ATE238296T1 - Wasserlösliche azole als breitspektrum-antifungus - Google Patents

Wasserlösliche azole als breitspektrum-antifungus

Info

Publication number: ATE238296T1
Authority: AT; Austria
Prior art keywords: antifungus; water soluble; broad spectrum; soluble azoles; azoles
Prior art date: 1998-05-14

Application number

AT99924942T

Other languages

English (en)

Inventor

Lieven Meerpoel

Leo Jacobus Jozef Backx

Der Veken Louis Jozef Elis Van

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-14

Filing date

1999-05-06

Publication date

2003-05-15

1999-05-06 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE238296T1 publication Critical patent/ATE238296T1/de

Links

150000003851 azoles Chemical class 0.000 title 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT99924942T 1998-05-14 1999-05-06 Wasserlösliche azole als breitspektrum-antifungus ATE238296T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98201588A EP0957101A1 (de)	1998-05-14	1998-05-14	Wasserlösliche Azole als Breitspektrum-antifungus
PCT/EP1999/003242 WO1999058529A1 (en)	1998-05-14	1999-05-06	Water soluble azoles as broad-spectrum antifungals

Publications (1)

Publication Number	Publication Date
ATE238296T1 true ATE238296T1 (de)	2003-05-15

Family

ID=8233724

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT99926304T ATE221884T1 (de)	1998-05-14	1999-05-06	Wasserlösliche azole als breitspektrum-antifungus
AT99924942T ATE238296T1 (de)	1998-05-14	1999-05-06	Wasserlösliche azole als breitspektrum-antifungus

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT99926304T ATE221884T1 (de)	1998-05-14	1999-05-06	Wasserlösliche azole als breitspektrum-antifungus

Country Status (31)

Country	Link
US (2)	US6384030B1 (de)
EP (3)	EP0957101A1 (de)
JP (2)	JP2002514645A (de)
KR (2)	KR100593395B1 (de)
CN (2)	CN1135229C (de)
AR (2)	AR016482A1 (de)
AT (2)	ATE221884T1 (de)
AU (2)	AU751135B2 (de)
BG (2)	BG64388B1 (de)
BR (2)	BR9911057A (de)
CA (2)	CA2331141C (de)
CO (1)	CO5021227A1 (de)
CZ (2)	CZ299481B6 (de)
DE (2)	DE69902461T2 (de)
DK (1)	DK1077976T3 (de)
EE (2)	EE04311B1 (de)
ES (2)	ES2198915T3 (de)
HR (2)	HRP20000740B1 (de)
HU (2)	HUP0102031A3 (de)
IL (2)	IL139647A0 (de)
MY (2)	MY120248A (de)
NO (2)	NO319851B1 (de)
NZ (2)	NZ507966A (de)
PL (2)	PL194086B1 (de)
PT (1)	PT1077976E (de)
SI (1)	SI1077976T1 (de)
SK (2)	SK285763B6 (de)
TR (2)	TR200003322T2 (de)
TW (2)	TWI259835B (de)
WO (2)	WO1999058529A1 (de)
ZA (2)	ZA200007173B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0957101A1 (de) *	1998-05-14	1999-11-17	Janssen Pharmaceutica N.V.	Wasserlösliche Azole als Breitspektrum-antifungus
PL365072A1 (en) *	2000-03-07	2004-12-27	Ranbaxy Laboratories Limited	Azole compounds as therapeutic agents for fungal infections
EP1413301A1 (de) *	2002-10-24	2004-04-28	Bayer CropScience SA	Antimykotische Medikamente auf der Basis von Arylamidinderivaten
ITMI20032020A1 (it)	2003-10-17	2005-04-18	Italfarmaco Spa	Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
AR052342A1 (es) *	2004-12-21	2007-03-14	Janssen Pharmaceutica Nv	Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
CN102906087B (zh) *	2010-05-19	2016-03-23	桑多斯股份公司	制备手性三唑酮的方法
US11028078B2 (en) *	2011-09-07	2021-06-08	The Johns Hopkins University	Itraconazole analogs and use thereof
US9346791B2 (en)	2011-09-07	2016-05-24	The Johns Hopkins University	Itraconazole analogs and use thereof
EP3626242B1 (de)	2013-06-07	2024-08-07	The Scripps Research Institute	Itraconazol-analoga als inhibitoren von fibrose
EP3227277B1 (de)	2014-12-05	2020-02-05	Pulmocide Limited	Antimykotische verbindung
JP6706023B2 (ja) *	2014-12-10	2020-06-03	ザ・スクリップス・リサーチ・インスティテュート	線維症の小分子阻害剤
KR102653821B1 (ko) *	2015-05-21	2024-04-02	풀모사이드 리미티드	항진균성 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-트리아졸-1-일)메틸)-5-(2,4-디플루오로페닐)테트라하이드로푸란-3-일)메톡시)-3-메틸페닐)피페라진-1-일)-n-(2-하이드록시사이클로헥실)벤즈아미드 또는 이의 약학적으로 허용가능한 염.
CN105237392B (zh) *	2015-11-24	2017-12-12	辽宁渤大化工有限公司	芳烷基水杨酸及其衍生物的制备方法
US11390613B2 (en)	2017-08-20	2022-07-19	University Of Connecticut	Azole analogues and methods of use thereof
WO2021030174A1 (en)	2019-08-09	2021-02-18	University Of Connecticut	Truncated itraconazole analogues and methods of use thereof
GB201917867D0 (en)	2019-12-06	2020-01-22	Pulmocide Ltd	Polymorphs
CN111138421A (zh) *	2019-12-26	2020-05-12	上海英诺富成生物科技有限公司	抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4267179A (en) *	1978-06-23	1981-05-12	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA2117651C (en) *	1992-03-18	2006-01-03	Jan Heeres	Itraconazole and saperconazole stereoisomers
PL181193B1 (pl) *	1993-12-21	2001-06-29	Schering Corp	Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków
SG48386A1 (en) *	1994-01-24	1998-04-17	Janssen Pharmaceutica Nv	Watersoluble azole antifungals
FI98688C (fi) *	1994-07-20	1997-07-25	Nokia Telecommunications Oy	Menetelmä lyhytsanomalähetyksen käynnistämiseksi solukkoradiojärjestelmässä, solukkoradiojärjestelmä sekä solukkoradiojärjestelmän tilaajarekisteri
HUP9701690A3 (en) *	1995-06-02	1998-04-28	Schering Corp Kenilwort	Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same
IL118668A0 (en) *	1995-06-19	1996-10-16	Schering Corp	Tetrahydrofuran antifungals
WO1998034934A1 (en) *	1997-02-11	1998-08-13	Janssen Pharmaceutica N.V.	Amino acid ester containing azole antifungals
EP0957101A1 (de) *	1998-05-14	1999-11-17	Janssen Pharmaceutica N.V.	Wasserlösliche Azole als Breitspektrum-antifungus

1998
- 1998-05-14 EP EP98201588A patent/EP0957101A1/de not_active Withdrawn
1999
- 1999-05-06 PL PL99344037A patent/PL194086B1/pl unknown
- 1999-05-06 IL IL13964799A patent/IL139647A0/xx not_active IP Right Cessation
- 1999-05-06 EP EP99924942A patent/EP1077975B1/de not_active Expired - Lifetime
- 1999-05-06 ES ES99924942T patent/ES2198915T3/es not_active Expired - Lifetime
- 1999-05-06 EE EEP200000657A patent/EE04311B1/xx not_active IP Right Cessation
- 1999-05-06 IL IL13964999A patent/IL139649A/en not_active IP Right Cessation
- 1999-05-06 CZ CZ20004108A patent/CZ299481B6/cs not_active IP Right Cessation
- 1999-05-06 EP EP99926304A patent/EP1077976B1/de not_active Expired - Lifetime
- 1999-05-06 DE DE69902461T patent/DE69902461T2/de not_active Expired - Lifetime
- 1999-05-06 AU AU41417/99A patent/AU751135B2/en not_active Ceased
- 1999-05-06 DK DK99926304T patent/DK1077976T3/da active
- 1999-05-06 TR TR2000/03322T patent/TR200003322T2/xx unknown
- 1999-05-06 EE EEP200000651A patent/EE04346B1/xx not_active IP Right Cessation
- 1999-05-06 CZ CZ20004109A patent/CZ298702B6/cs not_active IP Right Cessation
- 1999-05-06 CN CNB998060690A patent/CN1135229C/zh not_active Expired - Fee Related
- 1999-05-06 DE DE69907171T patent/DE69907171T2/de not_active Expired - Lifetime
- 1999-05-06 AU AU43615/99A patent/AU758876B2/en not_active Ceased
- 1999-05-06 BR BR9911057-1A patent/BR9911057A/pt not_active Application Discontinuation
- 1999-05-06 PL PL99344047A patent/PL194085B1/pl unknown
- 1999-05-06 HR HR20000740A patent/HRP20000740B1/xx not_active IP Right Cessation
- 1999-05-06 CA CA002331141A patent/CA2331141C/en not_active Expired - Fee Related
- 1999-05-06 JP JP2000548333A patent/JP2002514645A/ja active Pending
- 1999-05-06 NZ NZ507966A patent/NZ507966A/xx not_active IP Right Cessation
- 1999-05-06 BR BR9910448-2A patent/BR9910448A/pt not_active Application Discontinuation
- 1999-05-06 WO PCT/EP1999/003242 patent/WO1999058529A1/en not_active Ceased
- 1999-05-06 HR HR20000741A patent/HRP20000741B1/xx not_active IP Right Cessation
- 1999-05-06 JP JP2000548334A patent/JP2002514646A/ja active Pending
- 1999-05-06 CN CNB998059560A patent/CN1137118C/zh not_active Expired - Fee Related
- 1999-05-06 SK SK1682-2000A patent/SK285763B6/sk not_active IP Right Cessation
- 1999-05-06 KR KR1020007009640A patent/KR100593395B1/ko not_active Expired - Fee Related
- 1999-05-06 CA CA002331187A patent/CA2331187C/en not_active Expired - Fee Related
- 1999-05-06 HU HU0102031A patent/HUP0102031A3/hu unknown
- 1999-05-06 SK SK1681-2000A patent/SK286156B6/sk not_active IP Right Cessation
- 1999-05-06 NZ NZ507965A patent/NZ507965A/en not_active IP Right Cessation
- 1999-05-06 AT AT99926304T patent/ATE221884T1/de active
- 1999-05-06 US US09/700,251 patent/US6384030B1/en not_active Expired - Lifetime
- 1999-05-06 TR TR2000/03323T patent/TR200003323T2/xx unknown
- 1999-05-06 US US09/700,166 patent/US6448244B1/en not_active Expired - Lifetime
- 1999-05-06 KR KR1020007011624A patent/KR100575147B1/ko not_active Expired - Fee Related
- 1999-05-06 SI SI9930131T patent/SI1077976T1/xx unknown
- 1999-05-06 PT PT99926304T patent/PT1077976E/pt unknown
- 1999-05-06 HU HU0103536A patent/HUP0103536A3/hu unknown
- 1999-05-06 ES ES99926304T patent/ES2182531T3/es not_active Expired - Lifetime
- 1999-05-06 WO PCT/EP1999/003243 patent/WO1999058530A1/en not_active Ceased
- 1999-05-06 AT AT99924942T patent/ATE238296T1/de not_active IP Right Cessation
- 1999-05-10 TW TW088107505A patent/TWI259835B/zh not_active IP Right Cessation
- 1999-05-10 TW TW088107504A patent/TW572899B/zh not_active IP Right Cessation
- 1999-05-11 MY MYPI99001861A patent/MY120248A/en unknown
- 1999-05-11 MY MYPI99001862A patent/MY122147A/en unknown
- 1999-05-13 CO CO99029778A patent/CO5021227A1/es unknown
- 1999-05-13 AR ARP990102276A patent/AR016482A1/es active IP Right Grant
- 1999-05-13 AR ARP990102270A patent/AR016480A1/es active IP Right Grant
2000
- 2000-08-28 BG BG104717A patent/BG64388B1/bg unknown
- 2000-11-09 BG BG104933A patent/BG64954B1/bg unknown
- 2000-11-13 NO NO20005712A patent/NO319851B1/no not_active IP Right Cessation
- 2000-11-13 NO NO20005713A patent/NO319760B1/no not_active IP Right Cessation
- 2000-12-04 ZA ZA200007173A patent/ZA200007173B/en unknown
- 2000-12-13 ZA ZA200007459A patent/ZA200007459B/xx unknown

Also Published As

Publication number	Publication date
CN1300288A (zh)	2001-06-20
JP2002514646A (ja)	2002-05-21
EP0957101A1 (de)	1999-11-17
WO1999058530A1 (en)	1999-11-18
NO319851B1 (no)	2005-09-19
DE69907171T2 (de)	2004-02-05
IL139649A0 (en)	2002-02-10
DK1077976T3 (da)	2002-12-02
SK16812000A3 (sk)	2001-08-06
TR200003322T2 (tr)	2001-02-21
HK1033312A1 (en)	2001-08-24
EE200000651A (et)	2002-04-15
AU751135B2 (en)	2002-08-08
HUP0102031A3 (en)	2002-10-28
CO5021227A1 (es)	2001-03-27
ZA200007173B (en)	2002-03-04
CZ20004109A3 (en)	2001-05-16
PL194086B1 (pl)	2007-04-30
HRP20000740B1 (en)	2003-12-31
CZ298702B6 (cs)	2007-12-27
AU4141799A (en)	1999-11-29
PL194085B1 (pl)	2007-04-30
BR9911057A (pt)	2001-02-06
BG64388B1 (bg)	2004-12-30
MY122147A (en)	2006-03-31
PT1077976E (pt)	2002-12-31
KR20010042852A (ko)	2001-05-25
US6384030B1 (en)	2002-05-07
PL344037A1 (en)	2001-09-24
EP1077976A1 (de)	2001-02-28
SK285763B6 (sk)	2007-07-06
BG64954B1 (bg)	2006-10-31
IL139649A (en)	2004-09-27
AU4361599A (en)	1999-11-29
JP2002514645A (ja)	2002-05-21
MY120248A (en)	2005-09-30
ES2182531T3 (es)	2003-03-01
BR9910448A (pt)	2001-01-02
EP1077975B1 (de)	2003-04-23
EP1077976B1 (de)	2002-08-07
NZ507966A (en)	2002-10-25
HUP0102031A2 (hu)	2002-05-29
ATE221884T1 (de)	2002-08-15
TWI259835B (en)	2006-08-11
IL139647A0 (en)	2002-02-10
CA2331187C (en)	2008-11-18
US6448244B1 (en)	2002-09-10
CN1137118C (zh)	2004-02-04
BG104933A (en)	2001-10-31
NO319760B1 (no)	2005-09-12
HK1032781A1 (en)	2001-08-03
HUP0103536A3 (en)	2002-08-28
EE04346B1 (et)	2004-08-16
ZA200007459B (en)	2002-09-13
BG104717A (en)	2001-07-31
CA2331141C (en)	2008-10-28
WO1999058529A1 (en)	1999-11-18
AR016480A1 (es)	2001-07-04
CA2331141A1 (en)	1999-11-18
EP1077975A1 (de)	2001-02-28
KR20010041480A (ko)	2001-05-25
KR100593395B1 (ko)	2006-06-28
CN1135229C (zh)	2004-01-21
SK16822000A3 (sk)	2001-07-10
CZ299481B6 (cs)	2008-08-13
HRP20000740A2 (en)	2001-10-31
HRP20000741B1 (hr)	2009-02-28
HRP20000741A2 (en)	2001-06-30
CN1300287A (zh)	2001-06-20
NO20005713L (no)	2001-01-11
NO20005713D0 (no)	2000-11-13
NO20005712L (no)	2000-12-07
SK286156B6 (sk)	2008-04-07
TR200003323T2 (tr)	2001-02-21
EE04311B1 (et)	2004-06-15
DE69902461T2 (de)	2003-04-10
CA2331187A1 (en)	1999-11-18
DE69902461D1 (de)	2002-09-12
PL344047A1 (en)	2001-09-24
AU758876B2 (en)	2003-04-03
EE200000657A (et)	2002-04-15
NO20005712D0 (no)	2000-11-13
KR100575147B1 (ko)	2006-05-03
TW572899B (en)	2004-01-21
SI1077976T1 (en)	2003-02-28
DE69907171D1 (de)	2003-05-28
ES2198915T3 (es)	2004-02-01
CZ20004108A3 (en)	2001-05-16
HUP0103536A2 (hu)	2002-07-29
NZ507965A (en)	2002-05-31
AR016482A1 (es)	2001-07-04

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE244236T1 (de)	2003-07-15	Substituierte azole
ATE238296T1 (de)	2003-05-15	Wasserlösliche azole als breitspektrum-antifungus
DE69937633D1 (de)	2008-01-10	2-pyridylmethylamin-derivate verwendbar als fungizide
NO20006267D0 (no)	2000-12-11	Imidazolyl-derivater
PL365134A1 (pl)	2004-12-27	Pochodne imidazolu
DE60036978D1 (de)	2007-12-20	Wasserkammer
DE60007697D1 (de)	2004-02-19	Triazolderivate
EP1109803A4 (de)	2002-10-29	Substituierte imidazole mit cytokin-inhibierender wirkung
DE60026382D1 (de)	2006-04-27	Handzugangsöffnung
ATE427940T1 (de)	2009-04-15	Triazol derivate als cyclooxygenase inhibitoren
MXPA01006686A (es)	2003-07-21	Composiciones fungicidas quirales de imidazol y metodos para su utilizacion.
AU2002334270A1 (en)	2004-03-11	Azole derivatives as antifungal agents
DE19982933T1 (de)	2001-02-15	Kommunikationssummer
AU2002253456A1 (en)	2003-10-27	Azole derivatives as antifungal agents
ATE253822T1 (de)	2003-11-15	Wachstumsregulierende wässrige zusammensetzungen
DE19983264B8 (de)	2009-04-16	Spektrumwassergenerator
ATE280161T1 (de)	2004-11-15	Imidazolverbindungen als alpha2-adrenorezeptoren antagonisten
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