ATE427940T1 - Triazol derivate als cyclooxygenase inhibitoren - Google Patents
Triazol derivate als cyclooxygenase inhibitorenInfo
- Publication number
- ATE427940T1 ATE427940T1 AT02779943T AT02779943T ATE427940T1 AT E427940 T1 ATE427940 T1 AT E427940T1 AT 02779943 T AT02779943 T AT 02779943T AT 02779943 T AT02779943 T AT 02779943T AT E427940 T1 ATE427940 T1 AT E427940T1
- Authority
- AT
- Austria
- Prior art keywords
- triazole derivatives
- cyclooxygenase inhibitors
- cyclooxygenase
- inhibitors
- triazole
- Prior art date
Links
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 title 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR8782A AUPR878201A0 (en) | 2001-11-09 | 2001-11-09 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE427940T1 true ATE427940T1 (de) | 2009-04-15 |
Family
ID=3832601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02779943T ATE427940T1 (de) | 2001-11-09 | 2002-10-30 | Triazol derivate als cyclooxygenase inhibitoren |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6927230B2 (de) |
| EP (1) | EP1442026B9 (de) |
| JP (2) | JP3972208B2 (de) |
| KR (1) | KR100511884B1 (de) |
| CN (1) | CN100338042C (de) |
| AR (1) | AR037347A1 (de) |
| AT (1) | ATE427940T1 (de) |
| AU (1) | AUPR878201A0 (de) |
| CA (1) | CA2465757C (de) |
| DE (1) | DE60231897D1 (de) |
| DK (1) | DK1442026T3 (de) |
| ES (1) | ES2325318T3 (de) |
| PT (1) | PT1442026E (de) |
| TW (1) | TWI300713B (de) |
| WO (1) | WO2003040110A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002055502A1 (en) * | 2001-01-02 | 2002-07-18 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine derivatives useful as cyclooxygenase inhibitor |
| AUPR878201A0 (en) * | 2001-11-09 | 2001-12-06 | Fujisawa Pharmaceutical Co., Ltd. | New compounds |
| KR100470076B1 (ko) | 2002-11-27 | 2005-02-05 | 씨제이 주식회사 | 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물 |
| WO2004050632A1 (en) | 2002-12-02 | 2004-06-17 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazole derivatives useful as cox-i inhibitors |
| WO2004060367A1 (en) * | 2002-12-30 | 2004-07-22 | Fujisawa Pharmaceutical Co., Ltd. | Imidazole and triazole derivatives useful as selective cox-1 inhibitors |
| RU2332412C2 (ru) | 2003-02-07 | 2008-08-27 | Дайити Фармасьютикал Ко., Лтд. | Производные пиразола |
| EP1620406A2 (de) * | 2003-05-08 | 2006-02-01 | Astellas Pharma Inc. | 1,2-diarylimidazole und ihre verwendung als cox-inhibitoren |
| EP1803719A4 (de) * | 2004-10-19 | 2008-07-02 | Daiichi Seiyaku Co | 1,5-diheterocyclus-1h-triazolderivat |
| KR20100137448A (ko) * | 2008-04-01 | 2010-12-30 | 아스텔라스세이야쿠 가부시키가이샤 | 혈관성 질병의 예방제 및/또는 치료제 |
| WO2011152297A1 (ja) * | 2010-05-31 | 2011-12-08 | アステラス製薬株式会社 | トリアゾール化合物の固体分散体 |
| UA112418C2 (uk) * | 2010-09-07 | 2016-09-12 | Астеллас Фарма Інк. | Терапевтичний болезаспокійливий засіб |
| KR101178947B1 (ko) * | 2011-04-29 | 2012-09-03 | 한국생명공학연구원 | 올레아놀린산 아세테이트를 유효성분으로 포함하는 ｔｌｒ 및 ｉｌ-6 매개성 질환 예방 또는 치료용 약학적 조성물 |
| WO2012170839A2 (en) * | 2011-06-09 | 2012-12-13 | Cardeus Pharmaceuticals, Inc. | Treatment of neuroinflammatory disease with selective cox1 inhibitors |
| EA201590916A1 (ru) * | 2012-11-09 | 2016-02-29 | Корнэлл Юниверсити | Низкомолекулярные ингибиторы malt1 |
| CN113329754A (zh) | 2018-11-20 | 2021-08-31 | 麻雀制药股份有限公司 | 用于施用皮质类固醇的方法 |
| CN115611901B (zh) * | 2021-07-16 | 2024-04-30 | 华南理工大学 | 一种氮杂䓬类化合物或其药学上可接受的盐及其制备方法和应用 |
| IL316907A (en) | 2022-05-16 | 2025-01-01 | Sparrow Pharmaceuticals Inc | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOD EXCESS |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0051084A1 (de) | 1980-11-04 | 1982-05-12 | American Cyanamid Company | Substituierte 1H-1,2,4-Triazole |
| HU193891B (en) * | 1984-02-07 | 1987-12-28 | Gyogyszerkutato Intezet | Process for production of new derivatives of 1,2,4-triasole |
| FI850995A7 (fi) | 1984-03-16 | 1985-09-17 | Ciba Geigy Ag | Menetelmä uusien 3-merkapto-1,2,4 -triatsasykloalkadieenijohdannaisten valmistamiseksi. |
| FI850994L (fi) | 1984-03-16 | 1985-09-17 | Ciba Geigy Ag | Foerfarande foer framstaellning av nya 1,2,4-triazacykloalkadienderivat. |
| AU581216B2 (en) | 1984-04-17 | 1989-02-16 | Henkel Corporation | Production of d-alpha-tocopherol from natural plant sources |
| JPS60233066A (ja) * | 1984-05-07 | 1985-11-19 | Nippon Nohyaku Co Ltd | １．５−ジフエニルトリアゾ−ル誘導体及びその製造方法 |
| CA2327185A1 (en) | 1998-04-08 | 1999-10-14 | Abbott Laboratories | Pyrazole inhibitors of cytokine production |
| ES2221426T3 (es) | 1998-08-20 | 2004-12-16 | Smithkline Beecham Corporation | Nuevos compuestos de triazol sustituidos. |
| EP1099695A1 (de) | 1999-11-09 | 2001-05-16 | Laboratoire Theramex S.A. | 5-Aryl-1H-1,2,4-triazolverbindungen als Cyclooxygenase-2 Inhibitoren und diese enthaltende pharmazeutische Zusammensetzungen |
| AUPR878201A0 (en) * | 2001-11-09 | 2001-12-06 | Fujisawa Pharmaceutical Co., Ltd. | New compounds |
-
2001
- 2001-11-09 AU AUPR8782A patent/AUPR878201A0/en not_active Abandoned
-
2002
- 2002-10-25 TW TW091124998A patent/TWI300713B/zh not_active IP Right Cessation
- 2002-10-30 AT AT02779943T patent/ATE427940T1/de active
- 2002-10-30 PT PT02779943T patent/PT1442026E/pt unknown
- 2002-10-30 DE DE60231897T patent/DE60231897D1/de not_active Expired - Lifetime
- 2002-10-30 DK DK02779943T patent/DK1442026T3/da active
- 2002-10-30 KR KR10-2003-7002474A patent/KR100511884B1/ko not_active Expired - Fee Related
- 2002-10-30 US US10/344,416 patent/US6927230B2/en not_active Expired - Lifetime
- 2002-10-30 CA CA2465757A patent/CA2465757C/en not_active Expired - Fee Related
- 2002-10-30 CN CNB028269004A patent/CN100338042C/zh not_active Expired - Fee Related
- 2002-10-30 ES ES02779943T patent/ES2325318T3/es not_active Expired - Lifetime
- 2002-10-30 EP EP02779943A patent/EP1442026B9/de not_active Expired - Lifetime
- 2002-10-30 JP JP2003542156A patent/JP3972208B2/ja not_active Expired - Fee Related
- 2002-10-30 WO PCT/JP2002/011314 patent/WO2003040110A1/en not_active Ceased
- 2002-11-08 AR ARP020104295A patent/AR037347A1/es not_active Application Discontinuation
-
2007
- 2007-02-02 JP JP2007024703A patent/JP2007169290A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20030191155A1 (en) | 2003-10-09 |
| AR037347A1 (es) | 2004-11-03 |
| EP1442026B9 (de) | 2009-11-18 |
| CN100338042C (zh) | 2007-09-19 |
| CA2465757A1 (en) | 2003-05-15 |
| JP2007169290A (ja) | 2007-07-05 |
| KR20030060878A (ko) | 2003-07-16 |
| JP3972208B2 (ja) | 2007-09-05 |
| ES2325318T3 (es) | 2009-09-01 |
| CN1612865A (zh) | 2005-05-04 |
| PT1442026E (pt) | 2009-06-25 |
| JP2004521964A (ja) | 2004-07-22 |
| EP1442026B1 (de) | 2009-04-08 |
| EP1442026A1 (de) | 2004-08-04 |
| KR100511884B1 (ko) | 2005-09-05 |
| WO2003040110A1 (en) | 2003-05-15 |
| US6927230B2 (en) | 2005-08-09 |
| CA2465757C (en) | 2011-11-29 |
| DK1442026T3 (da) | 2009-07-06 |
| AUPR878201A0 (en) | 2001-12-06 |
| TWI300713B (en) | 2008-09-11 |
| DE60231897D1 (de) | 2009-05-20 |
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| UEP | Publication of translation of european patent specification |
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