ATE238774T1 - Darreichungsform zur verzögerten, vollständigen wirkstoffabgabe im verdauungstrakt - Google Patents

Darreichungsform zur verzögerten, vollständigen wirkstoffabgabe im verdauungstrakt

Info

Publication number
ATE238774T1
ATE238774T1 AT98949742T AT98949742T ATE238774T1 AT E238774 T1 ATE238774 T1 AT E238774T1 AT 98949742 T AT98949742 T AT 98949742T AT 98949742 T AT98949742 T AT 98949742T AT E238774 T1 ATE238774 T1 AT E238774T1
Authority
AT
Austria
Prior art keywords
core
drug
coating
insoluble
water
Prior art date
Application number
AT98949742T
Other languages
English (en)
Inventor
E Itzhak Lerner
Moshe Flashner
Adel Penhasi
Original Assignee
Dexcel Pharma Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dexcel Pharma Technologies Ltd filed Critical Dexcel Pharma Technologies Ltd
Application granted granted Critical
Publication of ATE238774T1 publication Critical patent/ATE238774T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98949742T 1997-10-09 1998-10-01 Darreichungsform zur verzögerten, vollständigen wirkstoffabgabe im verdauungstrakt ATE238774T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94823597A 1997-10-09 1997-10-09
US16320298A 1998-09-30 1998-09-30
PCT/US1998/020779 WO1999018938A1 (en) 1997-10-09 1998-10-01 Delayed total release gastrointestinal drug delivery system

Publications (1)

Publication Number Publication Date
ATE238774T1 true ATE238774T1 (de) 2003-05-15

Family

ID=26859435

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98949742T ATE238774T1 (de) 1997-10-09 1998-10-01 Darreichungsform zur verzögerten, vollständigen wirkstoffabgabe im verdauungstrakt

Country Status (20)

Country Link
EP (1) EP1021171B1 (de)
JP (1) JP2001519379A (de)
KR (1) KR20010031034A (de)
CN (1) CN100548279C (de)
AT (1) ATE238774T1 (de)
AU (1) AU740757B2 (de)
BR (1) BR9815240A (de)
CA (1) CA2305762C (de)
CZ (1) CZ301028B6 (de)
DE (1) DE69814122T2 (de)
DK (1) DK1021171T3 (de)
ES (1) ES2198756T3 (de)
HU (1) HUP0004945A3 (de)
IL (1) IL135502A (de)
NO (1) NO20001829L (de)
NZ (1) NZ503820A (de)
PL (1) PL203733B1 (de)
PT (1) PT1021171E (de)
TR (1) TR200000944T2 (de)
WO (1) WO1999018938A1 (de)

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US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
CA2378265C (en) 1999-08-09 2007-11-20 Dainippon Pharmaceutical Co., Ltd. Solid preparations containing chitosan powder and process for producing the same
CN1285333C (zh) * 2000-06-07 2006-11-22 张昊 结肠定位释放的口服制剂及其制备方法
US6932861B2 (en) 2000-11-28 2005-08-23 Fmc Corporation Edible PGA coating composition
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US20040156900A1 (en) * 2001-04-10 2004-08-12 Shanghvi Dilip Shantilal Time pulsed release composition
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CN102525993B (zh) 2003-04-24 2017-04-12 佳高泰克有限公司 具有限定内核几何形状的缓释片剂
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
KR100645019B1 (ko) * 2004-06-03 2006-11-14 주식회사 리젠 바이오텍 비수용성 무기화합물이 포집되어 있는 고분자 비드, 이의제조방법 및 용도
BRPI0606395A2 (pt) * 2005-01-05 2009-06-23 Univ Texas conjugados para ambas imagem e radioquimioterapia: composição, fabricação e aplicações
WO2007014084A1 (en) * 2005-07-22 2007-02-01 Dow Global Technologies Inc. Oral drug compliance monitoring using sound detection
DK1916995T4 (da) 2005-07-29 2022-10-03 Stichting Groningen Centre For Drug Res Ph-styret, pulserende indgivelsessystem, fremgangsmåder til fremstilling og anvendelse deraf
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
EP1991196B1 (de) 2006-03-03 2016-10-12 Fmc Corporation Verfahren und Vorrichtung zur Herstellung von Kapseln.
JP2007284483A (ja) * 2006-04-13 2007-11-01 Daito Kasei Kogyo Kk 吸湿性顔料およびそれを含有する化粧料
JP2009537548A (ja) * 2006-05-19 2009-10-29 アダマス・ファーマシューティカルズ・インコーポレーテッド ウイルス感染症の治療のための方法および組成物
SG174026A1 (en) 2006-08-03 2011-09-29 Nitec Pharma Ag Delayed-release glucocorticoid treatment of rheumatoid disease
WO2008044236A2 (en) * 2006-10-10 2008-04-17 Dexcel Pharma Technologies Ltd. Improved release of statins in the intestine
HUE038452T2 (hu) 2007-11-13 2018-10-29 Meritage Pharma Inc Gyomor és bélrendszeri gyulladások kezelésére szolgáló kompozíciók
US9050368B2 (en) 2007-11-13 2015-06-09 Meritage Pharma, Inc. Corticosteroid compositions
US20090264392A1 (en) * 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
ES2425762T3 (es) * 2008-10-27 2013-10-17 Roquette Freres Polímero insoluble en agua: revestimientos de película a base de derivados de almidón modificado para la liberación dirigida al colon
US20170079962A1 (en) 2009-11-11 2017-03-23 Rapamycin Holdings, Llc Oral Rapamycin Preparation and Use for Stomatitus
PH12013502325A1 (en) 2011-05-13 2014-02-10 Eb Ip Hybritabs B V Drug delivery system
AU2014373683B2 (en) 2013-12-31 2020-05-07 Rapamycin Holdings, Llc Oral rapamycin nanoparticle preparations and use
EP4681737A3 (de) 2014-02-21 2026-03-11 Principia Biopharma Inc. Salze und feste form eines btk-hemmers
US10485797B2 (en) 2014-12-18 2019-11-26 Principia Biopharma Inc. Treatment of pemphigus
EP3236953B1 (de) * 2014-12-24 2020-11-11 Principia Biopharma Inc. Ortsspezifische dosierung eines btk-inhibitor
TW201718572A (zh) 2015-06-24 2017-06-01 普林斯匹亞生物製藥公司 酪胺酸激酶抑制劑
GB201511284D0 (en) * 2015-06-26 2015-08-12 Univ Witwatersrand Jhb An oral pharmaceutical dosage form for the delivery of a peptide and/or protein
CN105434403A (zh) * 2015-12-30 2016-03-30 成都医学院 一种溴吡斯的明包衣缓释微丸及其制备方法
IL293621B2 (en) 2016-06-29 2023-09-01 Principia Biopharma Inc Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(oxane-3-yl)piperazine-1-yl)penta-2-ananitrile
JP6780412B2 (ja) * 2016-09-28 2020-11-04 ライオン株式会社 コーティング組成物ならびにコーティング製剤及びその製造方法
JP7795454B2 (ja) 2019-10-14 2026-01-07 プリンシピア バイオファーマ インコーポレイテッド （ｒ）－２－［３－［４－アミノ－３－（２－フルオロ－４－フェノキシ－フェニル）ピラゾロ［３，４－ｄ］ピリミジン－１－イル］ピペリジン－１－カルボニル］－４－メチル－４－［４－（オキセタン－３－イル）ピペラジン－１－イル］ペンタ－２－エンニトリルを投与することにより免疫性血小板減少症を治療する方法
AU2021209884A1 (en) 2020-01-22 2022-09-15 Principia Biopharma Inc. Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
WO2021250611A1 (en) * 2020-06-11 2021-12-16 Janssen Biotech, Inc. Controlled release of self-embedding particles for localized drug delivery
CN112544964B (zh) * 2020-12-28 2024-03-19 苏州大学 一种可服用胶囊及其制备方法与应用
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Also Published As

Publication number Publication date
NZ503820A (en) 2004-02-27
CA2305762C (en) 2006-09-26
DE69814122T2 (de) 2004-03-18
AU9600198A (en) 1999-05-03
CA2305762A1 (en) 1999-04-22
CZ301028B6 (cs) 2009-10-14
TR200000944T2 (tr) 2000-11-21
DE69814122D1 (de) 2003-06-05
WO1999018938A1 (en) 1999-04-22
PL339861A1 (en) 2001-01-15
ES2198756T3 (es) 2004-02-01
EP1021171B1 (de) 2003-05-02
CZ20001256A3 (cs) 2000-10-11
IL135502A (en) 2006-07-05
NO20001829L (no) 2000-06-07
JP2001519379A (ja) 2001-10-23
CN1274280A (zh) 2000-11-22
CN100548279C (zh) 2009-10-14
PT1021171E (pt) 2003-10-31
PL203733B1 (pl) 2009-11-30
DK1021171T3 (da) 2003-08-25
HUP0004945A2 (hu) 2001-08-28
AU740757B2 (en) 2001-11-15
HUP0004945A3 (en) 2005-03-29
IL135502A0 (en) 2001-05-20
NO20001829D0 (no) 2000-04-07
KR20010031034A (ko) 2001-04-16
EP1021171A1 (de) 2000-07-26
BR9815240A (pt) 2001-10-30

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