HRP940432B1 - Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin - Google Patents

Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin

Info

Publication number: HRP940432B1
Authority: HR; Croatia
Prior art keywords: insulin; dna sequences; sequences encoding; preparation; precursors
Prior art date: 1994-08-05

Application number

HR940432A

Other languages

English (en)

Inventor

Silvija Meuetri

J Peter Punt

Radovan Valinger

A M J J Cees Van Den Hondel

Original Assignee

Pliva Pharm & Chem Works

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-05

Filing date

1994-08-05

Publication date

2003-10-31

1994-08-05 Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works

1994-08-05 Priority to HR940432A priority Critical patent/HRP940432B1/xx

1995-08-01 Priority to SK971-95A priority patent/SK97195A3/sk

1995-08-03 Priority to CZ951999A priority patent/CZ199995A3/cs

1995-08-03 Priority to AT95112210T priority patent/ATE239791T1/de

1995-08-03 Priority to DE69530647T priority patent/DE69530647T2/de

1995-08-03 Priority to PT95112210T priority patent/PT704527E/pt

1995-08-03 Priority to BG99844A priority patent/BG62336B1/bg

1995-08-03 Priority to EP95112210A priority patent/EP0704527B1/de

1995-08-03 Priority to ES95112210T priority patent/ES2198428T3/es

1995-08-04 Priority to CN95115064A priority patent/CN1126761A/zh

1995-08-04 Priority to CA002155451A priority patent/CA2155451A1/en

1995-08-04 Priority to PL95309882A priority patent/PL309882A1/xx

1995-08-04 Priority to SI9500250A priority patent/SI9500250A/sl

1997-08-31 Publication of HRP940432A2 publication Critical patent/HRP940432A2/hr

2003-10-31 Publication of HRP940432B1 publication Critical patent/HRP940432B1/xx

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 10
102000004877 Insulin Human genes 0.000 title abstract 5
108090001061 Insulin Proteins 0.000 title abstract 5
229940125396 insulin Drugs 0.000 title abstract 5
108091028043 Nucleic acid sequence Proteins 0.000 title abstract 4
239000002243 precursor Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
230000001851 biosynthetic effect Effects 0.000 title 1
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical class OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 abstract 1
230000004988 N-glycosylation Effects 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
230000002538 fungal effect Effects 0.000 abstract 1
230000013595 glycosylation Effects 0.000 abstract 1
238000006206 glycosylation reaction Methods 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Plant Pathology (AREA)
Mycology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

HR940432A 1994-08-05 1994-08-05 Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin HRP940432B1 (en)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
HR940432A HRP940432B1 (en)	1994-08-05	1994-08-05	Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin
SK971-95A SK97195A3 (en)	1994-08-05	1995-08-01	Dnk - sequences coding the new biosynthetic precursors of insulin and method of insuline preparation
CZ951999A CZ199995A3 (en)	1994-08-05	1995-08-03	Dna sequence encoding novel insulin biosynthetic precursors and insulin preparation process
AT95112210T ATE239791T1 (de)	1994-08-05	1995-08-03	Für biosynthetische insulinvorstufen kodierende dna-sequenzen und verfahren zur herstellung von insulin
DE69530647T DE69530647T2 (de)	1994-08-05	1995-08-03	Für biosynthetische Insulinvorstufen kodierende DNA-Sequenzen und Verfahren zur Herstellung von Insulin
PT95112210T PT704527E (pt)	1994-08-05	1995-08-03	Sequencias de adn que codificam precursores de insulina biossinteticos e processo para a preparacao de insulina
BG99844A BG62336B1 (bg)	1994-08-05	1995-08-03	Днк последователности,кодиращи нови биосинтетични предшественици на инсулин и метод за получаване на инсулин
EP95112210A EP0704527B1 (de)	1994-08-05	1995-08-03	Für biosynthetische Insulinvorstufen kodierende DNA-Sequenzen und Verfahren zur Herstellung von Insulin
ES95112210T ES2198428T3 (es)	1994-08-05	1995-08-03	Secuencias de adn codificantes de precursores de insulina biosinteticos y procedimiento para la preparacion de insulina.
CN95115064A CN1126761A (zh)	1994-08-05	1995-08-04	编码新型生物合成胰岛素前体的dna序列以及胰岛素的制备方法
CA002155451A CA2155451A1 (en)	1994-08-05	1995-08-04	Dna sequences encoding novel biosynthetic insulin precursors and process for preparation of insulin
PL95309882A PL309882A1 (en)	1994-08-05	1995-08-04	Dna sequence encoding novel biosynthetic insulin precursors and insulin obtaining method
SI9500250A SI9500250A (en)	1994-08-05	1995-08-04	Dna sequences encoding novel biosynthetic insulin precursors and process for preparation of insulin.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR940432A HRP940432B1 (en)	1994-08-05	1994-08-05	Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin

Publications (2)

Publication Number	Publication Date
HRP940432A2 HRP940432A2 (en)	1997-08-31
HRP940432B1 true HRP940432B1 (en)	2003-10-31

Family

ID=10946142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR940432A HRP940432B1 (en)	1994-08-05	1994-08-05	Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin

Country Status (13)

Country	Link
EP (1)	EP0704527B1 (de)
CN (1)	CN1126761A (de)
AT (1)	ATE239791T1 (de)
BG (1)	BG62336B1 (de)
CA (1)	CA2155451A1 (de)
CZ (1)	CZ199995A3 (de)
DE (1)	DE69530647T2 (de)
ES (1)	ES2198428T3 (de)
HR (1)	HRP940432B1 (de)
PL (1)	PL309882A1 (de)
PT (1)	PT704527E (de)
SI (1)	SI9500250A (de)
SK (1)	SK97195A3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9513967D0 (en) *	1995-07-08	1995-09-06	Univ Leicester	Insulin
AU5504999A (en) *	1998-07-20	2000-02-14	Frenken, Leon Gerardus Joseph	Production of proteins
AU762351B2 (en)	1999-01-06	2003-06-26	Genentech Inc.	Insulin-like growth factor (IGF) I mutant variants
JP3406244B2 (ja)	1999-04-30	2003-05-12	伊藤ハム株式会社	新規な融合蛋白質からの組み換えインスリンの製造方法
DE19947456A1 (de)	1999-10-02	2001-04-05	Aventis Pharma Gmbh	C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
DE60120372T2 (de)	2000-03-24	2007-07-05	Genentech Inc., San Francisco	Verwendung von insulin zur behandlung von knorpelkrankheiten
AU2002316807A1 (en) *	2001-06-08	2002-12-23	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogs
JP2013535467A (ja) *	2010-07-28	2013-09-12	スマートセルズ・インコーポレイテツド	組換えにより発現されたインスリンポリペプチドおよびその使用
AR087433A1 (es) *	2011-08-08	2014-03-26	Merck Sharp & Dohme	Analogos de insulina n-glicosilados
CA3115240A1 (en)	2018-10-05	2020-04-09	International Institute Of Cancer Immunology, Inc.	Composition for preventing or treating benign tumor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1260858A (en) *	1985-03-28	1989-09-26	Lawrence S. Cousens	Expression using fused genes providing for protein product
FI872102L (fi) *	1986-06-06	1987-12-07	Panlabs Inc	Expressionssystem hos filamentala fungi.
CA1340772C (en) *	1987-12-30	1999-09-28	Patricia Tekamp-Olson	Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
DK300090D0 (da) *	1990-12-19	1990-12-19	Novo Nordisk As	Fremgangsmaade til fremstilling af leadersekvenser
BR9400600A (pt) *	1994-02-17	1995-10-24	Finep Financiadora De Estudos	Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos

1994
- 1994-08-05 HR HR940432A patent/HRP940432B1/xx not_active IP Right Cessation
1995
- 1995-08-01 SK SK971-95A patent/SK97195A3/sk unknown
- 1995-08-03 EP EP95112210A patent/EP0704527B1/de not_active Expired - Lifetime
- 1995-08-03 BG BG99844A patent/BG62336B1/bg unknown
- 1995-08-03 PT PT95112210T patent/PT704527E/pt unknown
- 1995-08-03 DE DE69530647T patent/DE69530647T2/de not_active Expired - Lifetime
- 1995-08-03 CZ CZ951999A patent/CZ199995A3/cs unknown
- 1995-08-03 AT AT95112210T patent/ATE239791T1/de active
- 1995-08-03 ES ES95112210T patent/ES2198428T3/es not_active Expired - Lifetime
- 1995-08-04 CA CA002155451A patent/CA2155451A1/en not_active Abandoned
- 1995-08-04 CN CN95115064A patent/CN1126761A/zh active Pending
- 1995-08-04 PL PL95309882A patent/PL309882A1/xx unknown
- 1995-08-04 SI SI9500250A patent/SI9500250A/sl unknown

Also Published As

Publication number	Publication date
DE69530647D1 (de)	2003-06-12
HRP940432A2 (en)	1997-08-31
PT704527E (pt)	2003-09-30
EP0704527B1 (de)	2003-05-07
ES2198428T3 (es)	2004-02-01
CN1126761A (zh)	1996-07-17
SK97195A3 (en)	1996-02-07
SI9500250A (en)	1996-02-29
CZ199995A3 (en)	1996-02-14
EP0704527A3 (de)	1997-08-27
CA2155451A1 (en)	1996-02-06
ATE239791T1 (de)	2003-05-15
EP0704527A2 (de)	1996-04-03
BG62336B1 (bg)	1999-08-31
DE69530647T2 (de)	2004-03-11
BG99844A (bg)	1996-02-28
PL309882A1 (en)	1996-02-19

Legal Events

Date	Code	Title	Description
1997-08-31	A1OB	Publication of a patent application
1997-10-23	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2003-10-31	B1PR	Patent granted
2013-07-29	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20130729 Year of fee payment: 20
2014-08-06	PB20	Patent expired after termination of 20 years	Effective date: 20140815

Publication	Publication Date	Title
EG19101A (en)	1994-09-29	Process for preparing of expression of human proapolipoprotein A.1.
AU704515C (en)	2002-03-28	Novel protein and process for producing the same
HU902697D0 (en)	1990-09-28	Process for the enzymatic removal of the n-terminal sequence of proteins
CA2223433A1 (en)	1996-12-19	Ob protein compositions and methods
EP1197220A3 (de)	2009-04-15	Therapeutische Verfahren und Zusammensetzungen auf Basis von Delta-Proteinen und Nukleinsäuren
HUT46061A (en)	1988-09-28	Dna sequences encoding hirudin-like protein and process for producing such proteins
IL148942A (en)	2010-02-17	Pre-insulin with C-peptide modified for improved insulin production and insulin analogues
WO1996011949A3 (en)	1996-12-12	Analogs of keratinocyte growth factor
AU3498189A (en)	1989-11-23	Fibronectin binding protein
NZ211827A (en)	1988-07-28	Production of polypeptides having interferon activity, polypeptide compositions and dna
FI20075338A7 (fi)	2007-05-10	gp350/220:n ei silmukoivia muutoksia
EP1396542A3 (de)	2004-05-06	P- Selectin Ligandenprotein
HRP940432B1 (en)	2003-10-31	Dna sequences encoding biosynthetic insulin precursors and process for preparation of insulin
WO1997011179A3 (de)	1997-05-09	VARIANTEN DES HUMANEN REKOMBINANTEN INTERFERON-η (RHU-IFN-η) MIT ERHÖHTER THERMISCHER STABILITÄT
AU2795989A (en)	1989-06-14	Production of gonorrheal pi proteins and vaccines
WO1995030001A3 (en)	1996-01-11	Novel p-selectin ligand protein
WO2001096527A3 (en)	2002-05-02	Peptides with physiological activity
HUT52551A (en)	1990-07-28	Process for production of neutrophil-activizating factor
EP0255233A3 (de)	1988-11-02	Produktion von menschlichem Lysozym
ES2088911T3 (es)	1996-10-01	Gen de la proteasa i de achromobacter y el producto de este gen.
AU7430500A (en)	2001-04-10	Monomeric analogues of human insulin
EP0238275A3 (en)	1989-05-10	Recombinant product
DE3767629D1 (de)	1991-02-28	Menschlicher b-zellen-differenzierungsfaktor und verfahren zu dessen herstellung.
ATE224403T1 (de)	2002-10-15	Verwendung von kaseinfragmenten als wachstumerförderer
CA2089111A1 (en)	1993-08-11	Smooth muscle mitogen and isolated dna coding therefor