ATE254628T1 - Meiose regulierende verbindungen. - Google Patents

Meiose regulierende verbindungen.

Info

Publication number
ATE254628T1
ATE254628T1 AT96918629T AT96918629T ATE254628T1 AT E254628 T1 ATE254628 T1 AT E254628T1 AT 96918629 T AT96918629 T AT 96918629T AT 96918629 T AT96918629 T AT 96918629T AT E254628 T1 ATE254628 T1 AT E254628T1
Authority
AT
Austria
Prior art keywords
meiosis regulating
regulating connections
connections
meiosis
regulating
Prior art date
Application number
AT96918629T
Other languages
English (en)
Inventor
Frederik Christian Groenvald
Peter Faarup
Erling Guddal
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE254628T1 publication Critical patent/ATE254628T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT96918629T 1995-06-23 1996-06-21 Meiose regulierende verbindungen. ATE254628T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK73095 1995-06-23
DK72895 1995-06-23
DK146195 1995-12-22
PCT/DK1996/000273 WO1997000884A1 (en) 1995-06-23 1996-06-21 Meiosis regulating compounds

Publications (1)

Publication Number Publication Date
ATE254628T1 true ATE254628T1 (de) 2003-12-15

Family

ID=27220892

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96918629T ATE254628T1 (de) 1995-06-23 1996-06-21 Meiose regulierende verbindungen.

Country Status (18)

Country Link
EP (1) EP0857173B1 (de)
JP (1) JPH11507929A (de)
KR (1) KR19990028366A (de)
CN (1) CN1191543A (de)
AR (1) AR003441A1 (de)
AT (1) ATE254628T1 (de)
AU (1) AU718246B2 (de)
BR (1) BR9608968A (de)
CA (1) CA2224866A1 (de)
CZ (1) CZ408097A3 (de)
DE (1) DE69630802T2 (de)
HU (1) HUP9900454A3 (de)
IL (1) IL122609A0 (de)
NO (1) NO314231B1 (de)
PL (1) PL185622B1 (de)
RU (1) RU2182909C2 (de)
TW (1) TW474943B (de)
WO (1) WO1997000884A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL337008A1 (en) * 1997-05-16 2000-07-31 Akzo Nobel Nv Derivatives of 20-aralkyl-5alpha-pregnane
DE69804611T2 (de) 1997-06-04 2002-10-02 Akzo Nobel N.V., Arnheim/Arnhem 17-beta.-allyloxy(thio)alkyl-androstan derivative zur modulation von meiose
ES2181321T3 (es) * 1997-12-18 2003-02-16 Akzo Nobel Nv Derivados 17beta-aril(arilmetil)oxi(tio)alquilandrostano.
EP0957108A1 (de) * 1998-05-14 1999-11-17 Schering Aktiengesellschaft Ungesättigte Cholestan-derivate zur Regulierung von Meiose und pharmazeutische Präparate davon
IL139241A0 (en) 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds
KR20010053031A (ko) * 1998-06-19 2001-06-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
ATE225366T1 (de) 1998-12-11 2002-10-15 Akzo Nobel Nv 22s-hydroxycholesta-8,14-dien derivate mit meiose regulierende aktivität
WO2000036132A1 (en) * 1998-12-14 2000-06-22 Merck & Co., Inc. Hiv integrase inhibitors
CZ20012866A3 (cs) * 1999-02-10 2002-01-16 Schering Aktiengesellschaft Nenasycené cholestanové deriváty, farmaceutické kompozice obsahující tyto deriváty a pouľití těchto derivátů pro přípravu léčiv regulujících meiozu
EP1156822B1 (de) * 1999-02-24 2006-02-08 Novo Nordisk A/S In vitro methode zur synchronisation von oozytenreifung
CZ20012968A3 (cs) 1999-02-24 2002-01-16 Novo Nordisk A/S Léčení neplodnosti
ATE306942T1 (de) 1999-09-16 2005-11-15 Novo Nordisk As Zusammensetzung zur in-vitro befruchtung
EP1127890A1 (de) 2000-02-22 2001-08-29 Schering Aktiengesellschaft Steroid Derivate mit einem an Ring A des Steroidgerüstes kondensierten Ring zur Regulierung der Meiose
MXPA02007818A (es) * 2000-02-25 2002-10-23 Schering Ag Tasa de implantacion mejorada utilizando ff-mas.
EP1245572A1 (de) 2001-03-26 2002-10-02 Schering Aktiengesellschaft Aminosterol-Verbindungen, ihre Verwendung zur Herstellung Meiose-regulierender Medikamenten und ein Vefahren zu ihrer Herstellung
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
FR2898272B1 (fr) * 2006-03-09 2008-07-04 Trophos Sa Utilisation de derives du 3,5-seco-4-nor-cholestrane pour l'obtention d'un medicament cytoprotecteur
CN102258004B (zh) * 2010-05-27 2013-07-17 中国科学院动物研究所 一种体外保存/培养卵母细胞以抑制卵母细胞生发泡破裂的方法
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
RS64332B1 (sr) 2011-09-08 2023-08-31 Sage Therapeutics Inc Neuroaktivni steroidi, kompozicije i njihova upotreba
DK3461834T3 (da) 2013-03-13 2021-08-23 Sage Therapeutics Inc Neuroaktive steroider
WO2015100312A1 (en) 2013-12-24 2015-07-02 Virginia Commonwealth University Uses of oxygenated cholesterol sulfates (ocs)
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EA024619B1 (ru) * 2014-11-21 2016-10-31 Эльвин Гаджи оглы Керимли ФРАКСИНОСТЕРИН - 24β-ЭТИЛХОЛЕСТА-20-КАРБОКСИ-6(7),8(9)-ДИЕН 3β-ОЛА И ЕГО ПРОИЗВОДНОЕ
MD3319612T2 (ro) 2015-07-06 2021-10-31 Sage Therapeutics Inc Oxisteroli și metode de utilizare a acestora
KR102703602B1 (ko) 2015-07-06 2024-09-06 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
JP6882996B2 (ja) 2015-07-06 2021-06-02 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびそれらの使用の方法
HRP20220716T1 (hr) 2016-04-01 2022-09-02 Sage Therapeutics, Inc. Oksisteroli i postupci za njihovu uporabu
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
RS62222B1 (sr) 2016-07-07 2021-09-30 Sage Therapeutics Inc 24-hidroksisteroli supstituisani na poziciji 11 za upotrebu u lečenju stanja povezanih sa nmda
EA201990438A1 (ru) 2016-08-02 2019-08-30 Вирджиния Коммонвелт Юниверсити Композиции, содержащие 5-холестен-3,25-диол, 3-сульфат (25hc3s) или его фармацевтически приемлемую соль и по меньшей мере один циклический олигосахарид, и способы их применения
PT3519422T (pt) 2016-09-30 2022-12-05 Sage Therapeutics Inc Oxisteróis substituídos em c7 e métodos como moduladores nmda
KR20250054838A (ko) 2016-10-18 2025-04-23 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
KR102583278B1 (ko) 2016-10-18 2023-09-27 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
CN112430251A (zh) * 2020-11-23 2021-03-02 广州瀚信通信科技股份有限公司 一种治疗白内障的化合物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716777A (en) * 1994-06-23 1998-02-10 Novo Nordisk A/S Regulation of meiosis using sterols

Also Published As

Publication number Publication date
DE69630802T2 (de) 2004-08-12
EP0857173B1 (de) 2003-11-19
HUP9900454A3 (en) 1999-11-29
PL324219A1 (en) 1998-05-11
HUP9900454A2 (hu) 1999-06-28
CA2224866A1 (en) 1997-01-09
MX9800123A (es) 1998-03-29
WO1997000884A1 (en) 1997-01-09
CZ408097A3 (cs) 1998-06-17
IL122609A0 (en) 1998-08-16
PL185622B1 (pl) 2003-06-30
NO976044D0 (no) 1997-12-22
NO976044L (no) 1998-02-20
BR9608968A (pt) 1999-06-29
AU718246B2 (en) 2000-04-13
NO314231B1 (no) 2003-02-17
KR19990028366A (ko) 1999-04-15
TW474943B (en) 2002-02-01
AU6122796A (en) 1997-01-22
JPH11507929A (ja) 1999-07-13
CN1191543A (zh) 1998-08-26
DE69630802D1 (de) 2003-12-24
EP0857173A1 (de) 1998-08-12
RU2182909C2 (ru) 2002-05-27
AR003441A1 (es) 1998-08-05

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