ATE258916T1 - Ungesättigte hydroximsäurederivate als parp inhibitoren - Google Patents
Ungesättigte hydroximsäurederivate als parp inhibitorenInfo
- Publication number
- ATE258916T1 ATE258916T1 AT99944721T AT99944721T ATE258916T1 AT E258916 T1 ATE258916 T1 AT E258916T1 AT 99944721 T AT99944721 T AT 99944721T AT 99944721 T AT99944721 T AT 99944721T AT E258916 T1 ATE258916 T1 AT E258916T1
- Authority
- AT
- Austria
- Prior art keywords
- acid derivatives
- hydroximic acid
- parp inhibitors
- unsaturated hydroximic
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9802001A HU9802001D0 (en) | 1998-09-03 | 1998-09-03 | New unsaturated hydroximic acid derivatives, process for producing them, and pharmaceutical compositions containing them |
| HU9902927A HUP9902927A3 (en) | 1999-08-31 | 1999-08-31 | New unsaturated hydroxym-acid-derivatives, process for their production and medicaments containing them |
| PCT/HU1999/000062 WO2000014054A1 (en) | 1998-09-03 | 1999-09-02 | Unsaturated hydroximic acid derivatives as parp inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE258916T1 true ATE258916T1 (de) | 2004-02-15 |
Family
ID=89999161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99944721T ATE258916T1 (de) | 1998-09-03 | 1999-09-02 | Ungesättigte hydroximsäurederivate als parp inhibitoren |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6500823B1 (de) |
| EP (1) | EP1115697B1 (de) |
| JP (1) | JP2002524439A (de) |
| KR (1) | KR100632522B1 (de) |
| CN (1) | CN1211353C (de) |
| AT (1) | ATE258916T1 (de) |
| AU (1) | AU771782B2 (de) |
| BR (1) | BR9913425A (de) |
| CA (1) | CA2342898A1 (de) |
| CZ (1) | CZ2001705A3 (de) |
| DE (1) | DE69914614T2 (de) |
| DK (1) | DK1115697T3 (de) |
| ES (1) | ES2215400T3 (de) |
| IL (2) | IL141756A0 (de) |
| MX (1) | MXPA01002315A (de) |
| NO (1) | NO20011091L (de) |
| NZ (1) | NZ510933A (de) |
| PL (1) | PL194275B1 (de) |
| PT (1) | PT1115697E (de) |
| RU (1) | RU2220953C2 (de) |
| SK (1) | SK2532001A3 (de) |
| TR (1) | TR200100645T2 (de) |
| UA (1) | UA65635C2 (de) |
| WO (1) | WO2000014054A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU783393B2 (en) * | 2000-03-20 | 2005-10-20 | N-Gene Research Laboratories Inc. | Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same |
| EP1408966B1 (de) | 2001-07-17 | 2008-02-20 | N-Gene Research Laboratories Inc. | Synergistische pharmazeutische zusammensetzungen zur behandlung bzw. prophylaxe von diabetes |
| WO2005023246A1 (en) * | 2003-09-04 | 2005-03-17 | Aventis Pharmaceuticals Inc. | Substituted indoles as inhibitors of poly (adp-ribose) polymerase (parp) |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| JP2008505176A (ja) * | 2004-06-30 | 2008-02-21 | コンビナトアールエックス インコーポレーティッド | 代謝障害を治療するための方法および試薬 |
| US20080262062A1 (en) * | 2006-11-20 | 2008-10-23 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
| US7763601B2 (en) * | 2006-11-02 | 2010-07-27 | N-Gene Research Laboratories, Inc. | Prevention and treatment of obesity |
| WO2018022851A1 (en) | 2016-07-28 | 2018-02-01 | Mitobridge, Inc. | Methods of treating acute kidney injury |
| RU2019114863A (ru) | 2016-11-02 | 2020-12-03 | Иммуноджен, Инк. | Комбинированное лечение конъюгатами антитело-лекарственное средство и ингибиторами parp |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
| CN113354557B (zh) * | 2021-06-07 | 2022-06-28 | 大连理工大学 | 一种3-苯基-2-丙烯-1-酮o-正丁基肟的制备方法及应用 |
| WO2023053008A1 (en) * | 2021-09-28 | 2023-04-06 | Kempharm Denmark A/S | Oximes and their use in treatment of gba-related diseases |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4308399A (en) * | 1977-08-30 | 1981-12-29 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| HU188250B (en) * | 1983-02-08 | 1986-03-28 | Egyt Gyogyszervegyeszeti Gyar,Hu | Process for producing of basical oxim-ethers |
| HUT54347A (en) | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
| HU213421B (en) * | 1993-04-09 | 1997-06-30 | Egyt Gyogyszervegyeszeti Gyar | New basic ethers, pharmaceutical compns. containing the said compds. and process for prepg. them |
| EP0841924B1 (de) | 1995-08-02 | 2002-10-02 | Newcastle University Ventures Limited | Benzimidazol verbindungen |
| DE19756236A1 (de) | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide |
-
1999
- 1999-02-09 UA UA2001042147A patent/UA65635C2/uk unknown
- 1999-09-02 US US09/786,200 patent/US6500823B1/en not_active Expired - Fee Related
- 1999-09-02 CA CA002342898A patent/CA2342898A1/en not_active Abandoned
- 1999-09-02 AU AU57537/99A patent/AU771782B2/en not_active Ceased
- 1999-09-02 KR KR1020017002835A patent/KR100632522B1/ko not_active Expired - Fee Related
- 1999-09-02 PT PT99944721T patent/PT1115697E/pt unknown
- 1999-09-02 CZ CZ2001705A patent/CZ2001705A3/cs unknown
- 1999-09-02 TR TR2001/00645T patent/TR200100645T2/xx unknown
- 1999-09-02 CN CNB998117358A patent/CN1211353C/zh not_active Expired - Fee Related
- 1999-09-02 WO PCT/HU1999/000062 patent/WO2000014054A1/en not_active Ceased
- 1999-09-02 IL IL14175699A patent/IL141756A0/xx active IP Right Grant
- 1999-09-02 BR BR9913425-0A patent/BR9913425A/pt not_active Application Discontinuation
- 1999-09-02 MX MXPA01002315A patent/MXPA01002315A/es not_active IP Right Cessation
- 1999-09-02 DE DE69914614T patent/DE69914614T2/de not_active Expired - Fee Related
- 1999-09-02 EP EP99944721A patent/EP1115697B1/de not_active Expired - Lifetime
- 1999-09-02 AT AT99944721T patent/ATE258916T1/de not_active IP Right Cessation
- 1999-09-02 DK DK99944721T patent/DK1115697T3/da active
- 1999-09-02 NZ NZ510933A patent/NZ510933A/xx unknown
- 1999-09-02 RU RU2001109228/04A patent/RU2220953C2/ru not_active IP Right Cessation
- 1999-09-02 SK SK253-2001A patent/SK2532001A3/sk unknown
- 1999-09-02 PL PL99346547A patent/PL194275B1/pl unknown
- 1999-09-02 JP JP2000568814A patent/JP2002524439A/ja active Pending
- 1999-09-02 ES ES99944721T patent/ES2215400T3/es not_active Expired - Lifetime
-
2001
- 2001-03-01 IL IL141756A patent/IL141756A/en not_active IP Right Cessation
- 2001-03-02 NO NO20011091A patent/NO20011091L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL194275B1 (pl) | 2007-05-31 |
| RU2220953C2 (ru) | 2004-01-10 |
| IL141756A (en) | 2006-08-01 |
| US6500823B1 (en) | 2002-12-31 |
| KR100632522B1 (ko) | 2006-10-09 |
| EP1115697A1 (de) | 2001-07-18 |
| DE69914614D1 (de) | 2004-03-11 |
| CN1322193A (zh) | 2001-11-14 |
| ES2215400T3 (es) | 2004-10-01 |
| EP1115697B1 (de) | 2004-02-04 |
| DK1115697T3 (da) | 2004-06-07 |
| MXPA01002315A (es) | 2002-05-08 |
| PL346547A1 (en) | 2002-02-11 |
| AU771782B2 (en) | 2004-04-01 |
| NZ510933A (en) | 2003-01-31 |
| DE69914614T2 (de) | 2005-01-05 |
| BR9913425A (pt) | 2001-11-27 |
| JP2002524439A (ja) | 2002-08-06 |
| NO20011091D0 (no) | 2001-03-02 |
| CA2342898A1 (en) | 2000-03-16 |
| SK2532001A3 (en) | 2001-08-06 |
| HK1040700A1 (en) | 2002-06-21 |
| UA65635C2 (uk) | 2004-04-15 |
| IL141756A0 (en) | 2002-03-10 |
| KR20010085760A (ko) | 2001-09-07 |
| WO2000014054A1 (en) | 2000-03-16 |
| CZ2001705A3 (cs) | 2001-08-15 |
| NO20011091L (no) | 2001-05-02 |
| TR200100645T2 (tr) | 2001-06-21 |
| CN1211353C (zh) | 2005-07-20 |
| PT1115697E (pt) | 2004-06-30 |
| AU5753799A (en) | 2000-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1115697 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |