ATE234819T1 - Imidazolderivate mit alpha2-rezeptor aktivität - Google Patents

Imidazolderivate mit alpha2-rezeptor aktivität

Info

Publication number: ATE234819T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; different; imidazole derivatives; alkoxy
Prior art date: 1995-10-03

Application number

AT96932609T

Other languages

English (en)

Inventor

Arto Karjalainen

Paavo Huhtala

Juha-Matti Savola

Siegfried Wurster

Maire Eloranta

Maarit Hillilae

Raimo Saxlund

Victor Cockcroft

Arja Karjalainen

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-03

Filing date

1996-10-02

Publication date

2003-04-15

1996-10-02 Application filed by Orion Corp filed Critical Orion Corp

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE234819T1 publication Critical patent/ATE234819T1/de

Links

229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 2
208000002193 Pain Diseases 0.000 abstract 2
230000036506 anxiety Effects 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
101100495911 Arabidopsis thaliana CHR10 gene Proteins 0.000 abstract 1
125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
-1 C3-C7-cycloalkyl Chemical group 0.000 abstract 1
208000000094 Chronic Pain Diseases 0.000 abstract 1
206010012335 Dependence Diseases 0.000 abstract 1
206010012735 Diarrhoea Diseases 0.000 abstract 1
208000010412 Glaucoma Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000023178 Musculoskeletal disease Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
208000005298 acute pain Diseases 0.000 abstract 1
229940124534 adjunct to anesthesia Drugs 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
208000010877 cognitive disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
201000009240 nasopharyngitis Diseases 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
208000020016 psychiatric disease Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
150000003573 thiols Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Virology (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Resins (AREA)
Plural Heterocyclic Compounds (AREA)

AT96932609T 1995-10-03 1996-10-02 Imidazolderivate mit alpha2-rezeptor aktivität ATE234819T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9520150.5A GB9520150D0 (en)	1995-10-03	1995-10-03	New imidazole derivatives
PCT/FI1996/000518 WO1997012874A1 (en)	1995-10-03	1996-10-02	Imidazole derivatives having affinity for alpha2 receptors activity

Publications (1)

Publication Number	Publication Date
ATE234819T1 true ATE234819T1 (de)	2003-04-15

Family

ID=10781676

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96932609T ATE234819T1 (de)	1995-10-03	1996-10-02	Imidazolderivate mit alpha2-rezeptor aktivität

Country Status (29)

Country	Link
US (2)	US6313311B1 (de)
EP (1)	EP0888309B1 (de)
JP (1)	JP4129891B2 (de)
KR (1)	KR19990064013A (de)
CN (1)	CN1068592C (de)
AT (1)	ATE234819T1 (de)
AU (1)	AU708002B2 (de)
BG (1)	BG63916B1 (de)
CA (1)	CA2231535C (de)
CZ (1)	CZ291576B6 (de)
DE (1)	DE69626862T2 (de)
DK (1)	DK0888309T3 (de)
EE (1)	EE04436B1 (de)
ES (1)	ES2195013T3 (de)
GB (1)	GB9520150D0 (de)
HU (1)	HU224197B1 (de)
IL (1)	IL123721A (de)
LT (1)	LT4460B (de)
LV (1)	LV12108B (de)
NO (1)	NO311024B1 (de)
NZ (1)	NZ319169A (de)
PL (1)	PL189110B1 (de)
PT (1)	PT888309E (de)
RO (1)	RO120409B1 (de)
RU (1)	RU2188194C2 (de)
SI (1)	SI9620111B (de)
SK (1)	SK283542B6 (de)
UA (1)	UA49847C2 (de)
WO (1)	WO1997012874A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
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PL341009A1 (en) *	1997-12-04	2001-03-12	Allergan Sales	Substitute derivatives of imidazole exhibiting agonist-like activity in respect to adrenergic alpha 2b or 2b/2c receptors
US6841684B2 (en)	1997-12-04	2005-01-11	Allergan, Inc.	Imidiazoles having reduced side effects
US6329369B1 (en)	1997-12-04	2001-12-11	Allergan Sales, Inc.	Methods of treating pain and other conditions
PL346908A1 (en)	1998-09-28	2002-03-11	Orion Corp	Use of 3-(1h-imidazol-4-ylmethyl)-indan-5-ol in the manufacture of a medicament for intraspinal, intrathecal or epidural administration
TWI283669B (en) *	1999-06-10	2007-07-11	Allergan Inc	Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors
EP1196168A2 (de) *	1999-06-25	2002-04-17	Orion Corporation	Verfahren zur verabreichung eines imidazolderivats um analgesie zu erhalten
EP1223931B1 (de)	1999-10-29	2005-12-14	Orion Corporation	Verwendung eines imidazolderivats zur behandlung oder verhütung von hypotension und schock
FI20000073A0 (fi) *	2000-01-14	2000-01-14	Orion Yhtymae Oy	Uusia imidatsolijohdannaisia
US6388090B2 (en)	2000-01-14	2002-05-14	Orion Corporation	Imidazole derivatives
DE60112917T2 (de)	2000-05-08	2006-06-08	Orion Corp.	Neue polyzyklische indanylimidazole mit alpha2 adrenergik aktivität
TW200306783A (en) *	2002-04-29	2003-12-01	Fmc Corp	Pesticidal heterocycles
FR2839719B1 (fr) *	2002-05-16	2004-08-06	Pf Medicament	Nouveaux composes imidazoliques, leur procede de preparation et leur utilisation a titre de medicaments
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JP2010510184A (ja) *	2006-11-16	2010-04-02	エフ．ホフマン−ラロシュアーゲー	置換４−イミダゾール類
CA2672617A1 (en)	2006-12-13	2008-06-19	F. Hoffmann-La Roche Ag	Novel 2-imidazoles as ligands for trace amine associated receptors (taar)
US20080146523A1 (en)	2006-12-18	2008-06-19	Guido Galley	Imidazole derivatives
CN101600700B (zh)	2007-02-02	2013-08-21	弗·哈夫曼-拉罗切有限公司	作为taar1配体用于cns病症的新的2-氨基噁唑啉
EP2398776A1 (de) *	2007-02-13	2011-12-28	Schering Corporation	Funktional selektive alpha2c-adrenorezeptor-agonisten
BRPI0807961A2 (pt)	2007-02-13	2017-05-16	Pharmacopeia Llc	agonista de alfa2c adrenorreceptor funcionalmente seletivos.
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1995
- 1995-10-03 GB GBGB9520150.5A patent/GB9520150D0/en active Pending
1996
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- 1996-10-02 EE EE9800101A patent/EE04436B1/xx unknown
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- 1996-10-02 PL PL96328167A patent/PL189110B1/pl unknown
- 1996-10-02 RO RO98-00825A patent/RO120409B1/ro unknown
- 1996-10-02 CN CN96197438A patent/CN1068592C/zh not_active Expired - Lifetime
- 1996-10-02 ES ES96932609T patent/ES2195013T3/es not_active Expired - Lifetime
- 1996-10-02 EP EP96932609A patent/EP0888309B1/de not_active Expired - Lifetime
- 1996-10-02 PT PT96932609T patent/PT888309E/pt unknown
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- 1996-10-02 AT AT96932609T patent/ATE234819T1/de active
- 1996-10-02 UA UA98031588A patent/UA49847C2/uk unknown
- 1996-10-02 DE DE69626862T patent/DE69626862T2/de not_active Expired - Lifetime
- 1996-10-02 KR KR1019980702490A patent/KR19990064013A/ko not_active Ceased
- 1996-10-02 RU RU98108027/04A patent/RU2188194C2/ru active
- 1996-10-02 SK SK439-98A patent/SK283542B6/sk not_active IP Right Cessation
- 1996-10-02 NZ NZ319169A patent/NZ319169A/xx not_active IP Right Cessation
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- 1996-10-02 JP JP51399497A patent/JP4129891B2/ja not_active Expired - Lifetime
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1998
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2001
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Also Published As

Publication number	Publication date
BG102324A (en)	1999-01-29
EE9800101A (et)	1998-10-15
US6313311B1 (en)	2001-11-06
LV12108A (lv)	1998-08-20
CA2231535A1 (en)	1997-04-10
SK283542B6 (sk)	2003-09-11
EP0888309B1 (de)	2003-03-19
PL189110B1 (pl)	2005-06-30
UA49847C2 (uk)	2002-10-15
SI9620111B (en)	2001-12-31
HU224197B1 (hu)	2005-06-28
WO1997012874A1 (en)	1997-04-10
AU7132796A (en)	1997-04-28
RU2188194C2 (ru)	2002-08-27
CA2231535C (en)	2005-09-20
PL328167A1 (en)	1999-01-18
HUP9802927A2 (hu)	1999-10-28
CN1068592C (zh)	2001-07-18
HK1014951A1 (en)	1999-10-08
IL123721A (en)	2004-07-25
SI9620111A (sl)	1998-10-31
CZ101898A3 (cs)	1998-09-16
IL123721A0 (en)	1998-10-30
US6479530B2 (en)	2002-11-12
HUP9802927A3 (en)	2003-02-28
AU708002B2 (en)	1999-07-29
RO120409B1 (ro)	2006-01-30
LV12108B (en)	1998-10-20
EE04436B1 (et)	2005-02-15
GB9520150D0 (en)	1995-12-06
EP0888309A1 (de)	1999-01-07
NO981496D0 (no)	1998-04-02
DK0888309T3 (da)	2003-04-22
LT4460B (lt)	1999-02-25
PT888309E (pt)	2003-07-31
BG63916B1 (bg)	2003-06-30
NZ319169A (en)	1999-07-29
SK43998A3 (en)	1998-10-07
JP2000507914A (ja)	2000-06-27
JP4129891B2 (ja)	2008-08-06
DE69626862T2 (de)	2003-12-24
NO981496L (no)	1998-04-02
US20020007074A1 (en)	2002-01-17
KR19990064013A (ko)	1999-07-26
CZ291576B6 (cs)	2003-04-16
ES2195013T3 (es)	2003-12-01
DE69626862D1 (de)	2003-04-24
CN1198741A (zh)	1998-11-11
LT98057A (en)	1998-09-25
NO311024B1 (no)	2001-10-01

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