ATE237594T1 - Sulfonylpyrimidine derivate mit antitumor wirkung - Google Patents
Sulfonylpyrimidine derivate mit antitumor wirkungInfo
- Publication number
- ATE237594T1 ATE237594T1 AT98108370T AT98108370T ATE237594T1 AT E237594 T1 ATE237594 T1 AT E237594T1 AT 98108370 T AT98108370 T AT 98108370T AT 98108370 T AT98108370 T AT 98108370T AT E237594 T1 ATE237594 T1 AT E237594T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- sulfonylpyrimidine
- tumor effect
- disulfonyl
- cytostatic
- Prior art date
Links
- IWEPSGGZINUNSM-UHFFFAOYSA-N 2-sulfonyl-1h-pyrimidine Chemical class O=S(=O)=C1N=CC=CN1 IWEPSGGZINUNSM-UHFFFAOYSA-N 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR970239A HRP970239B1 (en) | 1997-05-09 | 1997-05-09 | Process for the preparation of sulfonyl-pyrimidine derivatives with antitumor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE237594T1 true ATE237594T1 (de) | 2003-05-15 |
Family
ID=10946575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98108370T ATE237594T1 (de) | 1997-05-09 | 1998-05-07 | Sulfonylpyrimidine derivate mit antitumor wirkung |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0877022B1 (de) |
| AT (1) | ATE237594T1 (de) |
| CA (1) | CA2237267A1 (de) |
| CZ (1) | CZ142498A3 (de) |
| DE (1) | DE69813362T2 (de) |
| HR (1) | HRP970239B1 (de) |
| PL (1) | PL326236A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE325104T1 (de) * | 1998-03-30 | 2006-06-15 | Hoffmann La Roche | Verfahren zu fabrikation von alpha 1l- adrenorezeptor antagonisten |
| AR070228A1 (es) | 2008-01-22 | 2010-03-25 | Dow Agrosciences Llc | Derivados de 5-fluoro pirimidina |
| UA112284C2 (uk) | 2009-08-07 | 2016-08-25 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні 5-фторпіримідинону |
| AU2010279411B2 (en) * | 2009-08-07 | 2014-10-23 | Adama Makhteshim Ltd. | N1-sulfonyl-5-fluoropyrimidinone derivatives |
| UA106889C2 (uk) | 2009-08-07 | 2014-10-27 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-ацил-5-фторпіримідинону |
| UA107671C2 (en) | 2009-08-07 | 2015-02-10 | Dow Agrosciences Llc | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives |
| RU2547721C2 (ru) | 2010-01-07 | 2015-04-10 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | ТИАЗОЛО [5, 4-d] ПИРИМИДИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АГРОХИМИЧЕСКИХ СРЕДСТВ |
| CN102946730B (zh) * | 2010-04-26 | 2015-02-04 | 陶氏益农公司 | N3-取代的-n1-磺酰基-5-氟嘧啶酮衍生物 |
| HUE035248T2 (en) | 2011-08-17 | 2018-05-02 | Adama Makhteshim Ltd | 1-Substituted-5-fluoro-3,6-dihydro-6-imino-2 (1H) -pyrimidinone derivatives as fungicidal compositions for use in plant protection |
| UA117123C2 (uk) | 2012-12-28 | 2018-06-25 | Адама Махтешім Лтд. | Похідні 1-(заміщений бензоїл)-5-фтор-4-іміно-3-метил-3,4-дигідропіримідин-2(1h)-ону |
| HUE047711T2 (hu) | 2012-12-28 | 2020-05-28 | Adama Makhteshim Ltd | N-(szubsztituált)-5-fluor-4-imino-3-metil-2-oxo-3,4-dihidropirimidin-1(2H)-karboxilát származékok |
| RU2015131149A (ru) | 2012-12-28 | 2017-02-03 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | N-(замещенные)-5-фтор-4-имино-3-метил-2-оксо-3,4-дигидропиримидин-1(2н)-карбоксамидные производные |
| CA2894553C (en) | 2012-12-31 | 2021-03-02 | Dow Agrosciences Llc | 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1h)-one derivatives as fungicides |
| EA030030B1 (ru) | 2013-12-31 | 2018-06-29 | Адама Мактешим Лтд. | Синергетические фунгицидные смеси и синергетические фунгицидные композиции для борьбы с грибами |
| EP3097096A4 (de) | 2013-12-31 | 2017-10-11 | Adama Makhteshim Ltd. | 5-fluor-4-imin-3-(alkyl/substituierte alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one und verfahren zur herstellung davon |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5324952B2 (de) * | 1973-11-28 | 1978-07-24 | ||
| JPS51105080A (en) * | 1975-03-07 | 1976-09-17 | Mitsui Seiyaku Kogyo Kk | 55 furuororashirujudotainoseizohoho |
| DE2814202C2 (de) * | 1977-04-05 | 1985-12-19 | Taiho Pharmaceutical Co., Ltd., Tokio/Tokyo | Verwendung von Uracilderivaten zur Bekämpfung von Krebs oder krebsartigen Erkrankungen |
| JPS5587777A (en) * | 1978-12-27 | 1980-07-02 | Ono Pharmaceut Co Ltd | Pyrimidine derivative, its preparation and antitumorigenic agent |
| JPS6293281A (ja) * | 1985-10-17 | 1987-04-28 | Kyowa Hakko Kogyo Co Ltd | 抗腫瘍剤 |
-
1997
- 1997-05-09 HR HR970239A patent/HRP970239B1/xx not_active IP Right Cessation
-
1998
- 1998-05-07 DE DE69813362T patent/DE69813362T2/de not_active Expired - Lifetime
- 1998-05-07 CZ CZ981424A patent/CZ142498A3/cs unknown
- 1998-05-07 AT AT98108370T patent/ATE237594T1/de not_active IP Right Cessation
- 1998-05-07 EP EP98108370A patent/EP0877022B1/de not_active Expired - Lifetime
- 1998-05-08 CA CA002237267A patent/CA2237267A1/en not_active Abandoned
- 1998-05-11 PL PL98326236A patent/PL326236A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL326236A1 (en) | 1998-11-23 |
| CZ142498A3 (cs) | 1999-08-11 |
| CA2237267A1 (en) | 1998-11-09 |
| EP0877022A1 (de) | 1998-11-11 |
| HRP970239A2 (en) | 1999-02-28 |
| DE69813362D1 (de) | 2003-05-22 |
| HRP970239B1 (en) | 2004-04-30 |
| DE69813362T2 (de) | 2004-04-01 |
| EP0877022B1 (de) | 2003-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |