DK0888309T3 - Imidazolderivater med affinitet for alpha-2-receptor aktivitet - Google Patents

Imidazolderivater med affinitet for alpha-2-receptor aktivitet

Info

Publication number: DK0888309T3
Authority: DK; Denmark
Prior art keywords: alkyl; hydrogen; different; affinity; imidazole derivatives
Prior art date: 1995-10-03

Application number

DK96932609T

Other languages

English (en)

Inventor

Juha-Matti Savola

Siegfried Wurster

Maire Eloranta

Raimo Saxlund

Victor Cockcroft

Arja Karjalainen

Arto Karjalainen

Paavo Huhtala

Maarit Hillilae

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-03

Filing date

1996-10-02

Publication date

2003-04-22

1996-10-02 Application filed by Orion Corp filed Critical Orion Corp

2003-04-22 Application granted granted Critical

2003-04-22 Publication of DK0888309T3 publication Critical patent/DK0888309T3/da

Links

150000002460 imidazoles Chemical class 0.000 title abstract 2
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
102000005962 receptors Human genes 0.000 title 1
108020003175 receptors Proteins 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 2
208000002193 Pain Diseases 0.000 abstract 2
230000036506 anxiety Effects 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
101100495911 Arabidopsis thaliana CHR10 gene Proteins 0.000 abstract 1
125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
-1 C3-C7-cycloalkyl Chemical group 0.000 abstract 1
208000000094 Chronic Pain Diseases 0.000 abstract 1
206010012335 Dependence Diseases 0.000 abstract 1
206010012735 Diarrhoea Diseases 0.000 abstract 1
208000010412 Glaucoma Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000023178 Musculoskeletal disease Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
208000005298 acute pain Diseases 0.000 abstract 1
229940124534 adjunct to anesthesia Drugs 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
208000010877 cognitive disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
201000009240 nasopharyngitis Diseases 0.000 abstract 1
230000000926 neurological effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
208000020016 psychiatric disease Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
150000003573 thiols Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Resins (AREA)
Plural Heterocyclic Compounds (AREA)

DK96932609T 1995-10-03 1996-10-02 Imidazolderivater med affinitet for alpha-2-receptor aktivitet DK0888309T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9520150.5A GB9520150D0 (en)	1995-10-03	1995-10-03	New imidazole derivatives
PCT/FI1996/000518 WO1997012874A1 (en)	1995-10-03	1996-10-02	Imidazole derivatives having affinity for alpha2 receptors activity

Publications (1)

Publication Number	Publication Date
DK0888309T3 true DK0888309T3 (da)	2003-04-22

Family

ID=10781676

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96932609T DK0888309T3 (da)	1995-10-03	1996-10-02	Imidazolderivater med affinitet for alpha-2-receptor aktivitet

Country Status (29)

Country	Link
US (2)	US6313311B1 (da)
EP (1)	EP0888309B1 (da)
JP (1)	JP4129891B2 (da)
KR (1)	KR19990064013A (da)
CN (1)	CN1068592C (da)
AT (1)	ATE234819T1 (da)
AU (1)	AU708002B2 (da)
BG (1)	BG63916B1 (da)
CA (1)	CA2231535C (da)
CZ (1)	CZ291576B6 (da)
DE (1)	DE69626862T2 (da)
DK (1)	DK0888309T3 (da)
EE (1)	EE04436B1 (da)
ES (1)	ES2195013T3 (da)
GB (1)	GB9520150D0 (da)
HU (1)	HU224197B1 (da)
IL (1)	IL123721A (da)
LT (1)	LT4460B (da)
LV (1)	LV12108B (da)
NO (1)	NO311024B1 (da)
NZ (1)	NZ319169A (da)
PL (1)	PL189110B1 (da)
PT (1)	PT888309E (da)
RO (1)	RO120409B1 (da)
RU (1)	RU2188194C2 (da)
SI (1)	SI9620111B (da)
SK (1)	SK283542B6 (da)
UA (1)	UA49847C2 (da)
WO (1)	WO1997012874A1 (da)

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FI20000073A0 (fi) *	2000-01-14	2000-01-14	Orion Yhtymae Oy	Uusia imidatsolijohdannaisia
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KR101189348B1 (ko)	2006-12-13	2012-10-09	에프. 호프만-라 로슈 아게	미량 아민 결합 수용체(ｔａａｒ)에 대한 리간드로서의 신규한 2-이미다졸
US20080146523A1 (en)	2006-12-18	2008-06-19	Guido Galley	Imidazole derivatives
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1995
- 1995-10-03 GB GBGB9520150.5A patent/GB9520150D0/en active Pending
1996
- 1996-10-02 IL IL12372196A patent/IL123721A/en not_active IP Right Cessation
- 1996-10-02 NZ NZ319169A patent/NZ319169A/xx not_active IP Right Cessation
- 1996-10-02 EP EP96932609A patent/EP0888309B1/en not_active Expired - Lifetime
- 1996-10-02 ES ES96932609T patent/ES2195013T3/es not_active Expired - Lifetime
- 1996-10-02 JP JP51399497A patent/JP4129891B2/ja not_active Expired - Lifetime
- 1996-10-02 AU AU71327/96A patent/AU708002B2/en not_active Expired
- 1996-10-02 PL PL96328167A patent/PL189110B1/pl unknown
- 1996-10-02 US US09/051,151 patent/US6313311B1/en not_active Expired - Lifetime
- 1996-10-02 EE EE9800101A patent/EE04436B1/xx unknown
- 1996-10-02 SI SI9620111A patent/SI9620111B/sl unknown
- 1996-10-02 PT PT96932609T patent/PT888309E/pt unknown
- 1996-10-02 CZ CZ19981018A patent/CZ291576B6/cs not_active IP Right Cessation
- 1996-10-02 UA UA98031588A patent/UA49847C2/uk unknown
- 1996-10-02 RU RU98108027/04A patent/RU2188194C2/ru active
- 1996-10-02 SK SK439-98A patent/SK283542B6/sk not_active IP Right Cessation
- 1996-10-02 DE DE69626862T patent/DE69626862T2/de not_active Expired - Lifetime
- 1996-10-02 HU HU9802927A patent/HU224197B1/hu active IP Right Grant
- 1996-10-02 CN CN96197438A patent/CN1068592C/zh not_active Expired - Lifetime
- 1996-10-02 CA CA002231535A patent/CA2231535C/en not_active Expired - Lifetime
- 1996-10-02 RO RO98-00825A patent/RO120409B1/ro unknown
- 1996-10-02 WO PCT/FI1996/000518 patent/WO1997012874A1/en not_active Ceased
- 1996-10-02 AT AT96932609T patent/ATE234819T1/de active
- 1996-10-02 DK DK96932609T patent/DK0888309T3/da active
- 1996-10-02 KR KR1019980702490A patent/KR19990064013A/ko not_active Ceased
1998
- 1998-03-12 BG BG102324A patent/BG63916B1/bg unknown
- 1998-03-31 LV LVP-98-61A patent/LV12108B/en unknown
- 1998-04-02 NO NO19981496A patent/NO311024B1/no not_active IP Right Cessation
- 1998-04-22 LT LT98-057A patent/LT4460B/lt not_active IP Right Cessation
2001
- 2001-07-16 US US09/904,836 patent/US6479530B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SI9620111A (sl)	1998-10-31
GB9520150D0 (en)	1995-12-06
CA2231535A1 (en)	1997-04-10
HU224197B1 (hu)	2005-06-28
DE69626862T2 (de)	2003-12-24
DE69626862D1 (de)	2003-04-24
JP4129891B2 (ja)	2008-08-06
ES2195013T3 (es)	2003-12-01
IL123721A0 (en)	1998-10-30
EE9800101A (et)	1998-10-15
NO311024B1 (no)	2001-10-01
CZ291576B6 (cs)	2003-04-16
ATE234819T1 (de)	2003-04-15
CN1198741A (zh)	1998-11-11
NO981496L (no)	1998-04-02
US20020007074A1 (en)	2002-01-17
NZ319169A (en)	1999-07-29
US6479530B2 (en)	2002-11-12
HK1014951A1 (en)	1999-10-08
RO120409B1 (ro)	2006-01-30
HUP9802927A2 (hu)	1999-10-28
NO981496D0 (no)	1998-04-02
LV12108B (en)	1998-10-20
CZ101898A3 (cs)	1998-09-16
WO1997012874A1 (en)	1997-04-10
BG102324A (en)	1999-01-29
PT888309E (pt)	2003-07-31
PL328167A1 (en)	1999-01-18
UA49847C2 (uk)	2002-10-15
RU2188194C2 (ru)	2002-08-27
LT98057A (en)	1998-09-25
JP2000507914A (ja)	2000-06-27
US6313311B1 (en)	2001-11-06
CA2231535C (en)	2005-09-20
SK283542B6 (sk)	2003-09-11
CN1068592C (zh)	2001-07-18
AU7132796A (en)	1997-04-28
SI9620111B (en)	2001-12-31
EE04436B1 (et)	2005-02-15
EP0888309A1 (en)	1999-01-07
AU708002B2 (en)	1999-07-29
HUP9802927A3 (en)	2003-02-28
PL189110B1 (pl)	2005-06-30
SK43998A3 (en)	1998-10-07
LT4460B (lt)	1999-02-25
IL123721A (en)	2004-07-25
EP0888309B1 (en)	2003-03-19
LV12108A (lv)	1998-08-20
BG63916B1 (bg)	2003-06-30
KR19990064013A (ko)	1999-07-26

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EE04436B1 (et)	2005-02-15	Alfa2 retseptorite aktiivsuse suhtes afiinsed imidasooli derivaadid
ATE161821T1 (de)	1998-01-15	Azyklische ethylendiaminderivate als 'substance p rezeptor' antagonisten
GR3033947T3 (en)	2000-11-30	Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists.
ATE265419T1 (de)	2004-05-15	Spiro(2.4)heptanaminocarbonsäure und ihre derivate
RU98108027A (ru)	2000-04-27	Производные имидазола, обладающие аффинностью в отношении активности альфа2- рецепторов
DE60043349D1 (de)	2009-12-31	Chinazolin-derivate und ihre verwendung als arzneimittel
ATE135701T1 (de)	1996-04-15	Imidazolderivate, starke und selektive angiotensin-ii-rezeptor-antagonisten
YU85001A (sh)	2004-09-03	Derivati 5-fenil-pirimidina
NZ331060A (en)	2000-01-28	Quinoxalinediones, preparation and pharmaceutical compositions thereof
DE69512208D1 (de)	1999-10-21	Aminosäurederivate und ihre verwendung als phospholipase-a2-inhibitoren
PT1082116E (pt)	2003-08-29	Utilizacao de derivados de 4-piperidinometanol no tratamento de desordens do neurodesenvolvimento