PT1124842E - Acido betulinico e seus derivados uteis para o tratamento de tumores neuroectodermicos - Google Patents

Acido betulinico e seus derivados uteis para o tratamento de tumores neuroectodermicos

Info

Publication number: PT1124842E
Authority: PT; Portugal
Prior art keywords: derivatives; treatment; betulinic acid; user; tumors
Prior art date: 1998-10-28

Application number

PT99955899T

Other languages

English (en)

Inventor

Klaus Michael Debatin

Simone Fulda

Manfred Wiessler

Marek Los

Walter Mier

Original Assignee

Deutsches Krebsforsch

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-28

Filing date

1999-10-28

Publication date

2003-10-31

1999-10-28 Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch

2003-10-31 Publication of PT1124842E publication Critical patent/PT1124842E/pt

Links

QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 title abstract 4
CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 title abstract 4
DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 title abstract 4
QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 title abstract 4
PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 title abstract 4
MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 title abstract 4
206010028980 Neoplasm Diseases 0.000 title 1
208000009277 Neuroectodermal Tumors Diseases 0.000 abstract 4
239000003795 chemical substances by application Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000973 chemotherapeutic effect Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

PT99955899T 1998-10-28 1999-10-28 Acido betulinico e seus derivados uteis para o tratamento de tumores neuroectodermicos PT1124842E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/182,588 US6369109B1 (en)	1998-10-28	1998-10-28	Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor

Publications (1)

Publication Number	Publication Date
PT1124842E true PT1124842E (pt)	2003-10-31

Family

ID=22669114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99955899T PT1124842E (pt)	1998-10-28	1999-10-28	Acido betulinico e seus derivados uteis para o tratamento de tumores neuroectodermicos

Country Status (9)

Country	Link
US (1)	US6369109B1 (pt)
EP (1)	EP1124842B1 (pt)
AT (1)	ATE241641T1 (pt)
AU (1)	AU1266900A (pt)
DE (1)	DE69908397T2 (pt)
DK (1)	DK1124842T3 (pt)
ES (1)	ES2201800T3 (pt)
PT (1)	PT1124842E (pt)
WO (1)	WO2000024762A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0012528D0 (en)	2000-05-23	2000-07-12	Univ Palackeho	Triterpenoid derivatives
EP1292562A1 (en) *	2000-05-23	2003-03-19	Univerzita palackeho V Olomouci	Triterpenoid derivatives
GB2362649A (en) *	2000-05-25	2001-11-28	Univerzita Palackeho V Olomouc	Triterpenoid derivatives
AU2001294959A1 (en) *	2000-09-29	2002-04-08	Robert M. Carlson	Triterpenes having antibacterial activity
US6951847B2 (en)	2000-09-29	2005-10-04	Regents Of The University Of Minnesota	Methods of treating fungal infections using lupeol
JP2004509972A (ja)	2000-09-29	2004-04-02	リージェンツ　オブ　ザ　ユニバーシティ　オブ　ミネソタ	酵母に対する殺真菌活性を有するトリテルペン
WO2002091858A1 (en) *	2001-05-11	2002-11-21	University Of Ottawa	Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods
JPWO2003057224A1 (ja) *	2001-12-28	2005-08-25	日清オイリオグループ株式会社	アポトーシス誘導剤
US7041309B2 (en) *	2002-06-13	2006-05-09	Neuropro Technologies, Inc.	Spinal fusion using an HMG-CoA reductase inhibitor
EP1594885B8 (de)	2003-02-11	2009-03-25	Novelix Pharmaceuticals, Inc.	Medikament zur wachstumsinhibierung von tumoren
US7026305B2 (en) *	2003-04-14	2006-04-11	Meharry Medical College	Anti-HIV agents with dual sites of action
US20060019934A1 (en) *	2004-05-20	2006-01-26	Saxena Brij B	Anti-HIV-1 activity of betulinol derivatives
US7282521B2 (en) *	2004-05-24	2007-10-16	University Of North Carolina At Chapel Hill	Anti-retroviral moronic acid derivatives
CA2595749A1 (en) *	2005-01-27	2006-08-03	Research Development Foundation	Combination therapy with triterpenoid compounds and proteasome inhibitors
US20070232577A1 (en) *	2006-03-23	2007-10-04	Advanced Life Sciences, Inc.	Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
CA2586614A1 (en) *	2006-10-27	2008-04-27	Universite Du Quebec A Chicoutimi	Triterpenes derivatives and uses thereof as antitumor agents or anti-inflammatory agents
RU2317996C1 (ru) *	2006-10-30	2008-02-27	Институт нефтехимии и катализа РАН	N'-{n-[3-оксо-лупан-28-оил]-9-аминононаноил}-3-амино-3-фенил-пропионовая кислота и ее соли как противовирусные и иммуностимулирующие агенты
CZ200851A3 (cs) *	2008-01-30	2009-10-21	Institut Of Organic Chemistry, Polish Academy Of Sciences	Sacharidové deriváty lupanu, jejich použití a farmaceutické prípravky obsahující tyto deriváty
MX2010013333A (es)	2008-06-04	2011-04-05	Amgen Inc	Mutantes fgf21 y usos de los mismos.
US20110224159A1 (en) *	2008-09-10	2011-09-15	Universite du Quebec a Chicoutime	Bidesmosidic betulin and betulinic acid derivatives and uses thereof as antitumor agents
WO2010053817A1 (en) *	2008-11-04	2010-05-14	Trustees Of Dartmouth College	Betulinic acid derivatives and methods of use thereof
CZ301318B6 (cs) *	2008-11-13	2010-01-13	Univerzita Palackého v Olomouci	2-Deoxyglykosidy triterpenoidu, zpusob jejich prípravy a jejich použití jako lécivo
EP2517341B1 (en) *	2009-12-23	2019-06-26	Marvell World Trade Ltd.	Start-up supply for a switch mode power supply
CN103534915B (zh)	2011-05-16	2016-08-17	马维尔国际贸易有限公司	高压启动电路
US8742735B2 (en)	2011-05-16	2014-06-03	Marvell World Trade Ltd.	High-voltage startup circuit
RU2468031C1 (ru) *	2011-11-02	2012-11-27	Учреждение Российской академии наук Институт химии и химической технологии Сибирского отделения РАН (ИХХТ СО РАН)	Способ получения 3,28-дисульфата бетулина
RU2477285C1 (ru) *	2012-03-23	2013-03-10	Федеральное Государственное Бюджетное Учреждение Науки Институт Химии И Химической Технологии Сибирского Отделения Российской Академии Наук (Иххт Со Ран)	Способ получения 3-ацетата-28-сульфата бетулина
CN103768078B (zh)	2012-10-22	2019-02-05	北京大学	三萜衍生物及其抗流感用途
CN104910239B (zh) *	2014-03-14	2018-12-07	中国科学院上海药物研究所	五环三萜类化合物及其制备方法、药物组合物和用途
CN114133424B (zh) *	2020-09-03	2023-07-18	沈阳药科大学	三萜类化合物及其制备方法和应用
WO2023149727A1 (en) *	2022-02-02	2023-08-10	Sang Hyun Pyo	Novel betulin derivatives, and their manufacturing method and use as surfactant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5658947A (en)	1995-03-21	1997-08-19	Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma using betalinic acid
US5869535A (en)	1995-03-21	1999-02-09	The Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma
US5962527A (en) *	1995-03-21	1999-10-05	The Board Of Trustees Of The University Of Illinois	Method and composition for treating cancers
KR100205045B1 (ko)	1996-12-05	1999-06-15	김송배	신규한 트리테르펜 글리코사이드 화합물, 그의 제조방법 및 그를 함유하는 항암제 조성물

1998
- 1998-10-28 US US09/182,588 patent/US6369109B1/en not_active Expired - Lifetime
1999
- 1999-10-28 AT AT99955899T patent/ATE241641T1/de not_active IP Right Cessation
- 1999-10-28 DK DK99955899T patent/DK1124842T3/da active
- 1999-10-28 ES ES99955899T patent/ES2201800T3/es not_active Expired - Lifetime
- 1999-10-28 WO PCT/EP1999/008196 patent/WO2000024762A1/en not_active Ceased
- 1999-10-28 DE DE69908397T patent/DE69908397T2/de not_active Expired - Lifetime
- 1999-10-28 EP EP99955899A patent/EP1124842B1/en not_active Expired - Lifetime
- 1999-10-28 PT PT99955899T patent/PT1124842E/pt unknown
- 1999-10-28 AU AU12669/00A patent/AU1266900A/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2201800T3 (es)	2004-03-16
AU1266900A (en)	2000-05-15
US6369109B1 (en)	2002-04-09
DK1124842T3 (da)	2003-09-22
EP1124842B1 (en)	2003-05-28
WO2000024762A1 (en)	2000-05-04
DE69908397D1 (de)	2003-07-03
DE69908397T2 (de)	2004-04-01
EP1124842A1 (en)	2001-08-22
ATE241641T1 (de)	2003-06-15

Publication	Publication Date	Title
DK1124842T3 (da)	2003-09-22	Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer
PT896533E (pt)	2004-02-27	Pentafluorobenzenosulfonamidas e analogos
DE60118003D1 (de)	2006-05-11	Harnstoffderivate und ihre verwendung
CA2293382A1 (en)	1998-12-17	Piperazine derivatives and their use as anti-inflammatory agents
ATE249214T1 (de)	2003-09-15	Pentafluorobenzensulfonamide und analoge
ATE297203T1 (de)	2005-06-15	Antithrombotische mitteln
ATE306261T1 (de)	2005-10-15	Antithrombosemittel
HK1056181A1 (zh)	2004-02-06	作為抗炎劑的17β-硫代羧酸酯17α-芳基羰氧基氧雄甾烷衍生物
TR200100410T2 (tr)	2001-06-21	2-(purin-9-il)-tetrahidrofuran-3,4-diol türevleri.
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
ES2150808T3 (es)	2000-12-01	Forma cristalina de (4-trifluorometil)-anilida de acido 5-metilisoxazol-4-carboxilico.
EE03526B1 (et)	2001-10-15	Leukotrieen-antagonistliku toimega bensopüraanderivaadid, nende valmistamismeetod ja kasutamine
SE9804212D0 (sv)	1998-12-04	Compounds
AU4179399A (en)	1999-11-16	Use of nmda antagonists and/or sodium channel antagonists for the treatment of inflammatory disorders
UY26426A1 (es)	2001-05-31	Nuevos compuestos
ATE266029T1 (de)	2004-05-15	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
DE69911017D1 (en)	2003-10-09	Arylsulfonanilid-phosphate
IT1307786B1 (it)	2001-11-19	Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali.
IT1289154B1 (it)	1998-09-29	Derivati di isoflavone loro preparazione e loro impiego terapeutico
NO996128L (no)	1999-12-10	Nye pentaerytrittderivater, deres fremstilling og anvendelse så vel som mellomprodukter for deres syntese
TR200101729T2 (tr)	2001-10-22	IL-5 engelleyici 6-azaurasil türevleri
BG105178A (bg)	2001-12-29	Нови 2,3,3а,4,9,9а-хексахидро-8-хидрокси-1н-бенз/f/индоли, метод за получаването им и приложението им като лекарствени средства
EE200200302A (et)	2003-06-16	Küllastumata 14,15-tsüklopropanoandrostaanid, nende valmistamise meetod ja neid ühendeid sisaldavadfarmatseutilised kompositsioonid
MY128457A (en)	2007-02-28	2-aminocarbonyl-9h-purine derivatives
ATE268768T1 (de)	2004-06-15	Antithrombosemittel