art date
Application number
AT91908704T
Other languages
English (en)
Inventor
Michael Miller Harpold
Stephen Bradley Ellis
Paul Brust
Michael Akong
Gonul Velicelebi
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE226247T1 publication Critical patent/ATE226247T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT91908704T 1990-04-03 1991-04-03 Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes ATE226247T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/504,455 US5369028A (en) 1990-04-03 1990-04-03 DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
PCT/US1991/002311 WO1991015602A1 (en) 1990-04-03 1991-04-03 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Publications (1)

Publication Number Publication Date
ATE226247T1 true ATE226247T1 (de) 2002-11-15

Family

ID=24006339

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91908704T ATE226247T1 (de) 1990-04-03 1991-04-03 Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes

Country Status (7)

Country Link
US (2) US5369028A (de)
EP (1) EP0523187B1 (de)
AT (1) ATE226247T1 (de)
CA (1) CA2078572C (de)
DE (1) DE69133135T2 (de)
ES (1) ES2183801T3 (de)
WO (1) WO1991015602A1 (de)

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* Cited by examiner, † Cited by third party
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US5683912A (en) * 1994-07-21 1997-11-04 The Salk Institute For Biological Studies Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit
US6440681B1 (en) 1990-04-03 2002-08-27 Merck & Co., Inc. Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors
US5369028A (en) * 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
ES2157197T3 (es) 1990-09-13 2001-08-16 Univ Duke Expresion de receptores acoplados a una proteina g en levadura.
DE4138621A1 (de) * 1991-11-25 1993-06-17 Boehringer Ingelheim Int Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg
US5670113A (en) * 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
JP3628691B2 (ja) * 1993-03-08 2005-03-16 メルク エンド カンパニー インコーポレーテッド ヒト神経細胞性ニコチン性アセチルコリン受容体組成物およびそれらの使用方法
US6100042A (en) 1993-03-31 2000-08-08 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US7235648B1 (en) 1993-03-31 2007-06-26 Cadus Technologies, Inc. Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US6255059B1 (en) 1993-03-31 2001-07-03 Cadus Pharmaceutical Corporation Methods for identifying G protein coupled receptor effectors
GB2287941B (en) * 1993-11-08 1998-01-28 Salk Inst Biotech Ind Human alpha2 neuronal nicotinic acetylcholine receptor compositions and methods employing same
US6800452B1 (en) 1994-08-08 2004-10-05 Science Applications International Corporation Automated methods for simultaneously performing a plurality of signal-based assays
US6777236B1 (en) 1994-12-14 2004-08-17 Institut Pasteur Process for producing a neuronal host cell in vitro comprising regulatory sequences of the β2-subunit of the neuronal nicotinic acetylcholine receptor
US6177242B1 (en) * 1994-12-14 2001-01-23 Institut Pasteur Genomic DNA fragments containing regulatory and coding sequences for the β2-subunit of the neuronal nicotinic acetylcholine receptor and transgenic animals made using these fragments or mutated fragments
US6485967B1 (en) 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
US5691365A (en) * 1995-07-18 1997-11-25 University Of Kentucky Research Foundation Nicotinic receptor antagonists in the treatment of neuropharmacological disorders
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
US6528630B1 (en) 1997-12-03 2003-03-04 Merck & Co., Inc. Calcium channel compositions and methods
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
DE19850429A1 (de) * 1998-10-27 2000-05-04 Andre Schrattenholz Fragmente
DE60233728D1 (de) * 2001-06-06 2009-10-29 Neurosearch As Kationenleitende gaba-a-rezeptoren und deren verwendung
WO2003020954A2 (en) * 2001-08-31 2003-03-13 Agensys, Inc. 205p1b5 in treatment and detection of cancer
JP2005538683A (ja) * 2001-12-14 2005-12-22 ターガセプト，インコーポレイテッド 中枢神経系疾患の治療のための方法及び組成物
WO2005030145A2 (en) * 2003-09-24 2005-04-07 Targacept, Inc. Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors
US7879913B2 (en) * 2005-06-28 2011-02-01 Catholic Healthcare West Iptakalim hydrochloride for decreasing nicotine use
WO2007092938A2 (en) * 2006-02-08 2007-08-16 Invitrogen Corporation Cellular assays for signaling receptors
CA2777843A1 (en) 2009-10-16 2011-04-21 University Of South Florida Treatment of suicidal ideation or behavior using inhibitors of nicotinic acetylcholine receptors
WO2012050646A2 (en) 2010-06-29 2012-04-19 The Trustees Of The University Of Pennsylvania Biomimetic chemical sensors using nanoelectronic readout of olfactory receptors
US10983117B2 (en) 2011-08-31 2021-04-20 The Trustees Of The University Of Pennsylvania Carbon nanotube biosensors and related methods
US11415546B2 (en) 2014-09-05 2022-08-16 The Trustees Of The University Of Pennsylvania Volatile organic compound-based diagnostic systems and methods

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518527A (en) * 1983-08-16 1985-05-21 Mitsubishi Chemical Industries Limited Polypeptides related to the pre-acetylcholine receptor-α of the electric organ of Torpedo californica
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4837148A (en) * 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5024939A (en) * 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
US4929555A (en) * 1987-10-19 1990-05-29 Phillips Petroleum Company Pichia transformation
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
CA1341170C (en) * 1988-04-04 2001-01-16 Steven B. Ellis Calcium channel compositions and methods
EP0463064B1 (de) * 1989-03-14 1999-07-21 The Salk Institute For Biological Studies Neuronale nikotinacetylcholinrezeptorzusammensetzungen enthaltend die beta-4 subeinheit
EP0497894A4 (en) * 1989-10-25 1993-03-31 The Salk Institute For Biological Studies Receptor infection assay
US5091518A (en) * 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays
US5369028A (en) * 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
GB2287941B (en) * 1993-11-08 1998-01-28 Salk Inst Biotech Ind Human alpha2 neuronal nicotinic acetylcholine receptor compositions and methods employing same

Also Published As

Publication number Publication date
US5369028A (en) 1994-11-29
US5981193A (en) 1999-11-09
CA2078572C (en) 2001-05-22
EP0523187A4 (de) 1994-04-06
EP0523187B1 (de) 2002-10-16
CA2078572A1 (en) 1991-10-04
EP0523187A1 (de) 1993-01-20
ES2183801T3 (es) 2003-04-01
WO1991015602A1 (en) 1991-10-17
DE69133135T2 (de) 2003-06-18
DE69133135D1 (de) 2002-11-21

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