ATE246496T1 - Spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneiformen - Google Patents

Spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneiformen

Info

Publication number
ATE246496T1
ATE246496T1 AT98954683T AT98954683T ATE246496T1 AT E246496 T1 ATE246496 T1 AT E246496T1 AT 98954683 T AT98954683 T AT 98954683T AT 98954683 T AT98954683 T AT 98954683T AT E246496 T1 ATE246496 T1 AT E246496T1
Authority
AT
Austria
Prior art keywords
spheroids
production
forms containing
containing same
medicinal forms
Prior art date
Application number
AT98954683T
Other languages
English (en)
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Original Assignee
Ethypharm Lab Prod Ethiques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Lab Prod Ethiques filed Critical Ethypharm Lab Prod Ethiques
Application granted granted Critical
Publication of ATE246496T1 publication Critical patent/ATE246496T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98954683T 1997-11-21 1998-11-19 Spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneiformen ATE246496T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9714631A FR2771291B1 (fr) 1997-11-21 1997-11-21 Spheroides, procede de preparation et compositions pharmaceutiques
PCT/IB1998/001911 WO1999026608A1 (fr) 1997-11-21 1998-11-19 Spheroides, procede de preparation et compositions pharmaceutiques

Publications (1)

Publication Number Publication Date
ATE246496T1 true ATE246496T1 (de) 2003-08-15

Family

ID=9513635

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98954683T ATE246496T1 (de) 1997-11-21 1998-11-19 Spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneiformen

Country Status (29)

Country Link
US (1) US6077544A (de)
EP (1) EP1032374B1 (de)
JP (1) JP2001523706A (de)
KR (1) KR100502938B1 (de)
CN (1) CN1223341C (de)
AT (1) ATE246496T1 (de)
AU (1) AU744580B2 (de)
BG (1) BG65117B1 (de)
BR (1) BR9814672A (de)
CA (1) CA2310147C (de)
CZ (1) CZ299110B6 (de)
DE (1) DE69817010T2 (de)
DK (1) DK1032374T3 (de)
EA (1) EA003324B1 (de)
ES (1) ES2203989T3 (de)
FR (1) FR2771291B1 (de)
HR (1) HRP20000323B1 (de)
HU (1) HU230053B1 (de)
IL (2) IL136215A0 (de)
MX (1) MXPA00004959A (de)
NO (1) NO329728B1 (de)
NZ (1) NZ504662A (de)
PL (1) PL193878B1 (de)
PT (1) PT1032374E (de)
SK (1) SK284493B6 (de)
TR (1) TR200002130T2 (de)
WO (1) WO1999026608A1 (de)
YU (1) YU31000A (de)
ZA (1) ZA9810631B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
BR0009557A (pt) 1999-04-06 2002-05-28 Ethypharm Lab Prod Ethiques Suspensão farmacêutica para beber de ibuprofeno
FR2794646B1 (fr) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques Microgranules de sulfate de morphine, procede de preparation et composition les contenant
WO2003000625A2 (en) 2001-06-22 2003-01-03 Genencor International, Inc. Highly impact-resistant granules
AR034813A1 (es) † 2001-07-20 2004-03-17 Novartis Ag Composiciones farmaceuticas y uso de las mismas
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
FR2837100B1 (fr) 2002-03-18 2004-07-23 Flamel Tech Sa Comprimes a bases de microcapsules a liberation modifiee
MXPA04009968A (es) 2002-04-09 2004-12-13 Flamel Tech Sa Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s).
DE60323474D1 (de) * 2002-04-09 2008-10-23 Flamel Tech Sa Orale pharmazeutische formulierung in form einer wässrigen suspension von mikrokapseln zur modifizierten freisetzung von amoxicillin
FR2838647B1 (fr) * 2002-04-23 2006-02-17 Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
FR2845289B1 (fr) 2002-10-04 2004-12-03 Ethypharm Sa Spheroides, procede de preparation et compositions pharmaceutiques.
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
NZ523946A (en) * 2003-01-31 2004-06-25 Carl Ernest Alexander Portable hygiene compositions comprising a semi-solid gel and active ingredients in bead form for use in personal oral, dental or skin care
ES2221804B1 (es) * 2003-06-18 2006-04-01 Lipofoods, S.L. Microcapsulas para la administracion de ingredientes activos.
JP5171038B2 (ja) * 2003-10-10 2013-03-27 エティファルム イチョウ・エキスを含む放出持続性の微小顆粒およびそのような顆粒の製造方法
FR2861990B1 (fr) 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
RU2253464C1 (ru) * 2004-02-25 2005-06-10 Алтарёв Сергей Николаевич Способ получения термолабильных галеновых препаратов в процессе квазикавитации и низкотемпературного растворения
EP1737433B1 (de) * 2004-04-12 2007-11-14 Pfizer Products Incorporated Arzneiimittel mit verdecktem geschmack in aufbrechenden multipartikeln
EP1753405A4 (de) * 2004-06-10 2008-09-17 Glatt Air Tech Inc Pharmazeutische formulierung mit kontrollierter freisetzung
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
EP2091519B1 (de) * 2006-11-30 2015-06-24 Bend Research, Inc Multiteilchen eines spray-überzogenen arzneimittels und polymer auf einem schmelzbaren kern
US11116728B2 (en) 2006-11-30 2021-09-14 Bend Research, Inc. Multiparticulates of spray-coated drug and polymer on a meltable core
EP2468263A1 (de) 2010-12-23 2012-06-27 Laboratorios Del. Dr. Esteve, S.A. Komprimierte feste Darreichungsformen
US11370015B2 (en) 2018-05-11 2022-06-28 Stolle Machinery Company, Llc Drive assembly
CN112105571B (zh) 2018-05-11 2022-04-19 斯多里机械有限责任公司 馈入组件的快速更换特征结构
WO2019217667A1 (en) 2018-05-11 2019-11-14 Stolle Machinery Company, Llc Quick change tooling assembly
JP7312196B2 (ja) 2018-05-11 2023-07-20 ストール マシーナリ カンパニー，エルエルシー 回転マニホールド
CN112105572B (zh) 2018-05-11 2022-11-01 斯多里机械有限责任公司 处理轴工具组件
US11534817B2 (en) 2018-05-11 2022-12-27 Stolle Machinery Company, Llc Infeed assembly full inspection assembly
WO2019217614A1 (en) 2018-05-11 2019-11-14 Stolle Machinery Company, Llc Quick change transfer assembly
US11420242B2 (en) 2019-08-16 2022-08-23 Stolle Machinery Company, Llc Reformer assembly

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684516A (en) * 1983-08-01 1987-08-04 Alra Laboratories, Inc. Sustained release tablets and method of making same
NZ230763A (en) * 1988-09-27 1991-10-25 Takeda Chemical Industries Ltd Production of granules having a core by spraying the cores with a dispersion of hydroxypropylcellulose, optionally incorporating an active ingredient
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
JP2572673B2 (ja) * 1990-07-25 1997-01-16 エスエス製薬株式会社 徐放性錠剤
FR2679451B1 (fr) * 1991-07-22 1994-09-09 Prographarm Laboratoires Comprime multiparticulaire a delitement rapide.
GB9117361D0 (en) * 1991-08-12 1991-09-25 Euro Celtique Sa Oral dosage form
FR2692146B1 (fr) * 1992-06-16 1995-06-02 Ethypharm Sa Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention.
CN1071570C (zh) * 1993-06-14 2001-09-26 詹森药业有限公司 阿司咪唑和假麻黄碱的缓释薄膜包衣片
SE9402422D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New beads for controlled release and a pharmaceutical preparation containing the same
SE9600070D0 (sv) * 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
FR2771292B1 (fr) * 1997-11-21 2000-02-18 Ethypharm Lab Prod Ethiques Spheroides contenant de la tiagabine, procede de preparation et compositions pharmaceutiques

Also Published As

Publication number Publication date
CN1223341C (zh) 2005-10-19
NO329728B1 (no) 2010-12-06
AU1170499A (en) 1999-06-15
IL136215A (en) 2006-12-31
JP2001523706A (ja) 2001-11-27
CZ20001849A3 (cs) 2000-10-11
BR9814672A (pt) 2000-10-03
EA003324B1 (ru) 2003-04-24
CA2310147C (fr) 2010-05-25
US6077544A (en) 2000-06-20
HRP20000323A2 (en) 2001-06-30
KR100502938B1 (ko) 2005-07-25
FR2771291B1 (fr) 2000-02-25
ZA9810631B (en) 1999-05-24
EP1032374A1 (de) 2000-09-06
SK284493B6 (sk) 2005-05-05
YU31000A (sh) 2002-11-15
WO1999026608A1 (fr) 1999-06-03
CA2310147A1 (fr) 1999-06-03
CN1282239A (zh) 2001-01-31
ES2203989T3 (es) 2004-04-16
HRP20000323B1 (en) 2006-07-31
AU744580B2 (en) 2002-02-28
DK1032374T3 (da) 2003-11-24
HUP0100562A2 (hu) 2002-05-29
DE69817010T2 (de) 2004-05-27
FR2771291A1 (fr) 1999-05-28
HU230053B1 (hu) 2015-06-29
CZ299110B6 (cs) 2008-04-23
BG104511A (en) 2001-04-30
TR200002130T2 (tr) 2000-12-21
KR20010032329A (ko) 2001-04-16
NO20002605L (no) 2000-07-05
DE69817010D1 (de) 2003-09-11
EP1032374B1 (de) 2003-08-06
NZ504662A (en) 2002-09-27
SK7562000A3 (en) 2001-06-11
PL340659A1 (en) 2001-02-12
NO20002605D0 (no) 2000-05-19
PL193878B1 (pl) 2007-03-30
MXPA00004959A (es) 2002-10-17
HUP0100562A3 (en) 2002-08-28
PT1032374E (pt) 2003-12-31
IL136215A0 (en) 2001-05-20
BG65117B1 (bg) 2007-03-30
EA200000548A1 (ru) 2000-12-25

Similar Documents

Publication Publication Date Title
DE69817010D1 (de) Spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneiformen
ATE217525T1 (de) Tiagabin enthaltende spheroide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
ATE252080T1 (de) Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel
DE69634806D1 (de) Substituierte heterocyclische Verbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
ATE235507T1 (de) Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
ATE215951T1 (de) Tetracyclische campothecineanalogue, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen
ATE152448T1 (de) Heterozyklische alkylamide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ATE237610T1 (de) Substituierte dimere carboxamid-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
DE3766299D1 (de) 4-chinolon-3-carbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
AU7775398A (en) Novel glycosylated ginkgolide derivatives, their application as medicines and pharmaceutical compositions
DE3781627D1 (de) Indanderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, diese enthaltende pharmazeutische zusammensetzungen und erhaltene zwischenprodukte.
DK0557389T3 (da) Fremgangsmåde til fremstilling af tabletter indeholdende cephalosporansyrederivater ved direkte komprimering
DE60003662D1 (de) Pyridothienodiazepine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ATE294181T1 (de) (3,4-a:3,4-c)carbazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
MY115795A (en) Substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them
DE69804766D1 (de) Isoflavonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
PL338294A1 (en) Derivatives of streptogramins, method of obtaining them and compositions containing such derivatives
DE3850044D1 (de) Azelastin-Embonat, Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen, die als Wirkstoff Azelastin-Embonat enthalten.
DE59504643D1 (de) Neue phosphanoxide, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
DK0612763T3 (da) Cykliske angiopeptinderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
DE3880231D1 (de) Pyrazinoxid-verbindung aus nf-1616-904, diese enthaltende arzneimittelzubereitung und verfahren zu ihrer herstellung.
ATE484516T1 (de) 3.beta.,28-diacetoxy-18-oxo-19,20,21,29,30- pentanorlupan-22-säure solvate, verfahren zu ihrer herstellung und pharmazeutische präparate daraus
DE3575430D1 (de) Neue nb-quartaere dibromderivate von ajmalin, isoajmalin, sandwicin und isosandwicin sowie diese derivate enthaltende pharmazeutische zubereitungen und zwischenprodukte und verfahren zu ihrer herstellung.
ATE80393T1 (de) Indanderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, diese enthaltende pharmazeutische zusammensetzungen und erhaltene zwischenprodukte.
ATE93858T1 (de) Condensierte pyrimidinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1032374

Country of ref document: EP