ATE253569T1 - Pde-iv-hemmende pyridin-derivate - Google Patents

Pde-iv-hemmende pyridin-derivate

Info

Publication number: ATE253569T1
Authority: AT; Austria
Prior art keywords: pde; pyridine derivatives; inhibiting; inhibiting pyridine; derivatives
Prior art date: 1998-04-01

Application number

AT99913302T

Other languages

English (en)

Inventor

Eddy Jean Edgard Freyne

Gaston Stanislas Marcell Diels

Janssen-C Matesanz-Ballesteros

Adolfo Janssen-C Diaz-Martinez

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-01

Filing date

1999-03-24

Publication date

2003-11-15

1999-03-24 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE253569T1 publication Critical patent/ATE253569T1/de

Links

JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

AT99913302T 1998-04-01 1999-03-24 Pde-iv-hemmende pyridin-derivate ATE253569T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98201020		1998-04-01
PCT/EP1999/002045 WO1999050262A1 (en)	1998-04-01	1999-03-24	Pde iv inhibiting pyridine derivatives

Publications (1)

Publication Number	Publication Date
ATE253569T1 true ATE253569T1 (de)	2003-11-15

Family

ID=8233543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99913302T ATE253569T1 (de)	1998-04-01	1999-03-24	Pde-iv-hemmende pyridin-derivate

Country Status (33)

Country	Link
US (1)	US6656959B1 (de)
EP (1)	EP1068194B1 (de)
JP (1)	JP4778612B2 (de)
KR (1)	KR100596664B1 (de)
CN (1)	CN1172930C (de)
AR (1)	AR014972A1 (de)
AT (1)	ATE253569T1 (de)
AU (1)	AU760771B2 (de)
BG (1)	BG64705B1 (de)
BR (1)	BR9909326A (de)
CA (1)	CA2326045C (de)
CZ (1)	CZ298747B6 (de)
DE (1)	DE69912590T2 (de)
DK (1)	DK1068194T3 (de)
EA (1)	EA004207B1 (de)
EE (1)	EE04718B1 (de)
ES (1)	ES2211061T3 (de)
HR (1)	HRP20000619B1 (de)
HU (1)	HU229412B1 (de)
ID (1)	ID27207A (de)
IL (2)	IL138745A0 (de)
MY (1)	MY124696A (de)
NO (1)	NO319531B1 (de)
NZ (1)	NZ507022A (de)
PL (1)	PL196026B1 (de)
PT (1)	PT1068194E (de)
SI (1)	SI1068194T1 (de)
SK (1)	SK284468B6 (de)
TR (1)	TR200002801T2 (de)
TW (1)	TWI242558B (de)
UA (1)	UA66842C2 (de)
WO (1)	WO1999050262A1 (de)
ZA (1)	ZA200006190B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6639077B2 (en)	2000-03-23	2003-10-28	Merck Frosst Canada & Co.	Tri-aryl-substituted-ethane PDE4 inhibitors
MY123585A (en)	2000-03-23	2006-05-31	Merck Canada Inc	Tri-aryl-substituted-ethane pde4 inhibitors.
DE10130397A1 (de) *	2001-06-23	2003-01-09	Bayer Cropscience Gmbh	Herbizide substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbzide und Pflanzenwachstumsregulatoren
DE10318610A1 (de) *	2003-04-24	2004-11-11	Elbion Ag	7-Azaindole und deren Verwendung als Therapeutika
JP4185154B2 (ja)	2004-04-30	2008-11-26	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	中枢神経系障害治療用の置換モルホリン化合物
US7863446B2 (en)	2006-01-19	2011-01-04	Orchid Research Laboratories Limited	Heterocycles
JP2009525269A (ja)	2006-01-30	2009-07-09	ユーロ−セルティークエス．エイ．	カルシウムチャネルブロッカーとしての環状尿素化合物
DE602007011793D1 (de)	2006-10-18	2011-02-17	Pfizer Prod Inc	Biaryl-ether-harnstoffverbindungen
BRPI0912029A2 (pt)	2008-02-01	2020-06-30	Orchid Research Laboratories Limited	novos heterociclos
JOP20190060A1 (ar)	2016-09-26	2019-03-26	Chugai Pharmaceutical Co Ltd	مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3876657A (en) *	1971-06-03	1975-04-08	Ashland Oil Inc	Preparation of 1-substituted-2-imidazolidinones
US4600430A (en)	1985-02-22	1986-07-15	Eli Lilly And Company	Pyridinylimidazolidinone compounds
JP3775685B2 (ja) *	1993-07-28	2006-05-17	ローン−プーラン・ロレ・リミテツド	Ｐｄｅ▲ｉｖ▼およびｔｎｆ抑制剤としての化合物
GB9401460D0 (en) *	1994-01-26	1994-03-23	Rhone Poulenc Rorer Ltd	Compositions of matter
AU3272195A (en) *	1994-08-03	1996-03-04	Gics & Vermee, L.P.	Ovenable food package
TW375612B (en) *	1995-04-06	1999-12-01	Janssen Pharmaceutica Nv	1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same
TW332201B (en) *	1995-04-06	1998-05-21	Janssen Pharmaceutica Nv	1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
TW424087B (en)	1995-04-06	2001-03-01	Janssen Pharmaceutica Nv	1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives
AU6526896A (en) *	1995-07-22	1997-02-18	Rhone-Poulenc Rorer Limited	Substituted aromatic compounds and their pharmaceutical use
WO1997024122A1 (en) *	1995-12-29	1997-07-10	Smithkline Beecham Corporation	Vitronectin receptor antagonists
SK285878B6 (sk) *	1996-10-02	2007-10-04	Janssen Pharmaceutica N. V.	Derivát 2-kyaniminoimidazolu, prostriedok obsahujúci tento derivát, spôsob prípravy tohto prostriedku, uvedený derivát na použitie ako liečivo, použitie tohto derivátu na prípravu liečiva a spôsob prípravy tohto derivátu

1999
- 1999-03-24 SK SK1387-2000A patent/SK284468B6/sk not_active IP Right Cessation
- 1999-03-24 EP EP99913302A patent/EP1068194B1/de not_active Expired - Lifetime
- 1999-03-24 KR KR1020007008557A patent/KR100596664B1/ko not_active Expired - Lifetime
- 1999-03-24 WO PCT/EP1999/002045 patent/WO1999050262A1/en not_active Ceased
- 1999-03-24 JP JP2000541166A patent/JP4778612B2/ja not_active Expired - Lifetime
- 1999-03-24 ID IDW20001941A patent/ID27207A/id unknown
- 1999-03-24 HR HR20000619A patent/HRP20000619B1/xx not_active IP Right Cessation
- 1999-03-24 CZ CZ20003338A patent/CZ298747B6/cs not_active IP Right Cessation
- 1999-03-24 SI SI9930470T patent/SI1068194T1/xx unknown
- 1999-03-24 IL IL13874599A patent/IL138745A0/xx active IP Right Grant
- 1999-03-24 NZ NZ507022A patent/NZ507022A/en not_active IP Right Cessation
- 1999-03-24 DK DK99913302T patent/DK1068194T3/da active
- 1999-03-24 ES ES99913302T patent/ES2211061T3/es not_active Expired - Lifetime
- 1999-03-24 US US09/647,668 patent/US6656959B1/en not_active Expired - Lifetime
- 1999-03-24 AU AU31474/99A patent/AU760771B2/en not_active Expired
- 1999-03-24 TR TR2000/02801T patent/TR200002801T2/xx unknown
- 1999-03-24 AT AT99913302T patent/ATE253569T1/de active
- 1999-03-24 DE DE69912590T patent/DE69912590T2/de not_active Expired - Lifetime
- 1999-03-24 UA UA2000105769A patent/UA66842C2/uk unknown
- 1999-03-24 CA CA002326045A patent/CA2326045C/en not_active Expired - Lifetime
- 1999-03-24 PT PT99913302T patent/PT1068194E/pt unknown
- 1999-03-24 EA EA200001009A patent/EA004207B1/ru not_active IP Right Cessation
- 1999-03-24 CN CNB998047376A patent/CN1172930C/zh not_active Expired - Lifetime
- 1999-03-24 EE EEP200000569A patent/EE04718B1/xx unknown
- 1999-03-24 PL PL99343194A patent/PL196026B1/pl unknown
- 1999-03-24 BR BR9909326-0A patent/BR9909326A/pt not_active Application Discontinuation
- 1999-03-24 HU HU0101239A patent/HU229412B1/hu unknown
- 1999-03-26 MY MYPI99001169A patent/MY124696A/en unknown
- 1999-03-29 TW TW088104881A patent/TWI242558B/zh not_active IP Right Cessation
- 1999-03-31 AR ARP990101489A patent/AR014972A1/es not_active Application Discontinuation
2000
- 2000-08-28 BG BG104718A patent/BG64705B1/bg unknown
- 2000-09-28 IL IL138745A patent/IL138745A/en not_active IP Right Cessation
- 2000-09-29 NO NO20004906A patent/NO319531B1/no not_active IP Right Cessation
- 2000-10-31 ZA ZA200006190A patent/ZA200006190B/en unknown

Also Published As

Publication number	Publication date
KR100596664B1 (ko)	2006-07-06
SK13872000A3 (sk)	2001-11-06
WO1999050262A1 (en)	1999-10-07
HK1033579A1 (en)	2001-09-07
PL196026B1 (pl)	2007-11-30
CN1295571A (zh)	2001-05-16
ID27207A (id)	2001-03-08
EA200001009A1 (ru)	2001-02-26
AU760771B2 (en)	2003-05-22
CA2326045A1 (en)	1999-10-07
HUP0101239A2 (hu)	2002-05-29
IL138745A (en)	2007-06-17
JP2002509927A (ja)	2002-04-02
BG64705B1 (bg)	2005-12-30
DE69912590D1 (de)	2003-12-11
KR20010040681A (ko)	2001-05-15
CZ20003338A3 (cs)	2001-02-14
BR9909326A (pt)	2000-12-12
HUP0101239A3 (en)	2002-09-30
EE200000569A (et)	2002-04-15
AR014972A1 (es)	2001-04-11
ES2211061T3 (es)	2004-07-01
EA004207B1 (ru)	2004-02-26
SI1068194T1 (en)	2004-04-30
ZA200006190B (en)	2001-10-31
CA2326045C (en)	2008-12-09
BG104718A (en)	2001-04-30
NO319531B1 (no)	2005-08-29
DE69912590T2 (de)	2004-09-16
PL343194A1 (en)	2001-07-30
TR200002801T2 (tr)	2000-12-21
EE04718B1 (et)	2006-10-16
NZ507022A (en)	2002-06-28
CZ298747B6 (cs)	2008-01-16
NO20004906L (no)	2000-11-28
MY124696A (en)	2006-06-30
UA66842C2 (uk)	2004-06-15
NO20004906D0 (no)	2000-09-29
HRP20000619B1 (en)	2004-06-30
SK284468B6 (sk)	2005-04-01
CN1172930C (zh)	2004-10-27
JP4778612B2 (ja)	2011-09-21
HU229412B1 (en)	2013-12-30
PT1068194E (pt)	2004-03-31
US6656959B1 (en)	2003-12-02
EP1068194A1 (de)	2001-01-17
EP1068194B1 (de)	2003-11-05
AU3147499A (en)	1999-10-18
DK1068194T3 (da)	2004-03-15
TWI242558B (en)	2005-11-01
HRP20000619A2 (en)	2001-10-31
IL138745A0 (en)	2001-10-31

Legal Events

Date

Code

Title

Description

2004-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1068194

Country of ref document: EP

Publication	Publication Date	Title
DE69839398D1 (de)	2008-06-05	Pyridinderivate
NO20010193D0 (no)	2001-01-12	Tiobenzimidazol-derivater
DK0930302T3 (da)	2003-07-21	Benzosulfonderivater
NO20013003D0 (no)	2001-06-15	Kinolin-derivater
PT1095021E (pt)	2003-12-31	Derivados de quinolina
PT1073639E (pt)	2003-04-30	Derivados de quinolina
NO20010514D0 (no)	2001-01-30	Aminometylkarboksylsyre-derivater
ATE259810T1 (de)	2004-03-15	Phenyl-xanthinderivate
DE69934788D1 (de)	2007-02-22	Biozide benzylbiphenylderivative
ATE229005T1 (de)	2002-12-15	Chinolinderivate
PT928790E (pt)	2003-07-31	Derivados de tiazolo
ATE236884T1 (de)	2003-04-15	Pde-iv hemmende 2-cyanoiminoimidazol-derivate
DK1115716T3 (da)	2003-02-24	2-phenylpyran-4-on-derivater
PT1056716E (pt)	2003-04-30	Derivados de ciclo-hexanodiolo
DE69912590D1 (de)	2003-12-11	Pde-iv-hemmende pyridin-derivate
ATE233253T1 (de)	2003-03-15	Chromanderivate
DK1134219T3 (da)	2005-10-17	Cucloalkylsubstituerede aminomethylpyrrolidinderivater
FI980222A0 (fi)	1998-01-30	Stycke av isoleringsaemne med en genomgaoende primaerstroemledning
DK1060183T3 (da)	2003-08-11	5-deoxycytidinderivater
PT1123283E (pt)	2004-09-30	Derivados de tiazole
PT928793E (pt)	2002-10-31	Derivados de tiazol
DE59907635D1 (de)	2003-12-11	Pyrazolyldioxothiochromanoyl-derivate
FI980433A0 (fi)	1998-02-25	Foerfarande foer utnyttjande i samband med tillslutandet av en vaetskefoerpackning