ATE261966T1 - Wasserfreie mirtazapin-kristalle und ein verfahren zu ihrer herstellung - Google Patents

Wasserfreie mirtazapin-kristalle und ein verfahren zu ihrer herstellung

Info

Publication number: ATE261966T1
Authority: AT; Austria
Prior art keywords: crystals; anhydrous mirtazapine; mirtazapine crystals; production; anhydrous
Prior art date: 1999-11-24

Application number

AT00962908T

Other languages

English (en)

Inventor

Eiichi Iishi

Yoshiyuki Imamiya

Original Assignee

Sumika Fine Chemicals Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-24

Filing date

2000-09-28

Publication date

2004-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26574376&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE261966(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-09-28 Application filed by Sumika Fine Chemicals Co Ltd filed Critical Sumika Fine Chemicals Co Ltd

2004-04-15 Application granted granted Critical

2004-04-15 Publication of ATE261966T1 publication Critical patent/ATE261966T1/de

Links

239000013078 crystal Substances 0.000 title abstract 6
238000004519 manufacturing process Methods 0.000 title abstract 4
229960001785 mirtazapine Drugs 0.000 title abstract 4
RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
MHSHMTBXVDLHCQ-UHFFFAOYSA-N mirtazapine hydrate Chemical compound O.C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 MHSHMTBXVDLHCQ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT00962908T 1999-11-24 2000-09-28 Wasserfreie mirtazapin-kristalle und ein verfahren zu ihrer herstellung ATE261966T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP33304999		1999-11-24
JP2000067476		2000-03-10
PCT/JP2000/004835 WO2001038329A1 (en)	1999-11-24	2000-07-19	Anhydrous mirtazapine crystals and process for producing the same
PCT/JP2000/006687 WO2001038330A1 (en)	1999-11-24	2000-09-28	Anhydrous mirtazapine crystals and process for the production thereof

Publications (1)

Publication Number	Publication Date
ATE261966T1 true ATE261966T1 (de)	2004-04-15

Family

ID=26574376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00962908T ATE261966T1 (de)	1999-11-24	2000-09-28	Wasserfreie mirtazapin-kristalle und ein verfahren zu ihrer herstellung

Country Status (11)

Country	Link
US (3)	US6552189B2 (de)
EP (1)	EP1225174B2 (de)
JP (1)	JP3699680B2 (de)
AT (1)	ATE261966T1 (de)
AU (2)	AU6019900A (de)
CA (1)	CA2370376C (de)
DE (1)	DE60009117T2 (de)
DK (1)	DK1225174T3 (de)
ES (1)	ES2214318T5 (de)
PT (1)	PT1225174E (de)
WO (2)	WO2001038329A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6019900A (en) *	1999-11-24	2001-06-04	Sumika Fine Chemicals Co., Ltd.	Anhydrous mirtazapine crystals and process for producing the same
US7838029B1 (en)	2003-07-31	2010-11-23	Watson Laboratories, Inc.	Mirtazapine solid dosage forms
EP1689371A2 (de) *	2003-11-25	2006-08-16	Aurobindo Pharma Limited	Pharmazeutische zusammensetzung mirtazapine enthaltend
EP1688410B1 (de)	2003-11-27	2014-03-05	Ajinomoto Co., Inc.	Kristall eines phenylalaninderivats und verfahren zu dessen herstellung
WO2006023703A2 (en) *	2004-08-20	2006-03-02	Cypress Bioscience, Inc.	Method for treating sleep related breathing disorders
JP5192707B2 (ja) *	2007-03-22	2013-05-08	住友化学株式会社	ミルタザピンの製造方法
CA2682924A1 (en) *	2007-04-05	2008-10-16	Akzo Nobel N.V.	Process for improving optical properties of paper
KR101662186B1 (ko) *	2007-11-02	2016-10-04	애크럭스 디디에스 피티와이 리미티드	경피 전달 시스템
CN103520169B (zh) *	2013-10-25	2015-07-15	山东鲁药制药有限公司	米氮平片及其制备方法
JP6876003B2 (ja)	2015-02-27	2021-05-26	デクラリミテッド	イヌ及びネコにおける、食欲の刺激、体重減少の管理、及び拒食症の処置
JP6452575B2 (ja) *	2015-08-19	2019-01-16	株式会社トクヤマ	ミルタザピンの製造方法
JP2017088564A (ja) *	2015-11-13	2017-05-25	株式会社トクヤマ	ミルタザピンの製造方法
JP6571497B2 (ja) *	2015-11-13	2019-09-04	株式会社トクヤマ	ミルタザピンの製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL189199C (nl) *	1975-04-05	1993-02-01	Akzo Nv	Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
US4524146A (en) *	1982-12-08	1985-06-18	Ciba-Geigy Corporation	Certain -2-heterocycle substituted pyrazoloquinolines
NZ230711A (en) *	1988-09-23	1990-10-26	Ortho Pharma Corp	Substituted thienopyrans as antihypertensive agents
US5354763A (en) *	1993-11-17	1994-10-11	American Home Products Corporation	Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5468768A (en) *	1994-01-06	1995-11-21	Bristol-Myers Squibb Company	Antimigraine derivatives of indolylcycloalkanylamines
JPH07247286A (ja) *	1994-01-18	1995-09-26	Sankyo Co Ltd	含窒素環状化合物の光学分割方法
TR200103028T2 (tr) *	1999-04-19	2002-01-21	Teva Pharmaceutical Industries Ltd.	Piperazin halka içeren bileşiklerin yeni sentezi ve kristalleştirilmesi
US6545149B2 (en)	1999-04-19	2003-04-08	Teva Pharmaceutical Industries Ltd.	Synthesis and crystallization of piperazine ring-containing compounds
AU6019900A (en) *	1999-11-24	2001-06-04	Sumika Fine Chemicals Co., Ltd.	Anhydrous mirtazapine crystals and process for producing the same
US20020072602A1 (en)	2000-07-07	2002-06-13	Claude Singer	Micronized mirtazapine
US6660730B2 (en) *	2000-11-27	2003-12-09	Sumika Fine Chemicals Co., Ltd.	Anhydrous mirtazapine and process for preparing the same

2000
- 2000-07-19 AU AU60199/00A patent/AU6019900A/en not_active Abandoned
- 2000-07-19 WO PCT/JP2000/004835 patent/WO2001038329A1/ja not_active Ceased
- 2000-09-28 AU AU74471/00A patent/AU763502B2/en not_active Ceased
- 2000-09-28 ES ES00962908T patent/ES2214318T5/es not_active Expired - Lifetime
- 2000-09-28 JP JP2001540093A patent/JP3699680B2/ja not_active Expired - Lifetime
- 2000-09-28 PT PT00962908T patent/PT1225174E/pt unknown
- 2000-09-28 AT AT00962908T patent/ATE261966T1/de not_active IP Right Cessation
- 2000-09-28 EP EP00962908A patent/EP1225174B2/de not_active Expired - Lifetime
- 2000-09-28 DK DK00962908T patent/DK1225174T3/da active
- 2000-09-28 CA CA002370376A patent/CA2370376C/en not_active Expired - Fee Related
- 2000-09-28 DE DE60009117T patent/DE60009117T2/de not_active Expired - Lifetime
- 2000-09-28 WO PCT/JP2000/006687 patent/WO2001038330A1/ja not_active Ceased
2002
- 2002-01-10 US US10/041,495 patent/US6552189B2/en not_active Expired - Fee Related
2003
- 2003-01-07 US US10/337,277 patent/US6723845B2/en not_active Expired - Fee Related
- 2003-12-24 US US10/743,740 patent/US7297790B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT1225174E (pt)	2004-05-31
EP1225174B2 (de)	2010-06-02
JP3699680B2 (ja)	2005-09-28
AU7447100A (en)	2001-06-04
US20030130504A1 (en)	2003-07-10
ES2214318T3 (es)	2004-09-16
US7297790B2 (en)	2007-11-20
DE60009117D1 (de)	2004-04-22
AU763502B2 (en)	2003-07-24
EP1225174A4 (de)	2002-10-23
CA2370376C (en)	2005-08-02
WO2001038329A1 (en)	2001-05-31
EP1225174B1 (de)	2004-03-17
DK1225174T3 (da)	2004-07-05
DE60009117T2 (de)	2004-10-21
WO2001038330A1 (en)	2001-05-31
EP1225174A1 (de)	2002-07-24
US20020103372A1 (en)	2002-08-01
US6723845B2 (en)	2004-04-20
US20040138447A1 (en)	2004-07-15
US6552189B2 (en)	2003-04-22
CA2370376A1 (en)	2001-05-31
AU6019900A (en)	2001-06-04
ES2214318T5 (es)	2010-10-15

Legal Events

Date

Code

Title

Description

2004-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1225174

Country of ref document: EP

2010-12-15

RER

Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60009117T2 (de)	2004-10-21	Wasserfreie mirtazapin-kristalle und ein verfahren zu ihrer herstellung
ATE95519T1 (de)	1993-10-15	4h-1-benzopyran-4-on-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE10333239A1 (de)	2005-03-10	Verfahren zur Herstellung von gereinigten 1,3- substituierten Imidazoliumsalzen
ATE544744T1 (de)	2012-02-15	Verfahren zur herstellung von benzoesaure derivaten
ATE242241T1 (de)	2003-06-15	Imidazopyridinderivate und verfahren zu ihrer herstellung
ATE440817T1 (de)	2009-09-15	Bicalutamidkristalle und verfahren zu deren herstellung
ATE190972T1 (de)	2000-04-15	Verfahren zur herstellung von antimikrobiellen verbindungen
CA2221946A1 (en)	1996-11-28	Production process of cyclic compound
ATE140213T1 (de)	1996-07-15	N-monosubstituierte cyclopentenylamine, ein verfahren zu ihrer herstellung, und ihre verwendung als medikament
EP1433832A4 (de)	2006-01-11	Phosphorhaltige carbonsäurederivate, verfahren zu deren herstellung sowie flammschutzmittel
EP0710652A3 (de)	1996-10-09	Verfahren zur Herstellung von optisch aktiven Piperazinderivaten und Zwischenprodukten für ihre Herstellung
DE69937988D1 (de)	2008-03-06	Verfahren zur herstellung von 3-cephemderivaten
CA2245080A1 (en)	1999-02-19	Process for the preparation of heteroarylcarboxylic amides and esters
DE69113851D1 (de)	1995-11-23	Verfahren zur Herstellung von optisch aktiven Norbornylaminderivaten.
DE602004020050D1 (de)	2009-04-30	Verfahren zur herstellung substituierter imidazolderivate und in dem verfahren verwendete zwischenprodukte
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