ATE250423T1 - Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel - Google Patents

Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel

Info

Publication number: ATE250423T1
Authority: AT; Austria
Prior art keywords: cartilage; analogues; aii; bones; healing
Prior art date: 1998-07-13

Application number

AT99933921T

Other languages

English (en)

Inventor

Kathleen Rodgers

Gere Dizerega

Original Assignee

Univ Southern California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-13

Filing date

1999-07-12

Publication date

2003-10-15

1999-07-12 Application filed by Univ Southern California filed Critical Univ Southern California

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE250423T1 publication Critical patent/ATE250423T1/de

Links

210000000845 cartilage Anatomy 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 2
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 5
ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 abstract 4
102000005862 Angiotensin II Human genes 0.000 abstract 3
101800000733 Angiotensin-2 Proteins 0.000 abstract 3
229950006323 angiotensin ii Drugs 0.000 abstract 3
210000000988 bone and bone Anatomy 0.000 abstract 3
101800000734 Angiotensin-1 Proteins 0.000 abstract 2
102400000344 Angiotensin-1 Human genes 0.000 abstract 2
102000004881 Angiotensinogen Human genes 0.000 abstract 1
108090001067 Angiotensinogen Proteins 0.000 abstract 1
210000001612 chondrocyte Anatomy 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
238000002513 implantation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
239000000018 receptor agonist Substances 0.000 abstract 1
229940044601 receptor agonist Drugs 0.000 abstract 1
210000001519 tissue Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/32—Angiotensins [AT], angiotensinogen

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Wood Science & Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Orthopedic Medicine & Surgery (AREA)
Microbiology (AREA)
Diabetes (AREA)
General Engineering & Computer Science (AREA)
Cell Biology (AREA)
Vascular Medicine (AREA)
Biophysics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Materials For Medical Uses (AREA)

AT99933921T 1998-07-13 1999-07-12 Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel ATE250423T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US9265398P	1998-07-13	1998-07-13
US13085599P	1999-04-22	1999-04-22
PCT/US1999/015735 WO2000002905A2 (en)	1998-07-13	1999-07-12	Methods for accelerating bone and cartilage growth and repair

Publications (1)

Publication Number	Publication Date
ATE250423T1 true ATE250423T1 (de)	2003-10-15

Family

ID=26785912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99933921T ATE250423T1 (de)	1998-07-13	1999-07-12	Verfahren zur beschleunigen den zuwachs und heilen von knochen und knorpel

Country Status (9)

Country	Link
US (1)	US6258778B1 (de)
EP (1)	EP1094829B8 (de)
JP (2)	JP3686335B2 (de)
AT (1)	ATE250423T1 (de)
AU (1)	AU756785B2 (de)
CA (1)	CA2328871C (de)
DE (1)	DE69911609T2 (de)
ES (1)	ES2207258T3 (de)
WO (1)	WO2000002905A2 (de)

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AU3077299A (en) *	1998-03-11	1999-09-27	University Of Southern California	Method of promoting production of living tissue equivalents

1999
- 1999-07-12 DE DE69911609T patent/DE69911609T2/de not_active Expired - Lifetime
- 1999-07-12 CA CA002328871A patent/CA2328871C/en not_active Expired - Fee Related
- 1999-07-12 WO PCT/US1999/015735 patent/WO2000002905A2/en not_active Ceased
- 1999-07-12 JP JP2000559134A patent/JP3686335B2/ja not_active Expired - Fee Related
- 1999-07-12 AT AT99933921T patent/ATE250423T1/de not_active IP Right Cessation
- 1999-07-12 AU AU49869/99A patent/AU756785B2/en not_active Ceased
- 1999-07-12 ES ES99933921T patent/ES2207258T3/es not_active Expired - Lifetime
- 1999-07-12 US US09/352,191 patent/US6258778B1/en not_active Expired - Lifetime
- 1999-07-12 EP EP99933921A patent/EP1094829B8/de not_active Expired - Lifetime
2004
- 2004-10-19 JP JP2004304559A patent/JP2005120094A/ja active Pending

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Publication number	Publication date
AU756785B2 (en)	2003-01-23
US6258778B1 (en)	2001-07-10
EP1094829B1 (de)	2003-09-24
EP1094829A2 (de)	2001-05-02
DE69911609D1 (de)	2003-10-30
EP1094829B8 (de)	2004-09-22
DE69911609T2 (de)	2004-07-01
JP2002520334A (ja)	2002-07-09
JP3686335B2 (ja)	2005-08-24
WO2000002905A3 (en)	2000-02-24
CA2328871A1 (en)	2000-01-20
WO2000002905A2 (en)	2000-01-20
JP2005120094A (ja)	2005-05-12
CA2328871C (en)	2002-10-01
AU4986999A (en)	2000-02-01
ES2207258T3 (es)	2004-05-16

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2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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