ATE227346T1 - Verfahren zur spezifischen kopplung einer schutzgruppe an das 5'-ende eines mrna-fragmentes und die herstellung von mrna und vollständiger cdna - Google Patents

Verfahren zur spezifischen kopplung einer schutzgruppe an das 5'-ende eines mrna-fragmentes und die herstellung von mrna und vollständiger cdna

Info

Publication number
ATE227346T1
ATE227346T1 AT96914259T AT96914259T ATE227346T1 AT E227346 T1 ATE227346 T1 AT E227346T1 AT 96914259 T AT96914259 T AT 96914259T AT 96914259 T AT96914259 T AT 96914259T AT E227346 T1 ATE227346 T1 AT E227346T1
Authority
AT
Austria
Prior art keywords
mrna
pct
fragment
protection group
complete cdna
Prior art date
Application number
AT96914259T
Other languages
English (en)
Inventor
Irena Nicolaevna Merenkova
Milne Edwards Jean-Bapti Dumas
Original Assignee
Genset Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9505221A external-priority patent/FR2733765B1/fr
Application filed by Genset Sa filed Critical Genset Sa
Application granted granted Critical
Publication of ATE227346T1 publication Critical patent/ATE227346T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
AT96914259T 1995-05-02 1996-04-29 Verfahren zur spezifischen kopplung einer schutzgruppe an das 5'-ende eines mrna-fragmentes und die herstellung von mrna und vollständiger cdna ATE227346T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9505221A FR2733765B1 (fr) 1995-05-02 1995-05-02 Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm
FR9509467A FR2733762B1 (fr) 1995-05-02 1995-08-03 Methode de couplage specifique de la coiffe de l'extremite 5' d'un fragment d'arnm et preparation d'arnm et d'adnc complet
PCT/FR1996/000651 WO1996034981A2 (fr) 1995-05-02 1996-04-29 METHODE DE COUPLAGE SPECIFIQUE DE LA COIFFE DE L'EXTREMITE 5' D'UN FRAGMENT D'ARNm ET PREPARATION D'ARNm ET D'ADNc COMPLET

Publications (1)

Publication Number Publication Date
ATE227346T1 true ATE227346T1 (de) 2002-11-15

Family

ID=26231928

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96914259T ATE227346T1 (de) 1995-05-02 1996-04-29 Verfahren zur spezifischen kopplung einer schutzgruppe an das 5'-ende eines mrna-fragmentes und die herstellung von mrna und vollständiger cdna

Country Status (12)

Country Link
US (1) US6022715A (de)
EP (1) EP0824598B1 (de)
JP (1) JPH11510364A (de)
AT (1) ATE227346T1 (de)
AU (1) AU719217B2 (de)
CA (1) CA2220045C (de)
DE (1) DE69624695T2 (de)
DK (1) DK0824598T3 (de)
ES (1) ES2186778T3 (de)
FR (1) FR2733762B1 (de)
PT (1) PT824598E (de)
WO (1) WO1996034981A2 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766891A (en) 1994-12-19 1998-06-16 Sloan-Kettering Institute For Cancer Research Method for molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase
JP3441899B2 (ja) * 1996-11-01 2003-09-02 理化学研究所 完全長ｃＤＮＡライブラリーの作成方法
EP0920526B1 (de) * 1997-06-12 2004-11-24 Sloan-Kettering Institute For Cancer Research Kovalente bindung von dna zu rna strängen katalysiert durch vaccinia topoisomerase
AU8555198A (en) * 1997-08-01 1999-02-22 Genset 5' ests for secreted proteins expressed in prostate
PT1000146E (pt) * 1997-08-01 2006-10-31 Serono Genetics Inst Sa Ests 5' para proteinas secretadas sem especificidade tecidular
DK1000151T3 (da) * 1997-08-01 2006-10-02 Serono Genetics Inst Sa 5'EST'er for secernerede proteiner udtrykt i forskellige væv
US6222029B1 (en) * 1997-08-01 2001-04-24 Genset 5′ ESTs for secreted proteins expressed in brain
EP1367124A1 (de) * 1997-08-01 2003-12-03 Genset 5' Ests für sekretierte Proteine, die im Muskel und anderen mesodermalen Geweben exprimiert werden
EP1000149B1 (de) * 1997-08-01 2007-05-09 Serono Genetics Institute S.A. 5' ests für sekretierte proteine aus gehirngeweben
EP0994899A2 (de) * 1997-08-01 2000-04-26 Serono Genetics Institute S.A. 5' ests für sekretierte proteine, die im endoderm exprimiert werden
CA2297157A1 (en) * 1997-08-01 1999-02-11 Genset 5' ests for secreted proteins expressed in testis and other tissues
US7393663B2 (en) 1997-08-01 2008-07-01 Serono Genetics Institute S.A. Expressed sequence tags and encoded human proteins
FR2767135B1 (fr) 1997-08-06 2002-07-12 Genset Sa Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes
EP1026242A1 (de) * 1997-10-22 2000-08-09 Helix Research Institute Methode für das screenen von cdna-klonen mit kompletter länge.
US20060286639A1 (en) * 1997-11-13 2006-12-21 Serono Genetics Institute S.A. Complementary DNAs encoding proteins with signal peptides
EP1903111A3 (de) * 1997-11-13 2008-07-02 Serono Genetics Institute S.A. Erweiterte cDNA für sekretierte Proteine
US6548633B1 (en) 1998-12-22 2003-04-15 Genset, S.A. Complementary DNA's encoding proteins with signal peptides
US6573068B1 (en) 1997-11-13 2003-06-03 Genset, S. A. Claudin-50 protein
WO1999031236A2 (en) * 1997-12-17 1999-06-24 Genset EXTENDED cDNAs FOR SECRETED PROTEINS
CA2302644A1 (en) * 1997-11-13 1999-05-27 Genset S.A. Extended cdnas for secreted proteins
AU764441B2 (en) * 1998-02-09 2003-08-21 Genset S.A. cDNAs encoding secreted proteins
CA2319089A1 (en) 1998-04-09 1999-10-21 Genset S.A. 5' ests and encoded human proteins
US7223727B2 (en) 1998-04-09 2007-05-29 Serono Genetics Institute S.A. GSSP4 polynucleotides and polypeptides and uses thereof
US6783961B1 (en) 1999-02-26 2004-08-31 Genset S.A. Expressed sequence tags and encoded human proteins
WO2000026363A1 (en) 1998-11-04 2000-05-11 Genset GENOMIC AND COMPLETE cDNA SEQUENCES OF HUMAN ADIPOCYTE-SPECIFIC APM1 AND BIALLELIC MARKERS THEREOF
US6455280B1 (en) 1998-12-22 2002-09-24 Genset S.A. Methods and compositions for inhibiting neoplastic cell growth
DE60041912D1 (de) 1999-02-10 2009-05-14 Serono Genetics Inst Sa Polymorphe marker des lsr-gens
EP1586645A3 (de) 1999-02-25 2006-02-22 Ceres Incorporated DNA-Fragmente mit bestimmter Sequenz und die dadurch kodierte Polypeptide
EP1165768A1 (de) * 1999-03-19 2002-01-02 Invitrogen Corporation Methode zur herstellung nucleinsäuresequenzen voller länge mittels topoisomerase iii aus e. coli und ihren homologen
WO2000056913A1 (en) * 1999-03-19 2000-09-28 Genetics Institute, Inc. Primers-attached vector elongation (pave): a 5'-directed cdna cloning strategy
US7485715B2 (en) 1999-06-18 2009-02-03 Ceres, Inc. Sequence-determined DNA encoding AP2 domain polypeptides
US7479555B2 (en) 1999-07-21 2009-01-20 Ceres, Inc. Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity
CA2311201A1 (en) 1999-08-05 2001-02-05 Genset S.A. Ests and encoded human proteins
US7338787B2 (en) 2000-01-14 2008-03-04 Serono Genetics Institute S.A. Nucleic acids encoding OBG3 globular head and uses thereof
US6989367B2 (en) 2000-01-14 2006-01-24 Genset S.A. OBG3 globular head and uses thereof
US6566332B2 (en) 2000-01-14 2003-05-20 Genset S.A. OBG3 globular head and uses thereof for decreasing body mass
US20020058617A1 (en) 2000-01-14 2002-05-16 Joachim Fruebis OBG3 globular head and uses thereof for decreasing body mass
AU2001243232A1 (en) 2000-02-25 2001-09-03 University Of South Carolina Research Foundation Topoisomerase linker-mediated amplification methods
US6387624B1 (en) * 2000-04-14 2002-05-14 Incyte Pharmaceuticals, Inc. Construction of uni-directionally cloned cDNA libraries from messenger RNA for improved 3′ end DNA sequencing
WO2002016594A2 (en) 2000-08-21 2002-02-28 Invitrogen Corporation Methods and reagents for molecular cloning
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6875907B2 (en) 2000-09-13 2005-04-05 Pioneer Hi-Bred International, Inc. Antimicrobial peptides and methods of use
WO2002061034A2 (en) 2000-12-08 2002-08-08 Invitrogen Corporation Compositions and methods for rapidly generating recombinant nucleic acid molecules
US20060008817A1 (en) 2000-12-08 2006-01-12 Invitrogen Corporation Methods and compositions for generating recombinant nucleic acid molecules
AU2002331897A1 (en) 2001-09-27 2003-04-07 Pioneer Hi-Bred International, Inc. Phytate polynucleotides and methods of use
CA2481504C (en) 2002-04-08 2011-08-23 Pioneer Hi-Bred International, Inc. Enhanced silk exsertion under stress
US20050250100A1 (en) * 2002-06-12 2005-11-10 Yoshihide Hayashizaki Method of utilizing the 5'end of transcribed nucleic acid regions for cloning and analysis
JP4517114B2 (ja) * 2003-03-28 2010-08-04 国立障害者リハビリテーションセンター総長 ｃＤＮＡ合成方法
ATE469984T1 (de) 2003-12-01 2010-06-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
GB0417887D0 (en) 2004-08-11 2004-09-15 Ares Trading Sa Protein
WO2008032574A1 (en) * 2006-09-11 2008-03-20 Osaka University TRACE mRNA AMPLIFICATION METHOD AND USE THEREOF
BRPI0819743A2 (pt) 2007-11-20 2014-10-07 Pioneer Hi Bred Int Ácido nucléico isolado, cassete de expressão, célula hospedeira, planta transgênica, semente transgênica, método para modular a resposta de etileno em uma planta, proteína isolada
US20100035249A1 (en) * 2008-08-05 2010-02-11 Kabushiki Kaisha Dnaform Rna sequencing and analysis using solid support
US8716553B2 (en) 2009-03-02 2014-05-06 Pioneer Hi Bred International Inc NAC transcriptional activators involved in abiotic stress tolerance
US20110035843A1 (en) 2009-08-05 2011-02-10 Pioneer Hi-Bred International, Inc. Novel eto1 genes and use of same for reduced ethylene and improved stress tolerance in plants
US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
DK4108671T3 (da) 2010-10-01 2025-01-06 Modernatx Inc Modificerede nukleosider, nukleotider og nukleinsyrer samt anvendelser deraf
JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
JP6113737B2 (ja) 2011-10-03 2017-04-12 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． 修飾型のヌクレオシド、ヌクレオチドおよび核酸、ならびにそれらの使用方法
CN103906835A (zh) 2011-10-25 2014-07-02 先锋国际良种公司 改变植物细胞壁组成以改善生物燃料生产和青贮饲料可消化性的方法
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
EP2834259A4 (de) 2012-04-02 2016-08-24 Moderna Therapeutics Inc Modifizierte polynukleotide
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
EP2684954A1 (de) 2012-07-10 2014-01-15 Lexogen GmbH 5'-schutzabhängige Verstärkung
US9422602B2 (en) * 2012-08-15 2016-08-23 Bio-Rad Laboratories, Inc. Methods and compositions for determining nucleic acid degradation
US9597380B2 (en) 2012-11-26 2017-03-21 Modernatx, Inc. Terminally modified RNA
EP3578663A1 (de) 2013-03-15 2019-12-11 ModernaTX, Inc. Herstellungsverfahren zur herstellung von rna-transkripten
WO2014152507A2 (en) 2013-03-15 2014-09-25 Pioneer Hi-Bred International, Inc. Modulation of acc deaminase expression
WO2014152030A1 (en) 2013-03-15 2014-09-25 Moderna Therapeutics, Inc. Removal of dna fragments in mrna production process
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2014144767A1 (en) 2013-03-15 2014-09-18 Moderna Therapeutics, Inc. Ion exchange purification of mrna
US11377470B2 (en) 2013-03-15 2022-07-05 Modernatx, Inc. Ribonucleic acid purification
DK3019619T3 (da) 2013-07-11 2021-10-11 Modernatx Inc Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
EP3052511A4 (de) 2013-10-02 2017-05-31 Moderna Therapeutics, Inc. Polynukleotidmoleküle und verwendungen davon
EP3052521A1 (de) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynukleotide zur codierung von low-density-lipoprotein-rezeptor
US11479766B2 (en) * 2013-12-05 2022-10-25 New England Biolabs, Inc. Methods for labeling a population of RNA molecules
US10407683B2 (en) 2014-07-16 2019-09-10 Modernatx, Inc. Circular polynucleotides
PL3350333T3 (pl) 2015-09-17 2022-03-07 Modernatx, Inc. Polinukleotydy zawierające region stabilizujący ogon
WO2017049286A1 (en) 2015-09-17 2017-03-23 Moderna Therapeutics, Inc. Polynucleotides containing a morpholino linker
ES2914225T3 (es) 2015-10-16 2022-06-08 Modernatx Inc Análogos de cap de ARNm con enlace de fosfato modificado
WO2017066797A1 (en) 2015-10-16 2017-04-20 Modernatx, Inc. Trinucleotide mrna cap analogs
WO2017130750A1 (ja) 2016-01-27 2017-08-03 株式会社ダナフォーム Ｒｎａの末端領域に対応する核酸の塩基配列を解読する方法およびｄｎａエレメントの分析方法
US12385034B2 (en) 2016-06-24 2025-08-12 Modernatx, Inc. Methods and apparatus for filtration
CA3036831A1 (en) 2016-09-14 2018-03-22 Modernatx, Inc. High purity rna compositions and methods for preparation thereof
MA49914A (fr) 2017-08-18 2021-04-21 Modernatx Inc Procédés analytiques par hplc
EP3668979A4 (de) 2017-08-18 2021-06-02 Modernatx, Inc. Verfahren zur hplc-analyse
CN113874502A (zh) 2019-03-11 2021-12-31 摩登纳特斯有限公司 补料分批体外转录方法
US12329811B2 (en) 2021-01-11 2025-06-17 Modernatx, Inc. Seasonal RNA influenza virus vaccines
JP2024541993A (ja) 2021-10-28 2024-11-13 ビオンテック・ソシエタス・エウロパエア Ｒｎａコンストラクト及びその使用
WO2023127774A1 (ja) * 2021-12-28 2023-07-06 株式会社ダナフォーム 遺伝子包含体の検出方法及び検出用キット
US20250333783A1 (en) 2022-06-09 2025-10-30 Vestlandets Innovasjonsselskap As Method of characterizing capped rna
CN115896239A (zh) * 2022-07-25 2023-04-04 四川康德赛医疗科技有限公司 一种rna修饰效率的定量方法、试剂盒及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661450A (en) * 1983-05-03 1987-04-28 Molecular Genetics Research And Development Limited Partnership Molecular cloning of RNA using RNA ligase and synthetic oligonucleotides
US4710566A (en) * 1984-12-27 1987-12-01 Yale University Purification of the messenger RNA cap-binding protein
US5273879A (en) * 1987-07-23 1993-12-28 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
US5219989A (en) * 1988-12-13 1993-06-15 Mcgill University Bifunctional protein for the isolation of capped mRNA
CA2005252C (en) * 1988-12-13 2001-07-17 Nahum Sonenberg Isolation of full-length cdna clones and capped mrna
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
JP3315439B2 (ja) * 1992-07-21 2002-08-19 住友電気工業株式会社 細胞特異的ｃＤＮＡの分離法及びライブラリー作製法
JP3337748B2 (ja) * 1992-09-25 2002-10-21 財団法人神奈川科学技術アカデミー 完全長ｃＤＮＡの合成方法、その中間体の製造方法及び完全長ｃＤＮＡを含む組換えベクターの製造方法

Also Published As

Publication number Publication date
EP0824598B1 (de) 2002-11-06
FR2733762A1 (fr) 1996-11-08
WO1996034981A2 (fr) 1996-11-07
ES2186778T3 (es) 2003-05-16
EP0824598A2 (de) 1998-02-25
CA2220045C (fr) 2001-10-30
DE69624695D1 (de) 2002-12-12
US6022715A (en) 2000-02-08
CA2220045A1 (fr) 1996-11-07
DK0824598T3 (da) 2003-03-10
DE69624695T2 (de) 2003-07-31
WO1996034981A3 (fr) 1997-01-03
PT824598E (pt) 2003-03-31
AU719217B2 (en) 2000-05-04
FR2733762B1 (fr) 1997-08-01
AU5982996A (en) 1996-11-21
JPH11510364A (ja) 1999-09-14

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