NO983472L - Taxoider, deres fremstilling og farmas°ytiske preparater inneholdende taxoidene - Google Patents
Taxoider, deres fremstilling og farmas°ytiske preparater inneholdende taxoideneInfo
- Publication number
- NO983472L NO983472L NO983472A NO983472A NO983472L NO 983472 L NO983472 L NO 983472L NO 983472 A NO983472 A NO 983472A NO 983472 A NO983472 A NO 983472A NO 983472 L NO983472 L NO 983472L
- Authority
- NO
- Norway
- Prior art keywords
- taxoids
- res
- compounds
- preparation
- pharmaceutical preparations
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 R3 is alkoyl Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Nye «axoider med den genere.le forme, (.), der Z betyr et hydrogenatom eller en res, med den generelle forme (I. der R, be,y en bloylres, som eventuelt er substituert med R,0-C0-, der R2 betyr a.koyl, a.kenyl, alkyny., cyk.oalkoy, cykloa, enyl, b.ykloa, oy eventuelt substituert fenyl. R3 betyr alkoyl, alkenyl, alkynyl, cykloalkoyl, fenyl. nafty. eller en aromat.sk heterocyke R4 betyr hydrok elter en rest alkoksy, aikenyloksy, alkynyloksy, alkoksyacety, eller alkoy.oksykarbonyloksy, e,,er cykloalkoylo sy e er cykloa, eny, eller arylkarbonyloksy eller hcteroeyklylkarbonyloksy, og Rs betyr alkoksy som eventuelt er substituert med cykloalkoyloksy eller eyklo- alkenyloksy. Forbindelsenes fremstilling beskrives. Videre beskrives farmasøytiske preparater inneholdende forbindelsene. Forbindelsene med forme. (I) der Z, betyr en res, med den generelle formel (II) oppviser interessante antUumorale og an,,.eukem,ske egenskaper.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9602804A FR2745814B1 (fr) | 1996-03-06 | 1996-03-06 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR1997/000386 WO1997032869A1 (fr) | 1996-03-06 | 1997-03-05 | Taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO983472D0 NO983472D0 (no) | 1998-07-28 |
| NO983472L true NO983472L (no) | 1998-07-28 |
Family
ID=9489910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO983472A NO983472L (no) | 1996-03-06 | 1998-07-28 | Taxoider, deres fremstilling og farmas°ytiske preparater inneholdende taxoidene |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6160135A (no) |
| EP (1) | EP0885208B1 (no) |
| JP (1) | JP2000506158A (no) |
| KR (1) | KR19990087398A (no) |
| CN (1) | CN1210525A (no) |
| AP (1) | AP1023A (no) |
| AT (1) | ATE204266T1 (no) |
| AU (1) | AU715228B2 (no) |
| BG (1) | BG63693B1 (no) |
| BR (1) | BR9707887A (no) |
| CA (1) | CA2248195A1 (no) |
| CZ (1) | CZ283498A3 (no) |
| DE (1) | DE69706146T2 (no) |
| DK (1) | DK0885208T3 (no) |
| EA (1) | EA001516B1 (no) |
| EE (1) | EE03611B1 (no) |
| ES (1) | ES2161446T3 (no) |
| FR (1) | FR2745814B1 (no) |
| GE (1) | GEP20012517B (no) |
| GR (1) | GR3036410T3 (no) |
| HU (1) | HUP9902425A3 (no) |
| IL (1) | IL125998A (no) |
| IS (1) | IS4809A (no) |
| NO (1) | NO983472L (no) |
| NZ (1) | NZ331040A (no) |
| OA (1) | OA10855A (no) |
| PL (1) | PL328691A1 (no) |
| PT (1) | PT885208E (no) |
| SK (1) | SK121598A3 (no) |
| TR (1) | TR199801732T2 (no) |
| TW (1) | TW474928B (no) |
| WO (1) | WO1997032869A1 (no) |
| YU (1) | YU38398A (no) |
| ZA (1) | ZA971746B (no) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5973160A (en) | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
| US6372780B2 (en) | 1995-03-27 | 2002-04-16 | Aventis Pharma S.A. | Methods of treating cell lines expressing multidrug resistance P-glycoprotein |
| MA23823A1 (fr) | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
| KR100551945B1 (ko) * | 1997-12-19 | 2006-02-20 | 가부시키가이샤 야쿠루트 혼샤 | 택산 유도체 |
| EP1020188A1 (en) * | 1999-01-13 | 2000-07-19 | Aventis Pharma S.A. | New use of taxoid derivatives |
| CO5280224A1 (es) * | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| SK13632001A3 (sk) * | 2000-02-02 | 2002-06-04 | Florida State University Research Foundation, Inc. | C10 karbonátom substituované taxány ako protinádorové činidlá |
| MXPA03002494A (es) | 2000-09-22 | 2004-05-24 | Bristol Myers Squibb Co | Metodo para reducir toxicidad de quimio terapias combinadas. |
| FR2859996B1 (fr) * | 2003-09-19 | 2006-02-03 | Aventis Pharma Sa | Solvat acetonique du dimethoxy docetaxel et son procede de preparation |
| PA8625301A1 (es) | 2004-03-05 | 2006-06-02 | Univ Florida State Res Found | Taxanos con sustituyente lactiloxilo en el c7 |
| US20110118473A1 (en) * | 2007-08-22 | 2011-05-19 | 6570763 Canada Inc. | Process for converting 9-dihydro-13acetylbaccatin iii paclitaxel and docetaxel |
| FR2926551A1 (fr) * | 2008-01-17 | 2009-07-24 | Aventis Pharma Sa | Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation |
| EP2493466B1 (en) | 2009-10-29 | 2021-03-10 | Sanofi Mature IP | Novel antitumoral use of cabazitaxel |
| CN104650012A (zh) * | 2013-11-22 | 2015-05-27 | 天士力控股集团有限公司 | 一种紫杉烷类化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
| KR930702323A (ko) * | 1991-07-17 | 1993-09-08 | 하지메 나까가와 | 항종양 활성을 가진 화합물(nsc-lsc1) 및 그의 제조방법 |
| CA2100808A1 (en) * | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
| DK0690867T3 (da) * | 1993-03-22 | 2003-06-10 | Univ Florida State | Taxaner med furyl- eller thienylsubstitueret sidekæde |
| FR2711369B1 (fr) * | 1993-10-20 | 1995-11-17 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent. |
| HU222496B1 (hu) * | 1994-07-26 | 2003-07-28 | Indena S.P.A. | Félszintetikus taxánszármazékok, eljárás ezek előállítására, valamint ezeket tartalmazó gyógyászati készítmények |
| US6201140B1 (en) * | 1994-07-28 | 2001-03-13 | Bristol-Myers Squibb Company | 7-0-ethers of taxane derivatives |
-
1996
- 1996-03-06 FR FR9602804A patent/FR2745814B1/fr not_active Expired - Fee Related
-
1997
- 1997-02-26 TW TW086102360A patent/TW474928B/zh active
- 1997-02-27 ZA ZA9701746A patent/ZA971746B/xx unknown
- 1997-03-05 TR TR1998/01732T patent/TR199801732T2/xx unknown
- 1997-03-05 DE DE69706146T patent/DE69706146T2/de not_active Expired - Fee Related
- 1997-03-05 CZ CZ982834A patent/CZ283498A3/cs unknown
- 1997-03-05 KR KR1019980706814A patent/KR19990087398A/ko not_active Withdrawn
- 1997-03-05 IL IL12599897A patent/IL125998A/en not_active IP Right Cessation
- 1997-03-05 AU AU20302/97A patent/AU715228B2/en not_active Ceased
- 1997-03-05 EA EA199800795A patent/EA001516B1/ru not_active IP Right Cessation
- 1997-03-05 PL PL97328691A patent/PL328691A1/xx unknown
- 1997-03-05 AP APAP/P/1998/001335A patent/AP1023A/en active
- 1997-03-05 ES ES97908304T patent/ES2161446T3/es not_active Expired - Lifetime
- 1997-03-05 SK SK1215-98A patent/SK121598A3/sk unknown
- 1997-03-05 BR BR9707887-5A patent/BR9707887A/pt unknown
- 1997-03-05 WO PCT/FR1997/000386 patent/WO1997032869A1/fr not_active Ceased
- 1997-03-05 EP EP97908304A patent/EP0885208B1/fr not_active Expired - Lifetime
- 1997-03-05 CN CN97192042A patent/CN1210525A/zh active Pending
- 1997-03-05 PT PT97908304T patent/PT885208E/pt unknown
- 1997-03-05 DK DK97908304T patent/DK0885208T3/da active
- 1997-03-05 GE GEAP19974503A patent/GEP20012517B/en unknown
- 1997-03-05 CA CA002248195A patent/CA2248195A1/fr not_active Abandoned
- 1997-03-05 NZ NZ331040A patent/NZ331040A/en unknown
- 1997-03-05 HU HU9902425A patent/HUP9902425A3/hu unknown
- 1997-03-05 AT AT97908304T patent/ATE204266T1/de not_active IP Right Cessation
- 1997-03-05 JP JP9531523A patent/JP2000506158A/ja active Pending
- 1997-03-05 US US09/117,659 patent/US6160135A/en not_active Expired - Fee Related
- 1997-03-05 EE EE9800264A patent/EE03611B1/xx not_active IP Right Cessation
-
1998
- 1998-07-24 IS IS4809A patent/IS4809A/is unknown
- 1998-07-28 NO NO983472A patent/NO983472L/no not_active Application Discontinuation
- 1998-09-03 YU YU38398A patent/YU38398A/sh unknown
- 1998-09-04 BG BG102753A patent/BG63693B1/bg unknown
- 1998-09-04 OA OA9800161A patent/OA10855A/fr unknown
-
2001
- 2001-08-20 GR GR20010400596T patent/GR3036410T3/el not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |