EE04718B1 - PDE IV inhibeerivad püridiini derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon ja selle valmistamismeetod - Google Patents

PDE IV inhibeerivad püridiini derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon ja selle valmistamismeetod

Info

Publication number
EE04718B1
EE04718B1 EEP200000569A EEP200000569A EE04718B1 EE 04718 B1 EE04718 B1 EE 04718B1 EE P200000569 A EEP200000569 A EE P200000569A EE P200000569 A EEP200000569 A EE P200000569A EE 04718 B1 EE04718 B1 EE 04718B1
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical composition
pyridine derivatives
inhibiting pde
derivatives inhibiting
Prior art date
Application number
EEP200000569A
Other languages
English (en)
Inventor
Jean Edgard Freyne Eddy
Stanislas Marcella Diels Gaston
Encarnacion Matesanz-Ballesteros Maria
Diaz-Martinez Adolfo
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200000569A publication Critical patent/EE200000569A/et
Publication of EE04718B1 publication Critical patent/EE04718B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
EEP200000569A 1998-04-01 1999-03-24 PDE IV inhibeerivad püridiini derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon ja selle valmistamismeetod EE04718B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201020 1998-04-01
PCT/EP1999/002045 WO1999050262A1 (en) 1998-04-01 1999-03-24 Pde iv inhibiting pyridine derivatives

Publications (2)

Publication Number Publication Date
EE200000569A EE200000569A (et) 2002-04-15
EE04718B1 true EE04718B1 (et) 2006-10-16

Family

ID=8233543

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000569A EE04718B1 (et) 1998-04-01 1999-03-24 PDE IV inhibeerivad püridiini derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon ja selle valmistamismeetod

Country Status (33)

Country Link
US (1) US6656959B1 (et)
EP (1) EP1068194B1 (et)
JP (1) JP4778612B2 (et)
KR (1) KR100596664B1 (et)
CN (1) CN1172930C (et)
AR (1) AR014972A1 (et)
AT (1) ATE253569T1 (et)
AU (1) AU760771B2 (et)
BG (1) BG64705B1 (et)
BR (1) BR9909326A (et)
CA (1) CA2326045C (et)
CZ (1) CZ298747B6 (et)
DE (1) DE69912590T2 (et)
DK (1) DK1068194T3 (et)
EA (1) EA004207B1 (et)
EE (1) EE04718B1 (et)
ES (1) ES2211061T3 (et)
HR (1) HRP20000619B1 (et)
HU (1) HU229412B1 (et)
ID (1) ID27207A (et)
IL (2) IL138745A0 (et)
MY (1) MY124696A (et)
NO (1) NO319531B1 (et)
NZ (1) NZ507022A (et)
PL (1) PL196026B1 (et)
PT (1) PT1068194E (et)
SI (1) SI1068194T1 (et)
SK (1) SK284468B6 (et)
TR (1) TR200002801T2 (et)
TW (1) TWI242558B (et)
UA (1) UA66842C2 (et)
WO (1) WO1999050262A1 (et)
ZA (1) ZA200006190B (et)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY123585A (en) 2000-03-23 2006-05-31 Merck Canada Inc Tri-aryl-substituted-ethane pde4 inhibitors.
US6639077B2 (en) 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
DE10130397A1 (de) * 2001-06-23 2003-01-09 Bayer Cropscience Gmbh Herbizide substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbzide und Pflanzenwachstumsregulatoren
DE10318610A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 7-Azaindole und deren Verwendung als Therapeutika
BRPI0510453A (pt) 2004-04-30 2007-10-30 Warner Lambert Co composto substituìdos com morfolina para o tratamento de distúrbios do sistema nervoso central
US7863446B2 (en) 2006-01-19 2011-01-04 Orchid Research Laboratories Limited Heterocycles
JP2009525269A (ja) 2006-01-30 2009-07-09 ユーロ−セルティーク エス．エイ． カルシウムチャネルブロッカーとしての環状尿素化合物
DK2076508T3 (da) 2006-10-18 2011-02-21 Pfizer Prod Inc Biaryl-ether-urinstof-forbindelser
MX336946B (es) 2008-02-01 2016-02-08 Orchid Res Lab Ltd Heterociclos novedosos.
JOP20190060A1 (ar) 2016-09-26 2019-03-26 Chugai Pharmaceutical Co Ltd مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876657A (en) * 1971-06-03 1975-04-08 Ashland Oil Inc Preparation of 1-substituted-2-imidazolidinones
US4600430A (en) 1985-02-22 1986-07-15 Eli Lilly And Company Pyridinylimidazolidinone compounds
CA2160928C (en) * 1993-07-28 2005-07-05 Garry Fenton Compounds as pde iv and tnf inhibitors
GB9401460D0 (en) * 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
WO1996004186A1 (en) * 1994-08-03 1996-02-15 Gics & Vermee, L.P. Ovenable food package
TW332201B (en) * 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
TW375612B (en) 1995-04-06 1999-12-01 Janssen Pharmaceutica Nv 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same
TW424087B (en) * 1995-04-06 2001-03-01 Janssen Pharmaceutica Nv 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives
AU6526896A (en) * 1995-07-22 1997-02-18 Rhone-Poulenc Rorer Limited Substituted aromatic compounds and their pharmaceutical use
EP0895475A4 (en) * 1995-12-29 2000-08-23 Smithkline Beecham Corp VITRONECTIN RECEPTOR ANTAGONISTS
US6051718A (en) 1996-10-02 2000-04-18 Janssen Pharmaceutica, N.V. PDE IV inhibiting 2-cyanoiminoimidazole derivatives

Also Published As

Publication number Publication date
EA200001009A1 (ru) 2001-02-26
PL196026B1 (pl) 2007-11-30
DE69912590D1 (de) 2003-12-11
HUP0101239A3 (en) 2002-09-30
AU3147499A (en) 1999-10-18
PL343194A1 (en) 2001-07-30
BR9909326A (pt) 2000-12-12
HK1033579A1 (en) 2001-09-07
SK13872000A3 (sk) 2001-11-06
IL138745A (en) 2007-06-17
TWI242558B (en) 2005-11-01
CN1295571A (zh) 2001-05-16
HU229412B1 (en) 2013-12-30
HRP20000619A2 (en) 2001-10-31
SI1068194T1 (en) 2004-04-30
US6656959B1 (en) 2003-12-02
EE200000569A (et) 2002-04-15
CA2326045C (en) 2008-12-09
NO319531B1 (no) 2005-08-29
EA004207B1 (ru) 2004-02-26
UA66842C2 (uk) 2004-06-15
AR014972A1 (es) 2001-04-11
CZ298747B6 (cs) 2008-01-16
CN1172930C (zh) 2004-10-27
HUP0101239A2 (hu) 2002-05-29
ZA200006190B (en) 2001-10-31
IL138745A0 (en) 2001-10-31
MY124696A (en) 2006-06-30
JP4778612B2 (ja) 2011-09-21
KR100596664B1 (ko) 2006-07-06
BG104718A (en) 2001-04-30
WO1999050262A1 (en) 1999-10-07
NO20004906L (no) 2000-11-28
HRP20000619B1 (en) 2004-06-30
CZ20003338A3 (cs) 2001-02-14
KR20010040681A (ko) 2001-05-15
PT1068194E (pt) 2004-03-31
DK1068194T3 (da) 2004-03-15
EP1068194B1 (en) 2003-11-05
NZ507022A (en) 2002-06-28
ID27207A (id) 2001-03-08
JP2002509927A (ja) 2002-04-02
SK284468B6 (sk) 2005-04-01
EP1068194A1 (en) 2001-01-17
BG64705B1 (bg) 2005-12-30
NO20004906D0 (no) 2000-09-29
AU760771B2 (en) 2003-05-22
CA2326045A1 (en) 1999-10-07
ES2211061T3 (es) 2004-07-01
ATE253569T1 (de) 2003-11-15
DE69912590T2 (de) 2004-09-16
TR200002801T2 (tr) 2000-12-21

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231