ATE235057T1 - Cell test und diagnostischer kit für alzheimer- erkrankung - Google Patents

Cell test und diagnostischer kit für alzheimer- erkrankung

Info

Publication number
ATE235057T1
ATE235057T1 AT95935666T AT95935666T ATE235057T1 AT E235057 T1 ATE235057 T1 AT E235057T1 AT 95935666 T AT95935666 T AT 95935666T AT 95935666 T AT95935666 T AT 95935666T AT E235057 T1 ATE235057 T1 AT E235057T1
Authority
AT
Austria
Prior art keywords
alzheimer
cells
disease
differences
diagnostic kit
Prior art date
Application number
AT95935666T
Other languages
English (en)
Inventor
Daniel L Alkon
Rene Etcheberrigaray
Christopher S Kim
Yi-Fan Han
Tom J Nelson
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE235057T1 publication Critical patent/ATE235057T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95935666T 1994-09-26 1995-09-26 Cell test und diagnostischer kit für alzheimer- erkrankung ATE235057T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/312,202 US5976816A (en) 1993-05-03 1994-09-26 Cell tests for alzheimer's disease
PCT/US1995/012433 WO1996010182A1 (en) 1994-09-26 1995-09-26 Cell tests and diagnostic index for alzheimer's disease

Publications (1)

Publication Number Publication Date
ATE235057T1 true ATE235057T1 (de) 2003-04-15

Family

ID=23210345

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95935666T ATE235057T1 (de) 1994-09-26 1995-09-26 Cell test und diagnostischer kit für alzheimer- erkrankung

Country Status (8)

Country Link
US (2) US5976816A (de)
EP (2) EP1310798A2 (de)
JP (1) JPH10506990A (de)
AT (1) ATE235057T1 (de)
AU (1) AU714118B2 (de)
CA (1) CA2200963A1 (de)
DE (1) DE69529992D1 (de)
WO (1) WO1996010182A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107050A (en) * 1993-05-03 2000-08-22 The United States Of America As Represented By The Department Of Health And Human Services Diagnostic test for alzheimers disease
WO1997037228A1 (en) 1996-03-29 1997-10-09 The Trustees Of Boston University Methods for diagnosing and treating alzheimer's disease
US6248222B1 (en) * 1998-09-08 2001-06-19 Acm Research, Inc. Methods and apparatus for holding and positioning semiconductor workpieces during electropolishing and/or electroplating of the workpieces
WO2001077686A2 (en) * 2000-04-05 2001-10-18 Neurologic, Inc. Cellular calcium responce for diagnosis of alzheimer's disease
AU2002254029A1 (en) * 2001-02-27 2002-09-12 Daniel L. Alkon Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation
EP1925315A3 (de) * 2001-02-27 2009-11-18 Blanchette Rockefeller Neurosciences Institute Alzheimer-Diagnose auf Basis von mitogenaktivierter Proteinkinasephosphorylierung
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
EP1335028B1 (de) * 2002-02-12 2008-01-16 University of Utah Research Foundation Multi-Test-Analyse von Echzeit-Nukleinsäureamplifikationen
US20050065205A1 (en) * 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US20080004332A1 (en) * 2002-03-07 2008-01-03 Alkon Daniel L Methods for alzheimer's disease treatment and cognitive enhancement
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20040049134A1 (en) * 2002-07-02 2004-03-11 Tosaya Carol A. System and methods for treatment of alzheimer's and other deposition-related disorders of the brain
AU2003289859A1 (en) * 2002-11-11 2004-06-03 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of arl7 for alzheimer's disease
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
EP1641806B1 (de) * 2003-05-29 2009-07-29 Jay W. Pettegrew Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen
TW201206425A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
CA2582270A1 (en) * 2004-11-15 2006-05-26 Blanchette Rockefeller Neurosciences Institute Abnormalities of phosphatase 2a (pp2a) for diagnosis and treatment of alzheimer's disease
US20070054890A1 (en) 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
US20090029873A1 (en) * 2005-10-11 2009-01-29 Blanchette Rockefeller Neurosciences Institute Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb)
US20080025961A1 (en) 2006-07-28 2008-01-31 Alkon Daniel L Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory
EP3332797A3 (de) * 2007-02-09 2018-08-01 Blanchette Rockefeller Neurosciences Institute Therapeutische wirkungen von bryostatinen, bryologen und anderen damit zusammenhängenden substanzen auf durch kopftraumata herbeigeführte gedächtnisstörungen und hirnverletzungen
EP2669386A1 (de) 2008-07-28 2013-12-04 Blanchette Rockefeller Neurosciences Institute Stimulierte ausgelöste genomische Profilmarker von Morbus Alzheimer
CA2731171C (en) 2008-07-28 2016-10-18 Blanchette Rockefeller Neurosciences Institute Pkc-activating compounds for the treatment of neurodegenerative diseases
US8575112B2 (en) * 2009-09-18 2013-11-05 University Of Houston System Small peptide modulators of potassium channel trafficking
EP2483695A2 (de) * 2009-10-02 2012-08-08 Blanchette Rockefeller Neurosciences, Institute Unnormale änderungen der verarbeitung von pkc-isozymen in morbus-alzheimer-peripherzellen
EP2483684B1 (de) * 2009-10-02 2018-04-18 Blanchette Rockefeller Neurosciences, Institute Fibroblast wachstumsmuster zur diagnose der alzheimer-krankheit
US20140038186A1 (en) * 2010-02-22 2014-02-06 Tapan Kumar Khan Alzheimer's disease-specific alterations of protein kinase c epsilon (pkc-epsilon) protein levels
EP2707693B1 (de) * 2011-05-12 2016-10-12 Florin V. Chirila Periphere diagnostische verfahren zum screening von morbus alzheimer mit beta-amyloid und interzellulärer kommunikation
EP2764120B1 (de) 2011-10-05 2020-06-10 Blanchette Rockefeller Neurosciences, Institute Durch stimulus ausgelöste genomische profilmarker für eine neurodegenerative erkrankung
EP2780316B1 (de) 2011-11-13 2020-04-15 Blanchette Rockefeller Neurosciences Institute Ester von dcpla und behandlungsverfahren damit
US20220128577A1 (en) * 2019-02-26 2022-04-28 NeuroDiagnostics LLC Methods for Diagnosing Alzheimer's Disease Based on Cell Growth Rate, Size and Protein Amount

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
JPH03505868A (ja) * 1988-04-08 1991-12-19 マサチユセツツ・インスチチユート・オブ・テクノロジー 神経性疾患を治療するための方法及び組成物
IL90189A0 (en) * 1988-06-01 1989-12-15 Squibb & Sons Inc Pharmaceutical compositions containing a benzazepine-type calcium channel blocker
JPH069693A (ja) * 1992-01-23 1994-01-18 Eiken Chem Co Ltd アルツハイマー病関連蛋白
AU3440593A (en) * 1993-01-14 1994-08-15 Nelson Arispe Methods and compositions for blocking amyloid protein ion channels
US5580748A (en) * 1993-05-03 1996-12-03 The United States Of America As Represented By The Department Of Health And Human Services Diagnostic tests for alzheimers disease

Also Published As

Publication number Publication date
AU3759295A (en) 1996-04-19
JPH10506990A (ja) 1998-07-07
US5976816A (en) 1999-11-02
AU714118B2 (en) 1999-12-16
EP1310798A2 (de) 2003-05-14
US6080582A (en) 2000-06-27
CA2200963A1 (en) 1996-04-04
EP0783695A1 (de) 1997-07-16
EP0783695B1 (de) 2003-03-19
DE69529992D1 (de) 2003-04-24
WO1996010182A1 (en) 1996-04-04

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