ATE249420T1 - Herstellung von iodixanol - Google Patents

Herstellung von iodixanol

Info

Publication number: ATE249420T1
Authority: AT; Austria
Prior art keywords: iodixanol; production; dimerisation; compound; triiodo
Prior art date: 1999-02-11

Application number

AT00902754T

Other languages

English (en)

Inventor

Ole Magne Homestad

Original Assignee

Amersham Health As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-11

Filing date

2000-02-10

Publication date

2003-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE249420(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-02-10 Application filed by Amersham Health As filed Critical Amersham Health As

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE249420T1 publication Critical patent/ATE249420T1/de

Links

NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 title abstract 3
229960004359 iodixanol Drugs 0.000 title abstract 3
229940126062 Compound A Drugs 0.000 abstract 2
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
BHCBLTRDEYPMFZ-UHFFFAOYSA-N 5-acetamido-1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound CC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I BHCBLTRDEYPMFZ-UHFFFAOYSA-N 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Compounds Of Unknown Constitution (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT00902754T 1999-02-11 2000-02-10 Herstellung von iodixanol ATE249420T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9903109.8A GB9903109D0 (en)	1999-02-11	1999-02-11	Process
PCT/GB2000/000413 WO2000047549A1 (en)	1999-02-11	2000-02-10	Preparation of iodixanol

Publications (1)

Publication Number	Publication Date
ATE249420T1 true ATE249420T1 (de)	2003-09-15

Family

ID=10847565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00902754T ATE249420T1 (de)	1999-02-11	2000-02-10	Herstellung von iodixanol

Country Status (18)

Country	Link
US (8)	US6974882B2 (de)
EP (1)	EP1150943B1 (de)
JP (1)	JP4545945B2 (de)
KR (1)	KR100625139B1 (de)
CN (1)	CN1178899C (de)
AT (1)	ATE249420T1 (de)
AU (1)	AU2449500A (de)
CA (1)	CA2356942C (de)
CZ (1)	CZ296353B6 (de)
DE (1)	DE60005143T2 (de)
ES (1)	ES2206190T3 (de)
GB (1)	GB9903109D0 (de)
HU (1)	HU228226B1 (de)
IL (1)	IL143969A0 (de)
NO (1)	NO329363B1 (de)
PL (1)	PL197893B1 (de)
PT (1)	PT1150943E (de)
WO (1)	WO2000047549A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100574087B1 (ko)	2004-09-09	2006-04-27	주식회사태준제약	아이오디사놀의 제조방법
KR100700701B1 (ko) *	2004-10-28	2007-03-28	동국정밀화학(주)	이오딕사놀의 제조방법
NO20053687D0 (no) *	2005-07-29	2005-07-29	Amersham Health As	Crystallisation Process.
NO20055702D0 (no) *	2005-12-02	2005-12-02	Amersham Health As	Contrast agents
US20070148096A1 (en) *	2005-12-15	2007-06-28	Lars-Goran Wistrand	Contrast Agents
EP1966110B1 (de)	2005-12-19	2013-04-24	Ge Healthcare As	Verfahren zur aufreinigung von iodixanol
CN101195587B (zh) *	2006-12-19	2010-07-21	浙江尖峰海洲制药有限公司	一种碘克沙醇水解物的制备方法
CN101293855B (zh) *	2007-04-27	2012-08-29	上海冠杰生物医药科技有限公司	一种碘克沙醇的纯化方法
BRPI0814811A2 (pt) *	2007-07-12	2015-02-03	Ge Healthcare As	Composto, agente, método, e composição de diagnóstico, uso de um composto, e, método de formação de imagem
ES2650800T5 (en)	2007-07-19	2025-05-05	Medical Components Inc	Venous access port assembly with x-ray discernable indicia
US20110021832A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Synthesis of iodixanol in water
US20110021833A1 (en)	2009-07-21	2011-01-27	Ge Healthcare As	Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US8962887B2 (en) *	2009-07-21	2015-02-24	Ge Healthcare As	Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US7999134B2 (en)	2009-07-21	2011-08-16	Ge Healthcare As	Crystallization of iodixanol using milling
US7696381B1 (en) *	2009-07-21	2010-04-13	Ge Healthcare As	Alternative dimerisation reagents for synthesis of iodixanol
US20110021825A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Process for isolating iodixanol from an aqueous solution
US20110020238A1 (en)	2009-07-21	2011-01-27	Ge Healthcare As	Stabilizing aqueous solution of iodine chloride by adding sodium chloride
US20110021821A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US20110021828A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
US8962886B2 (en) *	2009-07-21	2015-02-24	Ge Healthcare As	Synthesis of iodixanol in methanol
US20110021822A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US8969619B2 (en) *	2009-07-21	2015-03-03	Ge Healthcare As	Synthesis of iodixanol in propyleneglycol
US7754920B1 (en) *	2009-07-21	2010-07-13	Ge Healthcare As	Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US20110021823A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Processing crude iodixanol mixture by nanofiltration
US7999135B2 (en)	2009-07-21	2011-08-16	Ge Healthcare As	Crystallization of iodixanol using ultrasound
US8461600B2 (en) *	2009-09-11	2013-06-11	Ut-Battelle, Llc	Method for morphological control and encapsulation of materials for electronics and energy applications
CN102079716B (zh) *	2009-11-26	2014-03-05	浙江台州海神制药有限公司	碘克沙醇的制备与纯化
KR101699226B1 (ko) *	2009-11-26	2017-01-24	호비온 차이나 홀딩 리미티드	이오딕사놀의 제조 및 정제
US9474808B2 (en)	2010-12-21	2016-10-25	Ge Healthcare As	Desalination of a composition comprising a contrast agent
CN103058880B (zh) *	2011-10-21	2015-08-05	连云港润众制药有限公司	碘克沙醇及其合成中间体的制备方法
MX354604B (es) *	2012-09-27	2018-03-07	Ge Healthcare As	Preparacion de un compuesto intermediario de ioforminol.
CN102875411A (zh) *	2012-10-30	2013-01-16	广州牌牌生物科技有限公司	一种用大孔树脂分离纯化碘克沙醇注射剂原料的方法
CN104768921A (zh) *	2012-11-12	2015-07-08	通用电气医疗集团股份有限公司	X-射线造影剂中间体的制备
CN103265449A (zh) *	2013-05-30	2013-08-28	四川铂瑞生物医药有限公司	5-氨基-2,4,6-三碘-n,n’-双(2,3-二羟基丙基)-1,3-苯二甲酰胺的合成
PT3077368T (pt)	2013-12-06	2018-10-19	Ge Healthcare As	Processo alternativo para a purificação de um intermediário na síntese de agentes de contraste não iónicos para raios-x
CN113831256B (zh) *	2021-09-17	2024-06-11	江苏宇田医药有限公司	一种碘克沙醇的中间体及其制备碘克沙醇的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3816521A (en) *	1967-10-02	1974-06-11	Ueno Pharm Co Ltd	Process for the production of p-hydroxy benzoic acid
ATE20733T1 (de) *	1982-11-08	1986-08-15	Nyegaard & Co As	Roentgenkontrastmittel.
US5235116A (en) *	1992-08-24	1993-08-10	Eastman Kodak Company	Process for the preparation of 2-(1-phenylethyl)hydroquinone and 2-(1-phenylethyl)hydroquinone diacetate
GB9618055D0 (en)	1996-08-29	1996-10-09	Nycomed Imaging As	Process
GB9624612D0 (en) *	1996-11-26	1997-01-15	Nycomed Imaging As	Process

1999
- 1999-02-11 GB GBGB9903109.8A patent/GB9903109D0/en not_active Ceased
2000
- 2000-02-10 HU HU0105096A patent/HU228226B1/hu unknown
- 2000-02-10 KR KR1020017010055A patent/KR100625139B1/ko not_active Expired - Lifetime
- 2000-02-10 IL IL14396900A patent/IL143969A0/xx not_active IP Right Cessation
- 2000-02-10 ES ES00902754T patent/ES2206190T3/es not_active Expired - Lifetime
- 2000-02-10 CZ CZ20012891A patent/CZ296353B6/cs not_active IP Right Cessation
- 2000-02-10 WO PCT/GB2000/000413 patent/WO2000047549A1/en not_active Ceased
- 2000-02-10 JP JP2000598470A patent/JP4545945B2/ja not_active Expired - Lifetime
- 2000-02-10 EP EP00902754A patent/EP1150943B1/de not_active Expired - Lifetime
- 2000-02-10 AU AU24495/00A patent/AU2449500A/en not_active Abandoned
- 2000-02-10 CA CA002356942A patent/CA2356942C/en not_active Expired - Lifetime
- 2000-02-10 PT PT00902754T patent/PT1150943E/pt unknown
- 2000-02-10 AT AT00902754T patent/ATE249420T1/de not_active IP Right Cessation
- 2000-02-10 DE DE60005143T patent/DE60005143T2/de not_active Expired - Lifetime
- 2000-02-10 CN CNB008037051A patent/CN1178899C/zh not_active Expired - Lifetime
- 2000-02-10 PL PL348857A patent/PL197893B1/pl unknown
2001
- 2001-08-06 US US09/923,074 patent/US6974882B2/en not_active Expired - Lifetime
- 2001-08-09 NO NO20013881A patent/NO329363B1/no not_active IP Right Cessation
2005
- 2005-11-28 US US11/288,029 patent/US20060137602A1/en not_active Abandoned
2007
- 2007-03-01 US US11/680,716 patent/US20070203362A1/en not_active Abandoned
- 2007-12-18 US US11/958,714 patent/US20080161606A1/en not_active Abandoned
2008
- 2008-10-06 US US12/245,886 patent/US20090112022A1/en not_active Abandoned
2009
- 2009-08-24 US US12/545,884 patent/US20100069669A1/en not_active Abandoned
2010
- 2010-08-24 US US12/862,023 patent/US20110207963A1/en not_active Abandoned
2011
- 2011-10-06 US US13/267,133 patent/US20120083625A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HUP0105096A3 (en)	2004-05-28
NO20013881L (no)	2001-08-09
AU2449500A (en)	2000-08-29
PL348857A1 (en)	2002-06-17
US20110207963A1 (en)	2011-08-25
HU228226B1 (en)	2013-02-28
CN1178899C (zh)	2004-12-08
EP1150943A1 (de)	2001-11-07
WO2000047549A1 (en)	2000-08-17
IL143969A0 (en)	2002-04-21
PL197893B1 (pl)	2008-05-30
US20080161606A1 (en)	2008-07-03
US20120083625A1 (en)	2012-04-05
US6974882B2 (en)	2005-12-13
JP4545945B2 (ja)	2010-09-15
GB9903109D0 (en)	1999-04-07
CA2356942C (en)	2008-09-02
KR100625139B1 (ko)	2006-09-20
US20100069669A1 (en)	2010-03-18
CN1340042A (zh)	2002-03-13
CZ296353B6 (cs)	2006-02-15
US20060137602A1 (en)	2006-06-29
NO20013881D0 (no)	2001-08-09
US20020010368A1 (en)	2002-01-24
US20070203362A1 (en)	2007-08-30
CZ20012891A3 (cs)	2001-12-12
HUP0105096A2 (hu)	2002-04-29
JP2002536429A (ja)	2002-10-29
CA2356942A1 (en)	2000-08-17
EP1150943B1 (de)	2003-09-10
NO329363B1 (no)	2010-10-04
US20090112022A1 (en)	2009-04-30
DE60005143T2 (de)	2004-07-08
ES2206190T3 (es)	2004-05-16
KR20010102005A (ko)	2001-11-15
PT1150943E (pt)	2004-02-27
DE60005143D1 (de)	2003-10-16

Legal Events

Date	Code	Title	Description
2004-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE249420T1 (de)	2003-09-15	Herstellung von iodixanol
EA200201046A1 (ru)	2003-04-24	7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное
ATE342112T1 (de)	2006-11-15	Reinigung von biologischen substanzen
ATE244279T1 (de)	2003-07-15	Verfahren zur synthese von phthalocyaninverbindungen
ATE206409T1 (de)	2001-10-15	N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1-h- benzo(b)(1,5)-diazepin-3-yl)-acetamide
ATE264268T1 (de)	2004-04-15	Verfahren zur herstellung von zsm-5 und zsm-11
ITMI20021737A1 (it)	2004-02-02	Processo di purificazione di nanotubi di carbonio.
BR0015202A (pt)	2002-07-23	Processo para a purificação de uma solução contendo aminoácido por meio de eletrodiálise, e processo integrado para a produção de um aminoácido livre
DE60123579D1 (de)	2006-11-16	Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
EP0832075A4 (de)	1998-10-07	Neue n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amiden
NZ334817A (en)	2000-09-29	Process for the manufacture of iohexol
DE60100238D1 (de)	2003-06-12	Synthese von 3,6-Dialkyl-5,6-Dihydro-4-Hydroxy-2H-Pyran-2-one
ATE442355T1 (de)	2009-09-15	Herstellung von 4,5-dialkyl-3-acylpyrrol-2- carbonsäurederivaten durch synthese nach fischer- fink und anschliebende acylierung
ATE414057T1 (de)	2008-11-15	Verfahren zur herstellung von iohexol
NO20016297L (no)	2002-02-04	Ny fremgangsmåte for rensing av aldehydurenheter
FI960301A0 (fi)	1996-01-22	Nikkelitön hemoglobiini ja menetelmät sellaisen hemoglobiinin tuottamiseksi
DE60126867D1 (de)	2007-04-12	Verfahren zur Herstellung von 2-Vinylcyclodecanon
DE69926223D1 (de)	2005-08-25	Verfahren zur herstellung von zwischenprodukten
ATE264306T1 (de)	2004-04-15	Synthese von 3-amino-2-chlor-4-methylpyridin aus malonsäuresäurenitril und aceton
DE59510633D1 (de)	2003-05-15	Verfahren zur herstellung von cyclischen lactamen
HUP0400825A2 (hu)	2004-08-30	Eljárás amorf cilastatin nátrium előállítására
DE60327813D1 (de)	2009-07-09	Verfahren zu herstellung von lovastatin.
ATE281428T1 (de)	2004-11-15	Verfahren zur herstellung von methoxyimino- essigsäureamiden
IT1212692B (it)	1989-11-30	Procedimento per la preparazione di 3,3'-o 3,4'-diammino-benzofenone.
DE50001638D1 (de)	2003-05-08	Verfahren zur herstellung von 4,6-dichlorpyrimidin