ATE233247T1 - Phtalazinonen - Google Patents

Phtalazinonen

Info

Publication number
ATE233247T1
ATE233247T1 AT98901959T AT98901959T ATE233247T1 AT E233247 T1 ATE233247 T1 AT E233247T1 AT 98901959 T AT98901959 T AT 98901959T AT 98901959 T AT98901959 T AT 98901959T AT E233247 T1 ATE233247 T1 AT E233247T1
Authority
AT
Austria
Prior art keywords
pct
date jul
sec
pub
phtalazinones
Prior art date
Application number
AT98901959T
Other languages
English (en)
Inventor
Der Mey Margaretha Van
Der Laan Ivonne Johanna Van
Hendrik Timmerman
Armin Hatzelmann
Hildegard Boss
Dietrich Haefner
Rolf Beume
Hans-Peter Kley
Geert Jan Sterk
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE233247T1 publication Critical patent/ATE233247T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT98901959T 1997-01-15 1998-01-12 Phtalazinonen ATE233247T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97100488 1997-01-15
PCT/EP1998/000124 WO1998031674A1 (en) 1997-01-15 1998-01-12 Phthalazinones

Publications (1)

Publication Number Publication Date
ATE233247T1 true ATE233247T1 (de) 2003-03-15

Family

ID=8226366

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98901959T ATE233247T1 (de) 1997-01-15 1998-01-12 Phtalazinonen

Country Status (26)

Country Link
US (1) US6103718A (de)
EP (1) EP0971901B1 (de)
JP (1) JP2001508078A (de)
KR (1) KR20000070150A (de)
CN (1) CN1127487C (de)
AT (1) ATE233247T1 (de)
AU (1) AU735934B2 (de)
BR (1) BR9806752A (de)
CA (1) CA2276455C (de)
CY (1) CY2446B1 (de)
CZ (1) CZ293815B6 (de)
DE (1) DE69811645T2 (de)
DK (1) DK0971901T3 (de)
EA (1) EA002764B1 (de)
EE (1) EE03968B1 (de)
ES (1) ES2193508T3 (de)
HU (1) HUP0001541A3 (de)
IL (1) IL130659A (de)
NO (1) NO313137B1 (de)
NZ (1) NZ336573A (de)
PL (1) PL189418B1 (de)
PT (1) PT971901E (de)
SI (1) SI0971901T1 (de)
SK (1) SK283270B6 (de)
TR (1) TR199901653T2 (de)
WO (1) WO1998031674A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3328499A (en) * 1998-03-14 1999-10-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone pde iii/iv inhibitors
CZ302882B6 (cs) 1999-08-21 2012-01-04 Nycomed Gmbh Farmaceutický prostredek
WO2001019818A1 (en) * 1999-09-14 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone derivatives as pd3/4 inhibitors
US6756371B1 (en) 1999-10-25 2004-06-29 Altana Pharma Ag Phthalazinone derivatives as PDE4 inhibitors
HRP20020350A2 (en) 1999-10-25 2004-02-29 Altana Pharma Ag Tetrahydrothiopy ranphtalazinone derivatives as pde4 inhibitors
SK17052002A3 (sk) * 2000-06-05 2003-12-02 Altana Pharma Ag Pyridazinónové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
US20040224316A1 (en) * 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
US7868015B2 (en) * 2000-08-10 2011-01-11 Cold Spring Harbor Laboratory Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
JP4301812B2 (ja) * 2001-02-15 2009-07-22 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしてのフタラインオン−ピペリジノ−誘導体
PL363544A1 (en) * 2001-04-25 2004-11-29 Altana Pharma Ag Piperazino-derivatives and their use as pde4 inhibitor
SK14342003A3 (sk) * 2001-04-25 2004-05-04 Altana Pharma Ag Ftalazinóny, farmaceutický prostriedok s ich obsahom a ich použitie
PL372171A1 (en) 2002-02-19 2005-07-11 Ono Pharmaceutical Co, Ltd. Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient
WO2004018449A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
EP1556369A1 (de) * 2002-08-10 2005-07-27 ALTANA Pharma AG Pyridazinonderivate als pde4-inhibitoren
DE60313472T2 (de) * 2002-08-10 2008-01-24 Nycomed Gmbh Pyrrolidindion-substituierte piperidin-phthalazone als pde4-inhibitoren
CA2494643A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-n-oxide-derivatives
US7153824B2 (en) 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
WO2004098633A1 (en) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprising a pde-4 inhibitor and a tnf alpha antagonist
CN1823051B (zh) * 2003-07-14 2010-07-07 宇部兴产株式会社 4-氨基四氢吡喃化合物及其酸盐的制造方法、其合成中间体及其制造方法
EP1716133B1 (de) * 2004-02-04 2008-03-26 Nycomed GmbH 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-on-derivate als pde4-inhibitoren
US20080227790A1 (en) * 2004-02-04 2008-09-18 Altana Pharma Ag Pyridazinone Derivatives and their Use as Pde4 Inhibitors
JPWO2006115221A1 (ja) * 2005-04-21 2008-12-18 日本新薬株式会社 フタラジノン誘導体及びその医薬
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
KR101601284B1 (ko) * 2007-05-16 2016-03-08 다케다 게엠베하 Ｐｄｅ4 억제제로서 피라졸론 유도체
AR074318A1 (es) * 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2012171900A1 (en) * 2011-06-17 2012-12-20 Nycomed Gmbh Novel phthalazinone-pyrrolopyrimidinecarboxamide derivatives
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US9783529B2 (en) 2013-03-13 2017-10-10 Flatley Discovery Lab, Llc Pyridazinone compounds and methods for the treatment of cystic fibrosis
US20150050626A1 (en) * 2013-03-15 2015-02-19 Dart Neuroscience, Llc Systems, Methods, and Software for Improving Cognitive and Motor Abilities

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845456A1 (de) * 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
WO1994012461A1 (en) * 1992-12-02 1994-06-09 Pfizer Inc. Catechol diethers as selective pdeiv inhibitors
EP0634404A1 (de) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazinderivate und deren Verwendung als pestizides Mittel
CA2173493C (en) * 1994-08-09 2008-03-25 Nobuhisa Watanabe Fused pyridazine compounds

Also Published As

Publication number Publication date
WO1998031674A1 (en) 1998-07-23
CY2446B1 (en) 2004-11-12
DK0971901T3 (da) 2003-06-10
CN1127487C (zh) 2003-11-12
EA002764B1 (ru) 2002-08-29
NO993301L (no) 1999-09-10
TR199901653T2 (xx) 1999-10-21
EP0971901B1 (de) 2003-02-26
HUP0001541A2 (hu) 2001-05-28
BR9806752A (pt) 2000-03-14
CN1249749A (zh) 2000-04-05
CA2276455C (en) 2006-10-31
SK283270B6 (sk) 2003-04-01
CZ253399A3 (cs) 2000-05-17
DE69811645T2 (de) 2003-12-04
DE69811645D1 (de) 2003-04-03
AU5862998A (en) 1998-08-07
NO313137B1 (no) 2002-08-19
IL130659A (en) 2002-07-25
HUP0001541A3 (en) 2001-11-28
CA2276455A1 (en) 1998-07-23
PT971901E (pt) 2003-07-31
CZ293815B6 (cs) 2004-08-18
EA199900620A1 (ru) 2000-04-24
US6103718A (en) 2000-08-15
SI0971901T1 (en) 2003-10-31
KR20000070150A (ko) 2000-11-25
IL130659A0 (en) 2000-06-01
PL334561A1 (en) 2000-03-13
EE9900274A (et) 2000-02-15
JP2001508078A (ja) 2001-06-19
EE03968B1 (et) 2003-02-17
NO993301D0 (no) 1999-07-02
PL189418B1 (pl) 2005-08-31
AU735934B2 (en) 2001-07-19
NZ336573A (en) 2000-10-27
HK1024692A1 (en) 2000-10-20
SK95199A3 (en) 1999-12-10
EP0971901A1 (de) 2000-01-19
ES2193508T3 (es) 2003-11-01

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