ATE254628T1 - Meiose regulierende verbindungen. - Google Patents

Meiose regulierende verbindungen.

Info

Publication number
ATE254628T1
ATE254628T1 AT96918629T AT96918629T ATE254628T1 AT E254628 T1 ATE254628 T1 AT E254628T1 AT 96918629 T AT96918629 T AT 96918629T AT 96918629 T AT96918629 T AT 96918629T AT E254628 T1 ATE254628 T1 AT E254628T1
Authority
AT
Austria
Prior art keywords
meiosis regulating
regulating connections
connections
meiosis
regulating
Prior art date
Application number
AT96918629T
Other languages
English (en)
Inventor
Frederik Christian Groenvald
Peter Faarup
Erling Guddal
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE254628T1 publication Critical patent/ATE254628T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT96918629T 1995-06-23 1996-06-21 Meiose regulierende verbindungen. ATE254628T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK73095 1995-06-23
DK72895 1995-06-23
DK146195 1995-12-22
PCT/DK1996/000273 WO1997000884A1 (en) 1995-06-23 1996-06-21 Meiosis regulating compounds

Publications (1)

Publication Number Publication Date
ATE254628T1 true ATE254628T1 (de) 2003-12-15

Family

ID=27220892

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96918629T ATE254628T1 (de) 1995-06-23 1996-06-21 Meiose regulierende verbindungen.

Country Status (18)

Country Link
EP (1) EP0857173B1 (de)
JP (1) JPH11507929A (de)
KR (1) KR19990028366A (de)
CN (1) CN1191543A (de)
AR (1) AR003441A1 (de)
AT (1) ATE254628T1 (de)
AU (1) AU718246B2 (de)
BR (1) BR9608968A (de)
CA (1) CA2224866A1 (de)
CZ (1) CZ408097A3 (de)
DE (1) DE69630802T2 (de)
HU (1) HUP9900454A3 (de)
IL (1) IL122609A0 (de)
NO (1) NO314231B1 (de)
PL (1) PL185622B1 (de)
RU (1) RU2182909C2 (de)
TW (1) TW474943B (de)
WO (1) WO1997000884A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177420B1 (en) 1997-05-16 2001-01-23 Akzo Nobel N.V. 20-aralkyl-5α-pregnane derivatives
AU8535398A (en) 1997-06-04 1998-12-21 Akzo Nobel N.V. 17beta-allyloxy(thio)alkyl-androstane derivatives for the modulation of meiosis
ES2181321T3 (es) * 1997-12-18 2003-02-16 Akzo Nobel Nv Derivados 17beta-aril(arilmetil)oxi(tio)alquilandrostano.
IL139241A0 (en) 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds
EP0957108A1 (de) * 1998-05-14 1999-11-17 Schering Aktiengesellschaft Ungesättigte Cholestan-derivate zur Regulierung von Meiose und pharmazeutische Präparate davon
AU4498299A (en) * 1998-06-19 2000-01-10 Novo Nordisk A/S Meiosis regulating compounds
DE69903346T2 (de) 1998-12-11 2003-01-30 Akzo Nobel N.V., Arnheim/Arnhem 22s-hydroxycholesta-8,14-dien derivate mit meiose regulierende aktivität
WO2000036132A1 (en) * 1998-12-14 2000-06-22 Merck & Co., Inc. Hiv integrase inhibitors
CZ20012866A3 (cs) * 1999-02-10 2002-01-16 Schering Aktiengesellschaft Nenasycené cholestanové deriváty, farmaceutické kompozice obsahující tyto deriváty a pouľití těchto derivátů pro přípravu léčiv regulujících meiozu
EP1156821B1 (de) * 1999-02-24 2007-05-02 Novo Nordisk A/S Behandlung von unfruchtbarkeit
CN1353617A (zh) * 1999-02-24 2002-06-12 诺沃挪第克公司 不孕症的治疗
DE60023324T2 (de) 1999-09-16 2006-07-20 Novo Nordisk A/S Zusammensetzung zur in-vitro befruchtung
EP1127890A1 (de) 2000-02-22 2001-08-29 Schering Aktiengesellschaft Steroid Derivate mit einem an Ring A des Steroidgerüstes kondensierten Ring zur Regulierung der Meiose
AU2001240624A1 (en) * 2000-02-25 2001-09-03 Novo-Nordisk A/S Improvement of implantation rate
EP1245572A1 (de) 2001-03-26 2002-10-02 Schering Aktiengesellschaft Aminosterol-Verbindungen, ihre Verwendung zur Herstellung Meiose-regulierender Medikamenten und ein Vefahren zu ihrer Herstellung
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
FR2898272B1 (fr) * 2006-03-09 2008-07-04 Trophos Sa Utilisation de derives du 3,5-seco-4-nor-cholestrane pour l'obtention d'un medicament cytoprotecteur
CN102258004B (zh) * 2010-05-27 2013-07-17 中国科学院动物研究所 一种体外保存/培养卵母细胞以抑制卵母细胞生发泡破裂的方法
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
FI2753632T3 (fi) 2011-09-08 2023-08-02 Sage Therapeutics Inc Neuroaktiivisia steroideja, koostumuksia ja niiden käyttöjä
RS67266B1 (sr) 2013-03-13 2025-10-31 Sage Therapeutics Inc Neuroaktivni steroidi i postupci za njihovu upotrebu
AU2014369916A1 (en) 2013-12-24 2016-06-16 Durect Corporation Uses of oxygenated cholesterol sulfates (OCS)
ES2970222T3 (es) 2014-06-18 2024-05-27 Sage Therapeutics Inc Oxiesteroles y procedimientos de uso de los mismos
EA024619B1 (ru) * 2014-11-21 2016-10-31 Эльвин Гаджи оглы Керимли ФРАКСИНОСТЕРИН - 24β-ЭТИЛХОЛЕСТА-20-КАРБОКСИ-6(7),8(9)-ДИЕН 3β-ОЛА И ЕГО ПРОИЗВОДНОЕ
FI3828194T3 (fi) 2015-07-06 2025-07-17 Sage Therapeutics Inc Oxysteroleita ja menetelmiä niiden käyttämiseksi
MX390271B (es) 2015-07-06 2025-03-20 Sage Therapeutics Inc Oxiesteroles y metodos de uso de los mismos
MA42409A (fr) 2015-07-06 2018-05-16 Sage Therapeutics Inc Oxystérols et leurs procédés d'utilisation
US20190330259A1 (en) 2016-04-01 2019-10-31 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
LT3481846T (lt) 2016-07-07 2021-08-25 Sage Therapeutics, Inc. 11-pakeistieji 24-hidroksisteroliai, skirti naudoti gydant su nmda susijusias būkles
PT3494125T (pt) 2016-08-02 2022-07-07 Durect Corp Composições compreendendo 5-colesten-3, 25-diol, 3-sulfato (25hc3s), ou seu sal farmaceuticamente aceitável, e, pelo menos, um oligossacárido cíclico
JP7149266B2 (ja) 2016-09-30 2022-10-06 セージ セラピューティクス， インコーポレイテッド Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
MA46566A (fr) 2016-10-18 2019-08-28 Sage Therapeutics Inc Oxystérols et leurs procédés d'utilisation
IL293231B2 (en) 2016-10-18 2025-10-01 Sage Therapeutics Inc Oxysterols and methods of use thereof
CN112430251A (zh) * 2020-11-23 2021-03-02 广州瀚信通信科技股份有限公司 一种治疗白内障的化合物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716777A (en) * 1994-06-23 1998-02-10 Novo Nordisk A/S Regulation of meiosis using sterols

Also Published As

Publication number Publication date
CZ408097A3 (cs) 1998-06-17
BR9608968A (pt) 1999-06-29
AR003441A1 (es) 1998-08-05
PL185622B1 (pl) 2003-06-30
WO1997000884A1 (en) 1997-01-09
NO976044L (no) 1998-02-20
CA2224866A1 (en) 1997-01-09
MX9800123A (es) 1998-03-29
RU2182909C2 (ru) 2002-05-27
IL122609A0 (en) 1998-08-16
EP0857173B1 (de) 2003-11-19
AU718246B2 (en) 2000-04-13
AU6122796A (en) 1997-01-22
EP0857173A1 (de) 1998-08-12
DE69630802T2 (de) 2004-08-12
JPH11507929A (ja) 1999-07-13
DE69630802D1 (de) 2003-12-24
KR19990028366A (ko) 1999-04-15
CN1191543A (zh) 1998-08-26
TW474943B (en) 2002-02-01
NO976044D0 (no) 1997-12-22
NO314231B1 (no) 2003-02-17
PL324219A1 (en) 1998-05-11
HUP9900454A3 (en) 1999-11-29
HUP9900454A2 (hu) 1999-06-28

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties