ATE234076T1 - Tränendrüsenspezifische emulsionen zur topischen anwendung an okuläre gewebe - Google Patents

Tränendrüsenspezifische emulsionen zur topischen anwendung an okuläre gewebe

Info

Publication number
ATE234076T1
ATE234076T1 AT00202069T AT00202069T ATE234076T1 AT E234076 T1 ATE234076 T1 AT E234076T1 AT 00202069 T AT00202069 T AT 00202069T AT 00202069 T AT00202069 T AT 00202069T AT E234076 T1 ATE234076 T1 AT E234076T1
Authority
AT
Austria
Prior art keywords
tarim
occular
gland
tissues
topical application
Prior art date
Application number
AT00202069T
Other languages
English (en)
Inventor
Shulin Ding
Walter L Tien
Orest Olejnik
Original Assignee
Allergan Sales Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22918100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE234076(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Sales Inc filed Critical Allergan Sales Inc
Application granted granted Critical
Publication of ATE234076T1 publication Critical patent/ATE234076T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00202069T 1994-05-17 1995-05-17 Tränendrüsenspezifische emulsionen zur topischen anwendung an okuläre gewebe ATE234076T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/243,279 US5474979A (en) 1994-05-17 1994-05-17 Nonirritating emulsions for sensitive tissue

Publications (1)

Publication Number Publication Date
ATE234076T1 true ATE234076T1 (de) 2003-03-15

Family

ID=22918100

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00202069T ATE234076T1 (de) 1994-05-17 1995-05-17 Tränendrüsenspezifische emulsionen zur topischen anwendung an okuläre gewebe
AT95921294T ATE203911T1 (de) 1994-05-17 1995-05-17 Tränendrüsen spezifische emulsion zur topischen anwendung an okulären geweben

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT95921294T ATE203911T1 (de) 1994-05-17 1995-05-17 Tränendrüsen spezifische emulsion zur topischen anwendung an okulären geweben

Country Status (16)

Country Link
US (1) US5474979A (de)
EP (2) EP1044678B1 (de)
JP (2) JP3441462B2 (de)
KR (2) KR100368181B1 (de)
CN (2) CN1229136C (de)
AT (2) ATE234076T1 (de)
AU (1) AU693213B2 (de)
BR (1) BR9507664A (de)
CA (1) CA2190485C (de)
DE (2) DE69522104T2 (de)
DK (2) DK0759773T3 (de)
ES (2) ES2161895T3 (de)
GR (1) GR3036945T3 (de)
NZ (1) NZ287635A (de)
PT (2) PT759773E (de)
WO (1) WO1995031211A1 (de)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585104A (en) * 1995-04-12 1996-12-17 The Procter & Gamble Company Cleansing emulsions
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
JPH10218760A (ja) * 1997-02-04 1998-08-18 Nobel Igaku Kenkyusho:Kk ドライアイ治療用の微量油添加目薬
US5981607A (en) * 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
AUPQ228199A0 (en) * 1999-08-18 1999-09-09 Sly, Anthony William Ophthalmic fluid
ATE402925T2 (de) * 1999-10-15 2008-08-15 Sucampo Ag Neue zusammensetzung enthaltend eine bicyclische verbindung und ein glycerid
US7270767B1 (en) 1999-10-18 2007-09-18 Foster-Miller, Inc. Environmentally friendly de-icer and anti-icer compositions
PT1142566E (pt) * 2000-04-07 2004-02-27 Medidom Lab Formulacao oftalmica topica na forma de uma solucao aquosa e uso de uma ciclosporina em associacao com acido hialuronico ou um de seus sais e com polisorbato 80
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
CA2416169C (en) 2000-07-14 2008-09-23 Allergan, Inc. Compositions containing therapeutically active components having enhanced solubility
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
US7112588B2 (en) 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
DK1393277T3 (da) 2001-05-21 2006-10-30 Alcon Inc Anvendelse af NF-Kappa-B inhibitorer til behandling af öjentörhedslidelser
ES2278049T3 (es) 2001-05-21 2007-08-01 Alcon, Inc. Uso de inhibidores de proteasoma para tratar trastornos de ojo seco.
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US6872705B2 (en) * 2001-07-13 2005-03-29 Allergan, Inc. Use of antimicrobial peptides as preservatives in ophthalmic preparations, including solutions, emulsions, and suspensions
EP1435910B9 (de) * 2001-10-19 2010-02-03 Isotechnika Inc. Neue cyclosporin-analoge mikroemulsionsvorkonzentrate
US6656460B2 (en) 2001-11-01 2003-12-02 Yissum Research Development Method and composition for dry eye treatment
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US6982079B2 (en) * 2002-04-26 2006-01-03 Allergan, Inc. Compositions for treating hyperemia
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US6635654B1 (en) 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
US6984628B2 (en) 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
FR2867684B1 (fr) * 2004-03-18 2006-05-05 Galderma Sa Gel creme contenant de l'ivermectine
AU2005262392A1 (en) 2004-07-01 2006-01-19 Johnson & Johnson Vision Care, Inc. Compositions and methods for treating eye disorders and conditions
KR100875042B1 (ko) 2004-07-01 2008-12-19 이-엘 매니지먼트 코포레이션 화장용 조성물 및 감각기관의 청량감 발생 방법
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
WO2010102078A1 (en) 2009-03-04 2010-09-10 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
CN100478025C (zh) * 2005-03-25 2009-04-15 中国科学院上海药物研究所 一种环孢菌素a眼用微乳制剂及其制备方法
CN100562340C (zh) * 2005-06-17 2009-11-25 中国科学院上海药物研究所 一种微乳型人工泪液
CN1319515C (zh) * 2005-07-12 2007-06-06 沈阳何氏生物工程有限公司 活肤眼霜
US8288348B2 (en) * 2005-07-13 2012-10-16 Allergan, Inc. Cyclosporin compositions
US7202209B2 (en) * 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) * 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US7288520B2 (en) * 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US8067433B2 (en) * 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
US9561178B2 (en) * 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
US10265265B2 (en) 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
CN101687013A (zh) * 2007-05-04 2010-03-31 阿勒根公司 环孢菌素在治疗具有人工晶状体的患者中的用途
FR2916636B1 (fr) * 2007-05-29 2009-09-04 Octalia Technologies Vehicule sous forme d'une emulsion huile-dans-eau notamment destine a une utilisation ophtalmique ou dermocosmetique
EP2008651A1 (de) 2007-06-26 2008-12-31 Drug Delivery Solutions Limited Biologisch erodierbares Patch
JP5668476B2 (ja) 2007-10-08 2015-02-12 オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物
KR100985279B1 (ko) * 2008-03-05 2010-11-05 디렉스 팜 (주) 안구건조증 치료를 위한 안약조성물 및 그 제조방법
US8716238B2 (en) * 2008-07-10 2014-05-06 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
US20100016219A1 (en) * 2008-07-19 2010-01-21 Jerry Zhang Ophthalmic compositions containing solubilized cyclosporin
FR2938757B1 (fr) * 2008-11-27 2010-12-31 Octalia Technologies Vehicule sous forme d'une emulsion huile-dans-eau notamment destine a une utilisation cosmetique ou dermatologique
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
JP2012514645A (ja) * 2009-01-08 2012-06-28 アラーガン インコーポレイテッド 爪成長の増進用組成物
US20110009339A1 (en) * 2009-04-14 2011-01-13 Allergan, Inc Method of treating blurred vision and other conditions of the eye with cyclosporin compositions
WO2010127301A1 (en) * 2009-05-01 2010-11-04 Allergan, Inc. Method of treating allergic conjunctivitis with cyclosporin compositions
NO2437762T3 (de) 2009-06-05 2018-01-06
EP2440185B1 (de) 2009-06-09 2015-04-08 Aurinia Pharmaceuticals Inc. Topische arzneimittelabgabesysteme zur ophthalmischen verwendung
NZ716349A (en) 2009-11-09 2017-07-28 Allergan Inc Compositions and methods for stimulating hair growth
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
CN101897949B (zh) * 2010-02-24 2016-07-06 温士顿医药股份有限公司 低刺激性透明乳化液剂型以供眼睛或眼睛周围有关组织表面免疫调节及消炎的眼用药物组合物
EP3078385A1 (de) * 2010-05-25 2016-10-12 Allergan, Inc. Cyclosporinemulsionen
WO2012015211A2 (ko) * 2010-07-30 2012-02-02 주식회사종근당 사이클로스포린 에이 함유 점안제 조성물
US8653123B2 (en) 2010-09-16 2014-02-18 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases
EP2627663B1 (de) 2010-10-12 2018-02-21 Allergan, Inc. Cyclosporinanaloga
AU2011316690C1 (en) 2010-10-12 2017-01-19 Allergan, Inc. Cyclosporin analogs
WO2013172838A1 (en) 2012-05-17 2013-11-21 Steven Yoelin Compositions and methods for hair growth
CA2818610C (en) 2010-11-18 2020-02-18 Steven Yoelin Compositions and methods for hair growth
US9018202B2 (en) 2010-12-03 2015-04-28 Allergan, Inc. Methods for treating diseases of the retina
EP2659903B1 (de) * 2010-12-28 2016-09-14 Hanlim Pharmaceutical Co., Ltd. Ophthalmische nanoemulsionszusammensetzung
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
AU2012209184B2 (en) 2011-01-26 2017-06-15 Allergan, Inc. Androgen composition for treating an opthalmic condition
US9610245B2 (en) 2011-03-14 2017-04-04 Drug Delivery Solutions Limited Ophthalmic composition
UA113627C2 (xx) 2011-05-27 2017-02-27 Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування
KR20140054005A (ko) * 2011-06-29 2014-05-08 알러간, 인코포레이티드 마크로골 15 하이드록시스테아레이트 제형
US20130029919A1 (en) * 2011-07-26 2013-01-31 Allergan, Inc. Two part formulation system for opthalmic delivery
DE102011108948A1 (de) 2011-07-29 2013-01-31 Achim Göpferich Wässrige, kolloidale Lösungen von lipophilen Substanzen,insbesondere Arzneistofflösungen
CN103987370A (zh) 2011-10-05 2014-08-13 阿勒根公司 用于增进指甲健康的组合物
WO2013052380A2 (en) * 2011-10-05 2013-04-11 Allergan, Inc. Compositions for enhancing nail health
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
CN108714137B (zh) 2011-11-15 2022-02-01 阿勒根公司 环孢菌素a形式2的可热压性悬浮液
JP6363506B2 (ja) 2011-11-15 2018-07-25 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ２型の懸濁剤
CA2856507C (en) 2011-11-21 2017-03-21 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US20130197002A1 (en) 2012-01-30 2013-08-01 Allergan, Inc. Brimonidine for treating visual disorders mediated by central visual projections from the eye
US9278132B2 (en) * 2012-02-13 2016-03-08 Bausch & Lomb Incorporated Ophthalmic pharmaceutical compositions and methods of making and using same
WO2013181339A2 (en) 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
WO2014138359A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Steroid antibiotic conjugates
KR101492447B1 (ko) 2013-05-20 2015-02-23 주식회사태준제약 사이클로스포린을 함유하는 나노에멀젼 점안 조성물 및 그의 제조 방법
RU2713953C2 (ru) 2014-07-18 2020-02-11 Аллерган, Инк. Суспензионные составы циклоспорина а для субконъюнктивального и периокулярного введения
KR102487299B1 (ko) 2014-11-25 2023-01-10 알러간, 인코포레이티드 안정화된 오메가-3 안과용 조성물
TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
US11324800B2 (en) 2015-01-15 2022-05-10 Wellspring Ophthalmics, Inc. Aqueous suspensions of cyclosporin
US20200237859A1 (en) 2019-01-25 2020-07-30 Newport Research, Inc. Aqueous suspensions of cyclosporin
JP6993231B2 (ja) 2015-02-06 2022-02-04 アールピー シーラー テクノロジーズ リミテッド ライアビリティ カンパニー 高分子で安定化された医薬製剤用水中油型エマルジョンの調製
EP3277704A1 (de) 2015-03-31 2018-02-07 Allergan, Inc. An der mebmt-seitenkette durch heterocyclische ringe modifizierte cyclosporine
KR101587385B1 (ko) 2015-07-29 2016-01-21 국제약품공업주식회사 사이클로스포린 함유 무자극성의 안약조성물 및 편리한 제조방법
US9820954B2 (en) 2015-08-19 2017-11-21 Jenivision Inc. Quantitative peri-orbital application of ophthalmology drugs
FR3041883B1 (fr) * 2015-10-02 2019-03-15 Chu Clermont-Ferrand Procede de preparation d'un collyre de ciclosporine a
EP3362096B1 (de) 2015-10-14 2023-12-13 Paul Gavaris Ophthalmische behandlungszusammensetzung und trägerstoff zur freisetzung von pharmazeutischen substanzen oder therapeutika
CN106692052B (zh) * 2015-11-13 2021-03-26 天津金耀集团有限公司 一种环孢素眼用乳剂组合物
EP3520778B1 (de) * 2016-11-17 2024-04-10 Senju Pharmaceutical Co., Ltd. Emulsionsaugentropfen
KR102115158B1 (ko) 2016-11-29 2020-05-26 주식회사 지트리파마슈티컬 티모신 베타 4 를 함유하는 제형
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
USD841152S1 (en) 2017-06-27 2019-02-19 Monica S. Naylor Eye drop container
EP3542788A1 (de) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topische zusammensetzung enthaltend calcipotriol und betamethason dipropionat
CN109010268B (zh) * 2018-09-28 2020-07-10 湖北远大天天明制药有限公司 一种提高氯霉素稳定性的眼用组合物及其制备方法
JP7569336B2 (ja) 2019-06-11 2024-10-17 サイファイ エス．ピー．エー． マイクロエマルション組成物
US20220378698A1 (en) * 2019-07-12 2022-12-01 Pharmathen S.A. Preservative free pharmaceutical composition for ophthalmic administration containing cyclosporine
MX2021014220A (es) 2019-08-07 2022-04-06 Aneira Pharma Inc Composiciones para el tratamiento de la perdida del cabello.
GR1010012B (el) * 2020-05-12 2021-05-27 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση περιεχον κυκλοσπορινη
CN113749092B (zh) * 2020-06-03 2024-10-11 迈克斯(如东)化工有限公司 不饱和脂肪酸酯化物应用、农化组合物和低眼刺农药制剂及其应用
IL294896B1 (en) * 2022-07-20 2026-06-01 LYOTROPIC DELIVERY SYSTEMS Ltd Topical administration of cyclosporine to the eye
EP4648746A1 (de) * 2023-01-09 2025-11-19 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Topische zusammensetzungen und verfahren zur behandlung von alopezie
CN119367291B (zh) * 2024-10-31 2025-11-18 国家纳米科学中心 一种纳米胶束眼用制剂及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH204625A (de) * 1937-07-13 1939-05-15 Telefunken Gmbh Eisenkernspule mit als Drehkondensator ausgebildetem Abgleichkondensator.
US2224205A (en) * 1938-07-18 1940-12-10 Hoover Co Suction cleaner
ATE6466T1 (de) * 1979-10-26 1984-03-15 Smith And Nephew Associated Companies P.L.C. Autoklavierbare emulsionen.
JPS59196816A (ja) * 1983-04-22 1984-11-08 Senjiyu Seiyaku Kk 水溶性アズレン誘導体の安定な水溶液の製造法
GB8903804D0 (en) * 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
JP2577049B2 (ja) * 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
WO1989001772A1 (en) * 1987-09-03 1989-03-09 University Of Georgia Research Foundation, Inc. Ocular cyclosporin composition
ES2033086T3 (es) * 1988-01-29 1993-03-01 Sankyo Company Limited Un procedimiento para la preparacion de una composicion farmaceutica.
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5364632A (en) * 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
CA2052950A1 (en) * 1990-10-10 1992-04-11 David P. Evitts Aqueous ophthalmic microemulsions of tepoxalin
JPH0558906A (ja) * 1991-09-06 1993-03-09 Sankyo Co Ltd シクロスポリン点眼製剤
JPH06219949A (ja) * 1993-01-25 1994-08-09 Mitsubishi Kasei Corp 抗トロンビン剤及びその製造方法

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CN1152876A (zh) 1997-06-25
US5474979A (en) 1995-12-12
AU693213B2 (en) 1998-06-25
EP0759773A1 (de) 1997-03-05
GR3036945T3 (en) 2002-01-31
JP3441462B2 (ja) 2003-09-02
JP4119284B2 (ja) 2008-07-16
DE69522104D1 (de) 2001-09-13
CN1198587C (zh) 2005-04-27
DK1044678T3 (da) 2003-07-14
EP1044678B1 (de) 2003-03-12
CA2190485C (en) 2003-04-15
MX9605599A (es) 1998-08-30
BR9507664A (pt) 1997-10-07
WO1995031211A1 (en) 1995-11-23
ES2194670T3 (es) 2003-12-01
JP2003231646A (ja) 2003-08-19
PT759773E (pt) 2002-02-28
ATE203911T1 (de) 2001-08-15
DK0759773T3 (da) 2001-11-26
PT1044678E (pt) 2003-08-29
CA2190485A1 (en) 1995-11-23
KR100450703B1 (ko) 2004-10-01
KR100368181B1 (ko) 2003-04-10
DE69529932T2 (de) 2003-12-18
DE69522104T2 (de) 2002-04-25
HK1034190A1 (en) 2001-10-19
CN1229136C (zh) 2005-11-30
JPH10500414A (ja) 1998-01-13
NZ287635A (en) 1998-09-24
DE69529932D1 (de) 2003-04-17
EP0759773B1 (de) 2001-08-08
ES2161895T3 (es) 2001-12-16
EP1044678A1 (de) 2000-10-18
AU2640995A (en) 1995-12-05
CN1288722A (zh) 2001-03-28

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