HRP970239B1 - Process for the preparation of sulfonyl-pyrimidine derivatives with antitumor activity - Google Patents
Process for the preparation of sulfonyl-pyrimidine derivatives with antitumor activityInfo
- Publication number
- HRP970239B1 HRP970239B1 HR970239A HRP970239A HRP970239B1 HR P970239 B1 HRP970239 B1 HR P970239B1 HR 970239 A HR970239 A HR 970239A HR P970239 A HRP970239 A HR P970239A HR P970239 B1 HRP970239 B1 HR P970239B1
- Authority
- HR
- Croatia
- Prior art keywords
- sulfonyl
- preparation
- antitumor activity
- pyrimidine derivatives
- derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- IWEPSGGZINUNSM-UHFFFAOYSA-N 2-sulfonyl-1h-pyrimidine Chemical class O=S(=O)=C1N=CC=CN1 IWEPSGGZINUNSM-UHFFFAOYSA-N 0.000 title 1
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR970239A HRP970239B1 (en) | 1997-05-09 | 1997-05-09 | Process for the preparation of sulfonyl-pyrimidine derivatives with antitumor activity |
| CZ981424A CZ142498A3 (cs) | 1997-05-09 | 1998-05-07 | Syntéza derivátů sulfonylpyrimidinu s protirakovinným účinkem |
| EP98108370A EP0877022B1 (de) | 1997-05-09 | 1998-05-07 | Sulfonylpyrimidine Derivate mit Antitumor Wirkung |
| DE69813362T DE69813362T2 (de) | 1997-05-09 | 1998-05-07 | Sulfonylpyrimidine Derivate mit Antitumor Wirkung |
| AT98108370T ATE237594T1 (de) | 1997-05-09 | 1998-05-07 | Sulfonylpyrimidine derivate mit antitumor wirkung |
| CA002237267A CA2237267A1 (en) | 1997-05-09 | 1998-05-08 | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity |
| PL98326236A PL326236A1 (en) | 1997-05-09 | 1998-05-11 | Novel compounds - derivatives of sulphonylpyrimidine exhibiting anticarcinogenous effect and method of obtaining them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR970239A HRP970239B1 (en) | 1997-05-09 | 1997-05-09 | Process for the preparation of sulfonyl-pyrimidine derivatives with antitumor activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP970239A2 HRP970239A2 (en) | 1999-02-28 |
| HRP970239B1 true HRP970239B1 (en) | 2004-04-30 |
Family
ID=10946575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR970239A HRP970239B1 (en) | 1997-05-09 | 1997-05-09 | Process for the preparation of sulfonyl-pyrimidine derivatives with antitumor activity |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0877022B1 (de) |
| AT (1) | ATE237594T1 (de) |
| CA (1) | CA2237267A1 (de) |
| CZ (1) | CZ142498A3 (de) |
| DE (1) | DE69813362T2 (de) |
| HR (1) | HRP970239B1 (de) |
| PL (1) | PL326236A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2263238T3 (es) * | 1998-03-30 | 2006-12-01 | F. Hoffmann-La Roche Ag | Procedimiento para la preparacion de antagonistas alfail-adrenoceptores. |
| EP2562163A1 (de) | 2008-01-22 | 2013-02-27 | Dow AgroSciences LLC | 5-fluor-pyrimidinderivate als fungizide |
| UA106889C2 (uk) | 2009-08-07 | 2014-10-27 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-ацил-5-фторпіримідинону |
| UA112284C2 (uk) | 2009-08-07 | 2016-08-25 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні 5-фторпіримідинону |
| UA107671C2 (en) | 2009-08-07 | 2015-02-10 | Dow Agrosciences Llc | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives |
| DK2462134T3 (da) | 2009-08-07 | 2014-08-11 | Dow Agrosciences Llc | N1-sulfonyl-5-fluorpyrimidinonderivater |
| RU2547721C2 (ru) | 2010-01-07 | 2015-04-10 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | ТИАЗОЛО [5, 4-d] ПИРИМИДИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АГРОХИМИЧЕСКИХ СРЕДСТВ |
| PL2563129T3 (pl) * | 2010-04-26 | 2017-08-31 | Adama Makhteshim Ltd | N3-podstawione pochodne n1-sulfonylo-5-fluoropirymidynonu |
| SI2775842T1 (en) | 2011-08-17 | 2018-01-31 | Adama Makhteshim Ltd. | 1-substituted-5-fluoro-3,6-dihydro-6-imino-2 (1H) -pyrimidinone derivatives as fungicidal agents for use in plant protection |
| KR20150100869A (ko) | 2012-12-28 | 2015-09-02 | 다우 아그로사이언시즈 엘엘씨 | N-(치환된)-5-플루오로-4-이미노-3-메틸-2-옥소-3,4-디히드로피리미딘-1(2h)-카르복스아미드 유도체 |
| RU2018118951A (ru) | 2012-12-28 | 2018-11-02 | Адама Мактешим Лтд. | Производные 1-(замещенный бензоил)-5-фтор-4-имино-3-метил-3,4-дигидропиримидин-2(1h)-она |
| JP6324994B2 (ja) | 2012-12-28 | 2018-05-16 | アダマ・マクテシム・リミテッド | Ｎ−（置換）−５−フルオロ−４−イミノ−３−メチル−２−オキソ−３，４−ジヒドロピリミジン−１（２ｈ）−カルボキシレート誘導体 |
| CN105007737A (zh) | 2012-12-31 | 2015-10-28 | 美国陶氏益农公司 | 作为杀真菌剂的3-烷基-5-氟-4-取代的-亚氨基-3,4-二氢嘧啶-2(1h)-酮衍生物 |
| JP6585057B2 (ja) | 2013-12-31 | 2019-10-02 | アダマ・マクテシム・リミテッド | ５−フルオロ−４−イミノ−３−（アルキル／置換アルキル）−１−（アリールスルホニル）−３，４−ジヒドロピリミジン−２（１ｈ）−オンおよびそれらの調製方法 |
| CN114794123B (zh) | 2013-12-31 | 2024-11-12 | 阿达玛马克西姆股份有限公司 | 用防治谷类中真菌的协同杀真菌混合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5324952B2 (de) * | 1973-11-28 | 1978-07-24 | ||
| JPS51105080A (en) * | 1975-03-07 | 1976-09-17 | Mitsui Seiyaku Kogyo Kk | 55 furuororashirujudotainoseizohoho |
| GB1570555A (en) * | 1977-04-05 | 1980-07-02 | Taiho Pharmaceutical Co Ltd | Anti-cancer composition |
| JPS5587777A (en) * | 1978-12-27 | 1980-07-02 | Ono Pharmaceut Co Ltd | Pyrimidine derivative, its preparation and antitumorigenic agent |
| JPS6293281A (ja) * | 1985-10-17 | 1987-04-28 | Kyowa Hakko Kogyo Co Ltd | 抗腫瘍剤 |
-
1997
- 1997-05-09 HR HR970239A patent/HRP970239B1/xx not_active IP Right Cessation
-
1998
- 1998-05-07 DE DE69813362T patent/DE69813362T2/de not_active Expired - Lifetime
- 1998-05-07 AT AT98108370T patent/ATE237594T1/de not_active IP Right Cessation
- 1998-05-07 CZ CZ981424A patent/CZ142498A3/cs unknown
- 1998-05-07 EP EP98108370A patent/EP0877022B1/de not_active Expired - Lifetime
- 1998-05-08 CA CA002237267A patent/CA2237267A1/en not_active Abandoned
- 1998-05-11 PL PL98326236A patent/PL326236A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL326236A1 (en) | 1998-11-23 |
| EP0877022A1 (de) | 1998-11-11 |
| CZ142498A3 (cs) | 1999-08-11 |
| DE69813362D1 (de) | 2003-05-22 |
| DE69813362T2 (de) | 2004-04-01 |
| HRP970239A2 (en) | 1999-02-28 |
| EP0877022B1 (de) | 2003-04-16 |
| ATE237594T1 (de) | 2003-05-15 |
| CA2237267A1 (en) | 1998-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| PPPP | Transfer of rights |
Owner name: INSTITUT RUDER BOSKOVIC, HR |
|
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20040408 Year of fee payment: 8 |
|
| B1PR | Patent granted | ||
| PPPP | Transfer of rights |
Owner name: BIOZYNE D.O.O., HR |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20050510 |