ATE258916T1 - Ungesättigte hydroximsäurederivate als parp inhibitoren - Google Patents

Ungesättigte hydroximsäurederivate als parp inhibitoren

Info

Publication number
ATE258916T1
ATE258916T1 AT99944721T AT99944721T ATE258916T1 AT E258916 T1 ATE258916 T1 AT E258916T1 AT 99944721 T AT99944721 T AT 99944721T AT 99944721 T AT99944721 T AT 99944721T AT E258916 T1 ATE258916 T1 AT E258916T1
Authority
AT
Austria
Prior art keywords
acid derivatives
hydroximic acid
parp inhibitors
unsaturated hydroximic
treatment
Prior art date
Application number
AT99944721T
Other languages
English (en)
Inventor
Nagy Peter Literati
Balazs Suemegi
Cs Kalman Tak
Original Assignee
Gene Kutato Kft N
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9802001A external-priority patent/HU9802001D0/hu
Priority claimed from HU9902927A external-priority patent/HUP9902927A3/hu
Application filed by Gene Kutato Kft N filed Critical Gene Kutato Kft N
Application granted granted Critical
Publication of ATE258916T1 publication Critical patent/ATE258916T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/50Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/58Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT99944721T 1998-09-03 1999-09-02 Ungesättigte hydroximsäurederivate als parp inhibitoren ATE258916T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU9802001A HU9802001D0 (en) 1998-09-03 1998-09-03 New unsaturated hydroximic acid derivatives, process for producing them, and pharmaceutical compositions containing them
HU9902927A HUP9902927A3 (en) 1999-08-31 1999-08-31 New unsaturated hydroxym-acid-derivatives, process for their production and medicaments containing them
PCT/HU1999/000062 WO2000014054A1 (en) 1998-09-03 1999-09-02 Unsaturated hydroximic acid derivatives as parp inhibitors

Publications (1)

Publication Number Publication Date
ATE258916T1 true ATE258916T1 (de) 2004-02-15

Family

ID=89999161

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99944721T ATE258916T1 (de) 1998-09-03 1999-09-02 Ungesättigte hydroximsäurederivate als parp inhibitoren

Country Status (24)

Country Link
US (1) US6500823B1 (de)
EP (1) EP1115697B1 (de)
JP (1) JP2002524439A (de)
KR (1) KR100632522B1 (de)
CN (1) CN1211353C (de)
AT (1) ATE258916T1 (de)
AU (1) AU771782B2 (de)
BR (1) BR9913425A (de)
CA (1) CA2342898A1 (de)
CZ (1) CZ2001705A3 (de)
DE (1) DE69914614T2 (de)
DK (1) DK1115697T3 (de)
ES (1) ES2215400T3 (de)
IL (2) IL141756A0 (de)
MX (1) MXPA01002315A (de)
NO (1) NO20011091L (de)
NZ (1) NZ510933A (de)
PL (1) PL194275B1 (de)
PT (1) PT1115697E (de)
RU (1) RU2220953C2 (de)
SK (1) SK2532001A3 (de)
TR (1) TR200100645T2 (de)
UA (1) UA65635C2 (de)
WO (1) WO2000014054A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU783393B2 (en) * 2000-03-20 2005-10-20 N-Gene Research Laboratories Inc. Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same
EP1408966B1 (de) 2001-07-17 2008-02-20 N-Gene Research Laboratories Inc. Synergistische pharmazeutische zusammensetzungen zur behandlung bzw. prophylaxe von diabetes
WO2005023246A1 (en) * 2003-09-04 2005-03-17 Aventis Pharmaceuticals Inc. Substituted indoles as inhibitors of poly (adp-ribose) polymerase (parp)
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
JP2008505176A (ja) * 2004-06-30 2008-02-21 コンビナトアールエックス インコーポレーティッド 代謝障害を治療するための方法および試薬
US20080262062A1 (en) * 2006-11-20 2008-10-23 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US7763601B2 (en) * 2006-11-02 2010-07-27 N-Gene Research Laboratories, Inc. Prevention and treatment of obesity
WO2018022851A1 (en) 2016-07-28 2018-02-01 Mitobridge, Inc. Methods of treating acute kidney injury
RU2019114863A (ru) 2016-11-02 2020-12-03 Иммуноджен, Инк. Комбинированное лечение конъюгатами антитело-лекарственное средство и ингибиторами parp
KR20230128462A (ko) 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정
CN113354557B (zh) * 2021-06-07 2022-06-28 大连理工大学 一种3-苯基-2-丙烯-1-酮o-正丁基肟的制备方法及应用
WO2023053008A1 (en) * 2021-09-28 2023-04-06 Kempharm Denmark A/S Oximes and their use in treatment of gba-related diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308399A (en) * 1977-08-30 1981-12-29 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU188250B (en) * 1983-02-08 1986-03-28 Egyt Gyogyszervegyeszeti Gyar,Hu Process for producing of basical oxim-ethers
HUT54347A (en) 1989-01-10 1991-02-28 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoximes
HU213421B (en) * 1993-04-09 1997-06-30 Egyt Gyogyszervegyeszeti Gyar New basic ethers, pharmaceutical compns. containing the said compds. and process for prepg. them
EP0841924B1 (de) 1995-08-02 2002-10-02 Newcastle University Ventures Limited Benzimidazol verbindungen
DE19756236A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide

Also Published As

Publication number Publication date
PL194275B1 (pl) 2007-05-31
RU2220953C2 (ru) 2004-01-10
IL141756A (en) 2006-08-01
US6500823B1 (en) 2002-12-31
KR100632522B1 (ko) 2006-10-09
EP1115697A1 (de) 2001-07-18
DE69914614D1 (de) 2004-03-11
CN1322193A (zh) 2001-11-14
ES2215400T3 (es) 2004-10-01
EP1115697B1 (de) 2004-02-04
DK1115697T3 (da) 2004-06-07
MXPA01002315A (es) 2002-05-08
PL346547A1 (en) 2002-02-11
AU771782B2 (en) 2004-04-01
NZ510933A (en) 2003-01-31
DE69914614T2 (de) 2005-01-05
BR9913425A (pt) 2001-11-27
JP2002524439A (ja) 2002-08-06
NO20011091D0 (no) 2001-03-02
CA2342898A1 (en) 2000-03-16
SK2532001A3 (en) 2001-08-06
HK1040700A1 (en) 2002-06-21
UA65635C2 (uk) 2004-04-15
IL141756A0 (en) 2002-03-10
KR20010085760A (ko) 2001-09-07
WO2000014054A1 (en) 2000-03-16
CZ2001705A3 (cs) 2001-08-15
NO20011091L (no) 2001-05-02
TR200100645T2 (tr) 2001-06-21
CN1211353C (zh) 2005-07-20
PT1115697E (pt) 2004-06-30
AU5753799A (en) 2000-03-27

Similar Documents

Publication Publication Date Title
SG47517A1 (en) (1-92-oxo-acetyl)-piperidine-2-carboxylic acid derivatives as multi-drug-resistant cancer cell sensitizers
TR200302242T2 (tr) Protein kinaz önleyicileri olarak pirolopirimidinler
MA27305A1 (fr) Derives de 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene et leur utilisation en tant qu'inhibiteurs de renine dans le traitement de l'hypertension, de maladies cardiovasculaires ou renales
DK0430045T3 (da) Ascorbinsyretocopherylphosphatdiestere til hæmning af Maillards reaktion
ATE448194T1 (de) Verwendung einer pharmazeutischen zusammensetzung mit einem para-aminophenylessigsäurederivat für die behandlung von entzündlichen erkrankungen des magen-darmtrakts
AR027533A1 (es) Derivados de acido malonico, procesos para su preparacion, su uso y composiciones farmaceuticas que los contienen
ATE258916T1 (de) Ungesättigte hydroximsäurederivate als parp inhibitoren
CA2370692A1 (en) Antitumor derivative of double dicarboxylic acid diaminoplatin complex, process for the preparing thereof, the pharmaceutical composition containing the same and application of the derivative
MY128014A (en) Thiol and thiocarbonyl derivatives which are useful as carboxypeptidase u inhibitors
AU5764496A (en) Cyclohexyl dihydrobenzofuranes
RU94038256A (ru) Производные пиразолопиримидина, способ их получения, фармацевтические композиции на их основе
IL163951A (en) Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them
ES2001703A6 (es) Procedimiento para la preparracion de derrrivados de acidos 2-(2-imidazolin -2-il)- piridin -3- carboxilicos.
TR199801229T2 (xx) ''Metalopeptidaz inhibisyon aktivitesini havi tiol t�revleri
AU530678B2 (en) Phosphono-hydroxy-acetic acid
BRPI0409683A (pt) 5-hidroxiindóis com grupos n-óxido e seu emprego como agentes terapêuticos
TW200505916A (en) 7-azaindoles and the use thereof as therapeutic agents
ATE179424T1 (de) N-heteroaryl substituierte propanamid-derivate brauchbar zur behandlung cardiovascularer krankheiten
YU119491A (sh) Novi protivirusni tetrahidroimidazo [1,4] benzodiazepin-2-(ti)oni i postupak njihovog dobijanja
IL83088A (en) Substituted 3-isoquinolinols,their preparation and pharmaceutical compositions containing them
ITMI950132A1 (it) Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
ATE26271T1 (de) Benzhydrylpiperazine-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DK162440C (da) Pyrazindiazohydroxidforbindelser
UA85195C2 (ru) Амидометилзамещенные производные 1-(карбоксиалкил)-циклопентилкарбониламинобензазепин-n-уксусной кислоты, способ их получения, промежуточное соединение и фармацевтическая композиции на их основе
MX9805168A (es) Derivados de tiol con actividad inhibitoria de la metalopeptidasa (ace-nep).

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1115697

Country of ref document: EP

REN Ceased due to non-payment of the annual fee