ATE253577T1 - Neue wasserlösliche fluoroethylcamptothecin- derivate und ein verfahren zu ihrer herstellung - Google Patents

Neue wasserlösliche fluoroethylcamptothecin- derivate und ein verfahren zu ihrer herstellung

Info

Publication number: ATE253577T1
Authority: AT; Austria
Prior art keywords: soluble; production; fluoroethyl; new water; camptothecine
Prior art date: 1995-06-08

Application number

AT96916306T

Other languages

English (en)

Inventor

Yosikazu Asahina

Yasuo Oomori

Original Assignee

Kyorin Seiyaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-08

Filing date

1996-06-05

Publication date

2003-11-15

1996-06-05 Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk

2003-11-15 Application granted granted Critical

2003-11-15 Publication of ATE253577T1 publication Critical patent/ATE253577T1/de

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
231100001231 less toxic Toxicity 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

AT96916306T 1995-06-08 1996-06-05 Neue wasserlösliche fluoroethylcamptothecin- derivate und ein verfahren zu ihrer herstellung ATE253577T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP7141819A JPH08333370A (ja)	1995-06-08	1995-06-08	水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法
PCT/JP1996/001512 WO1996041806A1 (en)	1995-06-08	1996-06-05	Novel water-soluble fluoroethylcamptothecin derivative and process for production thereof

Publications (1)

Publication Number	Publication Date
ATE253577T1 true ATE253577T1 (de)	2003-11-15

Family

ID=15300870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96916306T ATE253577T1 (de)	1995-06-08	1996-06-05	Neue wasserlösliche fluoroethylcamptothecin- derivate und ein verfahren zu ihrer herstellung

Country Status (13)

Country	Link
US (1)	US5942518A (de)
EP (1)	EP0861842B1 (de)
JP (1)	JPH08333370A (de)
KR (1)	KR100388159B1 (de)
CN (1)	CN1058716C (de)
AT (1)	ATE253577T1 (de)
AU (1)	AU695521B2 (de)
CA (1)	CA2219660C (de)
DE (1)	DE69630609D1 (de)
HU (1)	HUP9802760A3 (de)
MX (1)	MX9709812A (de)
TW (1)	TW360658B (de)
WO (1)	WO1996041806A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6288072B1 (en)	1999-12-29	2001-09-11	Monroe E. Wall	Camptothecin β-alanine esters with topoisomerase I inhibition
US6350756B1 (en)	2001-01-18	2002-02-26	California Pacific Medical Center	Camptothecin derivatives
US6403604B1 (en) *	2001-03-01	2002-06-11	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
US6855720B2 (en)	2001-03-01	2005-02-15	California Pacific Medical Center	Nitrogen-based camptothecin derivatives
WO2003033525A1 (en) *	2001-10-12	2003-04-24	Debio Recherche Pharmacuetique S.A.	Amino-substituted camptothecin polymer derivatives and use of the same for the manufacture of a medicament
US6933302B2 (en)	2002-06-03	2005-08-23	California Pacific Medical Center	Nitrogen-based homo-camptothecin derivatives
JP4959136B2 (ja) *	2002-12-13	2012-06-20	イミューノメディクス、インコーポレイテッド	細胞内で開裂可能な結合を有する免疫接合体
WO2004092205A1 (en) *	2003-04-16	2004-10-28	Debio Recherche Pharmacuetique S.A.	Hydroxy-substituted-20-acyloxy-camptothecin polymer derivatives and use of the same for the manufacture of a medicament
US7875602B2 (en)	2005-10-21	2011-01-25	Sutter West Bay Hospitals	Camptothecin derivatives as chemoradiosensitizing agents
CN102731516B (zh) *	2011-04-07	2014-07-02	宁波天衡药业股份有限公司	一类具有抗肿瘤活性的喜树碱衍生物
CN113372269A (zh) *	2021-06-25	2021-09-10	云南大学	一种席夫碱镓配合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4943579A (en) *	1987-10-06	1990-07-24	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Water soluble prodrugs of camptothecin
HU213136B (en) *	1990-08-14	1997-02-28	Kyorin Seiyaku Kk	Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP2848958B2 (ja) *	1990-09-28	1999-01-20	スミスクライン・ビーチャム・コーポレイション	水溶性カンプトテシン類似体、方法および手段
JPH05174179A (ja) *	1991-12-26	1993-07-13	Toshiba Corp	文書画像処理装置
AP9300587A0 (en) *	1992-11-12	1995-05-05	Glaxo Inc	Water soluble camptothecin derivatives.
US5646159A (en) *	1994-07-20	1997-07-08	Research Triangle Institute	Water-soluble esters of camptothecin compounds

1995
- 1995-06-08 JP JP7141819A patent/JPH08333370A/ja active Pending
1996
- 1996-06-05 US US08/952,366 patent/US5942518A/en not_active Expired - Fee Related
- 1996-06-05 AU AU59108/96A patent/AU695521B2/en not_active Ceased
- 1996-06-05 EP EP96916306A patent/EP0861842B1/de not_active Expired - Lifetime
- 1996-06-05 DE DE69630609T patent/DE69630609D1/de not_active Expired - Lifetime
- 1996-06-05 AT AT96916306T patent/ATE253577T1/de not_active IP Right Cessation
- 1996-06-05 WO PCT/JP1996/001512 patent/WO1996041806A1/ja not_active Ceased
- 1996-06-05 HU HU9802760A patent/HUP9802760A3/hu unknown
- 1996-06-05 CA CA002219660A patent/CA2219660C/en not_active Expired - Fee Related
- 1996-06-05 CN CN96194556A patent/CN1058716C/zh not_active Expired - Fee Related
- 1996-06-05 KR KR1019970707709A patent/KR100388159B1/ko not_active Expired - Fee Related
- 1996-06-05 MX MX9709812A patent/MX9709812A/es not_active IP Right Cessation
- 1996-07-04 TW TW085108075A patent/TW360658B/zh active

Also Published As

Publication number	Publication date
CA2219660A1 (en)	1996-12-27
HUP9802760A2 (hu)	1999-06-28
DE69630609D1 (de)	2003-12-11
CA2219660C (en)	2005-07-12
JPH08333370A (ja)	1996-12-17
TW360658B (en)	1999-06-11
KR19990008184A (ko)	1999-01-25
CN1058716C (zh)	2000-11-22
EP0861842B1 (de)	2003-11-05
EP0861842A4 (de)	2000-01-12
AU5910896A (en)	1997-01-09
WO1996041806A1 (en)	1996-12-27
HUP9802760A3 (en)	2000-01-28
CN1187195A (zh)	1998-07-08
MX9709812A (es)	1998-03-31
KR100388159B1 (ko)	2003-12-01
US5942518A (en)	1999-08-24
EP0861842A1 (de)	1998-09-02
AU695521B2 (en)	1998-08-13

Similar Documents

Publication	Publication Date	Title
MY138525A (en)	2009-06-30	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
CA2334775A1 (en)	1999-12-16	Benzo(b)thiepine-1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
ATE254612T1 (de)	2003-12-15	Zuckerderivate, geliermittel, geliermittelzubereitungen, verfahren zu ihrer herstellung und gelzubereitungen
MX9606331A (es)	1997-03-29	Nuevos compuestos, procesos para la preparacion de los mismos y agentes antitumor.
ATE242241T1 (de)	2003-06-15	Imidazopyridinderivate und verfahren zu ihrer herstellung
DE69630609D1 (de)	2003-12-11	Neue wasserlösliche fluoroethylcamptothecin-derivate und ein verfahren zu ihrer herstellung
ATE246180T1 (de)	2003-08-15	Benzofuranon-derivate und verfahren zu ihrer herstellung
ATE51622T1 (de)	1990-04-15	Beta-carbolin-3-oxadiazolylderivate, verfahren zu ihrer herstellung und ihre verwendung.
HU912649D0 (en)	1992-01-28	New tricyclic compounds production threreof and anti-microbic preparatives
ATE277932T1 (de)	2004-10-15	Taxan-derivate und verfahren zu ihrer herstellung
ATE154008T1 (de)	1997-06-15	Lacton-verbindung und verfahren zu ihrer herstellung
ATE100097T1 (de)	1994-01-15	Benzoxepin-derivate.
ATE227703T1 (de)	2002-11-15	Aminotetralon-derivate und verfahren zu deren herstellung
AU9004591A (en)	1992-07-09	1,4-benzothiazine-2-acetic acid derivatives, processes for production thereof
ATE353937T1 (de)	2007-03-15	Verfahren zur synthese einer oxonolverbindung
BG105825A (en)	2002-04-30	Process for preparing alendronic acid
DE3781879D1 (de)	1992-10-29	Anthracyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
AU3210593A (en)	1993-08-05	Improvements in or relating to organic compounds
ATE189887T1 (de)	2000-03-15	Vitamin-d-derivat und verfahren zu seiner herstellung
ATE233781T1 (de)	2003-03-15	Neue polyenantibiotika 3874 h1 bis h6, verfahren zu ihrer herstellung und verwendung
ATE150752T1 (de)	1997-04-15	Zns mittel, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zubereitungen
AU9462298A (en)	1999-05-10	Process for producing 3-cephem compounds
ATE73767T1 (de)	1992-04-15	Fluorine enthaltende vitamin-d3-derivate und verfahren zu ihrer herstellung.
WO1995007279A3 (en)	1995-04-27	Process for the preparation of indolizine derivatives
DE59405089D1 (de)	1998-02-26	Verfahren zur Herstellung von 4,5-Difluorbenzaldehyden

Legal Events

Date	Code	Title	Description
2004-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties