ATE239791T1 - Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin - Google Patents

Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin

Info

Publication number: ATE239791T1
Authority: AT; Austria
Prior art keywords: insulin; dna sequences; sequences encoding; precursors; relates
Prior art date: 1994-08-05

Application number

AT95112210T

Other languages

English (en)

Inventor

Silvija Mestric

Peter J Punt

Radovan Valinger

Den Hondel Cees A M J J Van

Original Assignee

Pliva Pharm & Chem Works

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-05

Filing date

1995-08-03

Publication date

2003-05-15

1995-08-03 Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE239791T1 publication Critical patent/ATE239791T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 10
102000004877 Insulin Human genes 0.000 title abstract 5
108090001061 Insulin Proteins 0.000 title abstract 5
229940125396 insulin Drugs 0.000 title abstract 5
108091028043 Nucleic acid sequence Proteins 0.000 title abstract 4
239000002243 precursor Substances 0.000 title abstract 3
230000001851 biosynthetic effect Effects 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical class OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 abstract 1
230000004988 N-glycosylation Effects 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
230000002538 fungal effect Effects 0.000 abstract 1
230000013595 glycosylation Effects 0.000 abstract 1
238000006206 glycosylation reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Plant Pathology (AREA)
Mycology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT95112210T 1994-08-05 1995-08-03 Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin ATE239791T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR940432A HRP940432B1 (en)	1994-08-05	1994-08-05	Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin

Publications (1)

Publication Number	Publication Date
ATE239791T1 true ATE239791T1 (de)	2003-05-15

Family

ID=10946142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95112210T ATE239791T1 (de)	1994-08-05	1995-08-03	Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin

Country Status (13)

Country	Link
EP (1)	EP0704527B1 (de)
CN (1)	CN1126761A (de)
AT (1)	ATE239791T1 (de)
BG (1)	BG62336B1 (de)
CA (1)	CA2155451A1 (de)
CZ (1)	CZ199995A3 (de)
DE (1)	DE69530647T2 (de)
ES (1)	ES2198428T3 (de)
HR (1)	HRP940432B1 (de)
PL (1)	PL309882A1 (de)
PT (1)	PT704527E (de)
SI (1)	SI9500250A (de)
SK (1)	SK97195A3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9513967D0 (en) *	1995-07-08	1995-09-06	Univ Leicester	Insulin
WO2000005389A2 (en) *	1998-07-20	2000-02-03	Unilever N.V.	Production of proteins
AU762351B2 (en)	1999-01-06	2003-06-26	Genentech Inc.	Insulin-like growth factor (IGF) I mutant variants
JP3406244B2 (ja) *	1999-04-30	2003-05-12	伊藤ハム株式会社	新規な融合蛋白質からの組み換えインスリンの製造方法
DE19947456A1 (de) *	1999-10-02	2001-04-05	Aventis Pharma Gmbh	C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
AU4935701A (en)	2000-03-24	2001-10-08	Genentech Inc	Use of insulin for the treatment of cartilagenous disorders
AU2002316807A1 (en) *	2001-06-08	2002-12-23	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogs
JP2013535467A (ja) *	2010-07-28	2013-09-12	スマートセルズ・インコーポレイテツド	組換えにより発現されたインスリンポリペプチドおよびその使用
AR087433A1 (es) *	2011-08-08	2014-03-26	Merck Sharp & Dohme	Analogos de insulina n-glicosilados
US12440546B2 (en)	2018-10-05	2025-10-14	International Institute Of Cancer Immunology, Inc.	Composition for preventing or treating benign tumor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE63757T1 (de) *	1985-03-28	1991-06-15	Chiron Corp	Expression durch verwendung von fusionsgenen fuer proteinproduktion.
FI872102A7 (fi) *	1986-06-06	1987-12-07	Panlabs Inc	Rihmasienten ilmentymisjärjestelmät.
CA1340772C (en) *	1987-12-30	1999-09-28	Patricia Tekamp-Olson	Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
DK300090D0 (da) *	1990-12-19	1990-12-19	Novo Nordisk As	Fremgangsmaade til fremstilling af leadersekvenser
BR9400600A (pt) *	1994-02-17	1995-10-24	Finep Financiadora De Estudos	Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos

1994
- 1994-08-05 HR HR940432A patent/HRP940432B1/xx not_active IP Right Cessation
1995
- 1995-08-01 SK SK971-95A patent/SK97195A3/sk unknown
- 1995-08-03 PT PT95112210T patent/PT704527E/pt unknown
- 1995-08-03 DE DE69530647T patent/DE69530647T2/de not_active Expired - Lifetime
- 1995-08-03 ES ES95112210T patent/ES2198428T3/es not_active Expired - Lifetime
- 1995-08-03 BG BG99844A patent/BG62336B1/bg unknown
- 1995-08-03 EP EP95112210A patent/EP0704527B1/de not_active Expired - Lifetime
- 1995-08-03 AT AT95112210T patent/ATE239791T1/de active
- 1995-08-03 CZ CZ951999A patent/CZ199995A3/cs unknown
- 1995-08-04 CN CN95115064A patent/CN1126761A/zh active Pending
- 1995-08-04 PL PL95309882A patent/PL309882A1/xx unknown
- 1995-08-04 SI SI9500250A patent/SI9500250A/sl unknown
- 1995-08-04 CA CA002155451A patent/CA2155451A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP0704527A2 (de)	1996-04-03
SK97195A3 (en)	1996-02-07
BG99844A (bg)	1996-02-28
SI9500250A (en)	1996-02-29
CA2155451A1 (en)	1996-02-06
DE69530647D1 (de)	2003-06-12
CZ199995A3 (en)	1996-02-14
HRP940432A2 (en)	1997-08-31
CN1126761A (zh)	1996-07-17
DE69530647T2 (de)	2004-03-11
ES2198428T3 (es)	2004-02-01
EP0704527B1 (de)	2003-05-07
BG62336B1 (bg)	1999-08-31
HRP940432B1 (en)	2003-10-31
EP0704527A3 (de)	1997-08-27
PT704527E (pt)	2003-09-30
PL309882A1 (en)	1996-02-19

Legal Events

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2003-12-15

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