ATE241641T1 - Betulinsäure derivate zur behandlung von neuroektodermalen tumoren - Google Patents

Betulinsäure derivate zur behandlung von neuroektodermalen tumoren

Info

Publication number: ATE241641T1
Authority: AT; Austria
Prior art keywords: treatment; betulinic acid; tumors; neuroectdermal; acid derivatives
Prior art date: 1998-10-28

Application number

AT99955899T

Other languages

English (en)

Inventor

Klaus Michael Debatin

Simone Fulda

Manfred Wiessler

Marek Los

Walter Mier

Original Assignee

Deutsches Krebsforsch

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-28

Filing date

1999-10-28

Publication date

2003-06-15

1999-10-28 Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE241641T1 publication Critical patent/ATE241641T1/de

Links

QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 title abstract 4
206010028980 Neoplasm Diseases 0.000 title 1
208000009277 Neuroectodermal Tumors Diseases 0.000 abstract 4
QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 abstract 3
CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 abstract 3
DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 abstract 3
PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 abstract 3
MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 abstract 3
239000003795 chemical substances by application Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000973 chemotherapeutic effect Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

AT99955899T 1998-10-28 1999-10-28 Betulinsäure derivate zur behandlung von neuroektodermalen tumoren ATE241641T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/182,588 US6369109B1 (en)	1998-10-28	1998-10-28	Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor
PCT/EP1999/008196 WO2000024762A1 (en)	1998-10-28	1999-10-28	Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumors

Publications (1)

Publication Number	Publication Date
ATE241641T1 true ATE241641T1 (de)	2003-06-15

Family

ID=22669114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99955899T ATE241641T1 (de)	1998-10-28	1999-10-28	Betulinsäure derivate zur behandlung von neuroektodermalen tumoren

Country Status (9)

Country	Link
US (1)	US6369109B1 (de)
EP (1)	EP1124842B1 (de)
AT (1)	ATE241641T1 (de)
AU (1)	AU1266900A (de)
DE (1)	DE69908397T2 (de)
DK (1)	DK1124842T3 (de)
ES (1)	ES2201800T3 (de)
PT (1)	PT1124842E (de)
WO (1)	WO2000024762A1 (de)

Families Citing this family (31)

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GB0012528D0 (en)	2000-05-23	2000-07-12	Univ Palackeho	Triterpenoid derivatives
EP1292562A1 (de) *	2000-05-23	2003-03-19	Univerzita palackeho V Olomouci	Triterpenen derivaten
GB2362649A (en) *	2000-05-25	2001-11-28	Univerzita Palackeho V Olomouc	Triterpenoid derivatives
US6689767B2 (en)	2000-09-29	2004-02-10	Regents Of The University Of Minnesota	Triterpenes having antibacterial activity
AU2001294953A1 (en)	2000-09-29	2002-04-08	Regents Of The University Of Minnesota	Triterpenes having fungicidal activity against yeast
US6951847B2 (en)	2000-09-29	2005-10-04	Regents Of The University Of Minnesota	Methods of treating fungal infections using lupeol
EP2567625A1 (de) *	2001-05-11	2013-03-13	University Of Ottawa	Präparat enthaltend Betulinsäure, das von einer Pflanze der Familie Marcgraviaceae erhalten wurde
JPWO2003057224A1 (ja) *	2001-12-28	2005-08-25	日清オイリオグループ株式会社	アポトーシス誘導剤
US7041309B2 (en) *	2002-06-13	2006-05-09	Neuropro Technologies, Inc.	Spinal fusion using an HMG-CoA reductase inhibitor
CN100432094C (zh)	2003-02-11	2008-11-12	诺瓦利克斯制药公司	抑制肿瘤生长的药物
US7026305B2 (en) *	2003-04-14	2006-04-11	Meharry Medical College	Anti-HIV agents with dual sites of action
WO2005112929A2 (en) *	2004-05-20	2005-12-01	Cornell Research Foundation, Inc.	Anti-hiv-1 activity of betulinol derivatives
US7282521B2 (en) *	2004-05-24	2007-10-16	University Of North Carolina At Chapel Hill	Anti-retroviral moronic acid derivatives
CA2595749A1 (en) *	2005-01-27	2006-08-03	Research Development Foundation	Combination therapy with triterpenoid compounds and proteasome inhibitors
US20070232577A1 (en) *	2006-03-23	2007-10-04	Advanced Life Sciences, Inc.	Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
CA2586614A1 (en) *	2006-10-27	2008-04-27	Universite Du Quebec A Chicoutimi	Triterpenes derivatives and uses thereof as antitumor agents or anti-inflammatory agents
RU2317996C1 (ru) *	2006-10-30	2008-02-27	Институт нефтехимии и катализа РАН	N'-{n-[3-оксо-лупан-28-оил]-9-аминононаноил}-3-амино-3-фенил-пропионовая кислота и ее соли как противовирусные и иммуностимулирующие агенты
CZ200851A3 (cs) *	2008-01-30	2009-10-21	Institut Of Organic Chemistry, Polish Academy Of Sciences	Sacharidové deriváty lupanu, jejich použití a farmaceutické prípravky obsahující tyto deriváty
US8034770B2 (en)	2008-06-04	2011-10-11	Amgen Inc.	FGF21 polypeptides comprising two or more mutations
US20110224159A1 (en) *	2008-09-10	2011-09-15	Universite du Quebec a Chicoutime	Bidesmosidic betulin and betulinic acid derivatives and uses thereof as antitumor agents
WO2010053817A1 (en) *	2008-11-04	2010-05-14	Trustees Of Dartmouth College	Betulinic acid derivatives and methods of use thereof
CZ301318B6 (cs) *	2008-11-13	2010-01-13	Univerzita Palackého v Olomouci	2-Deoxyglykosidy triterpenoidu, zpusob jejich prípravy a jejich použití jako lécivo
WO2011077253A2 (en) *	2009-12-23	2011-06-30	Marvel World Trade Ltd	Start-up supply
KR101909696B1 (ko)	2011-05-16	2018-12-19	마벨 월드 트레이드 리미티드	고전압 스타트업 회로
US8742735B2 (en)	2011-05-16	2014-06-03	Marvell World Trade Ltd.	High-voltage startup circuit
RU2468031C1 (ru) *	2011-11-02	2012-11-27	Учреждение Российской академии наук Институт химии и химической технологии Сибирского отделения РАН (ИХХТ СО РАН)	Способ получения 3,28-дисульфата бетулина
RU2477285C1 (ru) *	2012-03-23	2013-03-10	Федеральное Государственное Бюджетное Учреждение Науки Институт Химии И Химической Технологии Сибирского Отделения Российской Академии Наук (Иххт Со Ран)	Способ получения 3-ацетата-28-сульфата бетулина
CN103768078B (zh)	2012-10-22	2019-02-05	北京大学	三萜衍生物及其抗流感用途
CN104910239B (zh) *	2014-03-14	2018-12-07	中国科学院上海药物研究所	五环三萜类化合物及其制备方法、药物组合物和用途
CN114133424B (zh) *	2020-09-03	2023-07-18	沈阳药科大学	三萜类化合物及其制备方法和应用
EP4472994A4 (de) *	2022-02-02	2026-04-08	Sang Hyun Pyo	Neue betulinderivate, verfahren zu ihrer herstellung und ihre verwendung als tensid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5869535A (en)	1995-03-21	1999-02-09	The Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma
US5962527A (en) *	1995-03-21	1999-10-05	The Board Of Trustees Of The University Of Illinois	Method and composition for treating cancers
US5658947A (en)	1995-03-21	1997-08-19	Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma using betalinic acid
KR100205045B1 (ko)	1996-12-05	1999-06-15	김송배	신규한 트리테르펜 글리코사이드 화합물, 그의 제조방법 및 그를 함유하는 항암제 조성물

1998
- 1998-10-28 US US09/182,588 patent/US6369109B1/en not_active Expired - Lifetime
1999
- 1999-10-28 DE DE69908397T patent/DE69908397T2/de not_active Expired - Lifetime
- 1999-10-28 AT AT99955899T patent/ATE241641T1/de not_active IP Right Cessation
- 1999-10-28 PT PT99955899T patent/PT1124842E/pt unknown
- 1999-10-28 DK DK99955899T patent/DK1124842T3/da active
- 1999-10-28 AU AU12669/00A patent/AU1266900A/en not_active Abandoned
- 1999-10-28 ES ES99955899T patent/ES2201800T3/es not_active Expired - Lifetime
- 1999-10-28 WO PCT/EP1999/008196 patent/WO2000024762A1/en not_active Ceased
- 1999-10-28 EP EP99955899A patent/EP1124842B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1124842A1 (de)	2001-08-22
WO2000024762A1 (en)	2000-05-04
DE69908397T2 (de)	2004-04-01
DK1124842T3 (da)	2003-09-22
AU1266900A (en)	2000-05-15
DE69908397D1 (de)	2003-07-03
EP1124842B1 (de)	2003-05-28
US6369109B1 (en)	2002-04-09
PT1124842E (pt)	2003-10-31
ES2201800T3 (es)	2004-03-16

Legal Events

Date

Code

Title

Description

2004-03-15

UEP

Publication of translation of european patent specification

Ref document number: 1124842

Country of ref document: EP

2006-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE241641T1 (de)	2003-06-15	Betulinsäure derivate zur behandlung von neuroektodermalen tumoren
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