ATE238993T1 - Bicyclische fibrinogenantagonisten - Google Patents

Bicyclische fibrinogenantagonisten

Info

Publication number
ATE238993T1
ATE238993T1 AT95908006T AT95908006T ATE238993T1 AT E238993 T1 ATE238993 T1 AT E238993T1 AT 95908006 T AT95908006 T AT 95908006T AT 95908006 T AT95908006 T AT 95908006T AT E238993 T1 ATE238993 T1 AT E238993T1
Authority
AT
Austria
Prior art keywords
fibrinogen antagonists
bicyclic fibrinogen
bicyclic
antagonists
fibrinogen
Prior art date
Application number
AT95908006T
Other languages
English (en)
Inventor
William Edward Bondinell
James Francis Callahan
William Francis Huffman
Richard Mcculloch Keenan
Thomas Wen-Fu Ku
Kenneth Allen Newlander
James Martin Samanen
Irene Nijole Uzinskas
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE238993T1 publication Critical patent/ATE238993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
AT95908006T 1994-01-07 1995-01-09 Bicyclische fibrinogenantagonisten ATE238993T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17901194A 1994-01-07 1994-01-07
PCT/US1995/000248 WO1995018619A1 (en) 1994-01-07 1995-01-09 Bicyclic fibrinogen antagonists

Publications (1)

Publication Number Publication Date
ATE238993T1 true ATE238993T1 (de) 2003-05-15

Family

ID=22654859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95908006T ATE238993T1 (de) 1994-01-07 1995-01-09 Bicyclische fibrinogenantagonisten

Country Status (26)

Country Link
US (1) US6117866A (de)
EP (1) EP0738150B1 (de)
JP (1) JPH09508620A (de)
KR (1) KR100388772B1 (de)
CN (1) CN1117569C (de)
AP (1) AP542A (de)
AT (1) ATE238993T1 (de)
AU (1) AU699186B2 (de)
BG (2) BG62844B1 (de)
BR (1) BR9506499A (de)
CZ (1) CZ292323B6 (de)
DE (1) DE69530571T2 (de)
DK (1) DK0738150T3 (de)
ES (1) ES2197914T3 (de)
HU (1) HUT76282A (de)
IL (1) IL112243A (de)
MA (1) MA23420A1 (de)
NO (1) NO962859L (de)
NZ (1) NZ279394A (de)
OA (1) OA10368A (de)
PT (1) PT738150E (de)
SG (1) SG64884A1 (de)
SK (1) SK86996A3 (de)
TW (1) TW420682B (de)
WO (1) WO1995018619A1 (de)
ZA (1) ZA9545B (de)

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JPH10504825A (ja) * 1994-08-22 1998-05-12 スミスクライン・ビーチャム・コーポレイション 二環式化合物
DE19516483A1 (de) * 1995-05-05 1996-11-07 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
ZA9610853B (en) * 1995-12-29 1998-04-06 Smithkline Beecham Corp Processes and intermediates for preparing pharmaceuticals.
PL332006A1 (en) * 1996-09-03 1999-08-16 Smithkline Beecham Corp Crystalline pharmaceutic product
EP0964928A1 (de) * 1996-12-27 1999-12-22 Smithkline Beecham Plc Enzymatische auflösung von benzodiazepin essigsäure estern mit einer lipase
EP1044980A1 (de) * 1997-12-09 2000-10-18 Ihara Chemical Industry Co., Ltd. Verfahren zur herstellung von toluolderivaten
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
EP1140864A2 (de) 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Pharmazeutische zusammensetzungen, vitronectinrezeptor antagonisten enthaltend
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
GB9908662D0 (en) * 1999-04-15 1999-06-09 Smithkline Beecham Plc Novel process for preparing benzodiazepines
CO5180550A1 (es) * 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
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ATE285821T1 (de) 1999-10-08 2005-01-15 Affinium Pharm Inc Fab i inhibitoren
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EP2246086A3 (de) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosolverabreichungsvorrichtung mit Schlag gezündete Heizeinheit
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EP2395992A2 (de) 2009-02-10 2011-12-21 The Scripps Research Institute Chemisch programmierte impfung
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BR122023021456A2 (pt) 2016-02-26 2024-02-20 Debiopharm International S.A. Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica
EP3746138B1 (de) 2018-02-02 2025-12-10 Alexza Pharmaceuticals, Inc. Elektrische kondensationsaerosolvorrichtung
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Also Published As

Publication number Publication date
PT738150E (pt) 2003-08-29
OA10368A (en) 2001-11-15
IL112243A0 (en) 1995-03-30
CN1117569C (zh) 2003-08-13
MA23420A1 (fr) 1995-10-01
DE69530571D1 (de) 2003-06-05
CN1143323A (zh) 1997-02-19
AP9500710A0 (en) 1995-01-31
IL112243A (en) 1999-12-31
CZ198196A3 (en) 1997-06-11
SK86996A3 (en) 1997-02-05
NZ279394A (en) 1998-05-27
ES2197914T3 (es) 2004-01-16
DE69530571T2 (de) 2004-03-04
HU9601849D0 (en) 1996-09-30
HK1014668A1 (en) 1999-09-30
BG100698A (bg) 1997-02-28
WO1995018619A1 (en) 1995-07-13
TW420682B (en) 2001-02-01
HUT76282A (en) 1997-07-28
AU1600195A (en) 1995-08-01
SG64884A1 (en) 1999-05-25
BG62844B1 (bg) 2000-09-29
CZ292323B6 (cs) 2003-09-17
NO962859D0 (no) 1996-07-05
BR9506499A (pt) 1997-09-09
EP0738150A1 (de) 1996-10-23
KR100388772B1 (ko) 2003-11-20
EP0738150A4 (de) 1997-03-19
WO1995018619A9 (en) 2004-10-21
AP542A (en) 1996-10-01
BG102863A (en) 1999-05-31
US6117866A (en) 2000-09-12
JPH09508620A (ja) 1997-09-02
EP0738150B1 (de) 2003-05-02
AU699186B2 (en) 1998-11-26
ZA9545B (en) 1996-01-23
DK0738150T3 (da) 2003-08-25
NO962859L (no) 1996-09-05

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