ATE228132T1 - Trifluoromethylpyrroloindolcarbonsäure und dessen esterderivat sowie ein verfahren zu seiner herstellung - Google Patents

Trifluoromethylpyrroloindolcarbonsäure und dessen esterderivat sowie ein verfahren zu seiner herstellung

Info

Publication number
ATE228132T1
ATE228132T1 AT94908108T AT94908108T ATE228132T1 AT E228132 T1 ATE228132 T1 AT E228132T1 AT 94908108 T AT94908108 T AT 94908108T AT 94908108 T AT94908108 T AT 94908108T AT E228132 T1 ATE228132 T1 AT E228132T1
Authority
AT
Austria
Prior art keywords
trifluoromethylpyrroloindole
production
carboxylic acid
ester derivative
arylsulfonyloxy
Prior art date
Application number
AT94908108T
Other languages
English (en)
Inventor
Shiro Terashima
Yasumichi Fukuda
Yasuo Oomori
Original Assignee
Kyorin Seiyaku Kk
Sagami Chem Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk, Sagami Chem Res filed Critical Kyorin Seiyaku Kk
Application granted granted Critical
Publication of ATE228132T1 publication Critical patent/ATE228132T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Laminated Bodies (AREA)
AT94908108T 1992-08-21 1993-08-19 Trifluoromethylpyrroloindolcarbonsäure und dessen esterderivat sowie ein verfahren zu seiner herstellung ATE228132T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22286292 1992-08-21
JP20425593A JP3514490B2 (ja) 1992-08-21 1993-08-18 トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法
PCT/JP1993/001159 WO1994004535A1 (fr) 1992-08-21 1993-08-19 Derive d'ester carboxylique de trifluoromethylpyrroloindole et procede pour sa fabrication

Publications (1)

Publication Number Publication Date
ATE228132T1 true ATE228132T1 (de) 2002-12-15

Family

ID=26514369

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94908108T ATE228132T1 (de) 1992-08-21 1993-08-19 Trifluoromethylpyrroloindolcarbonsäure und dessen esterderivat sowie ein verfahren zu seiner herstellung

Country Status (13)

Country Link
US (1) US5629430A (de)
EP (1) EP0656360B1 (de)
JP (1) JP3514490B2 (de)
KR (2) KR100312444B1 (de)
AT (1) ATE228132T1 (de)
CA (1) CA2142869C (de)
DE (1) DE69332504T2 (de)
DK (1) DK0656360T3 (de)
ES (1) ES2188608T3 (de)
HU (1) HU221041B1 (de)
PT (1) PT656360E (de)
TW (1) TW394774B (de)
WO (1) WO1994004535A1 (de)

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CN1051552C (zh) * 1994-11-29 2000-04-19 杏林制药株式会社 丙烯酰胺衍生物及其制造方法
WO1998003509A1 (en) * 1996-07-23 1998-01-29 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
AU5576098A (en) * 1997-01-24 1998-08-18 Kyorin Pharmaceutical Co. Ltd. Pyrroloindole derivatives and intermediates in producing the same
NZ504884A (en) * 1997-12-08 2002-10-25 Scripps Research Inst Synthesis of the dihydroindole C-ring of CC-1065/duocarmycin analogs and certain intermediates
US6989452B2 (en) * 2001-05-31 2006-01-24 Medarex, Inc. Disulfide prodrugs and linkers and stabilizers useful therefor
WO2004035571A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
GB0403038D0 (en) 2004-02-11 2004-03-17 Novartis Ag Organic compounds
US7691962B2 (en) * 2004-05-19 2010-04-06 Medarex, Inc. Chemical linkers and conjugates thereof
JP4806680B2 (ja) * 2004-05-19 2011-11-02 メダレックス インコーポレイテッド 自己犠牲リンカー及び薬剤複合体
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP2008529556A (ja) * 2005-02-18 2008-08-07 メダレックス， インク． 前立腺特異的膜抗原（ｐｓｍａ）に対するヒトモノクローナル抗体
US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
EP2354163A3 (de) * 2005-09-26 2013-04-24 Medarex, Inc. Konjugate von Duocarmycin und Anti-CD70 oder Anti-PSMA Antikörpern
RS52100B (sr) 2005-10-26 2012-06-30 Medarex, Inc. Postupci i jedinjenja za pripremu analoga cc-1065
WO2007059404A2 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh) 2006-12-28 2013-10-21 梅達雷克斯有限責任公司 化學鏈接劑與可裂解基質以及其之綴合物
AR065404A1 (es) 2007-02-21 2009-06-03 Medarex Inc Conjugados farmaco-ligando, los que se unen a citotoxinas potentes, composicion farmaceutica que los contienen y su uso para retardar o detener el crecimiento de un tumor en un mamifero
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CA2706378C (en) * 2007-11-20 2017-09-12 Lankenau Institute For Medical Research Disulfide chemotherapeutic agents and methods of use thereof
ES2647317T3 (es) * 2008-11-03 2017-12-20 Syntarga B.V. Análogos de CC-1065 y sus conjugados
US8697391B2 (en) 2009-05-15 2014-04-15 Lankenau Institute For Medical Research Method of determining cell number or viability using hydroxyethyldisulfide
PT3056203T (pt) 2010-04-21 2018-02-15 Syntarga Bv Conjugados de análogos de cc-1065 e ligantes bifuncionais
CA2891280C (en) 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
CA2935433C (en) 2014-01-10 2019-04-02 Synthon Biopharmaceuticals B.V. Duocarmycin anti-her2 antibody drug conjucates with activity against her2 expressing malignancies
RU2680404C2 (ru) 2014-01-10 2019-02-21 Синтон Байофармасьютикалс Б. В. Способ очистки cys-связанных конъюгатов антитело-лекарственное средство
RU2686085C2 (ru) 2014-01-10 2019-04-24 Синтон Байофармасьютикалс Б. В. Конъюгаты антитело-лекарственное средство (adc) с дуокармицином, применяемые для лечения рака эндометрия
US10464955B2 (en) 2014-02-28 2019-11-05 Hangzhou Dac Biotech Co., Ltd. Charged linkers and their uses for conjugation
NZ739830A (en) 2015-07-12 2021-12-24 Hangzhou Dac Biotech Co Ltd Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR20220150408A (ko) 2016-11-14 2022-11-10 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
KR20230067637A (ko) * 2020-09-11 2023-05-16 더 리전트 오브 더 유니버시티 오브 캘리포니아 근이영양증을 치료하기 위한 조성물 및 방법
CN112724068A (zh) * 2020-12-30 2021-04-30 蔡桂坡 具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用
EP4426727A2 (de) 2021-11-03 2024-09-11 Hangzhou Dac Biotech Co., Ltd. Spezifische konjugation eines antikörpers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978757A (en) * 1984-02-21 1990-12-18 The Upjohn Company 1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds
JP2598116B2 (ja) * 1988-12-28 1997-04-09 協和醗酵工業株式会社 新規物質ｄｃ１１３
JP2510335B2 (ja) * 1989-07-03 1996-06-26 協和醗酵工業株式会社 Ｄｃ―８８ａ誘導体
JP3037965B2 (ja) * 1990-06-20 2000-05-08 財団法人相模中央化学研究所 ２―アルコキシカルボニル―２―メチル―１―オキソ―１，２，３，６，７，８―ヘキサヒドロ―ベンゾ〔１，２―ｂ；４，３―ｂ´〕ジピロール誘導体
JPH0499774A (ja) * 1990-08-14 1992-03-31 Sagami Chem Res Center ２―エピデュオカルマイシンａおよびその製造中間体

Also Published As

Publication number Publication date
DE69332504T2 (de) 2003-10-02
US5629430A (en) 1997-05-13
EP0656360A1 (de) 1995-06-07
ES2188608T3 (es) 2003-07-01
EP0656360A4 (de) 1995-08-30
AU4761893A (en) 1994-03-15
EP0656360B1 (de) 2002-11-20
PT656360E (pt) 2003-02-28
DE69332504D1 (de) 2003-01-02
KR100312445B1 (ko) 2001-11-09
HU9500494D0 (en) 1995-04-28
DK0656360T3 (da) 2003-03-17
CA2142869C (en) 2002-01-01
CA2142869A1 (en) 1994-03-03
JP3514490B2 (ja) 2004-03-31
AU689443B2 (en) 1998-04-02
HU221041B1 (hu) 2002-07-29
KR100312444B1 (ko) 2002-02-28
JPH06116269A (ja) 1994-04-26
TW394774B (en) 2000-06-21
HUT71493A (en) 1995-11-28
WO1994004535A1 (fr) 1994-03-03

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